The Knowledge
Mosquitoes carrying malaria are evolving more quickly than insecticides can kill them – researchers pinpoint how
Jacob A Tennessen, Harvard University
The fight against infectious disease is a race against evolution. Bacteria become resistant to antibiotics. Viruses adapt to spread more quickly. Diseases transmitted by insects present another evolutionary front: Insects themselves can evolve resistance to the poisons that people use to kill them.
In particular, the mosquito-borne disease malaria kills over 600,000 people annually. Since World War II, people have battled malaria with insecticides – chemical weapons intended to kill Anopheles mosquitoes infected with the Plasmodium parasites that cause the disease.
However, mosquitoes are quickly evolving counterstrategies that make these insecticides ineffective, putting millions of people at greater risk of deadly infection. My colleagues and I have newly published research showing how.
Insecticide resistance threatens public health
As an evolutionary geneticist, I study natural selection – the basis for adaptive evolution. Genetic variants that best promote survival can replace less advantageous versions, causing species to change. Anopheles mosquitoes are frustratingly adept at evolving.
In the mid-1990s, most African Anopheles were susceptible to pyrethroids, a popular type of insecticide originally derived from chrysanthemums. Anopheles control relies on two pyrethroid-based methods: insecticide-treated bed nets to protect sleepers, and indoor residual spraying of insecticide against the walls of homes. These two methods alone likely prevented over a half-billion cases of malaria between 2000 and 2015.
However, mosquitoes today from Ghana to Malawi are often able to survive insecticide concentrations 10 times the previously lethal dose. Along with Anopheles control efforts, agriculture also inadvertently exposes mosquitoes to pyrethroids and contributes to insecticide resistance.
In some African locales, Anopheles is already showing resistance to all four main classes of insecticide used for malaria control.
Adaptation in Latin American mosquitoes
Anopheles mosquitoes and the malaria-causing Plasmodium also occur outside Africa, where insecticide resistance is less well-researched.
In much of South America, the main malaria vector is Anopheles darlingi. This mosquito species has diverged evolutionarily from the African vectors so extensively that it might be a different genus, Nyssorhynchus. Along with colleagues from eight countries, I analyzed over 1,000 Anopheles darlingi genomes to understand its genetic diversity, including any recent changes due to human activity. My collaborators collected these mosquitoes at 16 locations ranging from the Atlantic coast of Brazil to the Pacific side of the Andes in Colombia.
We found that, like its African counterparts, Anopheles darlingi shows extremely high genetic diversity – more than 20 times that of humans – indicating that very large populations of this insect exist. A species with such a vast gene pool is well poised to adapt to new challenges. The right mutation giving it the advantage it needs is more likely to pop up when there are so many individuals. And once that mutation starts to spread, it’s protected by numbers since it won’t be wiped out if a few mosquitoes die by chance.
In contrast, bald eagles in the contiguous U.S. were never able to evolve resistance against the insecticide DDT and approached extinction. Evolution is more efficient among millions of insects than mere thousands of birds. And indeed, we saw signals of adaptive evolution in the resistance-related genes of Anopheles darlingi occurring over the past few decades.
Mosquitoes evolve to detoxify poisons
Insecticides like pyrethroids and DDT share the same molecular target: channels in nerve cells that can open and close. When open, the nerve cell stimulates other cells. These insecticides force the channels to remain open and continuously fire, causing paralysis and death. However, insects can evolve resistance by changing the shape of the channel itself.
Earlier genetic scans performed by other researchers had not detected this type of resistance in Anopheles darlingi, and neither did ours. Instead, we found that resistance is evolving in another way: a group of genes encoding enzymes that break down toxic compounds. High activity of these enzymes, called P450, frequently underlies resistance to insecticides in other mosquitoes. The same cluster of P450 genes has changed independently at least seven times across South America since insecticide use began in the mid-20th century.
In French Guiana, a different set of P450 genes exhibits a similar evolutionary pattern, cementing the clear connection between these enzymes and adaptation. Moreover, when we exposed mosquitoes to pyrethroids in sealed bottles, differences among the P450 genes of individual mosquitoes were linked to the length of time they stayed alive.
Insecticide-heavy campaigns against malaria have been only sporadic in South America and may not be the main driver behind this evolution. Instead, it’s possible that mosquitoes are being exposed indirectly to agricultural insecticides. Intriguingly, we saw the strongest signs of evolution in places where farming is prevalent.
Toward more sophisticated vector control
Despite new vaccines and other recent advances against malaria, mosquito control remains essential for reducing disease.
Some countries are launching trials of gene drives to control malaria, which involve forcing a genetic modification into a mosquito population to reduce their numbers or their tolerance for Plasmodium. Such prospects are exciting, though the relentless adaptability of mosquitoes could be an obstacle.
I and others are revising methods to efficiently test for emerging insecticide resistance. Genome-scale sequencing remains important to detect new or unexpected evolutionary responses. The risk of adaptation is highest under a continuous, strong selection pressure, so minimizing, switching and staggering pesticides can help thwart resistance.
Success in the fight against evolving resistance will require a coordinated effort of monitoring, and reacting accordingly. Unlike evolution, humans can think ahead.
Jacob A Tennessen, Research Scientist in Immunology and Infectious Diseases, Harvard University
This article is republished from The Conversation under a Creative Commons license. Read the original article.
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Forgotten Genius Fridays
Octavia E. Butler: The Black Woman Who Helped Change Science Fiction
Discover how Octavia E. Butler transformed science fiction, explored Black identity, and helped shape Afrofuturism through her groundbreaking novels.
Last Updated on October 16, 2026 by Daily News Staff
Forgotten Genius Friday | The Knowledge | STM Daily News
Octavia E. Butler: The Woman Who Reimagined the Future
When we think about science fiction, we often picture spaceships, robots, alien civilizations, and futuristic technology. But what happens when science fiction becomes a way to explore racism, inequality, human survival, and the consequences of our choices?
That is exactly what Octavia E. Butler brought to the genre.
Long before Afrofuturism became a widely recognized cultural movement, Butler was creating extraordinary stories that placed Black characters—especially Black women—at the center of imagined futures.
Her work challenged conventional ideas about who could be a hero, whose experiences mattered, and what science fiction could accomplish.
A Young Girl With a Powerful Imagination
Octavia Estelle Butler was born on June 22, 1947, in Pasadena, California.
Raised primarily by her mother and grandmother after her father’s death, Butler grew up shy and found comfort in books and storytelling.
Her mother worked as a domestic employee, and Butler sometimes accompanied her to work. Those experiences exposed her to the racial and economic inequalities that would later influence her fiction.
As a child, Butler loved science fiction, but she noticed something missing: people who looked like her.
Rather than accepting that absence, she began creating stories of her own.
She would eventually become one of the most influential writers in speculative fiction.
Breaking Barriers in Science Fiction
During the 1970s, mainstream American science fiction was largely associated with white male writers and protagonists.
Butler entered that literary world with a different perspective.
Her first published novel, Patternmaster, appeared in 1976. It introduced readers to a world shaped by extraordinary mental abilities, social hierarchies, and struggles for power.
Butler continued developing complex stories that explored humanity’s relationship with authority, identity, biology, and survival.
In 1979, she published one of her best-known novels, Kindred.
The book follows Dana, a Black woman living in 1970s California who is repeatedly transported back to a Maryland plantation before the Civil War.
Through Dana’s experiences, Butler forced readers to confront the brutality of American slavery and its continuing influence on the present.
Rather than treating history as something safely confined to the past, Kindred makes that history immediate and deeply personal.
Imagining the Future—and Warning Us About It
In 1993, Butler published Parable of the Sower, a novel set in a collapsing American society struggling with economic inequality, environmental destruction, violence, and weakened institutions.
Its central character, Lauren Olamina, is a young Black woman who develops a philosophy called Earthseed while searching for a way to survive and build a community.
The novel takes place beginning in 2024, making its imagined future particularly striking to modern readers.
Butler followed it with Parable of the Talents in 1998, continuing her examination of social instability, religious extremism, authoritarianism, and the struggle to create a better future.
Her novels were not literal predictions. They were works of speculative fiction that used recognizable social trends to ask difficult questions about where humanity might be headed.
Octavia Butler and Afrofuturism
Afrofuturism brings together African and African diasporic experiences with science fiction, technology, history, mythology, and imaginative visions of the future.
While artists such as Sun Ra and George Clinton explored cosmic identity through music, performance, and futuristic imagery, Butler used literature to investigate power, history, and humanity’s possible futures.
Her novels frequently placed Black women in situations where they had to navigate extraordinary challenges and reshape the societies around them.
Butler’s work is widely discussed within Afrofuturist scholarship, although her literary contributions also extend beyond any single cultural label.
She demonstrated that Black people did not have to remain secondary characters in someone else’s vision of the future.
They could be the architects of entirely new worlds.
Recognition and a Lasting Legacy
Butler received some of science fiction’s most significant honors, including Hugo and Nebula Awards.
In 1995, she became the first science-fiction writer to receive a MacArthur Fellowship, often called a genius grant.
Her work also included the Xenogenesis trilogy, later collected as Lilith’s Brood, which explored humanity’s encounter with an extraterrestrial species and raised questions about consent, adaptation, identity, and survival.
Butler died on February 24, 2006, at age 58.
Yet her influence has continued to grow.
Her novels are studied in classrooms, discussed by scholars, and embraced by new generations of readers and creators interested in science fiction, social justice, and Afrofuturism.
A Genius Who Made Us Think Differently About Tomorrow
Octavia E. Butler was more than a science-fiction author.
She was a visionary storyteller who understood that imagining the future also meant examining the past and questioning the present.
Her stories asked readers to consider how power operates, how communities survive, and how human beings might change.
And perhaps her greatest contribution was demonstrating that the future belongs in the imagination of everyone.
Why Octavia E. Butler Belongs in Forgotten Genius Friday
At STM Daily News, our Forgotten Genius Friday series celebrates extraordinary individuals whose ideas, innovations, and accomplishments helped shape our world, even if their stories aren’t widely known. Octavia E. Butler fits that mission perfectly. Although she received prestigious literary awards and recognition during her lifetime, her influence extends far beyond science fiction. Like the inventors, scientists, and trailblazers we’ve featured in this series, Butler challenged barriers, defied expectations, and opened doors for future generations. Through her imagination, she helped redefine who could tell stories about humanity’s future—and who could be at the center of those stories. Her inclusion in Forgotten Genius Friday reminds us that genius isn’t limited to laboratories and inventions. Sometimes, it begins with a pen, a powerful imagination, and the courage to envision a different world.
Sources and fact-checking
The Huntington Library holds Butler’s literary archive and confirms the chronology of her major novels, awards, and career. The MacArthur Foundation independently documents her 1995 fellowship.
- Official Octavia E. Butler biography
- The Huntington — Octavia E. Butler Papers
- MacArthur Foundation — Octavia Butler
- The Huntington — Telling My Stories exhibition
For more stories about overlooked innovators, writers, scientists, and visionaries who changed our world, explore The Knowledge and Forgotten Genius Friday at STM Daily News.
Food Truths
Soul Food Has African Roots—and a Distinct Black American History
Soul food connects African heritage with generations of Black American creativity and community. Here’s why shared roots and a distinct cultural identity both deserve recognition.
Last Updated on October 15, 2026 by Daily News Staff
Shared ancestry connects the African diaspora. It also makes understanding each community’s food traditions worth the effort.
A debate over who can claim soul food raises a question larger than any social media argument: When does a shared cultural inheritance become a distinct tradition?
People across Africa and the African diaspora have foods that evoke home, family, comfort, and belonging. Recognizing that connection is valuable. But using “soul food” as a general description of comforting food is different from identifying the cuisine historically known by that name.
Soul food is a distinctly African American culinary tradition with African roots, shaped by generations of Black life in the United States. Recognizing its American development does not erase Africa. Recognizing Africa should not erase what Black Americans created.
African Roots, American Development
Enslaved Africans arrived with agricultural knowledge, cooking skills, and food traditions. They adapted those traditions to unfamiliar surroundings and unequal access to food, drawing on available ingredients and encounters with Indigenous and European foodways.
Okra, black-eyed peas, and vegetable-centered cooking offer important connections to African traditions. Corn and cornmeal reflect Indigenous American agriculture. These ingredients and influences became part of an evolving food culture rather than remaining unchanged copies of dishes from another continent. [1]
The distinction is between ancestry and development. A cuisine can descend from older traditions and acquire its own identity through the experiences of the people who preserve and transform it.
More Than a Story About Scraps
Slavery and deprivation belong in this history. Enslaved people supplemented restricted food supplies through gardening and other means, and used small amounts of meat to season vegetables. But telling the entire story as “making something out of scraps” understates their knowledge and creativity.
Black food history also includes seafood work, farming, skilled cooking, and enterprise. The Smithsonian’s account of Black foodways, for example, documents African Americans’ extensive involvement in harvesting, processing, and selling oysters. [2]
These were people with expertise. Their contributions deserve recognition as culinary work and cultural creation.
Why the Name Matters
The food traditions are older than the widespread use of the name “soul food.” The term became prominent during the 1960s, amid movements asserting Black identity and cultural pride. Smithsonian histories describe the soul food movement as celebrating foods that mainstream America had often disparaged. [3]
That context gives the name meaning beyond a meal that tastes good or brings comfort.
For some families, a pot of greens or a pan of cornbread carries memories of relatives, church dinners, holidays, and recipes learned by watching someone cook. Calling those foods “soul food” places them within a particular cultural story.
Southern Roots Traveled
Soul food also developed beyond the South. During the Great Migration, Black Americans carried Southern food traditions into new cities and neighborhoods, preserving familiar dishes while adapting their cooking. Smithsonian programming connects that movement directly to soul food’s development. [4]
That helps explain how a cuisine rooted in the South became part of Black community life across the country.
It also makes geography an imperfect test of authenticity. Soul food cooked in London can still be African American soul food. A cuisine’s cultural origins do not change simply because someone prepares it elsewhere.
Shared Heritage Does Not Mean Identical Cultures
Africa is a continent of many food traditions. The diaspora is similarly diverse. African American, Afro-Caribbean, Afro-Latin American, and Black British identities encompass different histories and relationships to food.
Someone may use “soul food” figuratively to describe a cherished family dish. That emotional use is understandable. The difficulty arises when it becomes a historical claim that all Black cuisines are versions of the same named tradition.
Shared ingredients and ancestry establish connections; they do not make distinct cuisines interchangeable.
A useful conversation would ask which dishes are related, what techniques survived, and how different communities adapted them. That approach gives people more history to appreciate.
Respect Through Recognition
Defending soul food’s African American identity need not become an attack on Africans, Caribbean people, or Black Britons. Equally, celebrating connections across the diaspora should include respect for Black Americans’ particular contributions.
Anyone can cook, enjoy, study, and share soul food. Cultural recognition does not require closing the kitchen door. It requires crediting the people and history behind the cuisine.
Soul food’s African roots and African American identity belong in the same sentence. Both deserve to be remembered.
What dish connects you most strongly to your family’s history—and who taught you to make it? Share your story in the comments.
Explore more food stories and culinary traditions in STM Daily News’ Food & Drink section.
Sources and Further Reading
- African and Native American Foodways and Resilience: From 1619 to COVID-19 — Research on food traditions, adaptation, and cultural resilience.
- Black Foodways and Cuisine — National Museum of African American History and Culture.
- African American History Highlights — National Museum of American History, including the soul food movement.
- Cooking Up History — National Museum of American History programming on migration and soul food.
The Knowledge
Where Does Federal Money Go? The Biggest Costs Behind the Budget
Where does federal money go? Part two of our National Debt Explained series examines the biggest expenses in the 2025 budget and how spending connects to government borrowing.
Last Updated on October 13, 2026 by Daily News Staff
The Knowledge | National Debt Explained, Part 2
When discussing debt, ask: Who borrowed the money? That question helps distinguish a family’s finances from the federal budget. Our first episode explained why your credit card balance is separate from the national debt. Now comes the next question: What does the federal government spend money on?
Much of it pays for retirement benefits, health coverage, national defense, public services, and interest on previous borrowing.
Social Security was the largest individual program in fiscal year 2025, costing approximately $1.6 trillion. But combine the major health care programs—including Medicare, Medicaid, and health insurance subsidies—and their spending reached about $1.8 trillion, exceeding Social Security alone. cbo.gov
The figures below cover October 1, 2024, through September 30, 2025.Major expense FY 2025 spending What it supports Social Security About $1.6 trillion Retirement, survivor, and disability benefits Medicare, net $988 billion Health coverage for older adults and certain people with disabilities Net interest $970 billion Cost of servicing publicly held federal debt, after subtracting interest income Discretionary defense $893 billion Military personnel, operations, equipment, and research Medicaid $668 billion Federal contribution toward health coverage and care for eligible people
These are selected expenses, not the entire budget. Medicare spending is shown after premiums and other offsetting receipts. The combined health care total already includes Medicare and Medicaid, so it should not be added to those rows. cbo.gov
The government also supports veterans’ health care, transportation, education, housing assistance, courts, law enforcement, scientific research, disaster response, and environmental protection. Nondefense discretionary spending totaled approximately $980 billion in 2025, covering many of these services. Some funding for these areas falls elsewhere in the budget. cbo.gov
Federal spending falls into three broad groups:
- Mandatory spending: Payments governed by existing eligibility rules and benefit formulas, including Social Security and major health programs.
- Discretionary spending: Funding lawmakers control through appropriations legislation, including most defense spending and many public services.
- Net interest: The expense of servicing publicly held federal debt, minus government interest income. cbo.gov
Interest deserves attention because it pays for borrowing already undertaken. In 2025, net interest exceeded discretionary defense spending. Congressional Budget Office
A program’s cost does not automatically translate into an equal increase in national debt. Taxes and other receipts finance much of federal spending. Social Security and Medicare’s hospital insurance program receive dedicated payroll taxes, while Medicare also collects premiums.
In 2025, federal spending totaled approximately $7 trillion, compared with $5.2 trillion in revenue. The roughly $1.8 trillion shortfall was the deficit, requiring borrowing. Understanding national debt therefore means examining both what government spends and what it collects. cbo.gov
Explore more explanations behind the headlines at STM Daily News, home of The Knowledge.
Sources for this episode
- CBO: The Federal Budget in Fiscal Year 2025 — Overview of spending, revenue, deficits, and debt interest.
- CBO: Mandatory Spending in Fiscal Year 2025 — Breakdown of Social Security, Medicare, Medicaid, and other benefit programs.
- CBO: Discretionary Spending in Fiscal Year 2025 — Defense spending and services including transportation, education, and veterans’ health care.
- CBO: Overview of the FY 2025 Budget Infographics — Highlights the largest expenses and broader budget trends.
Related reading
- U.S. Treasury: Understanding the National Debt — What federal debt represents and how borrowing works.
- U.S. Treasury: Understanding the National Deficit — Explains the difference between an annual deficit and accumulated debt.
- U.S. Treasury: Federal Spending — Additional context about where federal money goes.
