The Knowledge
Mosquitoes carrying malaria are evolving more quickly than insecticides can kill them – researchers pinpoint how
Jacob A Tennessen, Harvard University
The fight against infectious disease is a race against evolution. Bacteria become resistant to antibiotics. Viruses adapt to spread more quickly. Diseases transmitted by insects present another evolutionary front: Insects themselves can evolve resistance to the poisons that people use to kill them.
In particular, the mosquito-borne disease malaria kills over 600,000 people annually. Since World War II, people have battled malaria with insecticides – chemical weapons intended to kill Anopheles mosquitoes infected with the Plasmodium parasites that cause the disease.
However, mosquitoes are quickly evolving counterstrategies that make these insecticides ineffective, putting millions of people at greater risk of deadly infection. My colleagues and I have newly published research showing how.
Insecticide resistance threatens public health
As an evolutionary geneticist, I study natural selection – the basis for adaptive evolution. Genetic variants that best promote survival can replace less advantageous versions, causing species to change. Anopheles mosquitoes are frustratingly adept at evolving.
In the mid-1990s, most African Anopheles were susceptible to pyrethroids, a popular type of insecticide originally derived from chrysanthemums. Anopheles control relies on two pyrethroid-based methods: insecticide-treated bed nets to protect sleepers, and indoor residual spraying of insecticide against the walls of homes. These two methods alone likely prevented over a half-billion cases of malaria between 2000 and 2015.
However, mosquitoes today from Ghana to Malawi are often able to survive insecticide concentrations 10 times the previously lethal dose. Along with Anopheles control efforts, agriculture also inadvertently exposes mosquitoes to pyrethroids and contributes to insecticide resistance.
In some African locales, Anopheles is already showing resistance to all four main classes of insecticide used for malaria control.
Adaptation in Latin American mosquitoes
Anopheles mosquitoes and the malaria-causing Plasmodium also occur outside Africa, where insecticide resistance is less well-researched.
In much of South America, the main malaria vector is Anopheles darlingi. This mosquito species has diverged evolutionarily from the African vectors so extensively that it might be a different genus, Nyssorhynchus. Along with colleagues from eight countries, I analyzed over 1,000 Anopheles darlingi genomes to understand its genetic diversity, including any recent changes due to human activity. My collaborators collected these mosquitoes at 16 locations ranging from the Atlantic coast of Brazil to the Pacific side of the Andes in Colombia.
We found that, like its African counterparts, Anopheles darlingi shows extremely high genetic diversity – more than 20 times that of humans – indicating that very large populations of this insect exist. A species with such a vast gene pool is well poised to adapt to new challenges. The right mutation giving it the advantage it needs is more likely to pop up when there are so many individuals. And once that mutation starts to spread, it’s protected by numbers since it won’t be wiped out if a few mosquitoes die by chance.
In contrast, bald eagles in the contiguous U.S. were never able to evolve resistance against the insecticide DDT and approached extinction. Evolution is more efficient among millions of insects than mere thousands of birds. And indeed, we saw signals of adaptive evolution in the resistance-related genes of Anopheles darlingi occurring over the past few decades.
Mosquitoes evolve to detoxify poisons
Insecticides like pyrethroids and DDT share the same molecular target: channels in nerve cells that can open and close. When open, the nerve cell stimulates other cells. These insecticides force the channels to remain open and continuously fire, causing paralysis and death. However, insects can evolve resistance by changing the shape of the channel itself.
Earlier genetic scans performed by other researchers had not detected this type of resistance in Anopheles darlingi, and neither did ours. Instead, we found that resistance is evolving in another way: a group of genes encoding enzymes that break down toxic compounds. High activity of these enzymes, called P450, frequently underlies resistance to insecticides in other mosquitoes. The same cluster of P450 genes has changed independently at least seven times across South America since insecticide use began in the mid-20th century.
In French Guiana, a different set of P450 genes exhibits a similar evolutionary pattern, cementing the clear connection between these enzymes and adaptation. Moreover, when we exposed mosquitoes to pyrethroids in sealed bottles, differences among the P450 genes of individual mosquitoes were linked to the length of time they stayed alive.
Insecticide-heavy campaigns against malaria have been only sporadic in South America and may not be the main driver behind this evolution. Instead, it’s possible that mosquitoes are being exposed indirectly to agricultural insecticides. Intriguingly, we saw the strongest signs of evolution in places where farming is prevalent.
Toward more sophisticated vector control
Despite new vaccines and other recent advances against malaria, mosquito control remains essential for reducing disease.
Some countries are launching trials of gene drives to control malaria, which involve forcing a genetic modification into a mosquito population to reduce their numbers or their tolerance for Plasmodium. Such prospects are exciting, though the relentless adaptability of mosquitoes could be an obstacle.
I and others are revising methods to efficiently test for emerging insecticide resistance. Genome-scale sequencing remains important to detect new or unexpected evolutionary responses. The risk of adaptation is highest under a continuous, strong selection pressure, so minimizing, switching and staggering pesticides can help thwart resistance.
Success in the fight against evolving resistance will require a coordinated effort of monitoring, and reacting accordingly. Unlike evolution, humans can think ahead.
Jacob A Tennessen, Research Scientist in Immunology and Infectious Diseases, Harvard University
This article is republished from The Conversation under a Creative Commons license. Read the original article.
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The Knowledge
Forgotten Genius Fridays: Madison Washington and the Slave Revolt That Changed History
Discover the inspiring story of Madison Washington, the courageous freedom fighter who led the 1841 Creole revolt, securing freedom for 128 enslaved people in the most successful slave uprising in American history.
When people think of heroic figures who fought against slavery, names like Harriet Tubman, Frederick Douglass, and Sojourner Truth often come to mind. Yet one remarkable man remains largely absent from history books despite leading the most successful slave revolt in American history.
His name was Madison Washington.
His courage aboard the brig Creole in 1841 transformed the lives of more than one hundred enslaved people and became a powerful symbol of the fight for freedom.
Born Into Slavery
Madison Washington was born into slavery in Virginia during the early 19th century. Like millions of enslaved African Americans, he endured the brutality and injustice of a system that denied him even the most basic human rights.
Determined to be free, Washington escaped slavery in 1839 and reached Canada with help from the Underground Railroad.
Freedom, however, came with heartbreak.
His wife remained enslaved in Virginia, and Washington made the extraordinary decision to risk everything by returning to rescue her.
Instead, he was captured and imprisoned.
The Voyage Aboard the Creole
In November 1841, Washington and 134 other enslaved people were forced aboard the American slave ship Creole. The vessel was headed from Virginia to New Orleans, where many of the captives would likely be sold to plantations across the Deep South.
Washington refused to accept that fate.
On November 7, he and several fellow captives launched a carefully planned revolt. During the struggle, one slave trader was killed, while much of the crew was subdued.
Rather than continue to New Orleans, Washington ordered the crew to sail to Nassau in the Bahamas.
Freedom in the Bahamas
The decision proved historic.
Great Britain had abolished slavery throughout most of its empire years earlier, and when the Creole arrived in Nassau, British authorities refused American demands to return the enslaved passengers as property.
Instead, 128 formerly enslaved people were granted their freedom.
The Creole revolt became the most successful slave uprising in United States history.
International Consequences
The incident sparked a diplomatic dispute between the United States and Great Britain that lasted for years.
Southern slaveholders demanded compensation for what they viewed as lost property, while abolitionists celebrated Madison Washington as a courageous freedom fighter who challenged one of history’s greatest injustices.
The event also strengthened arguments against slavery by demonstrating that people held in bondage would continue to resist oppression whenever opportunities arose.
Frederick Douglass Honors a Hero
Madison Washington’s bravery inspired one of America’s greatest abolitionists.
Frederick Douglass based his 1853 novella, The Heroic Slave, on Washington’s remarkable story. The work became one of the earliest pieces of African American fiction centered on a real historical figure and introduced many readers to Washington’s extraordinary leadership.
Although historical records about Washington’s later life remain scarce, his legacy lived on through Douglass’s writing and through the generations of freedom seekers who followed.
Why Madison Washington Matters Today
Madison Washington reminds us that history is filled with individuals whose contributions have been overlooked despite changing the course of events.
His story is about more than a shipboard revolt.
It is about courage in the face of impossible odds.
It is about sacrificing personal safety for loved ones.
And it is about the universal desire for freedom.
As we continue to uncover stories that have too often been left untold, Madison Washington deserves recognition alongside the great heroes of American history.
His determination helped secure freedom for more than one hundred people—and his legacy continues to inspire those who believe that justice is always worth fighting for.
Forgotten Genius Fridays
Every Friday, STM Daily News shines a light on remarkable people whose contributions have shaped our world but whose stories deserve greater recognition. Join us as we rediscover the innovators, pioneers, leaders, and trailblazers history should never forget.
What other forgotten heroes should we feature next? Share your suggestions in the comments, and don’t forget to subscribe to the STM Daily News newsletter for more inspiring stories delivered straight to your inbox.
Related External Links
For readers interested in learning more about Madison Washington, the Creole revolt, and the broader history of slavery and abolition, these trusted resources provide additional historical context:
- Library of Congress – Frederick Douglass Papers: https://www.loc.gov/collections/frederick-douglass-papers/
- National Park Service – Underground Railroad: https://www.nps.gov/subjects/undergroundrailroad/index.htm
- Smithsonian National Museum of African American History and Culture: https://nmaahc.si.edu/
- National Archives – African American History: https://www.archives.gov/research/african-americans
- Encyclopaedia Britannica – Creole Revolt: https://www.britannica.com/event/Creole-slave-revolt
- Encyclopaedia Britannica – Frederick Douglass: https://www.britannica.com/biography/Frederick-Douglass
- Library of Congress – Slavery and the Struggle for Freedom: https://www.loc.gov/classroom-materials/slavery-and-the-struggle-for-freedom/
Note: External links are provided for educational and informational purposes. STM Daily News is not responsible for the content or policies of third-party websites.
🧠 Discover the remarkable innovators, inventors, and trailblazers who helped shape our world but rarely receive the recognition they deserve. Share your thoughts in the comments and subscribe to the STM Daily News newsletter to catch every new Forgotten Genius Friday feature and more inspiring stories delivered to your inbox.
Forgotten Genius Fridays
Katherine Johnson: The Human Computer Who Helped America Reach the Moon
Discover how Katherine Johnson’s mathematical genius helped NASA send astronauts into space and to the Moon. Learn why she remains one of America’s most inspiring scientific pioneers.
Forgotten Genius Friday | The Knowledge | STM Daily News
When the United States raced to explore space during the 1950s and 1960s, rockets and astronauts often captured the headlines. Behind every successful mission, however, was a team of brilliant mathematicians and engineers whose calculations made spaceflight possible. Among them was Katherine Johnson, an extraordinary mathematician whose work helped America reach orbit, the Moon, and beyond.
Although her contributions remained largely unknown for decades, Katherine Johnson’s remarkable career transformed the U.S. space program and inspired generations of scientists, engineers, and mathematicians.
A Gift for Mathematics
Katherine Coleman Goble Johnson was born on August 26, 1918, in White Sulphur Springs, West Virginia. From an early age, her exceptional talent for mathematics was evident. She skipped several grades, graduated from high school at just 14 years old, and earned degrees in mathematics and French from West Virginia State College by the age of 18.
At a time when educational and career opportunities for African American women were limited, Johnson’s determination and love of mathematics helped her overcome barriers that stood in the way of many aspiring scientists.
Joining America’s Space Program
In 1953, Johnson joined the National Advisory Committee for Aeronautics (NACA), the agency that would later become NASA.
She worked in the segregated West Area Computing Unit, where African American women served as “human computers,” performing complex mathematical calculations by hand. Their work was essential to aircraft research and, later, the nation’s ambitious efforts in human spaceflight.
Johnson’s exceptional analytical skills quickly earned the respect of engineers and mission planners. Rather than simply solving equations, she asked questions, challenged assumptions, and helped develop solutions to problems that had never been encountered before.
The Woman John Glenn Trusted
One of Katherine Johnson’s most famous moments came in 1962 before astronaut John Glenn became the first American to orbit Earth.
NASA had begun using electronic computers to calculate flight trajectories, but Glenn wanted one final verification before launch. According to NASA’s historical accounts, he requested that Katherine Johnson personally check the computer’s calculations.
“If she says they’re good,” Glenn reportedly said, “then I’m ready to go.”
Johnson confirmed the numbers, and Glenn successfully completed three orbits around Earth, marking a major milestone in the Space Race.
Helping America Reach the Moon
Katherine Johnson’s contributions did not end with Project Mercury.
She calculated trajectories for the Apollo program, helping engineers plan missions that ultimately carried astronauts to the Moon and safely back to Earth. Her work also supported the Space Shuttle program and early concepts for future space exploration.
Her calculations contributed to some of the most significant achievements in aerospace history, demonstrating the critical role mathematics plays in exploration and discovery.
Recognition Long Overdue
For much of her career, Katherine Johnson worked behind the scenes, receiving little public recognition. That changed in later years as historians and researchers began highlighting the contributions of the women who helped build America’s space program.
In 2015, President Barack Obama awarded Katherine Johnson the Presidential Medal of Freedom, the nation’s highest civilian honor.
A year later, her story reached millions through the acclaimed film Hidden Figures, which introduced audiences around the world to Johnson and her colleagues Dorothy Vaughan and Mary Jackson.
The movie helped shine a long-overdue spotlight on the women whose brilliance helped change history.
A Legacy That Continues to Inspire
Katherine Johnson passed away on February 24, 2020, at the age of 101, leaving behind a legacy of excellence, perseverance, and intellectual curiosity.
Her work reminds us that history is often shaped not only by those who step into the spotlight but also by those working quietly behind the scenes to solve impossible problems.
Today, students pursuing careers in science, technology, engineering, and mathematics continue to draw inspiration from her life and achievements. Her story demonstrates that talent, determination, and curiosity can overcome even the greatest obstacles.
As NASA prepares for a new era of lunar exploration and future missions to Mars, Katherine Johnson’s legacy remains woven into the history of every successful journey beyond our planet.
Why We Remember
Forgotten Genius Friday celebrates innovators whose achievements deserve greater recognition. Katherine Johnson’s extraordinary mathematical talent helped make space exploration possible, proving that one brilliant mind can help change the course of history.
Her calculations guided astronauts through some of humanity’s greatest adventures—and her legacy continues to inspire the explorers of tomorrow.
Related Links
- NASA: Katherine Johnson Biography
- NASA History
- National Park Service: Katherine Johnson
- West Virginia State University
🧠 Discover the remarkable innovators, inventors, and trailblazers who helped shape our world but rarely receive the recognition they deserve. Share your thoughts in the comments and subscribe to the STM Daily News newsletter to catch every new Forgotten Genius Friday feature and more inspiring stories delivered to your inbox.
News
Joby Aviation and Toyota kick off manufacturing alliance to scale electric air taxi production
Joby Aviation and Toyota launch a joint venture to improve productivity, quality, and cost as they prepare to scale electric air taxi production.
Joby Aviation and Toyota Motor Corporation have launched the initial phase of a strategic manufacturing alliance aimed at accelerating commercial production of electric air taxis—an early step the companies say is designed to make “air mobility for all” a practical, everyday reality.
Announced June 30, 2026, the partnership formalizes a new joint venture that will combine Joby’s electric aviation development with Toyota’s production systems and operational expertise. The near-term focus: building the groundwork for commercial production while pushing improvements in productivity, quality, and cost—key factors as the industry moves from prototypes to scaled manufacturing.
What the joint venture is designed to do
According to the companies, the alliance will initially concentrate on:
- Establishing the foundation for commercial production capability
- Advancing manufacturing excellence with an emphasis on productivity, quality, and cost
- Supporting expansion of Joby’s production capacity as it works toward aircraft certification and prepares for anticipated demand
The announcement positions Toyota’s manufacturing playbook—known globally for lean production and continuous improvement—as a lever to help Joby move from development into repeatable, high-quality output at scale.
Why it matters: eVTOLs need scale, not just flight tests
Electric vertical take-off and landing (eVTOL) aircraft have become one of the most closely watched bets in next-generation transportation, but the path to viable air taxi services depends on more than successful test flights. Certification timelines, supply chain readiness, and the ability to produce aircraft consistently (and affordably) are often what separates promising technology from commercial reality.
By forming a joint venture focused on manufacturing readiness, Joby and Toyota are signaling that the next competitive frontier is industrialization—how quickly and reliably eVTOL aircraft can be built to meet safety standards and market demand.
Related Links for Further reading
- Joby Aviation (official): https://www.jobyaviation.com
- Joby Investor Relations / News (official updates & filings): https://ir.jobyaviation.com
- Toyota Newsroom (official): https://www.toyotanewsroom.com
- Toyota Global (corporate overview): https://global.toyota/en
- FAA Advanced Air Mobility / Air Taxis (context): https://www.faa.gov/air-taxis
What executives are saying
Joby founder and CEO JoeBen Bevirt emphasized the long-running relationship between the companies, calling the joint venture a reflection of shared confidence in the opportunity ahead.
“Toyota has been by Joby’s side for nearly a decade, providing invaluable guidance and support as we built the foundation for manufacturing our aircraft,” Bevirt said. “Together, we share a vision of making aerial mobility an everyday reality.”
Toyota Motor Corporation Chairman Akio Toyoda framed air mobility as an extension of the company’s broader mission.
“Since our founding, we’ve been guided by the philosophy of providing mobility for all,” Toyoda said, adding that Toyota views air mobility as “a natural extension of that philosophy—from the ground into the sky.”
About the companies
Joby Aviation (NYSE: JOBY) is a California-based transportation company developing an all-electric eVTOL air taxi. The company intends to operate its own air taxi service in cities worldwide and sell aircraft to other operators and partners.
Toyota (NYSE: TM) has operated in North America for nearly 70 years and says it is focused on sustainable, next-generation mobility through Toyota and Lexus brands. Toyota reports nearly 64,000 employees in North America, 14 manufacturing plants, and more than 1,800 dealerships. The company also noted that its North Carolina plant began assembling automotive batteries for electrified vehicles in 2025.
What to watch for next
For readers tracking the air taxi sector, the next milestones will likely center on:
- Details on how the joint venture will be structured operationally
- Updates on Joby’s certification progress and production ramp timelines
- Signs of how manufacturing improvements translate into cost reductions and throughput
- Additional agreements or expanded collaboration as the alliance progresses
While the companies highlighted expected benefits, they also noted the usual forward-looking risks—such as regulatory certification timelines, market conditions, and the ability to finalize additional agreements.
Source: Toyota Motor North America / PRNewswire (June 30, 2026)
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