The Knowledge
Mosquitoes carrying malaria are evolving more quickly than insecticides can kill them – researchers pinpoint how
Jacob A Tennessen, Harvard University
The fight against infectious disease is a race against evolution. Bacteria become resistant to antibiotics. Viruses adapt to spread more quickly. Diseases transmitted by insects present another evolutionary front: Insects themselves can evolve resistance to the poisons that people use to kill them.
In particular, the mosquito-borne disease malaria kills over 600,000 people annually. Since World War II, people have battled malaria with insecticides – chemical weapons intended to kill Anopheles mosquitoes infected with the Plasmodium parasites that cause the disease.
However, mosquitoes are quickly evolving counterstrategies that make these insecticides ineffective, putting millions of people at greater risk of deadly infection. My colleagues and I have newly published research showing how.
Insecticide resistance threatens public health
As an evolutionary geneticist, I study natural selection – the basis for adaptive evolution. Genetic variants that best promote survival can replace less advantageous versions, causing species to change. Anopheles mosquitoes are frustratingly adept at evolving.
In the mid-1990s, most African Anopheles were susceptible to pyrethroids, a popular type of insecticide originally derived from chrysanthemums. Anopheles control relies on two pyrethroid-based methods: insecticide-treated bed nets to protect sleepers, and indoor residual spraying of insecticide against the walls of homes. These two methods alone likely prevented over a half-billion cases of malaria between 2000 and 2015.
However, mosquitoes today from Ghana to Malawi are often able to survive insecticide concentrations 10 times the previously lethal dose. Along with Anopheles control efforts, agriculture also inadvertently exposes mosquitoes to pyrethroids and contributes to insecticide resistance.
In some African locales, Anopheles is already showing resistance to all four main classes of insecticide used for malaria control.
Adaptation in Latin American mosquitoes
Anopheles mosquitoes and the malaria-causing Plasmodium also occur outside Africa, where insecticide resistance is less well-researched.
In much of South America, the main malaria vector is Anopheles darlingi. This mosquito species has diverged evolutionarily from the African vectors so extensively that it might be a different genus, Nyssorhynchus. Along with colleagues from eight countries, I analyzed over 1,000 Anopheles darlingi genomes to understand its genetic diversity, including any recent changes due to human activity. My collaborators collected these mosquitoes at 16 locations ranging from the Atlantic coast of Brazil to the Pacific side of the Andes in Colombia.
We found that, like its African counterparts, Anopheles darlingi shows extremely high genetic diversity – more than 20 times that of humans – indicating that very large populations of this insect exist. A species with such a vast gene pool is well poised to adapt to new challenges. The right mutation giving it the advantage it needs is more likely to pop up when there are so many individuals. And once that mutation starts to spread, it’s protected by numbers since it won’t be wiped out if a few mosquitoes die by chance.
In contrast, bald eagles in the contiguous U.S. were never able to evolve resistance against the insecticide DDT and approached extinction. Evolution is more efficient among millions of insects than mere thousands of birds. And indeed, we saw signals of adaptive evolution in the resistance-related genes of Anopheles darlingi occurring over the past few decades.
Mosquitoes evolve to detoxify poisons
Insecticides like pyrethroids and DDT share the same molecular target: channels in nerve cells that can open and close. When open, the nerve cell stimulates other cells. These insecticides force the channels to remain open and continuously fire, causing paralysis and death. However, insects can evolve resistance by changing the shape of the channel itself.
Earlier genetic scans performed by other researchers had not detected this type of resistance in Anopheles darlingi, and neither did ours. Instead, we found that resistance is evolving in another way: a group of genes encoding enzymes that break down toxic compounds. High activity of these enzymes, called P450, frequently underlies resistance to insecticides in other mosquitoes. The same cluster of P450 genes has changed independently at least seven times across South America since insecticide use began in the mid-20th century.
In French Guiana, a different set of P450 genes exhibits a similar evolutionary pattern, cementing the clear connection between these enzymes and adaptation. Moreover, when we exposed mosquitoes to pyrethroids in sealed bottles, differences among the P450 genes of individual mosquitoes were linked to the length of time they stayed alive.
Insecticide-heavy campaigns against malaria have been only sporadic in South America and may not be the main driver behind this evolution. Instead, it’s possible that mosquitoes are being exposed indirectly to agricultural insecticides. Intriguingly, we saw the strongest signs of evolution in places where farming is prevalent.
Toward more sophisticated vector control
Despite new vaccines and other recent advances against malaria, mosquito control remains essential for reducing disease.
Some countries are launching trials of gene drives to control malaria, which involve forcing a genetic modification into a mosquito population to reduce their numbers or their tolerance for Plasmodium. Such prospects are exciting, though the relentless adaptability of mosquitoes could be an obstacle.
I and others are revising methods to efficiently test for emerging insecticide resistance. Genome-scale sequencing remains important to detect new or unexpected evolutionary responses. The risk of adaptation is highest under a continuous, strong selection pressure, so minimizing, switching and staggering pesticides can help thwart resistance.
Success in the fight against evolving resistance will require a coordinated effort of monitoring, and reacting accordingly. Unlike evolution, humans can think ahead.
Jacob A Tennessen, Research Scientist in Immunology and Infectious Diseases, Harvard University
This article is republished from The Conversation under a Creative Commons license. Read the original article.
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Food and Beverage
Lifesum Survey: 90% Say Ultra-Processed Foods Are Engineered to Be Hard to Stop Eating
A new nationally representative survey from health app Lifesum suggests Americans increasingly view ultra-processed foods (UPFs) as more than a “willpower” issue. The research, based on responses from 2,000 U.S. adults, found 90% believe UPFs are intentionally engineered to be hard to stop eating—while 81% say they’ve personally felt unable to stop once they start.
Ultra-Processed Foods Under Fire: New Data Shows Regret, Loss of Control, and Calls for Regulation
The survey also points to a widespread “control and regret” loop: 67% report they’ve tried and failed to cut back on certain ultra-processed foods, and 80% say they feel regret or frustration after eating them. The findings land as UPFs remain a dominant part of the American diet—federal dietary data indicates more than half of calories consumed in the U.S. come from ultra-processed foods, and high consumption has been linked in multiple studies to higher risks of obesity, type 2 diabetes, and cardiovascular disease.
Lifesum says the data reflects shifting public attitudes toward stronger oversight. In the survey, 81% support clearer warning labels on ultra-processed foods, 59% support restrictions on marketing, and 47% support regulation similar to tobacco or alcohol. The release also cites a recent report from researchers at Harvard University, the University of Michigan, and Duke University arguing that UPFs share similarities with cigarettes—such as engineered reward pathways and marketing designed to drive repeat consumption—strengthening the case for tighter regulation.
What to watch for
- Labeling momentum: With 81% backing warning labels, expect more debate over front-of-package disclosures and clearer definitions of “ultra-processed.”
- Marketing restrictions: The 59% support level signals potential policy focus on advertising practices—especially around kids and high-frequency digital targeting.
- Regulation framing shift: The 47% support for tobacco-style rules suggests UPFs may increasingly be discussed as a public health and consumer protection issue, not just nutrition advice.
- Scientific scrutiny vs. industry response: As more researchers compare UPFs to cigarettes, watch for counter-messaging from food manufacturers and lobbying around how UPFs are categorized.
- Consumer behavior tools: Demand may grow for evidence-based guidance and tracking tools (apps, labeling systems, education campaigns) that help people reduce UPF intake without relying solely on self-control.
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The Knowledge
“The Woman Who Invented the Home Security System”
Before smart homes, Marie Van Brittan Brown invented the first home security system in 1966—pioneering safety tech that still protects millions today.
Last Updated on May 1, 2026 by Daily News Staff
Part of the “Forgotten Genius Fridays” series from The Knowledge
🚨 Before Ring, There Was Marie Van Brittan Brown
Long before smart doorbells and mobile alerts became the norm, a nurse from Queens was already thinking ahead.
In 1966, Marie Van Brittan Brown, a Black woman living in New York City, felt unsafe in her neighborhood. Her husband, Albert, worked late hours, and she was often home alone. With crime on the rise and no real way to know who was at the door, she took matters into her own hands.
So she did what few people would think to do:
Home Security System
She invented the modern home security system.
🛠️ How It Worked
Marie and Albert Brown designed a closed-circuit television system with:
A camera mounted on the door Peepholes at different heights A live-feed monitor inside the home A microphone for two-way communication And a panic button to instantly alert the police.
In 1969, they were granted U.S. Patent No. 3,482,037, and that system laid the foundation for many of today’s smart home security tools.
📄 View the original patent here
Check out this Link: Marie Van Brittan Brown and Albert L. Brown ( Wikipedia)
🔄 Lasting Impact
Marie’s invention wasn’t just revolutionary—it was personal. Her system was designed for peace of mind, especially for women and families in vulnerable communities. Today, elements of her design show up in everything from Ring and Nest to intercom-equipped apartment doors.
She didn’t just protect her home—
she helped create the smart home.
🎥 Watch the full short video (under 75 seconds):
👉 YouTube Shorts – The Knowledge
📱 TikTok & Reels: @stmdailynews
🧠 Now you know.
— STM Daily News
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Forgotten Genius Fridays
Forgotten Genius Friday: The Legacy of Thomas Jennings — America’s First Black Patent Holder
Discover how Thomas Jennings, the first African American to receive a U.S. patent, revolutionized garment care with his dry-cleaning invention and supported abolitionist causes.
In the early 19th century, long before modern dry cleaners lined city streets, one man quietly transformed how Americans cared for their clothing. His name was Thomas Jennings—a tailor, entrepreneur, and trailblazer whose innovation would earn him a historic place in U.S. history.
Breaking Barriers in a Divided America
Born in 1791 in New York City, Jennings lived in an era when opportunities for African Americans were severely limited. Yet he built a successful tailoring business, gaining a reputation for craftsmanship and attention to detail.
At the time, cleaning delicate garments—especially wool—was a persistent challenge. Traditional washing methods often damaged fabrics, leaving customers frustrated and tailors searching for better solutions.
Jennings saw not just a problem, but an opportunity.
The Invention of “Dry Scouring”
In 1821, Jennings developed a cleaning method he called “dry scouring,” a precursor to modern dry cleaning. Unlike water-based washing, his technique used chemical solvents to remove dirt and stains without harming fabric fibers.
That same year, he achieved a groundbreaking milestone: Jennings became the first African American to receive a U.S. patent.
This was no small feat. Patent laws at the time largely excluded enslaved individuals, and systemic racism made legal recognition difficult even for free Black citizens. Jennings’ success marked a rare and powerful breakthrough.
“His achievement stands in stark contrast to what followed—when laws would deny many Black innovators the right to claim their own ideas.”
Innovation With Purpose
Jennings didn’t just profit from his invention—he used his success to support a broader cause. The income generated from his patent helped fund abolitionist efforts, contributing to the fight against slavery in the United States.
His work intersected with the growing abolitionist movement decades before the American Civil War, demonstrating how innovation and activism often went hand in hand.
Lasting Impact on Modern Life
Today, dry cleaning is a global industry, essential to fashion, hospitality, and everyday life. While technologies have evolved, the core concept Jennings pioneered remains intact.
His legacy can be seen in:
- The modern dry-cleaning industry
- Textile preservation techniques
- The broader recognition of Black inventors in American history
Why Thomas Jennings Still Matters
Jennings’ story is not just about an invention—it’s about access, perseverance, and impact. At a time when the odds were stacked against him, he secured intellectual property rights, built a business, and used his platform to support social change.
For today’s innovators, his journey underscores a powerful truth: meaningful breakthroughs often come from those willing to challenge both technical problems and societal barriers.
Final Word
As part of STM Daily News’ Forgotten Genius Friday series, the story of Thomas Jennings serves as a reminder that some of the most influential figures in American innovation history are still waiting to be fully recognized.
His invention didn’t just clean clothes—it helped clear a path for future generations of inventors.
Related Articles & Further Reading
External Sources
- Thomas Jennings – Wikipedia Overview
- National Park Service: Thomas Jennings Biography
- BlackPast.org – Thomas Jennings Profile
- USPTO – African American Inventors and Innovation History
- Smithsonian Institution – Thomas Jennings Feature
