Lifestyle
Stroke, Clot Risk Halved in Heart Disease and Arrhythmia Patients Who Took Blood Thinners Apixaban Versus Rivaroxaban
A difference in the effectiveness against strokes and other blood clots was easily visible in the first year among patients who’d taken the anticoagulant apixaban rather than rival rivaroxaban, according to researchers at the Perelman School of Medicine at the University of Pennsylvania.
Last Updated on November 16, 2024 by Daily News Staff
Newswise — PHILADELPHIA—A difference in the effectiveness against strokes and other blood clots was easily visible in the first year among patients who’d taken the anticoagulant apixaban rather than rival rivaroxaban, according to researchers at the Perelman School of Medicine at the University of Pennsylvania.
In the “emulated” clinical trial—an analysis comparing matched patients in a large health insurance database—all of the patients whose data were analyzed were those who have atrial fibrillation (AF) and associated valvular heart disease (VHD). Each patient took one form of an anticoagulant, also known as blood thinners, to slow down the formation of new blood clots and help avoid existing clots from growing larger and potentially more harmful. The study showed that those who took apixaban had their dangerous clot risk decrease almost by half compared with rivaroxaban.
At least several million Americans have AF, a type of irregular heartbeat that lead to blood clots in the heart, and it is thought that more than 60 percent of these patients have associated VHD, which essentially means that they also have significant heart valve damage. Stroke or systemic embolism risk increase by several times in those with AF compared to those without it, and VHD is suspected of adding to the risk of stroke or death.
Since 2016, apixaban and rivaroxaban have been the most prescribed anticoagulants for reducing stroke and systemic embolism risk in AF/VHD patients. While some traditional blood thinners can be affected by a patient’s diet, apixaban and rivaroxaban do not, making them easier to manage. But, so far, there have been no clinical trials directly comparing the two drugs in this patient population.
“The lack of clinical trial evidence and wide use of both drugs in patients with AF and VHD calls for real-world evidence that can guide treatment selection in clinical practice,” said Ghadeer Dawwas, PhD, a postdoctoral fellow in Biostatistics, Epidemiology, and Informatics at Penn, and first author of the study, published today in the Annals of Internal Medicine.
Almost 10,000 patients who had recently started taking apixaban were compared with another 10,000 newly taking rivaroxaban. The study was not of the clinical trial type, in which patients are randomly assigned to different groups to minimize differences between them. Rather, the researchers emulated a clinical trial by matching each patient in the apixaban group to one in the rivaroxaban group with similar age and other characteristics that could affect outcomes. The patient records compared in the study came from a large commercial health insurance database with de-identified data from 2013 to 2020.
The number of strokes, as well as blood clots in the body other than the brain (called “systemic embolisms”) in the patients seen over the span of several years after they began taking the medications suggested that patients in the apixaban group had a 43 percent lower risk of a clotting event, and a 49 percent lower risk of a gastrointestinal or intracranial bleeding event.
“Until evidence from randomized controlled trials becomes available, we believe clinicians should consider our findings when selecting anticoagulants in patients with AF and VHD,” said study senior author Sean Hennessy, PharmD, PhD, a professor of Epidemiology and director of Penn’s Center for Real-world Effectiveness and Safety of Therapeutics.
The analysis showed that the numbers of patients who had strokes or systemic emboli in each group diverged almost immediately. Patients in the rivaroxaban group had markedly more of these events at six months and twelve months of follow-up. The researchers calculated that the rate of stroke or systemic embolism per patient per year of follow-up was about one percent (0.91 percent) for rivaroxaban users, and about half that (0.52 percent) for apixaban users. Similarly, the rate of bleeding events in the rivaroxaban group was about double that in the apixaban group.
Overall the results suggested that, in comparison to the rivaroxaban group, the apixaban group had 43 percent lower risk of stroke or systemic embolism, and 49 percent the risk of a bleeding events compared with rivaroxaban.
Support for the research was provided by the National Institutes of Health (K99HL159230).
Source: Perelman School of Medicine at the University of Pennsylvania
Our Lifestyle section on STM Daily News is a hub of inspiration and practical information, offering a range of articles that touch on various aspects of daily life. From tips on family finances to guides for maintaining health and wellness, we strive to empower our readers with knowledge and resources to enhance their lifestyles. Whether you’re seeking outdoor activity ideas, fashion trends, or travel recommendations, our lifestyle section has got you covered. Visit us today at https://stmdailynews.com/category/lifestyle/ and embark on a journey of discovery and self-improvement.
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(Feature Impact) Whether you’re enjoying a leisurely weekend morning with the family or savoring those last few moments before rushing out the door, a filling, healthy breakfast is a perfect way to begin the day. Easy recipes that take less than 30 minutes (and can even be prepared the night before) make busy mornings a breeze.
Sheet Pan Pancakes are simple to whip up any day of the week – no flipping required – while Healthy Sausage Breakfast Muffins let you put protein on the menu in a kid-friendly package. When shopping for these delicious breakfasts, look for the Healthy Family Project and Produce for Kids logos to choose healthier foods and make a difference locally.
“Breakfast doesn’t have to be complicated to be powerful – a quick, balanced meal can help kids stay full, focused and energized for the day ahead,” said Tony Castillo, contributing registered dietitian at Healthy Family Project. “For growing kids, a protein-rich breakfast can help support energy, satiety and the building blocks they need as they develop. The best breakfast is one that’s simple, satisfying and realistic for busy mornings because consistency matters more than perfection.”
The versatility of these pancakes allows for endless customization and experimentation with different toppings, from fresh fruit and nuts to savory options like cheese and spinach, making them an ideal fit for the whole family. They also freeze well, so you can pop them in the toaster to have breakfast ready in a flash when hectic schedules interfere with your morning routine.
For another on-the-go solution, these breakfast muffins are made with just five ingredients, including protein pancake mix to help fuel the day. The savory combination of turkey sausage and cheddar cheese is complemented by the sweetness of onion, giving them the flavor your family desires.
To find more ways to put a nutritious breakfast on the family table, visit HealthyFamilyProject.com.
Sheet Pan Pancakes
Recipe courtesy of the Healthy Family Project
Prep time: 10 minutes
Cook time: 5 minutes
Servings: 6
- Nonstick cooking spray
- 1 1/2 cups all-purpose flour
- 3 1/2 teaspoons baking powder
- 1 tablespoon sugar
- 1 teaspoon salt
- 1 1/4 cups milk
- 1 large egg
- 2 tablespoons unsalted butter, melted
- 1/2 cup sliced strawberries
- 1/4 cup blueberries
- 1/4 cup mini chocolate chips
- Preheat oven to 425 F. Cover baking sheet with parchment paper and spray with nonstick cooking spray. Set aside.
- In large bowl, mix flour, baking powder, sugar and salt. Add milk, egg and melted butter; mix until smooth.
- Pour batter onto prepared baking sheet and smooth into even layer that covers pan. Top with strawberries, blueberries and chocolate chips.
- Bake 5-7 minutes, or until cooked and golden brown. Let cool slightly before cutting into squares.
Healthy Sausage Breakfast Muffins
Recipe courtesy of the Healthy Family Project
Prep time: 3 minutes
Cook time: 23 minutes
Servings: 12
- Nonstick cooking spray
- 1 onion, diced
- 1 pound turkey sausage
- 4 eggs
- 1/2 cup shredded cheddar cheese
- 1 cup protein pancake mix
- Preheat oven to 350 F.
- Spray 12-cup muffin pan with nonstick cooking spray; set aside.
- Spray large skillet with nonstick cooking spray.
- In prepared skillet over medium heat, cook onion until translucent. Add turkey sausage and cook until no longer pink. Remove from heat.
- In large mixing bowl, lightly beat eggs. Add shredded cheese, pancake mix and sausage and onion mixture; mix well.
- Fill prepared muffin cups about 3/4 full with mixture.
- Bake 18-20 minutes, or until golden brown on top.
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Visit our Food & Drink section to get the latest on Foodie News and recipes, offering a delightful blend of culinary inspiration and gastronomic trends to elevate your dining experience. https://stmdailynews.com/food-and-drink/
Last Updated on May 16, 2026 by Daily News Staff
National Small Business Month
Every May, communities across the United States recognize Small Business Month, a time dedicated to celebrating the entrepreneurs, family-owned companies, startups, and local shops that help drive the American economy. From neighborhood restaurants to innovative tech startups, small businesses continue to play a vital role in creating jobs, supporting communities, and inspiring innovation.
According to the U.S. Small Business Administration, small businesses account for millions of jobs nationwide and represent the backbone of local economies. Throughout May, organizations, chambers of commerce, and business leaders host networking events, educational workshops, and promotional campaigns to support entrepreneurs and encourage consumers to shop locally.
One of the highlights of the month is National Small Business Week, which honors outstanding entrepreneurs and business owners making a difference in their communities.
For consumers, Small Business Month is also a reminder that supporting local businesses helps strengthen neighborhoods and keeps communities thriving. Whether it’s dining at a local café, shopping at an independent store, or hiring a local service provider, every purchase can make an impact.
Learn more about Small Business Month and related events through the official U.S. Small Business Administrationwebsite.
Related External Links
- U.S. Small Business Administration (SBA)
- National Small Business Week – SBA
- SCORE – Mentoring and Resources for Small Businesses
- U.S. Chamber of Commerce – Small Business Resources
- Forbes Small Business News and Insights
Our Lifestyle section on STM Daily News is a hub of inspiration and practical information, offering a range of articles that touch on various aspects of daily life. From tips on family finances to guides for maintaining health and wellness, we strive to empower our readers with knowledge and resources to enhance their lifestyles. Whether you’re seeking outdoor activity ideas, fashion trends, or travel recommendations, our lifestyle section has got you covered. Visit us today at https://stmdailynews.com/category/lifestyle/ and embark on a journey of discovery and self-improvement.
Cruise travel is having more than a moment. It’s having a decade.
(Tiffany Miller) The cruise industry is not waiting for travelers to come around. By most measures, they already have. A projected 21.7 million Americans are expected to cruise in 2026, a record high and a 4.5 percent increase over last year, according to AAA.
“Cruising has come a long way since The Love Boat,” said writer and travel expert Sarah Greaves-Gabbadon, aka JetSetSarah. “Pull up to the port, unpack once and have the world come to you.”
This April, more than 11,500 attendees and 650 exhibitors gathered at Seatrade Cruise Global to map out what comes next.
Dining as the main event
Food has always been part of the cruise experience. The question the industry is now asking is what happens when it becomes the point.
Cruise lines are placing greater emphasis on the dining experience, with destination-inspired menus, port-specific drinks and more immersive, multi-course experiences.
Royal Caribbean introduced the Empire Supper Club this year, pairing multi-course menus with craft cocktails and live music into a single evening.
Expedition cruising finds a new audience
Expedition cruising is one of the fastest-growing types of cruising, and major cruise lines are moving into it.
These itineraries go where other ships do not. Travelers kayak among glaciers, contribute to citizen science programmes and spend time in the field with naturalists and researchers, with programming built around science and conservation rather than port stops.
National Geographic-Lindblad Expeditions has operated in this space for decades, with programs including the Visiting Scientist Program, the Lindblad Expeditions-National Geographic Fund and the Grosvenor Teacher Fellowship.
Wellness expands across the ship
Wellness is no longer a spa deck. It is becoming a reason to book.
A few years ago, a thermal suite was a selling point. Now it is closer to a baseline expectation. Meditation spaces, sleep-focused staterooms and recovery lounges are following the same trajectory. A dedicated wellness pavilion debuted at this year’s show, a signal that the category has grown large enough to need its own floor space.
Cunard’s Wellness at Sea program runs across multiple days. Its three tracks (Relax, Energise and Recover) each combine fitness, spa and mindfulness elements. Shore excursions and destination-specific spa offerings carry the experience beyond the ship.
Ships as cultural hubs
Entertainment on cruise ships used to mean a stage show. Cruise lines are now producing content that doesn’t exist anywhere else.
Holland America Line partnered with The Verdon Fosse Legacy to debut “Fosse and Verdon, The Duet That Changed Broadway,” a live musical and multimedia tribute to the work of Bob Fosse and Gwen Verdon. The production marks the first international staging of their work at sea.
Onboard retail is moving in the same direction. More cruise lines are curating locally sourced goods and destination-specific products at port, the kind passengers could only find by actually being there.
The bigger picture
The passenger numbers tell one part of the story. What cruise lines are building inside that growth tells another.
“Today’s ships offer amenities that are at least as good as, and often more comprehensive than, those in resorts and hotels,” Greaves-Gabbadon said. “A cruise can be equally enjoyable for solos, families, honeymooners, groups and adventurers, and that versatility is a large part of their appeal.”
What the show floor made clear is that the industry is not waiting to be discovered. It is building toward the traveler it wants next.
Photo courtesy of Shutterstock
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Our Lifestyle section on STM Daily News is a hub of inspiration and practical information, offering a range of articles that touch on various aspects of daily life. From tips on family finances to guides for maintaining health and wellness, we strive to empower our readers with knowledge and resources to enhance their lifestyles. Whether you’re seeking outdoor activity ideas, fashion trends, or travel recommendations, our lifestyle section has got you covered. Visit us today at https://stmdailynews.com/category/lifestyle/
