Health
First-line immune defences against COVID-19 are short-lived and may explain reinfection
A new study finds that antibodies produced in the nose decline nine months after COVID-19 infection, while antibodies found in the blood last at least a year.
Newswise — A new study finds that antibodies produced in the nose decline nine months after COVID-19 infection, while antibodies found in the blood last at least a year.
Antibodies in the nasal fluid (known as immunoglobulin A, or IgA) provide first-line defence against COVID-19 by blocking SARS-CoV-2 virus when it first enters the respiratory tract. These antibodies are very effective at preventing the virus from entering cells and causing infection.
However, the investigators found that the nasal antibodies were only present in those recently infected and were particularly short-lived against the Omicron variant, compared to earlier variants.
These new findings – which are published in eBioMedicine – may explain why people who have recovered from COVID are at risk of reinfection, and especially with Omicron and its subvariants.
The study also found that vaccination is very effective in creating and boosting antibodies in the blood, which prevent severe disease, but had very little effect on nasal IgA levels.
First author of the study, Dr Felicity Liew, from the National Heart and Lung Institute at Imperial College London, said: “Before our study, it was unclear how long these important nasal antibodies lasted. Our study found durable immune responses after infection and vaccination, but these key nasal antibodies were shorter-lived than those in the blood. While blood antibodies help to protect against disease, nasal antibodies can prevent infection altogether. This might be an important factor behind repeat infections with the SARS-CoV-2 virus and its new variants.”
The researchers note that studies that directly study these nasal antibodies and reinfections are needed to confirm their results.
The research was led by teams from Imperial College London and the University of Liverpool. It studied almost 450 people who had been hospitalised with COVID-19 between February 2020 and March 2021, before the emergence of Omicron variant and prior to vaccine rollout.
The study also found that whilst current vaccines are effective at boosting blood antibody which can prevent serious illness and death, they do not significantly boost nasal IgA antibodies.
The researchers call for the next generation of vaccines to include nasal spray or inhaled vaccines that target these antibodies more effectively. They say that vaccines capable of boosting these antibodies could potentially reduce infections more effectively and prevent transmission.
Co-senior author of the study, Professor Peter Openshaw, from the National Heart and Lung Institute at Imperial College London, said: “Our results highlight a need for nasal spray vaccines that can boost these local antibodies in the nose and lungs. Such vaccines might be able to prevent people from getting infected with the SARS-CoV-2 virus and reduce transmission of the virus between people. This could help us to better control the pandemic and stop new variants emerging.”
He continues: “Our current vaccines are designed to reduce severe disease and death and are dramatically effective in this aim. It’s now essential to also develop nasal spray vaccines that can provide better protection against infection. It’s brilliant that current vaccines mean fewer people are becoming seriously ill, but it would be even better if we could prevent them from getting infected and transmitting the virus.”
The study analysed antibodies of the participants to understand how long nasal antibodies lasted, compared with antibodies found in the blood. They also studied the effect of subsequent COVID-19 vaccines on antibodies in the nose and blood.
Samples were taken when people were hospitalised and at six months and one year after. Since most people were vaccinated during the study, many samples were also taken before and after vaccination.
They measured how well the antibodies neutralised the original SARS-CoV-2 virus, and the Delta and Omicron variants to see how long the antibodies were effective for after infection or vaccination.
The study included 446 people admitted to hospital in the early phase of the pandemic, including 141 who provided samples at the start of the study and six and 12 months later. For participants who only had one sample taken during the 12-month period of study, the researchers used modelling to estimate how the average antibody responses changed over time.
Of those who confirmed whether they had been vaccinated (323 people), 95% (307 people) received their first vaccination during the study follow-up period. This led to increases in all nasal and blood antibodies, but the change in the first-line defence nasal antibodies (IgA) was small and temporary. The researchers found that the participants’ sex, disease severity and age did not impact how long their nasal immunity lasted, but caution that their study was only in people with severe disease that required hospitalisation.
They also found that blood antibody from participants continued to bind the original SARS-CoV-2 virus, and the Delta and Omicron variants a year after infection, but found that booster vaccines are needed to maintain this immunity.
Co-senior author of the study, Dr Lance Turtle, Senior Clinical Lecturer at the University of Liverpool and Consultant in Infectious Diseases at Liverpool University Hospitals, said: “Our study suggests that this first-line defence immunity is separate from other immune responses, and although it is increased by vaccination and infection, it only lasts for about nine months. Nonetheless, booster vaccines can increase it slightly and otherwise have a significant impact on other areas of immunity, protecting against severe disease and death very effectively, so remain very important.”
The researchers note that their study did not screen participants for reinfection, but that this was unlikely to have occurred since the study took place during periods of national restrictions and lockdowns when COVID-19 incidence was low and people were not mixing. In a preliminary analysis, they found only two cases of reinfection in their study, suggesting that the overall trends seen are accurate.
The study was supported by the ISARIC4C, UKCIC and PHOSP-COVID consortia. It was jointly funded by the National Institute for Health and Care Research, UK Research and Innovation and the Medical Research Council.
–
This press release uses a labelling system developed by the Academy of Medical Sciences to improve the communication of evidence. For more information, please see: http://www.sciencemediacentre.org/wp-content/uploads/2018/01/AMS-press-release-labelling-system-GUIDANCE.pdf
About Imperial College London
Imperial College London is a global top ten university with a world-class reputation. The College’s 22,000 students and 8,000 staff are working to solve the biggest challenges in science, medicine, engineering and business.
The Research Excellence Framework (REF) 2021 found that it has a greater proportion of world-leading research than any other UK university, it was named University of the Year 2022 according to The Times and Sunday Times Good University Guide, University of the Year for Student Experience 2022 by the Good University Guide, and awarded a Queen’s Anniversary Prize for its COVID-19 response. https://www.imperial.ac.uk/
The National Institute for Health and Care Research (NIHR)
The mission of the National Institute for Health and Care Research (NIHR) is to improve the health and wealth of the nation through research. We do this by:
– Funding high quality, timely research that benefits the NHS, public health and social care;
– Investing in world-class expertise, facilities and a skilled delivery workforce to translate discoveries into improved treatments and services;
– Partnering with patients, service users, carers and communities, improving the relevance, quality and impact of our research;
– Attracting, training and supporting the best researchers to tackle complex health and social care challenges;
– Collaborating with other public funders, charities and industry to help shape a cohesive and globally competitive research system;
– Funding applied global health research and training to meet the needs of the poorest people in low and middle income countries.
NIHR is funded by the Department of Health and Social Care. Its work in low and middle income countries is principally funded through UK Aid from the UK government.
LinkL:
Source: Imperial College London
Health and Life Insurance
Review Your Medicare Coverage Options: Open Enrollment is Through Dec. 7
Medicare Coverage Options: Medicare Open Enrollment is your opportunity to give your Medicare plan a check-up. Plans change every year, and now is the time to check if a new plan could be better for you.
Review Your Medicare Coverage Options: Open Enrollment is Through Dec. 7
(Feature Impact)Medicare Open Enrollment is your opportunity to give your Medicare plan a check-up. Plans change every year, and now is the time to check if a new plan could be better for you.
If you have Medicare, taking the time to review your coverage options each fall is one of the most important health decisions you can make.
Give Your Medicare Plan a Check-up
- Check your coverage. Ensure your preferred doctors, prescriptions and preferred pharmacies are covered.
- Check your costs. Look at premiums, deductibles, copays and other out-of-pocket costs.
- Check for changes. See what will be different in your plan for the coming year.
- Check your options. Compare plans side by side based on the prescriptions you take. Find the right plan for your health needs and your budget. Make sure your drugs are covered.
Now is the one time you can make changes to your health and prescription drug plans and find a plan that’s better for you. Medicare Open Enrollment is your opportunity to review and compare options and take control of your expenditures and coverage.
Medicare plans change annually and so does your health. What worked for you last year may be different than what will work best this year. A review of your options can help you secure a plan best fit to your current lifestyle and health needs – while potentially saving you hundreds of dollars on out-of-pocket costs.
For instance, a person with Medicare compared drug plans to find the best costs and coverage for their prescriptions, including a blood thinner and a common cholesterol medication. Using medicare.gov, they found the yearly cost for a Medicare drug plan and these prescriptions ranged from $1,356-2,965. By choosing the lowest-cost plan, they saved more than $1,600 while keeping their essential medications covered.
Medicare.gov is the Official Source
For all your Open Enrollment needs, Medicare.gov is your official source. It’s the trusted resource to help you navigate Open Enrollment, allowing you to explore and compare every available Medicare health and drug plan available in your area. If you prefer speaking with someone directly, call 1-800-MEDICARE to connect with a team of experts who are available 24/7 to help you review your options and answer any questions about your Medicare coverage.
To get started, go to Medicare.gov and click on “Find Plans Now.” For the best shopping experience, log in or create a Medicare account. You can easily compare plan costs, side by side, based on the medications you take. Make sure the plan you choose covers your prescription drugs and your doctors.
Don’t Wait – Open Enrollment Ends Dec. 7
If you miss the Dec. 7 deadline, you may need to wait a full year before you can make any changes to your coverage. That’s why getting started early is important. Make sure you give yourself enough time to review and compare your options. You’ll want to consider factors like costs, benefits and prescription drug plans.
Medicare Open Enrollment is the perfect time to plan for the future and prioritize your health. Making sure you have a health plan that can support you in your wellness journey is critical, so don’t wait. Start reviewing your Medicare plan options today at Medicare.gov.
Information provided by the U.S. Department of Health & Human Services.
Photos courtesy of Shutterstock
SOURCE:
Centers for Medicare and Medicaid Services
health and wellness
Flu Season Arrives Early: Walgreens Launches 2026-2027 Flu Index as Activity Rises Across the U.S.
The 2026-2027 flu season is tracking four weeks ahead of recent years. Explore Walgreens’ new Flu Index, rising activity, and ways to stay protected.
Last Updated on October 31, 2026 by Daily News Staff
2026-2027 Flu Season: New tracking data suggests influenza activity is running approximately four weeks ahead of recent seasons, with increases reported across western states and Florida.
2026-2027 Flu Season Starts Early as Walgreens Launches New Flu Index
STM Daily News | Health & Wellness
October 30, 2026
Flu season may be getting an early start this year, and a new online tracking tool from Walgreens is giving Americans a closer look at respiratory illness activity in their communities.
On October 21, Walgreens announced the launch of its 2026-2027 Flu Index, an interactive tool that monitors influenza, COVID-19, and other acute respiratory illnesses across the United States.
According to the company’s initial findings, national flu activity is tracking approximately four weeks ahead of recent flu seasons, with increasing activity reported across several western states and Florida.
The early trends serve as a reminder that influenza doesn’t necessarily wait until winter to begin spreading.
Flu Activity Is Increasing Earlier Than Expected
Walgreens reports that its early-season data indicates influenza activity is already increasing in multiple parts of the country.
The company’s findings include:
- Earlier flu activity: National flu activity is tracking approximately four weeks ahead of recent seasons.
- Regional increases: Several western states and Florida are experiencing rising activity.
- More antiviral prescriptions: Walgreens reports dispensing more flu antiviral medications than during the same period in 2025.
- Growing demand for cold and flu products: Sales of cold and flu medications, at-home respiratory illness tests, cough drops, and tea have increased by double-digit percentages compared with last year.
Although these indicators suggest respiratory illness activity is increasing, they do not necessarily mean the current flu season will be more severe than previous seasons.
Increased purchases of cold medications and testing products can reflect changes in consumer behavior as well as illness trends.
The findings come from Walgreens’ pharmacy and retail data and should be considered alongside public health surveillance from the Centers for Disease Control and Prevention (CDC).
What Is the Walgreens Flu Index?
The Walgreens Flu Index is an interactive online platform designed to help consumers understand where respiratory illnesses are circulating and how activity is changing over time.
The tool combines several types of information, including:
- Flu and COVID-19 testing data from Walgreens locations
- Prescription antiviral medication trends
- Over-the-counter cold and flu product purchases
- Geographic patterns in respiratory illness activity
Using these indicators, Walgreens calculates an activity score ranging from 0 to 10.
A score of zero represents the lowest level of activity, while a score of ten represents the highest.
The index provides weekly information for states and territories, along with more than 1,500 counties where sufficient Walgreens data is available.
The map is updated every Monday, allowing users to compare current activity with previous weeks and the prior flu season.
Importantly, Walgreens emphasizes that the index measures relative illness activity, not disease severity. A higher score does not necessarily indicate more hospitalizations, more serious infections, or a greater risk of complications.
The index also does not represent a complete count of influenza cases nationwide.
Explore the interactive map:
https://www.walgreens.com/seasonal/respiratory-illness-index
Why Local Flu Activity Matters
Influenza does not spread evenly across the country.
Some communities may experience increasing cases weeks before others, making local information useful for families, schools, healthcare providers, and individuals who may be at higher risk of complications.
“Flu activity can vary significantly from one community to another, and knowing what’s happening locally can make a real difference,” said Rick Gates, Walgreens’ chief pharmacy and enterprise external affairs officer.
Gates added that the index is intended to help people make informed decisions about prevention, including vaccination before influenza becomes more widespread in their communities.
For residents of states such as Arizona, California, Nevada, and other western states, the reported regional increases make monitoring local respiratory illness trends particularly relevant.
However, the company’s announcement does not establish that every western county is experiencing elevated flu activity. Readers should consult the latest local data for a more accurate picture.
Why Getting a Flu Shot Still Matters
Annual influenza vaccination remains an important tool for reducing the risk of flu illness and serious complications.
Because influenza viruses change over time, flu vaccines are reviewed and updated each season to target strains expected to circulate.
The CDC recommends annual influenza vaccination for most people ages six months and older, with rare exceptions.
Vaccination is especially important for people who face a greater risk of serious complications, including:
- Adults ages 65 and older
- Young children, particularly those younger than five
- Pregnant individuals
- People with chronic conditions such as asthma, diabetes, or heart disease
- People with weakened immune systems
For adults 65 and older, the CDC preferentially recommends certain enhanced influenza vaccines, including higher-dose, recombinant, or adjuvanted options, when available.
Walgreens says its pharmacies offer standard-dose and higher-dose vaccines, along with a new mRNA influenza vaccine at select locations.
Vaccine selection should follow current CDC recommendations, individual eligibility, and guidance from a qualified healthcare professional.
It generally takes about two weeks after vaccination for the body to develop protective antibodies.
Even if influenza is already circulating locally, vaccination can still provide benefits throughout the season.
Practical Ways to Reduce Your Risk of Getting Sick
Vaccination is an important preventive measure, but it is not the only step people can take to reduce the spread of respiratory illnesses.
Public health guidance also encourages several everyday precautions.
Wash your hands regularly. Use soap and water, particularly after touching shared surfaces or being in public places. Alcohol-based hand sanitizer can help when soap and water are unavailable.
Cover coughs and sneezes. Use a tissue or your elbow to reduce the spread of respiratory droplets.
Improve indoor air quality. Opening windows when practical, improving ventilation, and using appropriate air filtration can help reduce exposure to airborne respiratory viruses.
Avoid close contact when sick. Staying home when experiencing respiratory illness symptoms can help protect coworkers, classmates, friends, and family members.
Consider wearing a well-fitting mask. Masks can provide an additional layer of protection, particularly in crowded indoor spaces or around people at higher risk.
Pay attention to symptoms. Fever, coughing, sore throat, fatigue, muscle aches, and congestion can occur with influenza and other respiratory infections.
Because flu and COVID-19 can produce similar symptoms, testing may help determine the cause of an illness.
People at higher risk of complications should contact a healthcare professional promptly if flu symptoms develop. Prescription antiviral medications work best when started early, ideally within the first two days of symptoms, although treatment can still benefit some patients later.
Walgreens Expands Vaccination Access for the 2026–2027 Season
Alongside the launch of its Flu Index, Walgreens announced several efforts to make seasonal vaccinations more convenient.
The company says it is increasing pharmacy staffing, expanding appointment availability, and allowing customers to schedule vaccinations further in advance.
Customers can arrange appointments through several methods:
- Online: https://www.walgreens.com/ScheduleVaccine
- Mobile: Walgreens app
- Text: Send “Flu” to 66879
- Telephone: 1-800-WALGREENS
- Walk-in: Participating Walgreens pharmacies, subject to availability
Walgreens also announced promotional Walgreens Cash rewards for eligible myWalgreens members receiving vaccinations.
Under the limited-time promotion, qualifying members may earn $15 in Walgreens Cash rewards on eligible purchases, along with an additional 10% back on qualifying purchases for a limited period.
Restrictions, exclusions, geographic limitations, and promotional deadlines apply. Customers should review the official terms before participating.
What About COVID-19 and Other Respiratory Illnesses?
Although influenza is the primary focus of the seasonal announcement, the Walgreens Flu Index also tracks COVID-19 and broader acute respiratory illness trends.
This distinction matters because several respiratory viruses can circulate simultaneously during the fall and winter months.
Influenza, COVID-19, respiratory syncytial virus (RSV), and common cold viruses can produce overlapping symptoms, but their potential complications and recommended treatments differ.
Vaccination eligibility and recommendations also vary by disease, age, and individual health circumstances.
Readers should consult current CDC guidance and their healthcare providers when considering flu, COVID-19, or RSV vaccination.
The Bottom Line: Flu Season May Be Early, but Prevention Still Matters
The launch of the 2026–2027 Walgreens Flu Index offers another resource for Americans who want to monitor respiratory illness activity in their communities.
While Walgreens’ early findings suggest influenza activity is increasing sooner than in recent years, it is still too early to determine how severe the overall season will become.
The most important message for consumers is to prepare before respiratory illnesses become widespread.
Staying current with recommended vaccinations, practicing good hygiene, monitoring local illness trends, and seeking medical attention when appropriate can help reduce the risk of serious illness.
With flu activity already rising in some regions, now is a good time for families to review their seasonal health plans.
Related Links for Further Information
Walgreens Resources
- Walgreens Respiratory Illness Index — Interactive map showing respiratory illness activity across the United States.
- Walgreens Vaccination Scheduling — Schedule a flu vaccination or explore available vaccines.
Public Health Resources
- CDC Seasonal Influenza Information — Information about influenza symptoms, prevention, vaccination, and treatment.
- CDC FluView Surveillance — National influenza surveillance and weekly activity reports.
- CDC: Flu and People 65 Years and Older — Guidance for older adults and influenza vaccination.
- CDC Respiratory Illnesses — Prevention information for flu, COVID-19, and RSV.
Source: Walgreen Co., press release, October 21, 2026, Walgreens Launches 2026–2027 Flu Index as Activity Tracks Four Weeks Ahead of Recent Seasons.
Editor’s Note: This article summarizes information from Walgreens’ October 21, 2026, announcement. The reported early-season trends reflect the company’s findings at that time and are not a substitute for current CDC surveillance or medical advice. Readers should consult healthcare professionals about individual vaccination and treatment decisions.
STM Daily News — News You Can Use This Moment!
Health and Life Insurance
Things Can Change So Review Your Medicare Coverage Options: Open Enrollment is Through Dec. 7
It’s time to visit your Medicare Coverage Options. Medicare Open Enrollment is your opportunity to give your Medicare plan a check-up. Plans change every year, and now is the time to check if a new plan could be better for you.
Things Can Change So Review Your Medicare Coverage Options: Open Enrollment is Through Dec. 7
(Feature Impact)Medicare Open Enrollment is your opportunity to give your Medicare plan a check-up. Plans change every year, and now is the time to check if a new plan could be better for you.
If you have Medicare, taking the time to review your coverage options each fall is one of the most important health decisions you can make.
Give Your Medicare Plan a Check-up
- Check your coverage. Ensure your preferred doctors, prescriptions and preferred pharmacies are covered.
- Check your costs. Look at premiums, deductibles, copays and other out-of-pocket costs.
- Check for changes. See what will be different in your plan for the coming year.
- Check your options. Compare plans side by side based on the prescriptions you take. Find the right plan for your health needs and your budget. Make sure your drugs are covered.
Now is the one time you can make changes to your health and prescription drug plans and find a plan that’s better for you. Medicare Open Enrollment is your opportunity to review and compare options and take control of your expenditures and coverage.
Medicare plans change annually and so does your health. What worked for you last year may be different than what will work best this year. A review of your options can help you secure a plan best fit to your current lifestyle and health needs – while potentially saving you hundreds of dollars on out-of-pocket costs.
For instance, a person with Medicare compared drug plans to find the best costs and coverage for their prescriptions, including a blood thinner and a common cholesterol medication. Using medicare.gov, they found the yearly cost for a Medicare drug plan and these prescriptions ranged from $1,356-2,965. By choosing the lowest-cost plan, they saved more than $1,600 while keeping their essential medications covered.
Medicare.gov is the Official Source
For all your Open Enrollment needs, Medicare.gov is your official source. It’s the trusted resource to help you navigate Open Enrollment, allowing you to explore and compare every available Medicare health and drug plan available in your area. If you prefer speaking with someone directly, call 1-800-MEDICARE to connect with a team of experts who are available 24/7 to help you review your options and answer any questions about your Medicare coverage.
To get started, go to Medicare.gov and click on “Find Plans Now.” For the best shopping experience, log in or create a Medicare account. You can easily compare plan costs, side by side, based on the medications you take. Make sure the plan you choose covers your prescription drugs and your doctors.
Don’t Wait – Open Enrollment Ends Dec. 7
If you miss the Dec. 7 deadline, you may need to wait a full year before you can make any changes to your coverage. That’s why getting started early is important. Make sure you give yourself enough time to review and compare your options. You’ll want to consider factors like costs, benefits and prescription drug plans.
Medicare Open Enrollment is the perfect time to plan for the future and prioritize your health. Making sure you have a health plan that can support you in your wellness journey is critical, so don’t wait. Start reviewing your Medicare plan options today at Medicare.gov.
Stay Vigilant Against Medicare Fraud
Stay vigilant against Medicare fraud, especially during Medicare Open Enrollment. Scammers take advantage of this time of year; they may pretend to be from Medicare or an insurance company in order to steal your personal information.
Remember that Medicare will never contact you unsolicited. If someone you do not know calls, texts or emails you about Medicare, simply hang up or delete the message. By staying alert, you can help stop fraud before it starts.
If you suspect Medicare fraud, report it immediately to Medicare at Medicare.gov/fraud or at 1-800-MEDICARE. As always, remember to never give out your Medicare Number, Social Security Number or financial information to anyone you don’t know.
Information provided by the U.S. Department of Health & Human Services.
Photos courtesy of Shutterstock
SOURCE:
Centers for Medicare and Medicaid Services
