Why do people get headaches and migraines? A child neurologist explains the science of head pain and how to treat it

Katherine Cobb-Pitstick, University of Pittsburgh Curious Kids is a series for children of all ages. If you have a question you’d like an expert to answer, send it to CuriousKidsUS@theconversation.com.

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Why do people get headaches? – Evie V., age 10, Corpus Christi, Texas

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Whether sharp and stabbing or dull and throbbing, a headache can ruin your day. But your brain doesn’t actually feel pain. So what is going on when it feels like your head is in a vise or about to explode? I am a child neurologist – that is, a doctor who specializes in diseases of the brain in kids. Most of my patients are kids and adolescents who are struggling with headaches. Head pain is complicated, and there is still a lot to learn about what causes it and how it can be treated. But researchers know there are a few key players that take part in generating pain.

What are headaches?

Nerves communicate information like pain through electrical signals between the body and the brain. While the brain itself doesn’t have any nerve sensors to feel pain, blood vessels in the head and structures that protect and surround the brain do sense pain. When these tissues detect injury or damage, they release chemicals that trigger transmission of electrical signals through nerves to tell the brain the head is hurting. The brain will also use nerves to signal the body to respond to pain with symptoms like feeling tired, teary eyes, runny nose, upset stomach and discomfort in bright or loud environments. It’s not clear why humans evolved to feel these symptoms, but some scientists theorize that this can lead to healthier lifestyle choices to decrease the chance of future headache attacks.

What causes headaches?

Often, headaches are a sign that the body is under some kind of stress. That stress triggers chemical and physical changes to the nerves and blood vessels around your brain, head and neck that can cause headaches. Many types of stresses can cause headaches, including an infection, allergies, hormone changes during puberty and menstrual cycles, not getting enough sleep, not drinking enough water, skipping meals or drinking too much caffeine or alcohol. Sometimes, headaches happen with emotional stress, like feeling anxious or depressed. Even pressure in your sinuses due to changes in the weather can cause your head to hurt. One in 11 kids have had a type of severe headache called a migraine. They feel like a pulsing and pounding pain in your head and come with other symptoms, including nausea or being sensitive to lights and sounds. During a migraine, it can be hard to do everyday activities because they can make the pain worse. It is also very common to feel unwell or irritable before the head pain starts and after the pain is gone.

Migraines occur when the nerves and other structures used in signaling and interpreting pain aren’t working properly, leading to pain and discomfort from stimulation that wouldn’t normally provoke this. There are many environmental and genetic factors that contribute to this dysfunction. Some people are born with a higher risk of developing migraines. Most people with migraines have someone in their family who also experiences them.

What can treat and prevent headaches?

Identifying what type of headache you’re experiencing is crucial to making sure it is treated properly. Because migraines can be severe, they’re the type of headache that most often leads to doctor’s visits for both kids and adults. There are several ways to reduce your chances of having headaches, such as drinking plenty of water and limiting caffeine. Eating, sleeping and exercising regularly are other ways you can help prevent headaches.

While painkillers like ibuprofen are often enough to relieve a headache, prescription medications are sometimes necessary to make head pain more bearable. Some medications can also help control or prevent headache episodes. Physical therapy to exercise the body or behavioral therapy to work on the mind can also help you manage headache pain. There are even electronic devices to treat headaches by stimulating different parts of the nervous system. It is important to talk with a doctor about headaches, especially if it’s a new problem or you experience a change in how they usually feel. Sometimes, brain imaging or blood tests are needed to rule out another health issue. Recognizing a headache problem early will help your doctor get started on helping you figure out the best way to treat it.

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Hello, curious kids! Do you have a question you’d like an expert to answer? Ask an adult to send your question to CuriousKidsUS@theconversation.com. Please tell us your name, age and the city where you live. And since curiosity has no age limit – adults, let us know what you’re wondering, too. We won’t be able to answer every question, but we will do our best. Katherine Cobb-Pitstick, Assistant Professor of Child Neurology, University of Pittsburgh This article is republished from The Conversation under a Creative Commons license. Read the original article.

Meet Irene Curie, the Nobel-winning atomic physicist who changed the course of modern cancer treatment

Artemis Spyrou, Michigan State University and Andrea Richard, Ohio University The adage goes “like mother like daughter,” and in the case of Irene Joliot-Curie, truer words were never spoken. She was the daughter of two Nobel Prize laureates, Marie Curie and Pierre Curie, and was herself awarded the Nobel Prize in chemistry in 1935 together with her husband, Frederic Joliot. While her parents received the prize for the discovery of natural radioactivity, Irene’s prize was for the synthesis of artificial radioactivity. This discovery changed many fields of science and many aspects of our everyday lives. Artificial radioactivity is used today in medicine, agriculture, energy production, food sterilization, industrial quality control and more.

We are two nuclear physicists who perform experiments at different accelerator facilities around the world. Irene’s discovery laid the foundation for our experimental studies, which use artificial radioactivity to understand questions related to astrophysics, energy, medicine and more.

Early years and battlefield training

Irene Curie was born in Paris, France, in 1897. In an unusual schooling setup, Irene was one of a group of children taught by their academic parents, including her own by then famous mother, Marie Curie.

World War I started in 1914, when Irene was only 17, and she interrupted her studies to help her mother find fragments of bombs in wounded soldiers using portable X-ray machines. She soon became an expert in these wartime radiology techniques, and on top of performing the measurements herself, she also spent time training nurses to use the X-ray machines. After the war, Irene went back to her studies in her mother’s lab at the Radium Institute. This is where she met fellow researcher Frederic Joliot, whom she later married. The two worked together on many projects, which led them to their major breakthrough in 1934.

A radioactive discovery

Isotopes are variations of a particular element that have the same number of protons – positively charged particles – and different numbers of neutrons, which are particles with no charge. While some isotopes are stable, the majority are radioactive and called radioisotopes. These radioisotopes spontaneously transform into different elements and release radiation – energetic particles or light – in a process called radioactive decay. At the time of Irene and Frederic’s discovery, the only known radioactive isotopes came from natural ores, through a costly and extremely time-consuming process. Marie and Pierre Curie had spent years studying the natural radioactivity in tons of uranium ores. In Irene and Frederic’s experiments, they bombarded aluminum samples with alpha particles, which consist of two protons and two neutrons bound together – they are atomic nuclei of the isotope helium-4. In previous studies, they had observed the different types of radiation their samples emitted while being bombarded. The radiation would cease when they took away the source of alpha particles. In the aluminum experiment, however, they noticed that even after they removed the alpha source, they could still detect radiation. The amount of radiation decreased by half every three minutes, and they concluded that the radiation came from the decay of a radioisotope of the element phosphorus. Phosphorus has two additional protons compared to aluminum and was formed when the alpha particles fused with the aluminum nuclei. This was the first identification of an artificially made radioisotope, phosphorus-30. Because phosphorus-30 was created after bombarding aluminum with alpha particles – rather than occurring in its natural state – Irene and Frederic induced the radioactivity. So, it is called artificial radioactivity.

After her major discovery, Irene stayed active not only in research but in activism and politics as well. In 1936, almost a decade before women gained the right to vote in France, she was appointed under secretary of state for scientific research. In this position, she laid the foundations for what would become the National Centre for Scientific Research, which is the French equivalent of the U.S. National Science Foundation or National Institutes of Health. She co-created the French Atomic Energy Commission in 1945 and held a six-year term, promoting nuclear research and development of the first French nuclear reactor. She later became director of the Curie Laboratory at the Radium Institute and a professor at the Faculty of Science in Paris.

Medical uses of artificial radioactivity

The Joliot-Curie discovery opened the road to the extensive use of radioisotopes in medical applications. Today, radioactive iodine is used regularly to treat thyroid diseases. Radioisotopes that emit positrons – the positive equivalent of the electron – are used in medical PET scans to image and diagnose cancer, and others are used for cancer therapy. To diagnose cancer, practitioners can inject a small amount of the radioisotope into the body, where it accumulates at specific organs. Specialized devices such as a PET scanner can then detect the radioactivity from the outside. This way, doctors can visualize how these organs are working without the need for surgery. To then treat cancer, practitioners use large amounts of radiation to kill the cancer cells. They try to localize the application of the radioisotope to just where the cancer is so that they’re only minimally affecting healthy tissue.

An enduring legacy

In the 90 years since the Joliot-Curie discovery of the first artificial radioisotope, the field of nuclear science has expanded its reach to roughly 3,000 artificial radioisotopes, from hydrogen to the heaviest known element, oganesson. However, nuclear theories predict that up to 7,000 artificial radioisotopes are possible. As physicists, we work with data from a new facility at Michigan State University, the Facility for Rare Isotope Beams, which is expected to discover up to 1,000 new radioisotopes.

While the Joliot-Curies were bombarding their samples with alpha particles at relatively low speeds, the Michigan State facility can accelerate stable isotopes up to half the speed of light and smash them on a target to produce new radioisotopes. Scientists using the facility have already discovered five new radioisotopes since it began operating in 2022, and the search continues. Each of the thousands of available radioisotopes has a different set of properties. They live for different amounts of time and emit different types of radiation and amounts of energy. This variability allows scientists to choose the right isotope for the right application. Iodine, for example, has more than 40 known radioisotopes. A main characteristic of radioisotopes is their half-life, meaning the amount of time it takes for half of the isotopes in the sample to transform into a new element. Iodine radioisotopes have half-lives that span from a tenth of a second to 16 million years. But not all of them are useful, practical or safe for thyroid treatment.

Radioisotopes that live for a few seconds don’t exist long enough to perform medical procedures, and radioisotopes that live for years would harm the patient and their family. Because it lives for a few days, iodine-131 is the preferred medical radioisotope. Artificial radioactivity can also help scientists study the universe’s mysteries. For example, stars are fueled by nuclear reactions and radioactive decay in their cores. In violent stellar events, such as when a star explodes at the end of its life, they produce thousands of different radioisotopes that can drive the explosion. For this reason, scientists, including the two of us. produce and study in the lab the radioisotopes found in stars. With the advent of the Facility for Rare Isotope Beams and other accelerator facilities, the search for new radioisotopes will continue opening doors to a world of possibilities. Artemis Spyrou, Professor of Nuclear Physics, Michigan State University and Andrea Richard, Assistant Professor of Physics and Astronomy, Ohio University This article is republished from The Conversation under a Creative Commons license. Read the original article.