STM Blog
Finding the Missing Piece: One man’s journey to a von Willebrand disease diagnosis
Frank, a 65-year-old man, spent decades suffering from von Willebrand disease (VWD) without a diagnosis. His journey, marked by severe bleeds and uncertainty, changed when his granddaughter was diagnosed with VWD. This discovery led to Frank’s diagnosis and treatment with VONVENDI, which allows him to better manage his condition and regain control of his life.
Last Updated on October 19, 2025 by Daily News Staff
Finding the Missing Piece: One man’s journey to a von Willebrand disease diagnosis
(Family Features) “I wanted to live my life like there was nothing wrong, but the fear was always there.”
That’s how 65-year-old Frank described life with von Willebrand disease (VWD), the most common bleeding disorder, affecting more than 3 million Americans.
For Frank, the signs started early with nosebleeds so severe they seemed unstoppable. In his 30s, one gastrointestinal bleed required nearly 7 pints of blood to stabilize him – a staggering amount, considering most adults only have 8-12 pints total.
Life with VWD can mean living in constant uncertainty. Any injury, surgery or even simple dental procedure can trigger a dangerous bleed. Symptoms like frequent bruising or heavy menstrual bleeding in women can affect quality of life. The consequences for Frank, even before his diagnosis, were often urgent and life-threatening.
Hospital visits and bleeds became routine, draining both his body and spirit. Frank lost weight, struggled with temperature swings and each trip home from the hospital felt like borrowed time before his next bleeding episode.
Eventually, his body began rejecting the blood transfusions meant to treat him during these mysterious bleeding episodes – a complication known as hemolytic anemia. With few options left, Frank and his partner, Carla, faced a future filled with fear and uncertainty, unsure how much longer his body could keep going.
Journey to a Diagnosis
Like many living with VWD, Frank spent years searching for answers – managing symptoms without understanding their cause. Bleeds came without warning. Triggers were a mystery. A diagnosis felt out of reach.
Through it all, Frank and Carla were their own fiercest advocates. Carla became his second set of eyes and ears by researching symptoms, writing down questions and sitting beside him in countless exam rooms.
“I realized when he was in the hospital, I must be there with him,” Carla said. “I needed to be there when the doctors and the nurses were talking to him. I slept in his room to be there for morning rounds to make sure everyone had the correct information.”
For years, they pressed on without answers or an official diagnosis until 2013, when everything changed.
Frank’s granddaughter was diagnosed with VWD, which they learned is a hereditary bleeding disorder. In that moment, something clicked. After decades of uncertainty, Frank finally had a clue and a connection.
He and Carla immediately sought out VWD education. Testing confirmed what they suspected: Frank had been living with VWD all along.
“Getting the diagnosis was a turning point,” Frank said. “For the first time, we weren’t just waiting for the next bleed – we finally had a way to take control.”
A Path Forward
Frank finally found hope and a path forward. After discussing which treatment option may be right for him with his health care team, Frank began using VONVENDI® [von Willebrand factor (Recombinant)] on-demand to treat and control his bleeding episodes.
VONVENDI is the only von Willebrand factor (VWF) treatment made without human blood or plasma with approved uses in both adults and children with VWD. For someone whose body had begun rejecting transfusions, having a recombinant option was important. But more than that – it worked for Frank.
“Since starting VONVENDI, I feel like I finally found the right path forward for me,” Frank said. “I can control my bleeds when they happen, and I have a plan in place to treat the next one.”
The U.S. Food and Drug Administration recently approved an expanded indication for VONVENDI, which is now indicated for adults and children with VWD to treat and control bleeding episodes (on-demand), to prevent excessive bleeding during and after surgery (perioperative) and for adult patients only, to reduce the number of bleeding episodes when used regularly (prophylaxis). Please see below for Detailed Important Risk Information or click here for the full Prescribing Information.
With this expanded indication, VONVENDI can now help more patients like Frank – not just control bleeds but also try to prevent them. Frank and Carla know there’s no cure, but for the first time in a long time, they have a plan to address Frank’s VWD bleeds.
Visit VONVENDI.com or speak with your doctor to learn more about VWD and discuss if treatment may be right for you.
VONVENDI [von Willebrand factor (Recombinant)] Important Information
What is VONVENDI?
VONVENDI is used in adults and children with von Willebrand disease to:
- treat and control bleeding episodes
- prevent excessive bleeding during and after surgery
For adult patients only:
- reduce the number of bleeding episodes when used regularly (prophylaxis)
Detailed Important Risk Information
Who should not use VONVENDI?
You should not use VONVENDI if you:
- Are allergic to any ingredients in VONVENDI.
- Are allergic to mice or hamsters.
Tell your healthcare provider if you are pregnant or breastfeeding because VONVENDI may not be right for you.
How should I use VONVENDI?
Your first dose of VONVENDI for each bleeding episode may be administered with a recombinant factor VIII as instructed by your healthcare provider.
Your healthcare provider will instruct you whether additional doses of VONVENDI with or without recombinant factor VIII are needed.
What should I tell my healthcare provider before I use VONVENDI?
You should tell your healthcare provider if you:
- Have or have had any medical problems.
- Take any medicines, including prescription and non-prescription medicines, such as over-the-counter medicines, supplements or herbal remedies.
- Have any allergies, including allergies to mice or hamsters.
- Are breastfeeding. It is not known if VONVENDI passes into your milk and if it can harm your baby.
- Are pregnant or planning to become pregnant. It is not known if VONVENDI can harm your unborn baby.
- Have been told that you have inhibitors to von Willebrand factor (because VONVENDI may not work for you).
- Have been told that you have inhibitors to blood coagulation factor VIII.
What else should I know about VONVENDI and von Willebrand Disease?
Your body can form inhibitors to von Willebrand factor or factor VIII. An inhibitor is part of the body’s normal defense system. If you form inhibitors, they may stop VONVENDI or factor VIII from working properly.
Consult with your healthcare provider to make sure you are carefully monitored with blood tests for the development of inhibitors to von Willebrand factor or factor VIII.
What are the possible side effects of VONVENDI?
You can have an allergic reaction to VONVENDI.
Call your healthcare provider right away and stop treatment if you get a rash or hives, itching, tightness of the throat, chest pain or tightness, difficulty breathing, lightheadedness, dizziness, nausea or fainting.
Side effects that have been reported with VONVENDI include: headache, nausea, vomiting, tingling or burning at infusion site, chest discomfort, dizziness, hot flashes, itching, high blood pressure, muscle twitching, unusual taste, blood clots and increased heart rate.
Tell your healthcare provider about any side effects that bother you or do not go away.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
Please see VONVENDI full Prescribing Information.
©2025 Takeda Pharmaceuticals U.S.A., Inc., 500 Kendall Street, Cambridge, MA 02142. 1-877-TAKEDA-7 (1-877-825-3327). All rights reserved. TAKEDA and the TAKEDA Logo are registered trademarks or registered trademarks of Takeda Pharmaceutical Company Limited. VONVENDI is a registered trademark of Baxalta Incorporated. US-VON-1006v1.0 10/25
SOURCE:
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The Knowledge
Exploring the Best Neighborhoods in Downtown Los Angeles
From the Arts District and Little Tokyo to the Historic Core and Bunker Hill, discover the best neighborhoods in Downtown Los Angeles and what makes each one worth exploring.
Last Updated on August 5, 2026 by Daily News Staff
The Best Neighborhoods in Downtown Los Angeles
Downtown Los Angeles has undergone one of the most remarkable transformations of any urban center in the United States. Once known primarily as the city’s business district, DTLA has evolved into a vibrant collection of neighborhoods, each offering its own unique character, history, dining, entertainment, and cultural experiences.
Whether you’re a first-time visitor, a longtime Angeleno, or planning your next weekend adventure, these are some of Downtown LA’s must-visit neighborhoods.
Arts District: Where Creativity Comes to Life
The Arts District has become one of the city’s most exciting destinations. Former warehouses have been transformed into lofts, art galleries, coffee shops, breweries, and award-winning restaurants.
Visitors can spend hours exploring colorful murals, browsing independent boutiques, and discovering public art around nearly every corner. It’s a neighborhood that celebrates creativity while preserving its industrial roots.
Perfect for: Art lovers, photographers, foodies, and nightlife.
Historic Core: A Walk Through Old Los Angeles
The Historic Core showcases Downtown LA’s architectural heritage. Along Broadway and surrounding streets, beautifully restored theaters, historic hotels, and early 20th-century buildings tell the story of a booming city during Hollywood’s Golden Age.
Highlights include the iconic Bradbury Building, Grand Central Market, and numerous rooftop restaurants overlooking the skyline.
Perfect for: History buffs and architecture enthusiasts.
South Park: Entertainment Central
South Park is home to some of Los Angeles’ biggest attractions, including LA Live and Crypto.com Arena. The neighborhood has added thousands of apartments, new restaurants, hotels, and entertainment venues over the past two decades.
Whether you’re attending a Lakers game, a concert, or simply enjoying dinner before an event, South Park offers something for everyone.
Perfect for: Sports fans, concerts, and nightlife.
Little Tokyo: A Cultural Treasure
One of only a handful of historic Japantowns remaining in the United States, Little Tokyo offers authentic Japanese cuisine, specialty shops, cultural events, museums, and peaceful gardens.
From fresh sushi and ramen to Japanese bakeries and tea houses, visitors can experience generations of cultural heritage in just a few city blocks.
Perfect for: Families, food lovers, and cultural exploration.
Bunker Hill: Downtown’s Cultural Heart
Bunker Hill combines modern architecture with world-class arts and culture. Home to Walt Disney Concert Hall, The Broad, the Museum of Contemporary Art, and Grand Park, this neighborhood is ideal for visitors looking to experience Downtown’s artistic side.
Its dramatic skyline and public spaces also make it one of the most photographed areas in Los Angeles.
Perfect for: Museum lovers and architecture fans.
Financial District: The Skyline of Los Angeles
Glass skyscrapers, luxury hotels, and bustling sidewalks define the Financial District. While it remains the city’s business center during the workweek, the neighborhood also offers excellent dining, rooftop lounges, and convenient access to other parts of Downtown.
Chinatown: Tradition Meets Modern LA
Los Angeles’ Chinatown blends rich history with a growing collection of contemporary restaurants, galleries, and community events. Visitors can enjoy traditional cuisine alongside modern culinary experiences while exploring one of the city’s oldest cultural neighborhoods.
Fashion District: A Shopper’s Paradise
Covering more than 100 city blocks, the Fashion District is one of the largest garment centers in the country. Whether you’re searching for fabrics, clothing, accessories, or bargains at Santee Alley, this neighborhood attracts shoppers from across Southern California.
A Downtown That Continues to Evolve
Downtown Los Angeles isn’t just one destination—it’s a collection of neighborhoods that reflect the city’s diversity, creativity, and resilience. From historic landmarks and world-class museums to vibrant street art and internationally inspired cuisine, DTLA offers something new around nearly every corner.
Whether you’re planning a day trip or an extended visit, exploring these neighborhoods is one of the best ways to experience the energy and history of Los Angeles.
Related External Links
- Discover Los Angeles – Explore Downtown LA
- Grand Central Market
- The Broad Museum
- Walt Disney Concert Hall
- Japanese American National Museum (Little Tokyo)
- Arts District Los Angeles
- LA Live
- LA Metro – Getting Around Downtown Los Angeles
- Olvera Street and El Pueblo Historic Monument
- Visit California – Los Angeles Travel Guide
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STM Blog
Association of Black Cardiologists to Celebrate Legacy and Leadership at 16th Annual Spirit of the Heart Awards
The Association of Black Cardiologists (ABC) is bringing its signature celebration of impact back to New York City this fall—spotlighting leaders and organizations working to make cardiovascular care more equitable, more accessible, and more effective. The 16th Annual Spirit of the Heart Awards Program & Fundraiser is set for Saturday, October 3, 2026 (6:00 p.m.–9:00 p.m.) at Cipriani Wall Street in Manhattan.
For ABC, the evening is more than a high-profile awards program. It’s a cornerstone fundraising event that helps power the organization’s year-round work—supporting medical student scholarships, fellowships, education, and programs designed to strengthen the pipeline of diverse clinicians and researchers while improving outcomes in communities that carry a disproportionate burden of heart disease.
A fundraising night with long-term stakes
ABC leaders say the Spirit of the Heart Awards is built around a simple idea: celebrating progress while investing in the people who will drive the next wave of change.
Event co-chair Icilma Fergus, MD—Director of the Cardiovascular Disparities Center at Mount Sinai Medical Center and Board Chair of ABC—framed the night as a forward-looking commitment.
“This gathering is about more than one evening of celebration; it is about investing in the future of cardiovascular health for years to come,” Fergus said in the announcement. She added that the support generated through the event helps expand opportunities for aspiring clinicians, researchers, and leaders whose work can transform care and improve lives nationwide.
Honorary Chairperson: Samin K. Sharma, MD
ABC announced Samin K. Sharma, MD as the event’s Honorary Chairperson. Sharma serves as Chief of Clinical Cardiology, Director of the Cardiovascular Clinical Institute, and the Anandi Lal Sharma Professor of Medicine at the Icahn School of Medicine at Mount Sinai.
In the release, ABC highlighted Sharma’s international reputation in interventional cardiology and physician education, noting that he has trained cardiovascular specialists from around the world while advancing the field through research, mentorship, and patient care.
“I am honored to serve as Honorary Chairperson for this important event,” Sharma said. “The Spirit of the Heart Awards Program reflects the power of partnership, philanthropy, and leadership to advance cardiovascular health.”
A full weekend of impact, including policy
The awards program is part of a broader weekend of programming. On Friday, October 2, ABC will host its Annual Policy Pulse Summit at Venable LLP in New York City, convening leaders to discuss policy issues shaping the future of cardiovascular health.
What to expect at the Spirit of the Heart Awards
ABC is positioning the evening as both a celebration and a community gathering—bringing together leaders from healthcare, philanthropy, industry, and advocacy.
The event will be co-emceed by:
- Sandra Bookman, award-winning journalist and anchor of Eyewitness News on ABC7/WABC-TV New York
- Thomas Cunningham IV, President and Chief Content Officer of BrandCunningham
The program is expected to include:
- Presentation of the Spirit of the Heart Awards
- Recognition of medical student scholarship recipients
- Special guest appearances
- A live auction
- Musical entertainment
Event co-chair Barbara Hutchinson, MD, PhD, President of Chesapeake Cardiac Care, emphasized the role of sustained collaboration in moving the needle on heart health.
“The Spirit of the Heart Awards Program is a reminder that lasting progress in cardiovascular health is achieved through vision, partnership, and sustained commitment,” Hutchinson said.
How to attend, sponsor, or support
ABC is directing attendees and supporters to its event site for tickets, sponsorship opportunities, and donations:
- Event info / tickets / sponsorship / donations: https://abcardioevents.org
About the Association of Black Cardiologists
Founded on the belief that “every heart counts,” the Association of Black Cardiologists works to promote prevention and treatment of cardiovascular disease and to advance health equity by eliminating disparities. ABC’s membership is open to all, regardless of race, ethnicity, or vocation. The organization’s work spans education, advocacy, research, patient and community outreach, and leadership development.
- Organization website: https://abcardio.org
Source and media contact
- Press release source (PRNewswire): https://www.prnewswire.com/news-releases/association-of-black-cardiologists-to-celebrate-legacy-and-leadership-at-16th-annual-spirit-of-the-heart-awards-302206000.html
Media Contact (from the release):
- Akeia Blue, VP of Communications
- 419395@email4pr.com
- 240-321-9227
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Travel
Escape the Everyday Routine: Summer Travel Experiences Worth Logging Off For
Summer Travels: Between busy schedules, daily responsibilities and the seemingly nonstop pace of everyday life, taking time to disconnect can feel impossible. This summer, make an effort to step away from daily distractions and reconnect with yourself, your passions and the moments that matter most.
Escape the Everyday Routine: Summer Travel Experiences Worth Logging Off For
(Feature Impact) Between busy schedules, daily responsibilities and the seemingly nonstop pace of everyday life, taking time to disconnect can feel impossible. This summer, make an effort to step away from daily distractions and reconnect with yourself, your passions and the moments that matter most.
Whether it’s a solo seaside escape, a culinary adventure with friends or a memory-making family vacation, World of Hyatt’s Global Summer Offers give members access to exclusive savings of up to 25% on stays at participating hotels and resorts across the U.S., Canada, Caribbean, Latin America, Europe and Africa, making it easy to plan a perfect getaway to escape the everyday this summer.
From paddleboarding in the Bahamas to wandering through Panama’s historic streets, these curated destination recommendations offer inspiration for every kind of traveler.
Sun-Soaked Seaside Escapes
Some summer vacations are about trading packed schedules for ocean breezes and sun-soaked days by the water. For a chic coastal escape, The Georgian, part of The Unbound Collection by Hyatt, brings timeless glamour to the shores of Santa Monica. Just steps from the ocean, this iconic art deco hotel serves as the perfect seaside retreat for biking along the boardwalk, relaxing on the beach and exploring Santa Monica’s vibrant dining scene.
Every detail of a stay at Dreams Puerto Morelos Resort & Spa is crafted to inspire relaxation, connection and discovery. The all-inclusive resort offers a vibrant escape where contemporary comfort meets timeless Caribbean charm in a tropical haven designed for couples and families alike.
Memory-Making Family Adventures
Families looking to make the most of summer together can head to Grand Hyatt Baha Mar, where every day brings a new adventure. From splashing through the resort’s waterpark and visiting the on-site wildlife sanctuary to enjoying family-friendly dining across more than 45 restaurants and lounges, there’s something for guests of all ages to enjoy together.
Along the shores of Kāʻanapali Beach in Maui, Hyatt Regency Maui Resort and Spa provides the perfect setting for families to create lasting memories together. Families can fill their days with everything from culinary experiences to sunrise yoga, snorkeling and wildlife tours. Younger guests can even channel their inner sea creature during the resort’s popular mermaid classes.
Flavor-Filled Getaways
Combining contemporary luxury with Moroccan charm, Park Hyatt Marrakech is an authentic gateway to the destination’s rich culinary heritage. Guests can immerse themselves in local culinary traditions through hands-on experiences, from mastering classic dishes alongside the hotel’s chefs to exploring a Berber village market and sharing a home-cooked lunch with a local family.
Travelers looking to immerse themselves in Panama’s vibrant culture and food scene can enjoy a stay at Hyatt Regency Panama City. Whether exploring the colorful streets of Casco Viejo or savoring authentic cuisine at the hotel’s signature restaurant, Rulfo, guests can experience the flavors and energy that define the destination.
Immersive Cultural Discovery
Just steps from Tallinn’s UNESCO-listed Old Town, Hyatt Place Tallinn places guests in the heart of the city’s rich heritage and within easy reach of landmarks such as Toompea Castle and Alexander Nevsky Cathedral, as well as cobbled medieval streets, world-class museums, independent galleries and vibrant cafés that bring centuries of history to life.
Steeped in history and tucked in the heart of Westminster, Great Scotland Yard Hotel, part of The Unbound Collection by Hyatt, blends modern luxury with its storied past. Once home to Scottish royalty and later the headquarters of London’s Metropolitan Police, the hotel’s legacy of sophistication and intrigue inspires every detail and standout experience, including its hidden speakeasy-style bar, where inventive cocktails are inspired by the building’s colorful history and Michelin-starred dining.
Set along Savannah’s vibrant riverfront, Thompson Savannah offers a stylish gateway to one of the South’s most charming and culturally rich destinations. Travelers can explore centuries-old architecture in the city’s beautifully preserved Historic District and immerse themselves in the renowned arts scene before unwinding in a private cabana on the hotel’s pool deck or enjoying a cocktail at the rooftop bar.
To find more destinations to aid in the escape from everyday routines, visit Hyatt.com for a full list of participating properties and full offer details.
SOURCE:
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