health and wellness
New test may predict COVID-19 immunity
Last Updated on June 1, 2024 by Daily News Staff
The paper test measures the level of neutralizing antibodies in a blood sample and could help people decide what protections they should take against infection.
Newswise — CAMBRIDGE, MA — Most people in the United States have some degree of immune protection against Covid-19, either from vaccination, infection or a combination of the two. But, just how much protection does any individual person have?
MIT researchers have now developed an easy-to-use test that may be able to answer that question. Their test, which uses the same type of “lateral flow” technology as most rapid antigen tests for Covid-19, measures the level of neutralizing antibodies that target the SARS-CoV-2 virus in a blood sample.
Easy access to this kind of test could help people determine what kind of precautions they should take against Covid infection, such as getting an additional booster shot, the researchers say. They have filed for a patent on the technology and are now hoping to partner with a diagnostic company that could manufacture the devices and seek FDA approval.
“Among the general population, many people probably want to know how well protected they are,” says Hojun Li, the Charles W. and Jennifer C. Johnson Clinical Investigator at MIT’s Koch Institute for Integrative Cancer Research. “But I think where this test might make the biggest difference is for anybody who is receiving chemotherapy, anybody who’s on immunosuppressive drugs for rheumatologic disorders or autoimmune diseases, and for anybody who’s elderly or doesn’t mount good immune responses in general. These are all people who might need to be boosted sooner or receive more doses to achieve adequate protection.”
The test is designed so that different viral spike proteins can be swapped in, allowing it to be modified to detect immunity against any existing or future variant of SARS-CoV-2, the researchers say.
Li, who is also an attending physician at the Dana-Farber/Boston Children’s Cancer and Blood Disorders Center, is the senior author of the study, which appears online today in Cell Reports Methods. Guinevere Connelly, a former Koch Institute research technician who is now a graduate student at Duke University, and Orville Kirkland, a research support associate at the Koch Institute, are the lead authors of the paper.
A simple test
Li, who joined the Koch Institute in the fall of 2019, studies blood cell development and how blood cells become cancerous. When SARS-CoV-2 emerged, he started thinking about ways to help combat the pandemic. Many other researchers were already working on diagnostic tests for infection, so he turned his attention to developing a test that would reveal how much immune protection someone has against Covid-19.
Currently, the gold standard approach to measuring immunity involves mixing a blood sample with live virus and measuring how many cells in the sample are killed by the virus. That procedure is too hazardous to perform in most labs, so the more commonly used approaches involve noninfectious modified “pseudoviral” particles, or they are based on a test called ELISA (enzyme-linked immunosorbent assay), which can detect antibodies that neutralize a fragment of a viral protein.
However, these approaches still require trained personnel working in a lab with specialized equipment, so they aren’t practical for use in a doctor’s office to get immediate results. Li wanted to come up with something that could be easily used by a health care provider or even by people at home. He drew inspiration from at-home pregnancy tests, which are based on a type of test called a lateral flow assay.
Lateral flow assays generally consist of paper strips embedded with test lines that bind to a particular target molecule if it is present in a sample. This technology is also the basis of most at-home rapid tests for Covid-19.
Li did not have experience working with this type of test, so he reached out to two MIT faculty members with expertise in devising diagnostics based on lateral flow assays: Hadley Sikes, an associate professor of chemical engineering, and Sangeeta Bhatia, the John and Dorothy Wilson Professor of Health Sciences and Technology and of Electrical Engineering and Computer Science, and a member of the Koch Institute.
With their help, his lab developed a device that can detect the presence of antibodies that block the SARS-CoV-2 receptor binding domain (RBD) from binding to ACE2, the human receptor that the virus uses to infect cells.
The first step in the test is to mix human blood samples with viral RBD protein that has been labeled with tiny gold particles that can be visualized when bound to a paper strip. After allowing time for antibodies in the sample to interact with the viral protein, a few drops of the sample are placed on a test strip embedded with two test lines.
One of these lines attracts free viral RBD proteins, while the other attracts any RBD that has been captured by neutralizing antibodies. A strong signal from the second line indicates a high level of neutralizing antibodies in the sample. There is also a control line that detects free gold particles, confirming that the solution flowed across the entire strip.
To develop the reagents needed for the test, members of Li’s lab worked with the labs of Angela Koehler, an associate professor of biological engineering, and Michael Yaffe, a David H. Koch Professor in Science, who are both members of the Koch Institute.
Predicting immunity
Along with a testing cartridge, which contains the paper test strip, the testing kit also includes a finger prick lancet that can be used to obtain a small blood sample, less than 10 microliters. This sample is then mixed with the reagents needed for the test. After about 10 minutes, the sample is exposed to the test cartridge, and the results are revealed in 10 minutes.
The output can be read two different ways: One, by simply looking at the lines, which indicate whether neutralizing antibodies are present or not. Or, the device can be used to obtain a more precise measurement of antibody levels, using a smartphone app that can measure the intensity of each line and calculate the ratio of neutralized RBD protein to infectious RBD protein. When this ratio is low, it might suggest that another booster shot is needed, or that the individual should take extra precautions to prevent infection.
The researchers tested their device with blood samples collected in December 2020 from about 60 people who had been infected with SARS-CoV-2 and 30 people who had not. They were able to detect neutralizing antibodies in the samples from people previously infected by the virus, with accuracy similar to that of existing laboratory tests. They also tested 30 serial samples from two people before they received an mRNA Covid-19 vaccine and at several time points after vaccination. The level of neutralizing antibodies in the vaccinated individuals peaked around seven weeks after the first dose, then began to slowly decline.
Previous studies of SARS-CoV-2 and other viruses have shown a strong correlation between the amount of neutralizing antibody circulating in an individual’s bloodstream and their likelihood of infection.
The test could be easily adapted to different variants of SARS-CoV-2 by swapping in a reagent that is specific to the RBD from the variant of interest, Li says. The researchers now hope to partner with a diagnostics company that could manufacture large quantities of the tests and obtain FDA approval for their use.
https://stmdailynews.com/category/lifestyle/health-and-wellness
Food and Beverage
Millions of Eggs Recalled Over Possible Salmonella Risk: What Consumers Need to Know
A major egg recall is affecting nearly 1.6 million dozen eggs sold under several popular brands. Here’s how to determine if your eggs are included and what steps to take if they are.
News You Can Use This Moment!
Consumers are being urged to check their refrigerators after a major recall involving nearly 1.6 million dozen shell eggs due to the potential presence of Salmonella Enteritidis, a bacterium that can cause serious foodborne illness.
The voluntary recall, announced by Midwest Poultry Services, L.P., affects white shell eggs and brown cage-free eggs produced at two Texas farms and distributed between June 6 and July 3, 2026. According to the U.S. Food and Drug Administration (FDA), the eggs were sold through grocery stores and foodservice distributors in Texas, Louisiana, Oklahoma, Arkansas, Mississippi, and New Mexico.
What Brands Are Included?
The recalled eggs were sold under several familiar brand names, including:
- Kroger
- Simple Truth
- Brookshire’s
- Country Morning
- Sunups
Not every carton under these brands is affected. Consumers should look for:
- Plant Code: P-1950 or 0840962
- Julian Dates: 157 through 184
- Best By/Sell By Dates: July 20, 2026, through August 17, 2026
Why the Recall Matters
Salmonella can cause symptoms including:
- Diarrhea
- Fever
- Stomach cramps
- Nausea
- Vomiting
Symptoms typically begin 12 to 72 hours after eating contaminated food and usually last four to seven days. While many healthy adults recover without treatment, infections can become severe in young children, older adults, pregnant women, and people with weakened immune systems.
The FDA and the Centers for Disease Control and Prevention (CDC) are investigating a multistate outbreak involving 98 confirmed illnesses across 17 states, resulting in 26 hospitalizations. No deaths have been reported. Investigators say the recalled eggs are linked to part of the outbreak, although they do not account for every reported illness.
What Should You Do?
If you have eggs matching the recalled codes:
- Do not eat them.
- Return them to the store for a refund or dispose of them safely.
- Wash your hands thoroughly after handling the carton.
- Clean and sanitize any refrigerator shelves, containers, or kitchen surfaces the eggs may have touched.
If you have already eaten the eggs and develop symptoms of Salmonella infection, contact your healthcare provider, especially if symptoms are severe or persist.
Are Arizona Consumers Affected?
The recalled products were officially distributed in six states, and Arizona is not listed among the primary distribution states. However, because food products can move through wholesalers, travelers, or secondary retailers, Arizona consumers who recently purchased eggs while traveling—or who received eggs from family or friends in affected states—should still check the carton codes.
The Bottom Line
Food recalls are an important part of protecting public health. Taking a few moments to inspect the eggs in your refrigerator could help prevent a serious illness. If your carton matches the recalled plant codes and date range, don’t take the risk—return it or throw it away.
STM Daily News will continue to monitor this developing story and provide updates as additional information becomes available.
Related Resources
- FDA Recalls, Market Withdrawals & Safety Alerts
- FDA Foodborne Illness Outbreak Investigations
- CDC: Salmonella Information
- FoodSafety.gov Consumer Resources
Child Health
How One Sweet Fruit Packs a Powerful Nutritional Punch
As conversations around nutrient-dense eating continue to grow, fresh fruit has become one of the simplest ways to add naturally occurring vitamins and minerals to everyday routines. One easy place to start is this Nut Butter and Kiwifruit Toast, which combines wholesome ingredients with the sweet tropical flavor of kiwifruit (sweet fruit) for a satisfying breakfast, snack or light meal.
How One Sweet Fruit Packs a Powerful Nutritional Punch
(Feature Impact) Consumers today are looking for foods that do more than simply taste good; they want foods that deliver nutrition in every bite. As conversations around nutrient-dense eating continue to grow, fresh fruit has become one of the simplest ways to add naturally occurring vitamins and minerals to everyday routines.
Kiwifruit is a standout example. According to the International Fresh Produce Association, kiwifruit climbed to No. 14 among the nation’s top-selling fresh fruits with household purchasing increasing 20%. What’s more, it’s now the fastest-growing fruit in the fruit bowl as more shoppers discover its unique combination of exceptional nutrition and naturally sweet flavor.
That success story has been more than a century in the making.
From Ancient Origins to Modern Favorite
Although many people associate kiwifruit with New Zealand, its story began in China’s Yangtze River Valley. In 1904, New Zealand educator Isabel Fraser returned home from China with green kiwifruit seeds, which she passed along to horticulturist Alexander Allison. Over the following decades, growers cultivated and refined the fruit, helping establish New Zealand as the world’s leading kiwifruit producer.
By the 1990s, years of natural breeding and cross-pollination led to the development of the first commercially successful yellow-fleshed kiwifruit, offering consumers a sweeter flavor and vibrant golden flesh. When a devastating vine disease threatened orchards worldwide in 2010, continued breeding innovation led to the development of Zespri SunGold Kiwifruit – a resilient variety with smooth skin, juicy golden flesh and a tropical-sweet flavor that helped revitalize the category.
Jam-Packed With Nutrition
Today, kiwifruit is recognized as one of the most nutrient-dense fruits available, making it an easy choice for people looking to get more nutritional value from the foods they eat. They provide more than 10 vitamins and minerals in every serving, including vitamin C to contribute to the normal function of the immune system, folate to support healthy cell growth and development and vitamin E to help protect cells from everyday damage.
“When people think about eating healthier, they often assume it has to be complicated,” registered dietitian Nisha Melvani said. “I encourage people to start with simple, whole foods that naturally deliver a variety of nutrients. Zespri SunGold Kiwifruit is an easy choice because it provides more than 10 vitamins and minerals, including 100% of your daily vitamin C needs, in one delicious fruit that fits seamlessly into breakfast, snacks or even dessert.”
From Orchard to Everyday Favorite
As more consumers embrace whole foods over complicated nutrition trends, kiwis are finding their way into everyday routines – and pop culture. Creators including Emma Chamberlain and musician Josh Conway have highlighted the fruit as part of their daily snacking habits, while “Good Housekeeping” featured golden kiwifruit in its 2025 Best Produce Snacks of the Year, highlighting its naturally sweet flavor, juicy texture and broad appeal.
Whether enjoyed on its own, added to smoothies, layered onto yogurt or incorporated into savory dishes, kiwifruit offers a simple, delicious way to enjoy more nutrition throughout the day. One easy place to start is this Nut Butter and Kiwifruit Toast, which combines wholesome ingredients with the sweet tropical flavor of Zespri SunGold Kiwifruit for a satisfying breakfast, snack or light meal.
Discover more fresh recipes, nutrition insights and delicious ways to enjoy kiwifruit at Zespri.com and see why one of today’s fastest-growing fruits is earning a permanent place in more fruit bowls.
Nut Butter and Kiwifruit Toast
Nut Butter:
- 1 cup roasted nuts (almonds, cashews, hazelnuts or pecans)
- sunflower oil
- 1/4 teaspoon salt
- 1 tablespoon seeds (chia, sunflower or hemp)
- 2 slices sprouted grain bread, toasted
- 1 Zespri SunGold Kiwifruit, sliced
- To make nut butter: In food processor, blend nuts at high speed until finely ground. Scrape sides of blender. Add few drizzles of sunflower oil, salt and seeds; blend until creamy. Transfer to jar and store up to 1 week in refrigerator.
- Spread nut butter onto toasted bread and top with slices of kiwi.
SOURCE:
Zespri
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How Invasive Pests Spread and How You Can Help Stop Them
(Feature Impact) Invasive pests can hide in places you’d never expect, and once they spread, they can destroy the trees, plants and food people rely on every day. These pests pose a serious threat to agriculture, forests, ecosystems and the food supply. Many invasive species cannot travel far on their own; instead people unknowingly move them from place to place.
According to the U.S. Department of Agriculture’s Animal and Plant Health Inspection Service, invasive pests hitchhike on everyday items such as plants, produce, firewood, vehicles and outdoor equipment. That makes many common activities – from traveling and online shopping to camping and gardening – potential “pathways” for invasive pests to move and reach new areas. Understanding these pathways is the first step to stopping pests before they spread.
Traveling Abroad
When you travel abroad and return from another country, the agricultural items you bring back can introduce new invasive pests into the U.S. and threaten crops or trees that have no natural defenses against them. Even harmless-looking fruit, seed packets or souvenirs made with plant materials can carry pests such as fruit flies and diseases like citrus canker. That’s why it’s critical travelers declare food, plants and other agricultural products when entering the country from abroad.
Shopping Online
Just because you can order seeds and plants from sellers around the world, it doesn’t mean those items are legal or safe to import. In fact, some invasive snails and plant diseases have entered the U.S. this way. Many agricultural products from overseas require permits, inspections or special paperwork before they can enter the country. Buyers should check where an item ships from, learn the import requirements before purchasing and make sure sellers follow all labeling and shipping rules.
Partaking in Outdoor Activities
When you spend time outdoors hiking, camping, hunting or fishing, you could inadvertently spread invasive species. For example, transporting firewood from one location to another can spread tree-killing insects, such as the emerald ash borer, which can live inside the wood and emerge later in a new area. The safest choice is to buy or use firewood where you burn it. Additionally, clean all outdoor clothing, gear, equipment and vehicles before leaving an area.
Moving Outdoor Equipment
When you move to a new home, your move can create another opportunity for invasive insects to travel. Before relocating patio furniture, grills, trailers or lawn equipment, inspect and clean them carefully. Look for insects, plant debris and egg masses like spotted lanternfly egg masses, which can blend into outdoor surfaces and look like smears of mud or clumps of dirt. A few minutes of checking and cleaning before you move can help prevent pests from invading your new neighborhood.
Invasive pests cost the U.S. billions of dollars every year and damage forests, farms, parks and backyards. Stopping invasive pests starts with simple steps anyone can take: checking what you pack, clean, move and buy. When everyone does their part, fewer pests spread and communities stay healthier and more resilient.
Visit aphis.usda.gov/hungrypests to learn more about how invasive pests spread and the simple steps you can take to help stop them and protect America’s agriculture and natural resources.
Invasive Pest Protection Checklist
- Declare all food, plants and agricultural items when returning from another country.
- When ordering items online, check where the products ship from and verify U.S. import rules before buying.
- If you’re camping, buy firewood where you plan to burn it. Clean clothing, gear and vehicles before leaving.
- Before moving to a new home, inspect outdoor furniture and equipment, looking closely for egg masses or insects.
Content courtesy of USDA.
SOURCE:
United States Department of Agriculture
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