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Largest U.S. Cardiac Database Shows Excellent Long-term Survival After Surgical Aortic Valve Replacement

Study in Low-Risk Patients Reveals 5-year Survival Rate of 93%

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Newswise — A study published today in The Annals of Thoracic Surgery demonstrates outstanding long-term survival following low-risk isolated surgical aortic valve replacement (SAVR).

The study reviewed 42,586 patients who underwent low-risk isolated SAVR between 2011 and 2019 at 981 different cardiac surgery programs across the U.S. Conducted by eight leading national investigators, the assessment relied on evidence from The Society of Thoracic Surgeons (STS) National Database, with linkage to the Centers for Disease Control and Prevention’s National Death Index (NDI).

The STS National Database, with nearly 10 million patient records, is the nation’s largest and most comprehensive clinical registry for cardiothoracic disease. The linkage to the NDI has permitted highly accurate survival information to now be available following heart and lung operations performed in the U.S.

All patients in the study were classified as low risk for SAVR mortality as defined by the STS predicted risk of operative mortality (PROM ≤ 4%). Overall, 92.9% survived after five years, and the eight-year survival was close to 90%. The study matched the criterion used in the current low-risk trials evaluating SAVR with transcatheter aortic valve replacement (TAVR). The average age of patients was 74.2 years with a mean PROM of 1.92%

“This study sets a benchmark for outcomes for management of aortic valve stenosis,” said Vinod Thourani, MD, Bernie Marcus Chair of Cardiovascular Surgery and the Marcus Valve Center, Piedmont Heart Institute, Atlanta, Georgia. “This analysis is significant because of the longitudinal follow-up with very large numbers of patients, and it is an important complement to results from randomized clinical trials that are commonly measured over just one year.”

Recent evidence has revealed that SAVR following failed TAVR requiring explant of the TAVR valve, has been the fastest-growing cardiac procedure over the last five years, associated with worse outcomes than those expected following primary SAVR surgeries.

The most recent mid-term results from the PARTNER 3 and Evolut Low-Risk trials comparing risk of death and stroke from SAVR and TAVR are expected to be released in fall 2023. As there have been some concerns raised regarding the representativeness of these trials, the current study was performed to establish real-world long-term results from SAVR to serve as a benchmark for outcomes.

“There remains absolutely no doubt that TAVR is an excellent primary option for patients of higher risk or advanced age. The aim of this study was to specifically evaluate patients of low risk, and this revealed that longitudinal outcomes of SAVR in this specific population are outstanding. As surgeons are consistently performing these surgeries with excellent outcomes, and now in minimally invasive fashion, these data should give providers of valve therapy, including cardiologists and surgeons, a point of reflection when it comes to deciding what the best option is for their patients,” said senior study author Vinay Badhwar, MD, Professor and Chairman of the Department of Cardiovascular and Thoracic Surgery of West Virginia University, and Executive Chair of the WVU Heart and Vascular Institute.

The STS National Database includes 97% of all cardiac operations performed in the U.S. with precise and validated statistical models for patients receiving adult cardiac, general thoracic, and congenital operations.

Study authors also included Robert H. Habib, PhD, Wilson Szeto, MD, Joseph Sabik, MD, Jennifer Romano, MD, MS, and Thomas MacGillivray, MD.

Link to “Survival Following Surgical Aortic Valve Replacement in Low-Risk Patients: A Contemporary Trial Benchmark:” https://www.annalsthoracicsurgery.org/article/S0003-4975(23)01064-0/fulltext

Journal Link: The Annals of Thoracic Surgery, Oct-2023

Source: The Society of Thoracic Surgeons

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5 Ways Heart Health Care Can Improve

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(Family Features) Before the advent of antibiotics, infectious diseases, such as pneumonia, tuberculosis and diphtheria, were the most common causes of death in the industrialized world. Today, heart disease is the leading cause of death in the United States, and has been since 1921, according to the Centers for Disease Control and Prevention.

However, more than half of people in the U.S. (51%) aren’t aware of that fact, according to a Harris Poll survey conducted on behalf of the American Heart Association. What’s more, nearly half of all people in the U.S. (48.6%) have some type of cardiovascular disease (CVD), including coronary heart disease, heart failure, stroke or, most notably, high blood pressure, according to the annual statistical update, “2024 Heart Disease and Stroke Statistics: A Report of U.S. and Global Data From the American Heart Association,” published in “Circulation.”

“Heart disease along with stroke, which is the fifth-leading cause of death, claim more lives in the U.S. than all forms of cancer and chronic lower respiratory disease combined, based on the most recent data available,” said Joseph C. Wu, M.D., Ph.D., FAHA, volunteer president of the American Heart Association, director of the Stanford Cardiovascular Institute and the Simon H. Stertzer Professor of Medicine and Radiology at Stanford School of Medicine. “Finding that most people do not know the significant impact of heart disease is discouraging and even a bit frightening.”

While death rates from CVD have declined 60% since 1950 and the number of people in the U.S. dying from heart attack has dropped from 1 in 2 in the ’50s to about 1 in 8 today, challenges still remain.

In 2024, with Bold Hearts – the American Heart Association’s centennial celebration – the organization celebrates 100 years of progress and identified several issues that must be addressed to make the next century of life-saving work as impactful as the first 100 years:

  • Scientific literacy must be enhanced to increase public knowledge and understanding about the methods and interpretation of scientific data.
  • Non-traditional approaches to health care are needed to address the social and structural determinants of health by moving evidence-based approaches rapidly into communities to address food insecurity, transportation problems, education, housing, access to care, chronic psychosocial stress and other social needs.
  • The interconnectedness of organ systems, mechanisms of disease and stages of life are critical to understanding the role cardiovascular health plays in overall health.
  • Appreciation of systems of care will beimportant to achieving significant clinical benefits. Reliance on individual physicians may not be realistic in managing diseases involving multiple organ systems such as cardiovascular-kidney-metabolic disease or disorders affecting the heart, brain and mind simultaneously.
  • More funding for research is a critical need due to the pace of scientific advances. In the next century, laboratory experiments may demand more sophisticated equipment, translational science will incorporate expensive new technologies like artificial intelligence and population health will require greater computing power and larger sample sizes.

“There is much to learn from this historic shift in the reduction of deaths from infectious diseases and the current prevalence in deaths from cardiovascular diseases,” Wu said. “Through scientific research, technological advances and public health policy, most of these infectious diseases have become controlled, and many have been or are nearly eradicated. As we apply these same clinical and epidemiological methods to the someday hopeful eradication of heart disease and stroke, the American Heart Association is making great progress. Although still too many people die each year, many are living longer, more productive lives while managing their cardiovascular disease and risk factors.”

To learn more, visit heart.org/centennial.


SOURCE:
American Heart Association

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Promoting Mental Health Awareness: A Year-Round Commitment

“Join the movement for mental health awareness and break the stigma. Together, we can make a difference in supporting those in need. #MentalHealthAwareness”

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In today’s fast-paced and demanding world, mental health awareness holds unprecedented significance. By understanding the urgent need for mental health awareness and access to proper care, we can create a more empathetic and supportive society. This blog post emphasizes the importance of Mental Health Awareness Month and highlights ways individuals can contribute to this cause throughout the year.

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Raise mental health awareness, break stigma. Together, we make a difference. #MentalHealthMatters #BreakTheStigma www.stmdailynews.com

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Breaking the Stigma:
Mental Health Awareness Month serves as a catalyst for open conversations about mental illness, aiming to dismantle the stigma surrounding mental health. Through education and awareness, we can dispel myths and misconceptions, enabling a more inclusive and understanding environment for those facing mental health challenges.

Supportive Initiatives:
During this significant month, a multitude of activities and events take place to show support for mental health. These include educational programs, workshops, community discussions, and fundraising efforts. Such initiatives provide individuals, families, and communities with valuable resources, information, and support networks.

Individual Contributions:
As individuals, we can make a remarkable impact in promoting mental health awareness. Educating ourselves about mental health conditions allows us to understand the experiences of those living with them, fostering empathy and compassion. By sharing our own experiences or supporting those who do, we can help break the silence and encourage others to seek help without fear of judgment.

Support and Empathy:
Offering support and empathy to those struggling with mental health conditions is crucial. By lending a listening ear, being there for someone, and checking in on their well-being, we create meaningful connections that alleviate feelings of isolation. Opening up honest conversations about mental health strengthens the support network, cultivating an environment where individuals feel safe seeking help.

Prioritizing Our Well-being:
In the pursuit of mental health awareness, it is essential to prioritize our own well-being. Practicing self-care, engaging in activities that bring joy and relaxation, and seeking help when needed are fundamental aspects of maintaining good mental health. By prioritizing our well-being, we become role models, fostering a culture that places as much value on mental health as physical health.

A Year-Round Commitment:
Mental Health Awareness Month serves as a reminder to carry the lessons learned throughout the year. By actively participating in mental health initiatives, advocating for equitable access to care, and supporting those facing mental health challenges, we create a society that genuinely values mental well-being. Let us work together to break down barriers, eliminate stigmas, and ensure that mental health is prioritized and addressed for all.


Mental Health Awareness Month acts as a rallying call to prioritize mental health and create a more compassionate and supportive society. By embracing the lessons learned during this month, we can contribute to the well-being of individuals, families, and communities throughout the year. Let us continue to educate ourselves, advocate for mental health, support others, and prioritize our own well-being, fostering an environment where mental health is celebrated and cared for. Together, we can make a difference.

What is Mental Health Awareness Month?

Since 1949, Mental Health Awareness Month has been observed in May in the United States. It is a time when various forms of media, local events, and film screenings are used to raise awareness about mental health. Mental Health America initiated this annual observance in the United States. (Source: Wikipedia)

Date: Wed, May 1, 2024 – Fri, May 31, 2024

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Mill Creek’s Frontier Dermatology Is First in Washington to Offer Nonsurgical Treatment for Common Skin Cancer Using Image-Guided Superficial Radiation Therapy

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BURR RIDGE, Ill. /PRNewswire/ — SkinCure Oncology, the world leader in providing a comprehensive model for the delivery of Image-Guided Superficial Radiation Therapy (Image-Guided SRT), a nonsurgical treatment with the highest cure rate for common skin cancers, today announced its availability in Washington at an event at Frontier Dermatology in Mill Creek. This is the first medical practice in the state to offer this GentleCure™ treatment experience.

Image-Guided SRT is the only treatment for nonmelanoma skin cancer (basal and squamous cell carcinoma) that uses ultrasound imaging to help clinicians direct low-level x-rays to targeted areas of the skin, killing cancer cells without bleeding, pain, surgical scarring or need for reconstructive surgery. A study published in the journal Oncology and Therapy showed that Image-Guided SRT produces a 99.3 percent cure rate for early stage nonmelanoma, making it just as effective as traditional surgical treatment.

Dieter Schmidt, M.D., FAAD, FACMS, of Frontier Dermatology, noted, “More than 68,000 Washingtonians are expected to be diagnosed with nonmelanoma skin cancer this year alone. It is essential for them to have information on all available treatment options, both surgical and nonsurgical, so they can make informed decisions about their care. Image-Guided SRT is one of the most exciting technological innovations in dermatology today. We call it the GentleCure experience, and we are proud to be the first in Washington to offer it.”

Joining Dr. Schmidt at the event was Mill Creek Mayor Brian Holtzclaw, who said, “We are a community of nature lovers and outdoor enthusiasts here in Mill Creek, and whether you’re swinging a driver at Mill Creek Country Club, a paddle on the pickleball courts at Heron or Highlands Park, or simply just taking in the scenery on one of our many nature trails and community parks, it’s critical that we take the necessary steps to protect ourselves from the sun’s rays. In those cases where exposure to the sun or other factors leads to a cancer diagnosis, patients now have more treatment options, including the new, nonsurgical standard of care called GentleCure. I want to thank Dr. Schmidt and Frontier Dermatology for bringing GentleCure to our city and state. It’s a proud moment for us all.”

“We at SkinCure Oncology are delighted to partner with Frontier Dermatology to offer this highly effective, noninvasive treatment option for their patients,” said Kerwin Brandt, Chief Executive Officer of the Chicago-based company. “Patients everywhere should have the choice of curing their nonmelanoma skin cancer without surgery.”

About SkinCure Oncology
SkinCure Oncology is the world leader in providing a comprehensive model for the delivery of Image-Guided Superficial Radiation Therapy (Image-Guided SRT), the most advanced nonsurgical treatment for common skin cancer. The company partners with quality-focused dermatologists, Mohs surgeons and other physicians to bring cancer center-level radiation therapy treatment to private practices. Presented to patients as the GentleCure™ experience, Image-Guided SRT is available from some 500 physicians nationwide, with more than 75,000 patients having been treated. Learn more about the company at SkinCureOncology.com, and visit GentleCure.com for helpful consumer and patient information.

SOURCE SkinCure Oncology

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