Health
Help Wanted: How clinical trials help fight disease
(Family Features) Clinical trials are necessary for finding new ways of preventing, detecting or treating diseases, but often, limited participation creates challenges for meeting clinical trial goals. Despite decades of effort and strategies to identify and address barriers to recruiting and enrolling study participants, recruitment challenges persist, particularly among women, older adults and diverse patient populations.
Clinical trials
“Potential study participants are reluctant to get involved for a variety of reasons, including the time commitment, lack of clarity regarding safeguards for their well-being and concerns about how their medical condition will be handled during the study,” said Alan Moss, MD, chief scientific officer with the Crohn’s & Colitis Foundation, the leading nonprofit organization focused on both research and support of people living with inflammatory bowel disease (IBD). “Taking part in a clinical trial gives patients an opportunity to access new therapies and can help shape future treatment, including how diseases are diagnosed, treated and even prevented.”
Learning more about the important role clinical trials play in health care may ultimately help you or someone you love find a new treatment or manage a condition, such as IBD, more effectively.
Importance of Clinical Trials
Finding a treatment that relieves patients’ symptoms and helps induce and maintain remission is important. However, these treatments wouldn’t be available without clinical trials. In fact, all U.S. Food & Drug Administration (FDA)-approved medicines currently available on the market are the result of clinical trials and the patients who participated in them. When enrollment targets aren’t reached due to low patient participation, there may be delays in the drug approval process.
What You Should Know
There are plenty of reasons to consider participating in a clinical trial, especially if you’re looking for further options to treat a serious condition. Taking part in a clinical trial is a big step, so it’s important to be well-informed.
- Safety: Investigational treatments must be studied extensively before the FDA will approve them. Each trial follows thorough protocols to ensure the health and safety of its participants. Additionally, patients are followed continuously throughout a trial to monitor their health.
- Eligibility: Who can participate in a clinical trial depends greatly on the specific limits of the study. Each clinical trial has its own goals to achieve, which means different trials have different criteria for patients to meet in order to enroll. Some trials are for patients who have moderate to severe disease and others may seek patients with mild disease. Other trials look for patients without any diagnosis. Prior to enrolling in a trial, a research coordinator will review your complete medical history to see if you meet the inclusion criteria.
- Treatment: When you decide to enroll in a clinical trial, you may have access to the study drug as a form of treatment. Typically, participants will not know if they are receiving the study drug during the trial. This helps reduce potential biases and ensures the fairness of the trial. However, all participants are monitored closely. If there is any change in your medical condition while participating in the study, the research staff will inform you immediately and discuss the situation.
- Cost: The majority of clinical trials are federally or privately funded, so there is typically no cost to participants. While federal law requires most health insurance plans to cover the majority of routine patient care costs associated with clinical trials, there are some costs you may incur, such as travel, gas, parking, child care and time away from work. Trial sponsors commonly cover these costs, as well as any non-routine patient care that isn’t covered by insurance. However, it’s a good idea to get a clear understanding of how the trial you’re considering would handle these expenses.
- Leaving the study: At any point you wish to drop out of the trial, you can, and for any reason. In that case, it’s common for a research coordinator to ask you to complete a final visit and schedule follow-up visits, if needed, to ensure you do not experience any side effects.
How to Learn More
If you’re interested in participating in a clinical trial, it’s important to go to trusted sources to learn more and ask questions. For example, the Crohn’s & Colitis Foundation can point you toward clinical trial opportunities. Your doctor’s office can also be a good source of information about local studies.
If you’re hesitant about joining a trial involving a treatment but are eager to help, you might consider other types of research studies, such as prevention, diagnostic, screening or quality of life trials instead.
Once you identify a clinical trial that interests you and you may be eligible for, contact the research coordinator to learn more. You’ll also want to discuss the study in greater detail with your doctor and talk to loved ones within your support system who may have questions or helpful insight to consider.
Visit crohnscolitisfoundation.org/clinical-trials-community to learn more about IBD clinical trials and find opportunities near you.
Understanding IBD
Inflammatory bowel disease (IBD) affects nearly 1 in 100 people living in the United States, according to a study led by the Crohn’s & Colitis Foundation. IBD is an umbrella term used to describe disorders that cause chronic inflammation of the gastrointestinal (GI) tract.
Symptoms include diarrhea, as well as abdominal pain, nausea, fever, loss of appetite, fatigue and, at times, rectal bleeding. No single test can confirm IBD, which includes Crohn’s disease and ulcerative colitis. There are currently no cures for IBD. Medication and managing your diet and nutrition are two of the most common treatment recommendations.
Photos courtesy of Shutterstock
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Crohn’s & Colitis Foundation
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Child Health
Changing the Landscape of Childhood Cancer Survivorship
Childhood Cancer: hile “cancer” is a term no family wants to hear, especially when it comes to their children, there is reason for hope. Today, 85% of children diagnosed with cancer survive at least five years. Survival is only part of the journey, however.
Changing the Landscape of Childhood Cancer Survivorship
(Feature Impact) While “cancer” is a term no family wants to hear, especially when it comes to their children, there is reason for hope. Today, 85% of children diagnosed with cancer survive at least five years, according to the National Cancer Institute, up from 75% three decades ago.
Watch this video to learn more
“This progress is driven in large part by dedicated research,” Hyundai Hope on Wheels Board Member Kevin Reilly said. “Over the last 28 years, Hyundai Hope on Wheels has committed over $300 million in pediatric cancer research and program grants, awarding more than 1,600 grants to 210 medical institutions nationwide, impacting thousands of young lives each year.”
Survival is only part of the journey, however. Nearly half (46%) of U.S. adults believe a child ringing the hospital bell after cancer treatment means the child is cancer-free and their medical journey is largely over, according to a survey conducted by Atomik Research on behalf of Hyundai Hope on Wheels. For the children and families living through a diagnosis, the reality is far more complex.
“The reality is that healing continues long after treatment, which is why sustained investment in survivorship care is a priority for us,” said John Guastaferro, executive director of Hyundai Hope on Wheels.
Isabella Franco-Capps, 11, understands that journey firsthand. Diagnosed with B-cell acute lymphoblastic leukemia at age 5, her journey took two years before she could say she’s “a cancer survivor.”
“I was diagnosed with b-cell acute lymphoblastic leukemia,” she said. “This began my two-year-long journey of scans, pokes, chemotherapy and hospital stays. And now I’m a cancer survivor.”
Fellow Hyundai Hope on Wheels National Youth Ambassador, Jackson Trihn, 12, is using his voice to call for continued research and to bring hope to others.
“The role … is being able to share my story,” he said. “Not just to spread awareness but to spread hope to kids that need it. And awareness is so important because people don’t understand how hard pediatric cancer can be.”
Continued progress can help ensure more children ring the bell and receive the care and support they need long after they’ve had the opportunity to do so. To learn more about these efforts and how you can help, visit HyundaiHopeOnWheels.org.
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(Feature Impact) Driven by rising rates of obesity, diabetes, high blood pressure and other risk factors,cardiovascular disease has surpassed cancer as the leading cause of death among Hispanic adults in the United States.
Hispanic people represent nearly 1 in 5 of the U.S. population and are the nation’s largest ethnic minority group, yet many continue to face barriers to achieving heart health and accessing high-quality healthcare. A new scientific statement published in the American Heart Association’s flagship journal, “Circulation,” revealed how social, economic, cultural and environmental factors contribute to persistent disparities in cardiovascular health, calling for culturally tailored prevention strategies, equitable access to care and greater representation of Hispanic populations in cardiovascular research.
“Hispanic populations in the U.S. are incredibly diverse even within their own communities with differences in genetic ancestry, language, cultural traditions and social experiences that can significantly influence cardiovascular health,” said Johanna Contreras, M.D., M.Sc., FAHA, director of the Division of Heart Failure and medical director of the Hispanic Heart Center within the Mount Sinai Health System. “Yet Hispanic people remain underrepresented overall in the research that guides prevention and treatment strategies… Without better representation and more detailed data, we risk overlooking important differences that can help us improve care and save lives.”
Hispanic Cardiovascular Health by the Numbers
Cardiovascular risk factors – obesity (nearly 46%), type 2 diabetes (15.5%) and high blood pressure (approximately 44%) – are prevalent among Hispanic adults and often emerge at younger ages and occur more frequently among Hispanic adults compared with white adults.
According to the report, only about 1 in 5 Hispanic adults achieves ideal cardiovascular health as defined by the American Heart Association’s original Life’s Simple 7 metrics. Updated analyses using the Life’s Essential 8 framework demonstrated persistent disparities for heart and brain health, as well as suboptimal dietary quality, sleep patterns and levels of physical activity.
Social and Economic Barriers Matter
Biology alone does not explain cardiovascular health disparities. The environments where people live, work and age, along with social and economic challenges, impact heart health. In fact, approximately 17% of Hispanics live below the federal poverty threshold, compared with 8.2% of white adults.
“Many Hispanic adults face obstacles that extend far beyond the doctor’s office,” Contreras said. “Limited health insurance coverage, language differences, food insecurity, environmental exposures and concerns related to immigration status can make it more difficult to prevent disease, manage chronic conditions and receive timely treatment.”
Contreras emphasized the cultural values and practices of Hispanic people also influence how they perceive their health and healthcare options.
“Family plays a central role in many Hispanic communities and can be an extraordinary source of strength, support and resilience,” Contreras said. “At the same time, family members are often called upon to translate medical information, navigate health systems and help make healthcare decisions for loved ones. Those responsibilities can shape how health information is understood and acted upon.”
An Action Plan for Improving Hispanic Health
There are practical opportunities to achieve equitable cardiovascular health and reduce disparities through community engagement, culturally responsive care, inclusive research and policies that address the underlying drivers of health.
“Reducing cardiovascular disease among Hispanic populations demands action at every level,” Contreras said, “from improving access to culturally responsive care and expanding research participation to addressing the social and environmental conditions that shape health.”
By addressing both medical risk factors and the social conditions that shape health, experts believe there is an important opportunity to reduce disparities and help more people live longer, healthier lives. Learn more at Heart.org.
Photo courtesy of Shutterstock
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Food and Beverage
Beyond Protein: 2 Nutrients Your Plate Might Be Missing
Nutrients: Everyone is talking about protein these days whether watching their weight or managing a disease like type 2 diabetes. However, fiber and healthy fats are nutrients many people are overlooking. One food that makes it easier to invest in your health, according to nutrition experts: avocados.
Beyond Protein: 2 Nutrients Your Plate Might Be Missing
(Feature Impact) Everyone is talking about protein these days whether watching their weight or managing a disease like type 2 diabetes. However, fiber and healthy fats are nutrients many people are overlooking. The latest reports show most Americans already meet or exceed recommendations for protein while nearly all (about 95%) do not eat enough fiber, and many people consume too much saturated fat versus unsaturated fat, according to the 2025 Dietary Guidelines Advisory Committee. Prioritizing ways to get more fiber and healthy fats on your plate could be key to managing weight and type 2 diabetes goals this summer.
One food that makes it easier to invest in your health, according to nutrition experts: avocados.
A growing body of research and materials from Avocados – Love One Today, a science-based resource, suggests fresh avocados offer weight management benefits, help with type 2 diabetes management and are good for blood sugar management.
According to a study* of more than 27,000 adults published in the journal “Internal Medicine Review,” people who ate just over half of an avocado per day weighed 7.5 pounds less, had smaller waist sizes and tended to have healthier overall eating habits, including higher intakes of fiber and healthy fats, compared to people who didn’t eat avocados. Among the list of benefits, this delicious and healthy fruit uniquely contains fiber and healthy fats in each nutrient-dense bite which slows digestion, helping you feel satisfied and fuller longer which can help you consume fewer calories overall. In fact, if you’re using a GLP-1, avocados are one of the foods to add to your menu to make small meals feel more filling and satisfying while supporting nutrient needs.
Scientists also recently took a second look at the largest study* about avocado consumption to-date involving close to 1,000 adults, per the journal “Current Developments in Nutrition,” and found that consistently eating one avocado every day for six months (no other diet changes required) significantly reduced dietary glycemic load (GL) by nearly 14 points, a metric that evaluates how what you are eating is affecting your blood sugar levels. GL may be an important consideration in the management of chronic diseases like type 2 diabetes. By slowing digestion, fiber and healthy fats also support stable blood sugar levels.
There are many ways to enjoy avocados, including chopped, sliced, mashed, blended, in baked goods or even frozen. Avocados add flavor, variety and nutrition across the day.
Try these recipes for Avocado and Blueberry Chia Pudding, Avocado Breakfast Bowl with Leafy Greens for your next breakfast or snack.
*Remember: Small, consistent food choices can add up over time. Research suggests regularly eating avocados may support weight management and blood sugar targets while providing the fiber and healthy fats that many Americans are overlooking. These studies were supported by the Avocado Nutrition Center. While these findings are encouraging, the studies highlighted show an association, not cause and effect, and thus more research is needed to confirm these findings in other populations.
To explore evidence-based avocado nutrition information, along with practical tips and easy recipes, visit Avocados – Love One Today, a leading resource for avocado nutrition information.
Avocado and Blueberry Chia Pudding
- 1 1/2 cups plain, unsweetened soy milk (or milk of choice)
- 1 ripe, fresh avocado, halved, pitted and peeled
- 3/4 cup frozen blueberries
- 1/2 cup unsweetened vanilla Greek yogurt
- 1 tablespoon maple syrup
- 1/3 cup chia seeds
To Serve:
- 1/3 cup granola
- 1/3 cup fresh blueberries
- 1 kiwi, chopped
- 1/2 fresh, ripe avocado, halved, pitted, peeled and chopped
- In blender, puree soy milk, avocado, blueberries, yogurt and maple syrup until smooth. Pour mixture into storage container or bowl and add chia seeds. Whisk well to combine. Cover with lid or plastic wrap and refrigerate 4 hours or overnight, until thickened.
- To serve, divide into bowls and top with granola, fresh blueberries, kiwi and avocado.
- Notes: Use any milk (dairy or non-dairy) that you prefer in pudding. Use fresh blueberries or conventional frozen blueberries. Other topping options include: nuts, seeds, hemp hearts, sliced banana or strawberries, or nut butter.
Avocado Breakfast Bowl with Leafy Greens
Bowl:
- 1 medium sweet potato, chopped (about 1 3/4 cup)
- nonstick cooking spray
- 1/4 teaspoon smoked paprika
- 1/4 teaspoon garlic powder
- 1/4 teaspoon salt
- 1/2 cup quinoa
- 1 cup water, plus additional for boiling eggs, divided
- 2 eggs
- 2 cups arugula
- 1 ripe, fresh avocado, halved, pitted, peeled and chopped
- 1/4 cup pickled red onions
Avocado Tahini Dressing:
- 1/2 large avocado
- 1/4 cup tahini
- 1 lemon, juice only (2 tablespoons)
- 3/4 cup water
- 1 tablespoon fresh chives
- salt, to taste
- pepper, to taste
- Preheat oven to 400 F. Add chopped sweet potato to baking sheet. Spray with cooking oil then add smoked paprika, garlic powder and salt. Toss to coat in spices. Bake 22-25 minutes, or until tender.
- In medium saucepan, add quinoa and water. Bring to simmer and cover, cooking 12-15 minutes, or until quinoa is tender and fluffy.
- Fill small saucepan with water and bring to boil. Use slotted spoon to lower eggs into water. Cook 8 minutes then transfer eggs to bowl of ice water to cool before peeling.
- To make dressing: In small blender, puree avocado, tahini, lemon juice, water and fresh chives until smooth. Add more water, 1 tablespoon at a time, if needed, to thin until pourable. Season with salt and pepper, to taste.
- Assemble bowls, each with 1/2 sweet potato, 1/2 cup quinoa, 1 egg, 1 cup arugula, 1/2 avocado, 2 tablespoons pickled red onion and 3 tablespoons dressing. Reserve remaining dressing in refrigerator.
Heart-Healthy Frozen Avocado Banana Paleta
- 1 ripe, fresh avocado, halved, pitted, peeled and diced
- 4 cups orange juice
- 2 medium bananas, peeled and sliced
- 1 tablespoon lime juice
- 8 paper cups (5 ounces)
- 8 wooden craft sticks
- In blender, blend avocado, orange juice, bananas and lime juice on high until smooth. Divide into paper cups. Cover cups with aluminum foil. Insert one stick through center of each foil. Freeze 4 hours until firm.
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