Health
Immunotherapy with two novel drugs shows activity in colorectal cancer
Newswise — BOSTON –A combination of two next-generation immunotherapy drugs has shown promising clinical activity in treating patients with refractory metastatic colorectal cancer, a disease which has not previously responded well to immunotherapies, according to a Dana-Farber Cancer Institute researcher.
The results of an expanded phase 1 trial of the two drugs, botensilimab and balstilimab, are to be presented at the ASCO Gastrointestinal Cancers Symposium Jan. 19-21 in San Francisco. The study is led by Benjamin L. Schlechter, MD, a senior physician in the Gastrointestinal Cancer Treatment Center at Dana-Farber.
The trial included 70 patients with metastatic colorectal cancer who had been previously treated with several lines of drugs, including immunotherapies. These patients all had tumors termed microsatellite stable, or MSS, meaning that their genes for repairing certain types of DNA damage were intact. MSS colorectal tumors account for the vast majority of colorectal cancers, and the first generation of immunotherapy drugs have had little effect on them. While immunotherapy has succeeded in microsatellite unstable (MSI) colorectal cancers, only about 3-5% advanced colorectal cancers are MSI and there are no approved immunotherapies for the far more common MSS colorectal cancers.
The two-drug combination being tested in the expanded phase 1a/1b trial of patients with metastatic MSS colorectal cancers were novel, next-generation antibodies. Botensilimab is an antibody directed against the T-cell receptor cytotoxic T-lymphocyte-associated antigen 4, or CTLA-4, which is an immune checkpoint that regulates T-cell activation. Balstilimab is a novel monoclonal antibody designed to block PD-1 – another immune checkpoint protein – from interacting with PD-L1 and PD-L2. By inhibiting this interaction, balstilimab is aimed at freeing the immune system to attack cancers.
The patients in the trial were followed for a median of 7 months after receiving the drug combination. During that period, 23% of the patients had a reduction in the size of their tumors, and the median duration of response was not reached. The disease control rate – the percentage of patients with metastatic cancer who had a complete or partial response and stable disease – was 76%. The 12-month overall survival was 63%. The main population of patients who benefited from the combination were those who did not have active metastatic cancer in their liver.
Treatment-related adverse events occurred in 91% of patients, including grade 3 in 40% and grade 4 in 3%. Twelve percent of patients discontinued both drugs because of adverse events.
The researchers concluded that “in patients with heavily pretreated metastatic MSS colorectal cancer, botensilimab plus balstilimab continues to demonstrate promising clinical activity with durable response, and was well tolerated, with no new immune-mediated safety signals.”
“Harnessing the power of immune therapy in refractory colorectal cancer has been a key goal of multiple clinical trials in advanced colorectal cancer, but in MSS colorectal cancer efforts have been universally disappointing,” said Schlechter. “These data are a meaningful and important advance in the care of this very sick population.”
Based on these findings, a randomized phase 2 trial in patients with MSS colorectal cancer is currently enrolling.
Funding for this research comes from Agenus, Inc.
About Dana-Farber Cancer Institute
Dana-Farber Cancer Institute is one of the world’s leading centers of cancer research and treatment. Dana-Farber’s mission is to reduce the burden of cancer through scientific inquiry, clinical care, education, community engagement, and advocacy. Dana-Farber is a federally designated Comprehensive Cancer Center and a teaching affiliate of Harvard Medical School.
We provide the latest treatments in cancer for adults through Dana-Farber Brigham Cancer Center and for children through Dana-Farber/Boston Children’s Cancer and Blood Disorders Center. Dana-Farber is the only hospital nationwide with a top 5 U.S. News & World Report Best Cancer Hospital ranking in both adult and pediatric care.
Source: Dana-Farber Cancer Institute
https://stmdailynews.com/category/lifestyle/health-and-wellness/health/
health and wellness
Millions of mobile gamers prize stress relief over winning
Mobile Gamers Prize Stress: In the school’s car pickup line, five minutes before it starts moving. In the doctor’s office waiting room for an appointment that you’ve been heavily anticipating. In bed, just before going to sleep. In these transitional moments, many people reach for their phones — not to scroll, but to play.
Millions of mobile gamers prize stress relief over winning
(Sheeka Sanahori) In the school’s car pickup line, five minutes before it starts moving. In the doctor’s office waiting room for an appointment that you’ve been heavily anticipating. In bed, just before going to sleep. In these transitional moments, many people reach for their phones — not to scroll, but to play.
According to a June 2026 survey of more than 128,000 KashKick mobile gamers, playing a mobile game is more than a way to pass the time. Stress relief and relaxation are the top reasons respondents play, beating out entertainment and fun. As KashKick reports, for many people, this means mobile games are less a simple distraction and more a coping mechanism for the daily stress of life.
A quick reset for life’s transitional moments
Most respondents identify as women, and 60% live in households that earn less than $50,000 per year. In the ranking of their reasons for playing, stress relief and relaxation topped the list, with boredom relief, entertainment and fun close behind.
The ranking reads less like a profile of a gaming hobby and more like a profile of a coping behavior.
More than half of the respondents play games daily or multiple times a day. When they reach for a mobile game, about 53% of the time it’s for a short session—usually 30 minutes or less. Where and when people play tells its own story: 58% play in bed before going to sleep and 40% play in the bathroom. These are private, solitary moments, not the times people typically plan entertainment into their day.
Coping with stress by gaming
To understand why respondents play games for stress relief more than for fun, it helps to look at who they are. Among those surveyed, 19% say they’re unemployed or looking for work, and 60% live in lower-income households. There are likely some areas of their life where they must make every dollar stretch to cover the things they need.
The survey findings coincide with research from the American Psychological Association’s 2025 Stress in America report. According to the report, 18% of men and 22% of women under age 65 rate their stress level at eight or higher on a scale of one to 10. Although the KashKick survey didn’t measure stress, respondents are mostly women and fall within the age and income groups the APA found to carry the most stress.
The APA’s report also describes loneliness as a major strain for Americans. The KashKick survey didn’t measure feelings of isolation, but 55% prefer to play alone, and 60% rarely or never discuss their gameplay with friends or family.
Overall, the survey identifies a group of people who have found a routine, low-cost approach to cope with stress. They’re not necessarily there to get the highest score. They’re playing a mobile game to help them navigate a day that, with all of life’s to-dos and challenges, could quickly feel overwhelming.
Methodology
The KashKick Gaming Habits Survey was fielded from June 8, 2026, through Aug. 10, 2026, among KashKick members in the United States who play mobile games. The Gaming Habits Survey was available to all members on KashKick’s Surveys page post-profile completion. The survey received 128,218 total responses, with question-level response counts ranging from approximately 109,793 to 128,218 depending on attrition. All findings describe KashKick mobile gamers and should not be interpreted as representative of U.S. mobile gamers overall. Industry and stress context references publicly available data from the American Psychological Association, Statista, and Newzoo.
Photo courtesy of Shutterstock
SOURCE:
KashKick
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Child Health
Pediatric Cancer Goes Beyond a Victory Bell: How Research and Innovation Improve Survivorship Rates
(Feature Impact) For every tear-jerking video found online of a child ringing a bell that signifies a cancer journey victory, there are dozens, if not more, people working behind the scenes. From leading minds in cancer research to doctors, nurses and support staff, a vast network of people and decades of medical advancements make those moments possible.
In fact, in the last 10 years, the FDA approved 10 new immunotherapies and 20 molecularly targeted therapies to treat pediatric cancers, according to the American Association for Cancer Research. Those breakthroughs – and the children they impact – come with a cost, which is why Hyundai Hope on Wheels has served as a pioneer in increasing survival rates by investing $303 million in pediatric cancer research over nearly three decades.
Those funds have supported more than 1,600 grants to 210 institutions, leading to new insights into cancer biology, clinical trials and new drug development while bringing hope at all stages of a child’s cancer journey.
However, there remains work to be accomplished. According to a survey conducted by Atomik Research on behalf of Hyundai Hope on Wheels, 46% of U.S. adults believe that a child ringing a hospital bell after cancer treatment signifies the child is cancer-free and their medical journey is largely over. The reality is more nuanced than that. In fact, more than one-third of respondents said they’re not familiar with the term cancer survivorship or they have heard the term but don’t fully understand what it means.
Many health care organizations define survivorship as beginning at the time of diagnosis and continuing through treatment and beyond. According to the American Association for Cancer Research, children who survive cancer face several long-term physical and psycho-social challenges due to their cancer and treatment, including planned surgeries, additional rounds of radiation or other forms of medical treatment to address common physical challenges stemming from chemotherapy.
Survival rates continue increasing with scientific and technological breakthroughs, up from 75% to 85% in nearly three decades, representing roughly 40,000 more children surviving their diagnoses. More than 3 in 4 U.S. adults are encouraged by that progress.
For survivors, treatment is just the beginning. Research, follow-up care and long-term funding determine what comes next, and every grant funded and every survivorship program backed means more children reaching adulthood.
According to the survey, more than 80% of adults said they’re more likely to support organizations that fund survivorship services, creating opportunities to fund crucial research and support for children facing pediatric cancer. Collaboration among leading minds, made possible by funding from organizations like Hyundai Hope on Wheels, has led to the development of comprehensive approaches to help children thrive during life after cancer, including enhanced medical records, AI integration, socioemotional support and combatting long-term side effects.
Find more information and ways you can join the fight by visiting HyundaiHopeOnWheels.org.
Photo courtesy of Shutterstock
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Food and Beverage
4 Daily Brain Health Habits for Better Cognition
Daily Brain Health Habits: Your brain works hard for you, so it’s only fair to return the favor by practicing simple everyday habits to keep this important organ strong and thriving. Start by tweaking your daily routine to focus on these four habits and eating nourishing recipes like California Grape and Sardine Avocado Toast.
4 Daily Brain Health Habits for Better Cognition
(Feature Impact) Your brain works hard for you, so it’s only fair to return the favor by practicing simple everyday habits to keep this important organ strong and thriving.
Start by tweaking your daily routine to focus on these four habits.
Prioritize Sleep
Getting quality sleep is vital for proper brain function. If you find you’ve slipped into the habit of staying up later than you should or notice your sleep being disrupted during the night, those are signs to revisit your sleep hygiene practices. Start by establishing a regular bedtime and wake-up time that will give you the recommended 7-9 hours of sleep. Turn your bedroom into a comfortable refuge from the world – keep it cool and dark, and set up fans or noise machines if you need them to quiet your mind. Avoid consuming caffeine or alcohol too close to bedtime and try switching to a book instead of a screen when it’s time to wind down.
Eat Smart
Just like the rest of the body, the brain is nourished by food. Some of its favorite foods are options rich in healthy fats like fish, avocado, olive oil and nuts, as well as vegetables like leafy greens, which offer carotenoids, and fruits such as grapes, which deliver antioxidants and other polyphenols.
Combine several of these powerful brain-boosting foods at once with this California Grape and Sardine Avocado Toast recipe. The fish is rich in omega-3 fatty acids and the avocado offers a boost of healthy unsaturated fat, while the grapes add protective dietary flavonols, which may help promote anti-inflammatory and beneficial antioxidant activity.
A study published in the scientific journal “Neurology” found a higher intake of certain flavonols – including three naturally found in grapes – is associated with a 48% decreased risk of developing Alzheimer dementia.
Get Moving
Adding even more proof that what’s good for your body is good for your mind, getting regular exercise is one of the best things you can do for your brain. Motivate yourself by choosing a form of movement you genuinely enjoy, whether it’s a daily walk on a nearby nature trail, a dance class, a bike ride or a heart-pumping workout video.
Challenge Your Mind
Don’t forget to give your brain its own workout, too. Doing something mentally stimulating every day is a great way to keep yourself sharp, and there are plenty of ideas to choose from. Try learning a new language, picking up a musical instrument, playing a mind-engaging card or board game, doing a puzzle, reading a book or immersing yourself in a creative writing or art project. The options are nearly endless, and if you want to make your brain extra happy, you can snack on handfuls of grapes as you enjoy your hobby.
Learn more about the connection between grapes and brain health and discover more recipes by visiting GrapesFromCalifornia.com.
California Grape and Sardine Avocado Toast
Prep time: 10 minutes
Servings: 4
- 1 large firm, ripe avocado, halved and pitted
- 4 small slices rustic whole grain bread (1/2-inch thick), toasted or grilled
- 1 individual container sardines in olive oil or water, drained
- 1/2 cup quartered red and black Grapes from California
- Aleppo pepper flakes
- fresh cilantro, snipped
- 1 lemon half
- salt (optional)
- With spoon, scoop avocado out of skin and use fork to coarsely mash.
- Spread onto bread slices and top with whole or torn sardines. Sprinkle grapes over sardines.
- Top with generous sprinkle of Aleppo pepper, cilantro, squeeze of fresh lemon and salt, if desired.
Nutritional information per serving: 290 calories; 11 g protein; 29 g carbohydrates; 16 g fat (50% calories from fat); 2.5 g saturated fat (8% calories from saturated fat); 20 mg cholesterol; 210 mg sodium; 6g fiber.
SOURCE:
California Table Grape Commission
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