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RUDN University doctors named risk factors for death in brain cyst

RUDN University physicians investigated known cases of sudden death from a colloid cyst. After analyzing the data, the authors named the main risk factors and told what to look for. The results are published in the Journal of Clinical Neuroscience.

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RUDN University physicians investigated known cases of sudden death from a colloid cyst. After analyzing the data, the authors named the main risk factors and told what to look for. The results are published in the Journal of Clinical Neuroscience.

The third ventricle of the brain is a cavity between the visual tubercles filled with cerebrospinal fluid. Sometimes a colloid cyst is formed in it. This is a benign formation, but it can block the opening of Monro, through which the third ventricle communicates with other cavities of the brain. This leads to hydrocephalus, an excess accumulation of cerebrospinal fluid. In extreme cases, acute deterioration can occur, leading to sudden death. Very few such outcomes are known, but it is important to learn how to avoid them. RUDN doctors analyzed the data on all described lethal cases associated with a colloid cyst of the third ventricle.

“Colloid cysts are benign tumors that are found almost exclusively in the third ventricle. It can cause hydrocephalus and, less commonly, acute deterioration and even sudden death. Since there are very few cases of sudden death described in the literature, not much is known about the patients and the characteristics of the cyst in these patients,” Musa Gerald, assistant of the Department of Neurology and Neurosurgery with a comprehensive rehabilitation course at RUDN University.

Doctors managed to find 65 described cases in which the death of a patient occurred with a diagnosed colloid cyst. The authors analyzed the collected data using statistical methods. To find possible relationships, RUDN doctors paid attention to all previous syndromes, the size of the cyst, hemorrhage into the cyst, and demographic indicators.

Of the 65 patients, 38 were men and 27 were women. The mean age was 27.4 and 28.5, respectively. There were no statistically significant differences between men and women in any of the clinical parameters. Most patients have experienced sudden and severe headaches in the past, accompanied by nausea. Almost all (97%) were diagnosed with ventriculomegaly , an abnormal increase in the volume of the ventricles of the brain, on radiological studies. Sudden death in most cases was preceded by hemorrhage into the cyst. The size of the cyst is also likely to play a role – all patients who died had cysts larger than 1 cm in diameter.

“Sudden death in colloid cysts is a rare event whose pathophysiology and risk factors still need to be investigated. All patients with acute headaches accompanied by nausea or vomiting should be carefully evaluated to rule out colloid cysts and other life-threatening conditions. Sudden deterioration and possible death should be discussed with all patients with cysts of all sizes. With a colloid cyst of more than one centimeter, surgical treatment should be recommended regardless of the presence or absence of symptoms,” Musa Gerald , assistant of the Department of Neurology and Neurosurgery with a comprehensive rehabilitation course at RUDN University.

Link: https://www.sciencedirect.com/science/article/abs/pii/S0967586820315915#f0005

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Source: Russian Foundation for Basic Research

Health

Observing World Cancer Day

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World Cancer Day is an international day marked on 4 February to raise awareness of cancer and to encourage its preventiondetection, and treatment. World Cancer Day is led by the Union for International Cancer Control (UICC) to support the goals of the World Cancer Declaration, written in 2008. The primary goal of World Cancer Day is to significantly reduce illness and death caused by cancer and is an opportunity to rally the international community to end the injustice of preventable suffering from cancer. The day is observed by the United Nations.

World Cancer Day targets misinformation, raises awareness, and reduces stigma. Multiple initiatives are run on World Cancer Day to show support for those affected by cancer. One of these movements are #NoHairSelfie, a global movement to have “hairticipants” shave their heads either physically or virtually to show a symbol of courage for those undergoing cancer treatment. Images of participants are then shared all over social media. Hundreds of events around the world also take place. (wikipedia)

https://stmdailynews.com/category/lifestyle/health-and-wellness/health/

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FDA Concludes that Existing Regulatory Frameworks for Foods and Supplements are Not Appropriate for Cannabidiol, Will Work with Congress on a New Way Forward

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Statement From:Janet Woodcock, M.D.
Principal Deputy Commissioner – Office of the Commissioner

January 26, 2023

Given the growing cannabidiol (CBD) products market, the U.S. Food and Drug Administration convened a high-level internal working group to explore potential regulatory pathways for CBD products. Today we are announcing that after careful review, the FDA has concluded that a new regulatory pathway for CBD is needed that balances individuals’ desire for access to CBD products with the regulatory oversight needed to manage risks. The agency is prepared to work with Congress on this matter. Today, we are also denying three citizen petitions that had asked the agency to conduct rulemaking to allow the marketing of CBD products as dietary supplements.  

The use of CBD raises various safety concerns, especially with long-term use. Studies have shown the potential for harm to the liver, interactions with certain medications and possible harm to the male reproductive system. CBD exposure is also concerning when it comes to certain vulnerable populations such as children and those who are pregnant. 

A new regulatory pathway would benefit consumers by providing safeguards and oversight to manage and minimize risks related to CBD products. Some risk management tools could include clear labels, prevention of contaminants, CBD content limits, and measures, such as minimum purchase age, to mitigate the risk of ingestion by children. In addition, a new pathway could provide access and oversight for certain CBD-containing products for animals.

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The FDA’s existing foods and dietary supplement authorities provide only limited tools for managing many of the risks associated with CBD products. Under the law, any substance, including CBD, must meet specific safety standards to be lawfully marketed as a dietary supplement or food additive. 

The working group, which I chair, has closely examined studies related to the CBD-based drug Epidiolex, published scientific literatureinformation submitted to a public docket, as well as studies both conducted and commissioned by the agency. Given the available evidence, it is not apparent how CBD products could meet safety standards for dietary supplements or food additives. For example, we have not found adequate evidence to determine how much CBD can be consumed, and for how long, before causing harm. Therefore, we do not intend to pursue rulemaking allowing the use of CBD in dietary supplements or conventional foods. 

CBD also poses risks to animals, and people could be unknowingly exposed to CBD through meat, milk and eggs from animals fed CBD. Because it is not apparent how CBD products could meet the safety standard for substances in animal food, we also do not intend to pursue rulemaking allowing the use of CBD in animal food. A new regulatory pathway could provide access and oversight for certain CBD-containing products for animals.

The FDA will continue to take action against CBD and other cannabis-derived products to protect the public, in coordination with state regulatory partners, when appropriate. We will remain diligent in monitoring the marketplace, identifying products that pose risks and acting within our authorities. The FDA looks forward to working with Congress to develop a cross-agency strategy for the regulation of these products to protect the public’s health and safety.

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Health

American Society of Nephrology Statement on U.S. Preventive Services Task Force Draft Research Plan on Screening for Kidney Diseases

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90% of Americans with kidney diseases are unaware that they are affected.

Newswise — Washington, DC (January 20, 2023) —The American Society of Nephrology (ASN) is encouraged by the recent U.S. Preventive Services Task Force (USPSTF) announcement to solicit comment on USPSTF’s draft research plan on screening for kidney diseases. This development follows more than a decade of advocacy in support of more kidney health screening by ASN and other stakeholders dedicated to intervening earlier to slow or stop the progression of kidney diseases.

More than 37 million Americans suffer from kidney diseases that impact virtually every aspect of their lives as well as their families and communities. Kidney diseases are the ninth leading cause of death in the United States, yet 90% of Americans with kidney diseases are unaware that they are affected. Prevention and early detection are key to preventing kidney failure and achieving kidney health.

People with a family history of kidney diseases and people with diabetesobesity, or other health issues, are at a higher risk of kidney diseases. Older adults, people with lower incomes, and people who are Black/African American, Hispanic/Latinx, Native/Indigenous American, Native Alaskan, Asian, and Native Hawaiian or other Pacific Islander are also most at risk for kidney diseases and kidney failure. Dialysis, the most common therapy for those with kidney failure, has a 5-year mortality rate worse than nearly all forms of cancer and requires billions of dollars annually to manage and treat. The recent approval of numerous therapies that successfully slow or stop the progression of kidney diseases mean it is more important than ever to screen Americans who are at-risk so they can access these effective, novel drugs as soon as possible.

“Early screening to drive faster more comprehensive intervention are critical components of a holistic prevention strategy for kidney diseases,” said ASN President Michelle A. Josephson, MD, FASN. “We fully support USPSTF and their efforts to advance the research agenda on this critical public health priority.” Dr. Josephson added, “The entire kidney community has contributed to this decades-long effort and ASN is committed to continuing our work with other advocates, including the Coalition 4 Kidney Health, and the USPSTF to prioritize screening for kidney diseases as USPSTF finalizes its draft research plan.”

For more information, please visit https://www.asn-online.org/policy/lac.aspx?ID=36

About ASN

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Since 1966, ASN has been leading the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge and advocating for the highest quality care for patients. ASN has more than 20,000 members representing 132 countries. For more information, visit www.asn-online.org and follow us on FacebookTwitterLinkedIn, and Instagram.

Source: American Society of Nephrology (ASN)

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