health and wellness
How to Talk to Your Doctor About Statin Intolerance
Last Updated on October 5, 2025 by Daily News Staff
How to Talk to Your Doctor About Statin Intolerance
(Family Features) If your doctor has concerns about your cholesterol levels, you may be familiar with statins. This is a class of medications that can help reduce your body’s cholesterol production, lowering your risk of heart attack or stroke.
However, up to 30% of adults in the United States have some degree of statin intolerance, according to research published in the “Journal of Clinical Lipidology.” Possible signs or symptoms of statin intolerance are muscle aches and cramps, fatigue, weakness, elevated liver enzymes and the onset of diabetes or impaired glucose tolerance.
As a result, nearly one-third of patients (29%) discontinue their statin within the first year, according to findings published in the “American Journal of Cardiology.” Unfortunately, patients with statin intolerance are at an increased risk of cardiovascular disease, including higher rates of coronary heart disease and recurrent heart attack.
Lowering Bad Cholesterol
A diagnosis of high cholesterol involves measuring low-density lipoprotein (LDL) cholesterol, which is commonly referred to as “bad” cholesterol because it leads to the accumulation of plaque in your arteries. Plaque reduces your blood flow, which can cause damage to your cardiovascular system.
Bloodwork is the best indicator of your cholesterol levels, since you may not experience any symptoms of high cholesterol until you already have damage and buildup in your arteries.
To help create your treatment plan, talk to your doctor about your medical history, including whether you’ve had a heart attack or any heart procedures, such as a stent placement or bypass surgery. You’ll also review current medications, recent lab results and notes on any symptoms you may be experiencing.
Your doctor is likely to recommend a series of steps to reduce your cholesterol. Some common recommendations include a healthy diet low in saturated and trans fats and high in fiber, especially fruits, vegetables and whole grains.
If you’re not already getting regular physical activity, your doctor will likely encourage you to get at least 30 minutes of exercise daily, find ways to include more movement in your everyday lifestyle and, if necessary, work toward shedding extra weight.
Lifestyle changes can help but may not make a big enough impact to reduce cholesterol to a recommended level. In those cases, doctors rely on cholesterol-lowering medications such as statins. Statins can be highly effective at reducing bad cholesterol, making them a powerful tool to reduce the risks associated with heart disease.
When Statins Are Intolerable or Aren’t Enough
For a variety of reasons, including intolerance to the medication, other health conditions or interactions with other medications, statins may not be the right choice for everyone.
“While statins remain the gold standard for cholesterol lowering, I often see patients who either can’t or won’t take a statin, as well as patients who require further LDL cholesterol reduction,” said Guy L. Mintz, Director of Cardiovascular Health & Lipidolology at Northwell Health System. “For those patients, I prescribe non-statin medications, such as NEXLETOL (an oral prescription medication with the cholesterol lowering agent bempedoic acid) and NEXLIZET (a combination of cholesterol-lowering medicines bempedoic acid and ezetimibe). I am comfortable using NEXLETOL and NEXLIZET, along with a healthy diet and exercise, to reduce LDL cholesterol in adults with high blood cholesterol levels and to reduce risk of heart events. Non-statins are another important therapeutic tool in our lipid lowering toolbox.”
To learn more visit Nexlizet.com.
Photo courtesy of Shutterstock
IMPORTANT SAFETY INFORMATION
What are NEXLIZET tablets and NEXLETOL tablets?
- Along with a diet:
- NEXLETOL is used, with other cholesterol-lowering medicines, or alone when use with other cholesterol-lowering medicines is not possible, to reduce low-density lipoprotein (LDL, or bad cholesterol) in adults with high blood cholesterol levels called primary hyperlipidemia, including a type of high blood cholesterol called heterozygous familial hypercholesterolemia (HeFH).
- NEXLIZET is used, with or without other cholesterol-lowering medicines, to reduce low- density lipoprotein (LDL, or bad cholesterol) in adults with high blood cholesterol levels called primary hyperlipidemia, including a type of high cholesterol called heterozygous familial hypercholesterolemia (HeFH).
- The bempedoic acid portion of NEXLIZET and NEXLETOL is used to lower the risk of heart attack and heart procedures like stent placement or bypass surgery, in adults who are unable to take recommended statin treatment (a cholesterol-lowering medicine), or are not taking a statin, who:
- have known heart disease, or
- are at high risk for heart disease but without known heart disease.
Do not take NEXLIZET if you are allergic to ezetimibe or bempedoic acid, or any ingredients in NEXLIZET or NEXLETOL. If you have any of the following signs and symptoms of a serious allergic reaction, call your healthcare provider or go to the nearest hospital emergency room:
- swelling of your face, lips, mouth, or tongue
- wheezing
- severe itching
- fast heartbeat or pounding in your chest
- trouble breathing
- skin rashes, redness, or swelling
- dizziness or fainting
What should I tell my healthcare provider before taking NEXLIZET or NEXLETOL? Tell your healthcare provider if you:
- have, or had, gout
- have or had tendon problems
- are pregnant or breastfeeding or may become pregnant or plan to breastfeed. It is not known if NEXLIZET or NEXLETOL passes into your breastmilk
- have severe kidney or severe liver problems
Tell your healthcare provider about all the medicines you take, including prescription and over-the- counter medicines, vitamins and herbal supplements.
Especially tell your healthcare provider if you take or plan to take simvastatin or pravastatin, as taking either with bempedoic acid may increase your risk of developing muscle pain or weakness. If you take NEXLIZET, tell your doctor if you take cyclosporine, fibrates, or cholestyramine.
What is the most important safety information I should know about NEXLIZET and NEXLETOL? NEXLIZET and NEXLETOL can cause serious side effects, including:
- increased levels of uric acid in the blood, which can lead to gout, a painful joint condition. Call your doctor if you have any of the following symptoms: severe foot pain especially in the toe joint, warm joints, swelling, tender joints or joint redness.
- tendon rupture or injury. Tendon problems can happen in people who take bempedoic acid, one of the medicines in NEXLIZET or NEXLETOL. The risk of getting tendon problems while you take NEXLIZET or NEXLETOL is higher if you: are over 60 years of age, are taking steroids, are taking antibiotics called fluoroquinolones, have renal failure, or have had tendon problems in the past. Stop taking NEXLIZET or NEXLETOL immediately and get medical help if you experience signs of tendon rupture such as snap or pop in tendon area, bruising after an injury in a tendon area, or unable to move or put weight on the affected area.
The most common side effects in people with primary hyperlipidemia:
- NEXLETOL includes symptoms of the common cold or flu-like symptoms, muscle spasms, back pain, stomach pain, bronchitis, pain in shoulder, legs, or arms, anemia and increased liver enzymes.
- NEXLIZET includes symptoms of the common cold or flu-like symptoms, muscle spasms, back pain, stomach pain, bronchitis, pain in shoulder, legs, or arms, anemia, increased liver enzymes, diarrhea, joint pain, swelling of sinuses and fatigue.
The most common side effects of bempedoic acid, a component of NEXLIZET and NEXLETOL, in people with heart problems include kidney problems, anemia, increased liver enzymes, muscle spasms, and gallstones.
These are not all the possible side effects of NEXLIZET and NEXLETOL. For more information, ask your healthcare provider or pharmacist for more information.
Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
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Child Health
Pediatric Cancer Goes Beyond a Victory Bell: How Research and Innovation Improve Survivorship Rates
(Feature Impact) For every tear-jerking video found online of a child ringing a bell that signifies a cancer journey victory, there are dozens, if not more, people working behind the scenes. From leading minds in cancer research to doctors, nurses and support staff, a vast network of people and decades of medical advancements make those moments possible.
In fact, in the last 10 years, the FDA approved 10 new immunotherapies and 20 molecularly targeted therapies to treat pediatric cancers, according to the American Association for Cancer Research. Those breakthroughs – and the children they impact – come with a cost, which is why Hyundai Hope on Wheels has served as a pioneer in increasing survival rates by investing $303 million in pediatric cancer research over nearly three decades.
Those funds have supported more than 1,600 grants to 210 institutions, leading to new insights into cancer biology, clinical trials and new drug development while bringing hope at all stages of a child’s cancer journey.
However, there remains work to be accomplished. According to a survey conducted by Atomik Research on behalf of Hyundai Hope on Wheels, 46% of U.S. adults believe that a child ringing a hospital bell after cancer treatment signifies the child is cancer-free and their medical journey is largely over. The reality is more nuanced than that. In fact, more than one-third of respondents said they’re not familiar with the term cancer survivorship or they have heard the term but don’t fully understand what it means.
Many health care organizations define survivorship as beginning at the time of diagnosis and continuing through treatment and beyond. According to the American Association for Cancer Research, children who survive cancer face several long-term physical and psycho-social challenges due to their cancer and treatment, including planned surgeries, additional rounds of radiation or other forms of medical treatment to address common physical challenges stemming from chemotherapy.
Survival rates continue increasing with scientific and technological breakthroughs, up from 75% to 85% in nearly three decades, representing roughly 40,000 more children surviving their diagnoses. More than 3 in 4 U.S. adults are encouraged by that progress.
For survivors, treatment is just the beginning. Research, follow-up care and long-term funding determine what comes next, and every grant funded and every survivorship program backed means more children reaching adulthood.
According to the survey, more than 80% of adults said they’re more likely to support organizations that fund survivorship services, creating opportunities to fund crucial research and support for children facing pediatric cancer. Collaboration among leading minds, made possible by funding from organizations like Hyundai Hope on Wheels, has led to the development of comprehensive approaches to help children thrive during life after cancer, including enhanced medical records, AI integration, socioemotional support and combatting long-term side effects.
Find more information and ways you can join the fight by visiting HyundaiHopeOnWheels.org.
Photo courtesy of Shutterstock
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Child Health
A child rings the cancer bell. Here’s what that moment doesn’t show
Cancer Bell: A child who’s been treated for cancer walks down the hall of a medical facility, nurses and doctors smiling at them from all corners of the room. The child rings a bell, and everyone cheers as the kid hugs their loved ones. These heartfelt videos appear regularly across social media. What helps make each of those moments possible is decades of research and innovation. For every bell-ringing child whose video goes viral online, a longer health journey awaits.
A child rings the cancer bell. Here’s what that moment doesn’t show
(Sheeka Sanahon) A child who’s been treated for cancer walks down the hall of a medical facility, nurses and doctors smiling at them from all corners of the room. The child rings a bell, and everyone cheers as the kid hugs their loved ones. These heartfelt videos appear regularly across social media. What helps make each of those moments possible is decades of research and innovation. In the last 10 years, the Food and Drug Administration (FDA) approved 10 new immunotherapies and 20 molecularly targeted therapies to treat pediatric cancers, according to the American Association for Cancer Research.
For every bell-ringing child whose video goes viral online, a longer health journey awaits. Hyundai Hope on Wheels, which has funded pediatric cancer research for nearly three decades, commissioned a survey to understand how much Americans know about that journey.
As September marks Childhood Cancer Awareness Month, what that journey actually looks like is worth understanding. According to the survey, 46% of U.S. adults believe that a child ringing a hospital bell after cancer treatment signifies the child is cancer-free and their medical journey is largely over. The reality is more nuanced than that.
When cancer survivorship begins
Many health care organizations define survivorship as beginning at the time of diagnosis and continuing through treatment and beyond. Understanding survivorship this way helps recognize that a child’s cancer journey is about more than reaching the end of treatment. It also includes managing long-term physical, emotional and medical needs that may continue for years to come.
More than a third of U.S. adults say they’re not familiar with the term cancer survivorship or they have heard theterm but don’t fully understand what it means.
According to the American Association for Cancer Research, children who survive cancer face several long-term physical and psycho-social challenges due to their cancer and treatment. Children could face planned surgeries, additional rounds of radiation, or other forms of medical treatment to address common physical challenges stemming from chemotherapy. Every child’s medical treatment plan is different based on their specific needs, but one thing is clear: Pediatric cancer survivors need ongoing support as they navigate long-term health challenges.
Supporting children to live long, full lives
More than 3 in 4 U.S. adults are encouraged by the progress in pediatric cancer, up 5 points from last year. There’s good reason to be hopeful, too. According to the American Cancer Society, the survival rate among pediatric cancer patients has increased from 75% to 85% in nearly three decades, representing 40,000 more children surviving their cancer diagnosis.
Survival rates continue to increase thanks to breakthrough science and technology, and higher standards of care. Pediatric cancer research has led to new insights into cancer biology, clinical trials, and new drug development.
More than 8 in 10 adults say they’re more likely to support organizations that fund survivorship services, which creates more opportunities to fund crucial research and support for children facing pediatric cancer.
Methodology
Hyundai Hope on Wheels commissioned Atomik Research to conduct an online survey of 1,005 adults throughout the United States. The margin of error is +/- 3 percentage points with a confidence level of 95%. Fieldwork took place March 19-26, 2026. Atomik Research, part of 4media group, is a creative market research agency.
Photo courtesy of Shutterstock
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Family
The back-to-school haircut is more than hair: Survey finds 94% of parents say their son’s appearance affects their confidence
(Sheeka Sanahon) Parents spend years styling their children, picking out just the right outfits for special occasions, choosing a haircut that suits their sweet little faces, and doing their best to keep up with how quickly they outgrow their shoes. Just as parents begin to master all the moving parts, a new variable gets thrown into the equation: the opinions of the child whose every style decision they once made.
According to survey data from Sport Clips Haircuts, a sports-themed haircutting franchise specializing in haircuts for men and boys, 84% of parents say that by the time their son reaches middle or high school, he cares significantly or somewhat more about his appearance. According to Psychology Today, physical appearance is important for adolescent children as a means to express identity and to fit in with the norms of their peers. What has changed is the amount of pressure on today’s generation of children to present themselves well; 71% of parents surveyed by Sport Clips say boys today face more pressure to look put together going into a new school year than they remember from their own school years.
Preteen and Teen Boys are Developing Their Own Sense of Style
The surveyed parents report that in the coming days and weeks before the new school year begins, more than a third of their preteen and teen boys ask for a back-to-school haircut. Another 22% of parents say both they and their boys bring it up around the same time. That’s more than half of boys already thinking about how they’ll show up on the first day.
If you thought mom and dad’s opinions mattered regarding the type of haircut they want, think again. More than half of boys ages 11 to 17 know exactly what haircut they want to get before the school year begins. Parents report that many of them are inspired by celebrities, athletes or people they follow online.
The Confidence Connection
As children get older and express more desire for choosing their style, giving them the choice to pick what’s right for them can be a great opportunity to boost their confidence. Ninety-five percent of parents say there is a connection between how confident their son feels about his appearance and how he shows up at school, in sports and social activities. Young boys and their parents are thinking about more than just the haircut. Finding clothes that their son feels good in, as well as talking through what he’s most excited and most nervous about for the new school year, are all part of the preparation.
The Back-to-School Checklist
This checklist creates an important set of traditions to get the school year started off on the right foot. While 71% of parents say getting their son a fresh haircut or new hairstyle has become a reliable part of their back-to-school routine, 20% notice their child shift back into school mode when they pick out their first day outfit. For 19%, it’s when he packs or organizes his bag.
The Styles Middle School and High School Boys Are Asking For
So what styles are boys most likely to ask for to start this school year? According to the survey data, 30% of boys want a tapered fade like the haircut U.S. goalkeeper Matt Freese wore during the 2026 World Cup. Nearly a quarter (24%) of respondents said their child wants a classic cut, like the kind of style YouTuber Caylus Cunningham tends to wear. Only 10% of boys are requesting a longer or shaggy style, like actor Jacob Elordi, and even fewer are looking for fringe bangs, the broccoli cut (which is short on the sides and curly on top) or a buzz cut.
A few parents aren’t sure what kind of look their child is going for this school year. Eight percent say they’re not even sure what to call the hairstyle preferred by the boys in their lives.
Methodology: Sport Clips Haircuts commissioned Atomik Research to conduct an online survey of 1,000 adults throughout the United States. The sample consists of U.S. parents of boys aged 11 to 17. The margin of error is +/- 3 percentage points with a confidence level of 95 percent. Fieldwork took place between July 9 and July 15, 2026. Atomik Research, part of 4media group, is a creative market research agency.
Photo courtesy of Shutterstock (children on school bus)
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