Health
Anti-ageing gene shown to rewind heart age by 10 years
Breakthrough offers a potential target for patients with heart failure
Newswise — An anti-ageing gene discovered in a population of centenarians has been shown to rewind the heart’s biological age by 10 years. The breakthrough, published in Cardiovascular Research and led by scientists at the University of Bristol and the MultiMedica Group in Italy, offers a potential target for patients with heart failure.
Associated with exceptional longevity, carriers of healthy mutant genes, like those living in blue zones of the planet, often live to 100 years or more and remain in good health. These individuals are also less prone to cardiovascular complications. Scientists funded by the British Heart Foundation believe the gene helps to keep their hearts young by protecting them against diseases linked to ageing, such as heart failure.
In this new study, researchers demonstrate that one of these healthy mutant genes, previously proved particularly frequent in centenarians, can protect cells collected from patients with heart failure requiring cardiac transplantation.
The Bristol team, led by Professor Paolo Madeddu, has found that a single administration of the mutant anti-ageing gene halted the decay of heart function in middle-aged mice. Even more remarkably, when given to elderly mice, whose hearts exhibit the same alterations observed in elderly patients, the gene rewound the heart’s biological clock age by the human equivalent of more than ten years.
Professor Madeddu, Professor of Experimental Cardiovascular Medicine from Bristol Heart Institute at the University of Bristol and one of the study’s authors, explained: “The heart and blood vessel function is put at stake as we age. However, the rate at which these harmful changes occur is different among people. Smoking, alcohol, and sedentary life make the ageing clock faster. Whereas eating well and exercising delay the heart’s ageing clock.
“In addition, having good genes inherited from parents can help to stay young and healthy. Genes are sequences of letters that encode proteins. By chance, some of these letters can mutate. Most of these mutations are insignificant; in a few cases, however, the mutation can make the gene function worse or better, like for the mutant anti-ageing gene we have studied here on human cells and older mice.”
The three-year study was also performed in test tube human cardiac cells in Italy. Researchers from the MultiMedica Group in Milan led by Professor Annibale Puca, administered the gene in heart cells from elderly patients with severe heart problems, including transplantation, and then compared their function with those of healthy individuals.
Monica Cattaneo, a researcher of the MultiMedica Group in Milan, Italy, and first author of the work said: “The cells of the elderly patients, in particular those that support the construction of new blood vessels, called ‘pericytes’, were found to be less performing and more aged. By adding the longevity gene/protein to the test tube, we observed a process of cardiac rejuvenation: the cardiac cells of elderly heart failure patients have resumed functioning properly, proving to be more efficient in building new blood vessels.”
Centenarians pass their healthy genes to their offspring. The study demonstrates for the first time that a healthy gene found in centenarians could be transferred to unrelated people to protect their hearts. Other mutations might be found in the future with similar or even superior curative potential than the one investigated by this research. Professor Madeddu and Professor Annibale Puca of the MultiMedica Group in Milan believe this study may fuel a new wave of treatments inspired by the genetics of centenarians.
Professor Madeddu added: “Our findings confirm the healthy mutant gene can reverse the decline of heart performance in older people. We are now interested in determining if giving the protein instead of the gene can also work. Gene therapy is widely used to treat diseases caused by bad genes. However, a treatment based on a protein is safer and more viable than gene therapy.
“We have received funding from the Medical Research Council to test healthy gene therapy in Progeria. This genetic disease, also known as Hutchinson-Gilford syndrome, causes early aging damage to children’s hearts and blood vessels. We have also been funded by the British Heart Foundation and Diabetes UK to test the protein in older and diabetic mice, respectively.”
Annibale Puca, Head of the laboratory at the IRCCS MultiMedica and Professor at the University of Salerno, added: “Gene therapy with the healthy gene in mouse models of disease has already been shown to prevent the onset of atherosclerosis, vascular ageing, and diabetic complications, and to rejuvenate the immune system.
“We have a new confirmation and enlargement of the therapeutic potential of the gene/protein. We hope to test its effectiveness soon in clinical trials on patients with heart failure.”
Professor James Leiper, Associate Medical Director at the British Heart Foundation, which funded the research, said: “We all want to know the secrets of ageing and how we might slow down age-related disease. Our heart function declines with age but this research has extraordinarily revealed that a variant of a gene that is commonly found in long-lived people can halt and even reverse ageing of the heart in mice.
“This is still early-stage research, but could one day provide a revolutionary way to treat people with heart failure and even stop the debilitating condition from developing in the first place.”
The study is funded by the British Heart Foundation and the Italian Ministry of Health.
Paper
‘The longevity-associated BPIFB4 gene supports cardiac function and vascularization in aging cardiomyopathy’ by Annibale Puca et al. in Cardiovascular Research [open access]
Source: University of Bristol
https://q5i.09c.myftpupload.com/category/lifestyle/health-and-wellness/health/
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health and wellness
What You Don’t Know Can Hurt: 3 facts about updated COVID-19 vaccines
Despite post-pandemic reunions, updated COVID-19 vaccines remain crucial for protection, especially for high-risk groups. Mild side effects are typical, severe ones rare.
(Family Features) Four and a half years after the start of the COVID-19 pandemic, people are once again enjoying time with friends and family and doing their favorite things. However, the virus that causes COVID-19 keeps changing, so it’s still important to stay up to date on your vaccinations. Respiratory viruses, including COVID-19, are common during the fall and winter months. That’s why now is a good time to take care of yourself and your loved ones by getting the facts on the updated COVID-19 vaccines.
“As the virus changes, we are learning more and more about how to protect people from COVID-19,” said Namandjé N. Bumpus, Ph.D., principal deputy commissioner at the U.S. Food and Drug Administration (FDA). “Getting the latest COVID-19 vaccine means your protection is as up to date as possible.”
Here is information about this season’s COVID-19 vaccines from the Risk Less. Do More. public education campaign:
Vaccines are the best way to protect yourself and your loved ones from COVID-19. Getting vaccinated against COVID-19 lowers your chances of getting very sick or being hospitalized. Some people who get the vaccines still get sick, but vaccination can make symptoms milder. This is important if you are over age 65 or have certain health conditions. Both can put you at a higher risk for serious or long-lasting health problems, such as Long COVID or even death from COVID-19. If you do get COVID-19, ask your doctor about treatment options to reduce your risk of severe illness.
COVID-19 vaccines are regularly updated to keep up with the changing virus. The COVID-19 vaccines are updated based on the latest variants of the virus. The updated vaccines offer the best protection against the changing virus that causes COVID-19. Getting the latest vaccine boosts your immunity and lowers your risk of severe sickness.
Side effects for COVID-19 vaccines are usually mild and go away on their own in a few days. The most common side effects are soreness or redness at the injection site, headache or body aches, or fever. Severe side effects like anaphylaxis are rare, with about five adverse events per 1 million doses given.
Staying informed and getting this season’s COVID-19 vaccine – and encouraging loved ones to do the same – is one of the best things you can do to protect yourself and others this fall and winter. Knowing the facts about COVID-19 vaccinations can give you peace of mind and support a safer, healthier future for all. For more information, visit cdc.gov/RiskLessDoMore or talk to your doctor.
If you think you have COVID-19, testing can help. All U.S. households are now eligible to receive four free COVID-19 test kits. Order them today at COVIDTests.gov.
The Impact of COVID-19 In Black and Hispanic Communities
For the first two years of the COVID-19 pandemic, people in Black and Hispanic communities were consistently more likely to get COVID-19, need medical or hospital care, and die from COVID-19 than people in other communities. That gap has narrowed over time, but this past summer, Black people were still more likely to be hospitalized for COVID-19 compared to the average across all races and ethnicities combined. Hispanic people had lower than average rates of hospitalization. For everyone, getting the latest COVID-19 vaccine offers the best protection against severe disease and hospitalization.
Photos courtesy of Shutterstock
SOURCE:
United States Department of Health and Human Services
Our Lifestyle section on STM Daily News is a hub of inspiration and practical information, offering a range of articles that touch on various aspects of daily life. From tips on family finances to guides for maintaining health and wellness, we strive to empower our readers with knowledge and resources to enhance their lifestyles. Whether you’re seeking outdoor activity ideas, fashion trends, or travel recommendations, our lifestyle section has got you covered. Visit us today at https://stmdailynews.com/category/lifestyle/ and embark on a journey of discovery and self-improvement.
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Lifestyle
Men are carrying the brunt of the ‘loneliness epidemic’ amid potent societal pressures
Alvin Thomas, University of Wisconsin-Madison and Quinn Kinzer, University of Wisconsin-Madison
A few weeks before Justin Bieber and his wife, Hailey, announced in May 2024 that they were expecting, the pop icon posted a selfie where he appears tearful and distraught.
While media attention quickly pivoted to the pregnancy, there was little attention paid to the significance of a male celebrity and expectant father publicly sharing his vulnerability.
Yet Bieber’s social media post is notable for making his internal struggle visible.
Emotional pain is linked to serious health issues. But the public’s response to male expressions of emotion and vulnerability is often minimizing, if not dismissive. In response to Bieber’s tearful post, for example, Hailey described him as a “pretty crier.”
A year ago, the Canadian rapper Dax released the song “To Be a Man.” He said at the time: “This is a song I poured my heart into. I’m praying this reaches everyone who needs it.”
Today, the song’s message remains timely. It includes the lyrics:
Yeah, I know this life can really beat you down, uh
You wanna scream but you won’t make a sound, uh
Got so much weight that you’ve been holdin’
But won’t show any emotion, as a man, that goes unspoken
As researchers who study fatherhood and the roles that men play in their families, we recognize the loneliness and pain in these lyrics. We have heard fathers describe the toll of attempting to keep a lid on their feelings.
In a recent study we conducted on 75 new and expectant Black fathers, they spoke of the need to address individual and collective trauma. This, they said, would ultimately help support their families. But they said resources to help men with their mental health are often unavailable or very limited. They said they often feel invisible to health providers.
“Being a father and a man,” one participant said, “you have to keep the peace and be strong on the outside. But on the inside, you know, you’re falling apart.”
Dax’s lyrics and our research reflect an enduring social health challenge – the deafening silence that typically surrounds men’s mental health.
The toll of isolation on men
In May 2023, U.S. Surgeon General Dr. Vivek Murthy released an advisory highlighting what he described as an epidemic of loneliness and isolation in the country. Our research confirms this scourge.
Since men’s social support networks – colleagues, family, close childhood friends – are often less robust than women’s, the epidemic disproportionately impacts men. The resulting solitude has very real health consequences.
In Murthy’s report, loneliness is associated with negative health outcomes, including a “29% increased risk of heart disease, a 32% increased risk of stroke, and a 50% increased risk of developing dementia for older adults. Additionally, lacking social connection increases risk of premature death by more than 60%.”
While Murthy’s report focuses on both men and women, research shows that men are less likely than women to seek mental health services. Additionally, men hold more negative attitudes toward seeking help, and they prematurely terminate treatment more often than women.
With these consequences in mind, a caring society may ask: Why are men carrying the brunt of this health risk, and what can be done about it?
Redefining men’s value beyond breadwinning
Many factors can contribute to feelings of isolation and disconnection among men.
In “To Be A Man,” Dax points toward one prominent factor:
As a man, we gotta pave our way
Our only function is to work and slave
There’s no respect for you if you ain’t paid
You’re disregarded as a human and you can’t complain
Traditional definitions of masculinity emphasize the importance of men’s role as breadwinners.
An uncertain economy and increasingly expensive housing and food prices make the ability to financially provide for a family elusive for many men. These factors also undermine men’s sense of self and contribute to loneliness and feelings of isolation.
As partners and fathers, men are still often perceived as deficient if they can’t provide economically. And societal norms stress that they are not valued for their capacity as caregivers, even if they are more involved in raising their children than ever before.
This is out of touch with reality.
Men play an important role as caregivers in their children’s lives, according to our research, and exert a powerful influence on children’s health and well-being. Men also find meaning in their roles as fathers.
As Dax says:
As a man, our son is our horizon
The cost of suppressed vulnerability
Beyond pressures to provide, men also have to overcome enduring stereotypes that suggest they should be stoic and keep their fears and sadness to themselves.
Here, too, gender norms are in need of an update. Boys and men need to feel comfortable presenting their true, authentic selves to the world. When they suppress their vulnerability, it creates a barrier to seeking help. It also perpetuates stigma and the epidemic of loneliness.
There is a complex interplay between society’s assumptions and beliefs about men and fatherhood.
Men, consequently, are less likely than women to seek mental health services. Health providers, as a result, are more likely to underdiagnose and misdiagnose men. Additionally, when health resources are made available, they are often not tailored to men’s needs.
Societal expectations can create unbearable pressure for men. And the most marginalized groups, like low-income Black fathers, bear a disproportionate burden, research shows. This became more evident during the COVID-19 pandemic, when Black fathers working in high-risk and essential jobs prioritized supporting their children and families over their own risk of infection and mental health.
As men continue to redefine their roles within families and communities, it’s important for society to create a space that acknowledges and embraces their vulnerabilities and full humanity in all social roles.
Men need outlets for their pain. They would benefit from relationships – with partners, family and friends – that support and nurture them in times of joy and through the emotional challenges. Their loneliness will continue to be disproportionate without the necessary connection to services.
Men can consider engaging in low-stakes discussion groups in their communities, with online groups and in their churches. They may also seek out therapists in person or online for introductory sessions to test out the therapeutic interaction before establishing a more consistent pattern of therapy services.
In “To Be a Man,” Dax sings:
No wonder most men are so depressed
All the things that they can’t express
It’s the circle of life, as a man, you provide
They don’t know what you’re worth ‘til the day that you die
As the Biebers adjust to life as parents, Justin may find people he can talk to about his experiences and emotions, people who see and value him fully. And we hope the same for every man and father, living their life out of the spotlight and doing the best they can for themselves and for their family.
Alvin Thomas, Associate Professor, Phyllis Northway Faculty Fellow, University of Wisconsin-Madison and Quinn Kinzer, Graduate student and PhD Candidate, Department of Consumer Science, University of Wisconsin-Madison
This article is republished from The Conversation under a Creative Commons license. Read the original article.
Our Lifestyle section on STM Daily News is a hub of inspiration and practical information, offering a range of articles that touch on various aspects of daily life. From tips on family finances to guides for maintaining health and wellness, we strive to empower our readers with knowledge and resources to enhance their lifestyles. Whether you’re seeking outdoor activity ideas, fashion trends, or travel recommendations, our lifestyle section has got you covered. Visit us today at https://stmdailynews.com/category/lifestyle/ and embark on a journey of discovery and self-improvement.
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Lifestyle
Keep Cold and Flu Season at Bay
During cold and flu season, preparation and proper treatment are crucial for recovery, minimizing illness spread, and maintaining overall health.
(Family Features) It doesn’t take much for cold and flu symptoms to take over. Even a mild case of the sniffles can make it difficult to navigate the demands of everyday life. It’s virtually impossible to avoid germs altogether, but you can make sure you’re ready to fight off an infection, whether it’s a minor cold or a full-blown case of the flu.
Cold and Flu Tips
“I always share a few easy and simple methods with my patients when cold and flu season comes back around to keep them in the best shape,” said Dr. Tim Tiutan, board-certified internal medicine physician. “Not only does getting ahead offer protection, but knowing what to do when symptoms start to come on, and what to have in your medicine cabinet, can help ease the burden of an oncoming illness.”
Preparation and prevention play important roles before a bug hits, but it’s also valuable to know how to effectively treat an illness and keep your loved ones from getting sick.
Prevent
Short of stashing yourself away in a bubble, there aren’t many failsafe ways to fully avoid germs. However, some basic hygiene and preventive care can go a long way toward minimizing your risk. Regularly washing your hands can help get rid of germs before you accidentally introduce them to your eyes, mouth or nose. Be especially diligent after spending time in crowded places.
Maintaining an overall healthy lifestyle also helps ensure you’re in optimal condition if you do get sick. That means eating a nutritious, well-rounded diet and keeping up with your exercise routine. Also be sure to talk to your doctor or pharmacist about getting a flu shot; while it may not fully prevent you from getting sick, in most cases it helps your body fight back and keeps your symptoms manageable.
Prepare
Knowing you can’t completely eliminate your exposure to germs, it’s a good idea to ensure you have everything you need to fight a cold or flu on hand. At least once a year, give your medicine cabinet a thorough cleaning. Discard any expired medications and replace products that have run low, especially those designed to help fight symptoms like pain relievers, fever reducers, decongestants, antihistamines and cough syrups.
It’s also a good time to restock items like tissues, cough drops, hand sanitizer and antibacterial soap. Medical supplies like thermometers and humidifiers also come in handy when you’re under the weather; check to be sure yours are in good working order and consider adding any supplies you don’t already have, such as a blood pressure cuff or home oximeter.
Treat
Once you’re sick, sleep is one of the best remedies. Your body can redirect energy toward healing when you’re sleeping, which helps boost your immune system, so give yourself permission to rest when you’re feeling down.
In addition to getting enough rest, it’s important to treat your symptoms, not just mask them. Because symptoms like fever, runny nose, chest congestion, cough and more can indicate a more serious problem, finding the root cause of the symptoms can be a more effective treatment strategy.
For example, some common remedies for chest congestion only mask the symptoms. Many doctors recommend an option like Mucinex 12-Hour because it treats the cause of chest congestion by thinning and loosening excess mucus. One dose lasts up to 12 hours, helping you clear mucus and relieve chest congestion.
Contain
Getting rest and managing your symptoms are easier when you stay at home, but it’s also the best way to prevent spreading germs to others. It’s not always practical, but if you can, limit yourself to one area of the house, away from family members. Cough into your elbow or a tissue, never your hands. Use antibacterial hand sanitizer and wipe down surfaces to minimize others’ contact with your germs.
Be especially wary of spending time with anyone who has a compromised immune system while you’re contagious, including those with pre-existing conditions, older adults and pregnant women. Take advantage of delivery or curbside services for essentials like groceries and talk with your employer about working remotely or using sick time until you’re feeling better.
Find more advice to help fight this cold and flu season at Mucinex.com. https://www.youtube.com/embed/zUpFn6VhRTM?feature=share/?utm_source=familyfeatures&utm_medium=referral&utm_campaign=#17187-Mucinex
When to Call for Help if You’re Feeling Lousy
If you’re experiencing cold symptoms, you might wonder when it’s appropriate to see a doctor for further evaluation. While most colds resolve on their own within a week or two, there are certain instances when seeking medical attention is advisable.
High Fever: If your fever persists for more than three days or reaches 102 F or higher, consult a health care provider.
Persistent or Severe Headaches: If you experience persistent or severe headaches that are not alleviated by over-the-counter medication, it’s advisable to consult a health care provider, as this could indicate a more serious underlying issue.
Persistent Symptoms: If your symptoms worsen or don’t improve after a week, seek medical advice.
Unusual Symptoms: If you experience uncommon or concerning symptoms during a cold, such as extreme fatigue, confusion, dehydration or a high fever that doesn’t respond to treatment, consult your doctor promptly for a proper diagnosis and treatment plan.
Trouble Breathing: Difficulty breathing, chest pain or wheezing can indicate a more severe respiratory condition and warrant medical attention.
High-Risk Individuals: For individuals at high risk of complications from colds, such as pregnant women, the elderly or individuals with conditions like diabetes or heart disease, it’s important to seek advice early to prevent any potential complications.
Remember, your health care provider can offer guidance tailored to your specific situation, helping you manage your cold effectively and ensure optimal recovery.
Photos courtesy of Shutterstock
SOURCE:
Mucinex
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