Lifestyle
How does your immune system stay balanced? A Nobel Prize-winning answer
immune system: The 2025 Nobel Prize in physiology recognizes key discoveries by Sakaguchi, Brunkow, and Ramsdell on regulatory T cells and the FOXP3 gene, essential for immune tolerance, impacting autoimmune disease and cancer treatment advancements with potential benefits in organ transplantation.
Last Updated on October 12, 2025 by Daily News Staff
Aimee Pugh Bernard, University of Colorado Anschutz Medical Campus
Every day, your immune system performs a delicate balancing act, defending you from thousands of pathogens that cause disease while sparing your body’s own healthy cells. This careful equilibrium is so seamless that most people don’t think about it until something goes wrong.
Autoimmune diseases such as Type 1 diabetes, lupus and rheumatoid arthritis are stark reminders of what happens when the immune system mistakes your own cells as threats it needs to attack. But how does your immune system distinguish between “self” and “nonself”?
The 2025 Nobel Prize in physiology or medicine honors three scientists – Shimon Sakaguchi, Mary Brunkow and Fred Ramsdell – whose groundbreaking discoveries revealed how your immune system maintains this delicate balance. Their work on two key components of immune tolerance – regulatory T cells and the FOXP3 gene – transformed how researchers like me understand the immune system, opening new doors for treating autoimmune diseases and cancer. https://www.youtube.com/embed/suywDNvyKwU?wmode=transparent&start=0 The 2025 Nobel Prize in physiology or medicine was awarded to Shimon Sakaguchi, Mary Brunkow and Fred Ramsdell.
How immune tolerance works
While the immune system is designed to recognize and eliminate foreign invaders such as viruses and bacteria, it must also avoid attacking the body’s own tissues. This concept is called self-tolerance.
For decades, scientists thought self-tolerance was primarily established in the parts of the body that make immune cells, such as the thymus for T cells and the bone marrow for B cells. There, newly created immune cells that attack “self” are eliminated during development through a process called central tolerance.
However, some of these self-reactive immune cells escape this process of elimination and are released into the rest of the body. Sakaguchi’s 1995 discovery of a new class of immune cells, called regulatory T cells, or Tregs, revealed another layer of protection: peripheral tolerance. These cells act as security guards of the immune system, patrolling the body and suppressing rogue immune responses that could lead to autoimmunity.
While Sakaguchi identified the cells, Brunkow and Ramsdell in 2001 uncovered the molecular key that controls them. They found that mutations in a gene called FOXP3 caused a fatal autoimmune disorder in mice. They later showed that similar mutations in humans lead to immune dysregulation and a rare and severe autoimmune disease called IPEX syndrome, short for immunodysregulation polyendocrinopathy enteropathy X-linked syndrome. This disease results from missing or malfunctioning regulatory T cells.
In 2003, Sakaguchi confirmed that FOXP3 is essential for the development of regulatory T cells. FOXP3 codes for a type of protein called a transcription factor, meaning it helps turn on the genes necessary for regulatory T cells to develop and function. Without this protein, these cells either don’t form or fail to suppress harmful immune responses.
Harnessing the immune system for medicine
Regulatory T cells can be heroes or villains, depending on the context. When regulatory T cells don’t work, it can lead to disease. A breakdown in immune tolerance can result in autoimmune diseases, where the immune system attacks healthy tissues. Conversely, in cancer, regulatory T cells can be too effective in suppressing immune responses that might otherwise destroy tumors.
Understanding how FOXP3 and regulatory T cells work launched a new era in immunotherapies that harness the immune system to treat autoimmune diseases and cancer. For autoimmune diseases such as rheumatoid arthritis and Type 1 diabetes, researchers are exploring ways to boost the function of Tregs. For cancer, the goal is to inhibit Tregs, allowing the immune system to target tumors more aggressively.
Beyond disease treatment, this research may also improve organ transplantation, where immune tolerance is crucial to prevent rejection. Scientists are exploring how to engineer or expand Tregs to help the body accept transplanted tissues over the long term.
Continuing to unlock the secrets of immune regulation can help lead to a future where the immune system can be precisely tuned like a thermostat – whether to turn it down in autoimmunity or rev it up against cancer.
The 2025 Nobel Prize reminds us that science, at its best, doesn’t just explain the world – it changes lives.
Aimee Pugh Bernard, Associate Professor of Immunology and Microbiology, University of Colorado Anschutz Medical Campus
This article is republished from The Conversation under a Creative Commons license. Read the original article.
https://stmdailynews.com/%e2%9d%84%ef%b8%8f-the-man-who-made-air-conditioning-cool/
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Lifestyle
Why the First Year Behind the Wheel is the Most Dangerous: Data Shows Teen Drivers 3 Times More Likely to be in Fatal Crash
Teen drivers are significantly at risk of fatal crashes, with those aged 16-19 being nearly three times more likely to be involved in accidents than older drivers. The first year of driving presents heightened dangers, but with proper preparation, including coaching, technology, and smart insurance, families can mitigate these risks and promote safety.
Why the First Year Behind the Wheel is the Most Dangerous: Data Shows Teen Drivers 3 Times More Likely to be in Fatal Crash
(Feature Impact) The driver’s license photo may be slightly awkward, but the milestone is unforgettable. For families, a newly licensed teen means independence, busy schedules and a new set of responsibilities.
Motor vehicle crashes remain one of the leading causes of death for U.S. teens, according to the Centers for Disease Control and Prevention (CDC). Data from the National Highway Traffic Safety Administration shows drivers ages 16-19 are nearly three times more likely to be involved in a fatal crash than drivers 20 and older, per mile driven.
The statistics are serious, but they’re also manageable.
“With the right preparation, teen driving doesn’t have to feel overwhelming,” said Susan Irace, manager, divisional claims at Mercury Insurance. “Experience is what young drivers are building. Parents can help shorten that learning curve with structure, technology and smart coverage decisions.”
Why the First Year Matters
Federal safety data shows crash risk is highest in a teen’s first year of independent driving. Night driving, teen passengers and distracted driving increase that risk – while seat belts, graduated licensing laws and supervised practice significantly reduce it.
In 2023, more than 2,800 teens ages 13-19 were killed in motor vehicle crashes nationwide, according to the CDC. However, teen crash rates have declined over time thanks to safer vehicles, graduated driver licensing programs and greater awareness of distracted driving.
Ways to Reduce Teen Driving Risk
The experts at Mercury Insurance encourage families to focus on preparation rather than panic.
1. Coach Early and Often
- Log supervised driving time in different conditions – highways, rain, nighttime
- Create a simple written driving agreement outlining expectations
- Limit teen passengers during the first year
- Make seatbelts non-negotiable
2. Let Technology Help
- Choose vehicles with safety features like automatic emergency braking and blind-spot monitoring
- Use telematics or safe-driving feedback tools to reinforce good habits
- Activate smartphone “Do Not Disturb While Driving” settings
3. Review Insurance Before the Keys Change Hands
- Add teens to your insurance policy promptly
- Revisit liability limits to protect family assets
- Ask about good student and driver training discounts
“Insurance is about preparation, not fear,” Irace said. “When families combine active coaching with the right coverage, they’re setting their teen up for safer miles ahead.”
Preparation Turns Risks into Confidence
The first solo drive is a milestone, but preparation determines what comes next. By pairing common-sense coaching with today’s vehicle safety technology and thoughtful insurance planning, families can support independence while managing risk responsibly.
For more teen driver safety tips and coverage guidance, visit MercuryInsurance.com/resources.
Photos courtesy of Shutterstock
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Our Lifestyle section on STM Daily News is a hub of inspiration and practical information, offering a range of articles that touch on various aspects of daily life. From tips on family finances to guides for maintaining health and wellness, we strive to empower our readers with knowledge and resources to enhance their lifestyles. Whether you’re seeking outdoor activity ideas, fashion trends, or travel recommendations, our lifestyle section has got you covered. Visit us today at https://stmdailynews.com/category/lifestyle/ and embark on a journey of discovery and self-improvement.
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Last Updated on March 13, 2026 by Daily News Staff
(Feature Impact) To add charm to your yard, encourage local wildlife and give you a front-row seat to nature, building a birdhouse is a simple weekend project that checks all of those boxes.
Building a Birdhouse
Seasoned DIYers and first-timers alike can follow this step-by-step guide to create a functional, welcoming birdhouse.
Step 1: Choose the Right Design
Start by deciding what type of birds you’d like to attract. Different birds prefer different house sizes and entrance types. A simple, classic birdhouse design makes the project beginner-friendly and works well for common backyard birds like wrens, chickadees and bluebirds. In general, plan for at least a 1-1 2/2-inch entrance hole, a 5-by-5-inch interior space and 2 inches or more of roof overhang.
Step 2: Gather Materials and Tools
Most DIY birdhouses can be built with basic materials and tools you may already have at home, including untreated cedar or pine wood, screws or nails, wood glue, sandpaper and exterior-safe paint as well as a measuring tape, pencil, saw and drill.
Step 3: Measure and Cut Wood
Measure and cut wood to make the front panel, back panel, two side panels, floor and roof. Then sand all edges for smooth assembly.
Step 4: Drill Holes
Using a hole-saw bit, drill the entrance hole into the front panel. Position it a few inches below the roofline to keep predators out. Next, drill 2-3 small drainage holes in the floor piece to prevent water buildup and help keep the birdhouse dry.
Step 5: Assemble the Birdhouse
Attach the side panels to the back panel using screws or nails. Add the front panel then secure the floor piece, slightly recessed, so rainwater can drain. Attach the roof last, making sure it slopes slightly to allow water to run off.
Step 6: Paint the Exterior
If you plan to paint your birdhouse, stick to neutral, nature-inspired colors. Light browns, soft greens or white help regulate temperature and blend into the environment.
Step 7: Mount Your Birdhouse
Once dry, place your birdhouse in a quiet, sheltered spot away from heavy foot traffic. Mount or hang it 5-10 feet off the ground, facing away from prevailing winds.
Visit eLivingtoday.com for more DIY project inspiration.
Photo courtesy of Shutterstock
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Our Lifestyle section on STM Daily News is a hub of inspiration and practical information, offering a range of articles that touch on various aspects of daily life. From tips on family finances to guides for maintaining health and wellness, we strive to empower our readers with knowledge and resources to enhance their lifestyles. Whether you’re seeking outdoor activity ideas, fashion trends, or travel recommendations, our lifestyle section has got you covered. Visit us today at https://stmdailynews.com/category/lifestyle/ and embark on a journey of discovery and self-improvement.
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Arizona Scholarships 2026: $1,500 Awards + Free ACF Virtual Workshops
Arizona scholarships 2026: Arizona scholarships are open through ACF: one application for 160+ awards, plus ARAC’s $1,500 Ashby-Herring scholarships due April 6, 2026.
Last Updated on March 11, 2026 by Daily News Staff
Arizona Scholarships 2026: $1,500 Awards + Free ACF Virtual Workshops
Scholarship season moves fast, and for a lot of Arizona families, the hardest part isn’t writing the essay or gathering transcripts—it’s simply finding the right opportunities in time.
The Archer Ragsdale Arizona Chapter (ARAC), Tuskegee Airmen, Inc. is encouraging students and the community to take advantage of scholarship resources through the Arizona Community Foundation (ACF), including an easy online application that can match applicants with 160+ scholarships—plus virtual workshops where students can get help directly from ACF’s scholarship team.
Whether you’re a high school senior, a current college student, or an adult re-entry student, ACF’s scholarship portal is designed to meet people where they are.
The Big Picture: One Application, 160+ Scholarships
According to the flyer, ACF awarded $6.3 million in scholarships last year, with over 160 scholarships available through a single, easy application.
- Application opens: January 1
- Most deadlines: March and April
- Where to start: https://azfoundation.org/scholarships
- ACF scholarship email: scholarship@azfoundation.org
What to watch for: Even if a student is only targeting one scholarship, completing the ACF application can surface additional matches they didn’t know existed.
ARAC Tuskegee Airmen Scholarship: Ashby-Herring Scholarships ($1,500) — Deadline April 6, 2026
ARAC (Tuskegee Airmen, Inc.) awards two or more scholarships to deserving Arizona students who are college-bound. The flyer highlights the Ashby-Herring scholarships, named in honor of late founding ARAC members who were original Tuskegee Airmen.
Award: Two Ashby-Herring scholarships (each $1,500)
Deadline:April 6, 2026
Apply here:https://www.azfoundation.org/archer-ragsdale
Eligibility:
- Graduating high school senior from Arizona
- Attending a 2-year or 4-year college/university
- African-American
- 3.0 GPA or higher
- Demonstrated financial need
Free Virtual Workshops (Zoom): Get Help With Your Application
If you’ve ever watched a student stall out halfway through an application, these workshops are a smart fix: they’re designed so applicants can work on their scholarship application with support from ACF’s scholarship team.
Workshop dates (Zoom):
- February 12, 2026 — 4:00 to 5:00 p.m.
- March 5, 2026 — 4:00 to 5:00 p.m.
- March 26 — 4:00 to 5:00 p.m. (date listed on flyer; confirm year when registering)
Register here:https://acf.cventevents.com/acfscholarships2026
View the flyer here: https://stmdailynews.com/wp-content/uploads/2026/03/Deadline-updated-12.29.2025-Archer-Ragsdale-Flyer-FINAL.pdf
Download Flyer (PDF)
What to watch for: Register for the dates you can attend and come prepared with what you already have (basic info, activities list, questions). One hour of guided progress can save days of procrastination.
Why This Matters (and Why Sharing Helps)
The Tuskegee Airmen legacy is rooted in excellence, discipline, and breaking barriers—and scholarships tied to that legacy are meant to elevate futures for the next generation.
If you’re a parent, teacher, coach, mentor, or neighbor, consider this your nudge: forward the link, post it in a group chat, or share it with a student who might qualify. Deadlines hit quickly, and the easiest scholarship to win is often the one you actually apply for.
View the press release: https://stmdailynews.com/wp-content/uploads/2026/03/FOR-IMMEDIATE-RELEASE.pdf
Related Links:
- https://azfoundation.org/scholarships
- https://acf.cventevents.com/acfscholarships2026
- https://www.azfoundation.org/archer-ragsdale
College Life
College isn’t just classes and credits — it’s learning how to manage your time, money, health, and relationships while you build a future that actually fits. In our College Life coverage, STM Daily News shares practical, real-world guides for students and families: campus living tips, study and productivity habits, career prep, budgeting basics, mental wellness check-ins, and smart ways to make the most of college in Arizona and beyond.
Expect quick reads, useful takeaways, and “what to do next” advice — whether you’re a first-year student, a transfer, or heading back to school.
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