Health
Study shows engineered gut bacteria can treat hypertension
Newswise — Scientists at The University of Toledo have proven that engineered bacteria can lower blood pressure, a finding that opens new doors in the pursuit of harnessing our body’s own microbiome to treat hypertension.
The study, published this month in the peer-reviewed journal Pharmacological Research, represents a paradigm shift, said Dr. Bina Joe, a hypertension researcher at UToledo and the paper’s senior author.
“The question we always ask is, can we exploit microbiota to help our health, for which optimal blood pressure is a cardinal sign. Until now, we have simply said changes in microbiota play a role in elevated blood pressure or hypertension. Those are important findings, but they don’t always have an immediately translational application,” she said. “This is the first time we have shown that we really can do this. It’s a proof of principle that you can use microbiota to make products that measurably improve your health.”
Joe, a Distinguished University Professor and chair of the Department of Physiology and Pharmacology in the UToledo College of Medicine and Life Sciences, is a pioneer in studying the connection between bacteria living in our gut and blood pressure regulation.
In her most recent research, Joe and her team tested Lactobacillus paracasei, a beneficial gut bacterium, that was specially modified to produce a protein called ACE2 in lab rats that are predisposed to hypertension and unable to naturally produce ACE2.
ACE2 has drawn considerable interest in recent years because of its role as a key receptor for the virus that causes COVID-19.
However, the protein also negatively regulates the renin-angiotensin system which generates angiotensin II, a hormone that raises blood pressure in a number of ways, including by the constriction of blood vessels.
By feeding rats the engineered Lactobacillus paracasei bacterium as a probiotic, researchers were able to introduce human ACE2 in their guts, which specifically reduced their gut angiotensin II and, in turn, lowered their blood pressure.
Interestingly, though, the blood-pressure-lowering effects were only seen in female rats. Though there was no difference in ACE2 expression between male and female rats, only the female rats saw a decrease in their blood pressure.
Researchers are unsure of exactly why that was the case, but Joe speculates it has something to do with the fact that females, but not males, have two functional copies of ACE2.
The gene encoding ACE2 is located in a region of the X-chromosome which escapes a genetic phenomenon called X-inactivation. It appears, Joe said, that having two functional copies of ACE2 is extremely important for females, because when both copies were lost, females had a much higher level of hypertension compared to males.
“Females therefore appear to readily accept all the help they can get from gut microbiota supplying ACE,” she said. “For now, this is a theory that requires further experimental proof.”
Even with the differing results between male and female rats, however, Joe said the findings are an important steppingstone between the theory of leveraging bacteria to treat hypertension and other chronic conditions and practically being able to bring it into the clinic.
“There have been questions about microbiome medicine — is it a fad or is it real? This is an extremely exciting demonstration that we can exploit bacteria to work for us, and it works for high blood pressure, something that affects a significant portion of the population,” she said. “It’s that ray of hope that you may not need traditional medications to keep your blood pressure in check.”
According to data from the U.S. Centers for Disease Control and Prevention, nearly half of U.S. adults have hypertension, and only about one in four of those have their blood pressure under control.
Though it rarely exhibits symptoms, uncontrolled blood pressure is a major risk factor for heart attack, stroke and kidney disease.
Joe said more research is needed, including studies on what happens when ACE2-producing bacteria are introduced in animals whose bodies already make the protein naturally and any side effects that might come with boosting ACE2 levels in the gut.
However, the first-of-its-kind research from UToledo opens a window into the substantial potential of exploiting the bacteria living in our gut for our benefit.
“It is a real possibility that we can use bacteria to correct hypertension. This is a big deal, and the concept could be applied to other diseases,” she said. “For example, if you are unable to control your sugar, can we have a bacteria make a protein that can lower your blood glucose? There are still a lot of questions that need answered, but now we know the paradigm works.”
Journal Link: Pharmacological Research
Source: University of Toledo
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(Family Features) In the U.S., 1 in 3 adults is at risk for a newly recognized syndrome that comes from a combination of heart disease, kidney disease, type 2 diabetes and excess body weight. This cluster of conditions, called cardiovascular-kidney-metabolic (CKM) syndrome, is an example of how problems in one part of your body can affect other parts.
To avoid CKM syndrome, health experts suggest paying close attention to four of the American Heart Association’s Life’s Essential 8 – blood pressure, lipids, body weight and blood sugar level – which are core health factors that impact your metabolic health.
Good metabolic health means your body uses energy well and keeps these factors in a normal range. However, when numbers are off in one area, it can affect others, raising your risk for heart disease, stroke, kidney disease and diabetes.
Consider these tips from the American Heart Association to help keep your core health factors under control.
Blood Pressure
High blood pressure, also known as hypertension, happens when the force of your blood pushing against the walls of your blood vessels is too high. High blood pressure is a leading cause of heart disease, stroke and kidney disease.
Because high blood pressure doesn’t have symptoms, the only way to know you have it is to get your blood pressure checked. Healthy blood pressure is below 120/80. If your blood pressure is 130/80 or higher, talk to your doctor about checking your other core health factors.
Lifestyle changes can help reduce high blood pressure. One example is a Dietary Approaches to Stop Hypertension (DASH) eating pattern that’s low in fat and rich in fruits, vegetables, whole grains and low-fat dairy products. Losing 10 pounds and reducing alcohol consumption can also reduce blood pressure.
Cholesterol
Cholesterol is a waxy substance your liver makes then circulates in the blood where your body uses it to build cells and make vitamins and hormones. You may also get cholesterol from eating animal products. If there’s too much cholesterol circulating, your risk of type 2 diabetes, heart disease and stroke may increase.
For optimal CKM health, your LDL cholesterol should be below 100 and triglycerides below 150. Triglycerides are the most common type of fat in the body. If your triglyceride level is 135 or higher, talk to your doctor about decreasing your risk.
Losing body weight and increasing physical activity decrease triglyceride levels. In addition, DASH and Mediterranean (plant-based, high-fiber, low-fat) eating patterns support healthy LDL and triglyceride levels.
Body Weight
Healthy weight may be determined by body mass index (BMI), a number that represents your weight in relation to your height. Extra body fat can mean a higher risk for many health problems, including heart disease, stroke, high blood pressure, high cholesterol and diabetes.
CKM syndrome starts when BMI is 25 or higher and waist circumference is 88 centimeters or higher for women and 102 centimeters or higher for men. Aim for a BMI between 18.5-25.
To lose weight and keep it off, start by setting realistic goals. Understand how much and why you eat, manage portion sizes, make smart snack substitutions and be physically active.
Blood Sugar
High blood sugar can slowly damage the kidneys. In fact, diabetes is the leading cause of kidney disease, and it increases the risk of heart attack and stroke.
Blood sugar is measured in two ways: a fasting blood glucose test (short term blood sugar) and an A1C test (long term blood sugar control). A normal fasting blood glucose level is 70-99 and a normal A1C level is below 5.7%. Fasting blood glucose above 125 and A1C of 6.5% or higher means you have diabetes.
Habits that help you avoid high blood pressure, weight gain and high cholesterol also keep your blood sugar in check. These are especially important if you have a family history of diabetes.
Learn more about CKM syndrome and how to manage your risk at heart.org/CKMhealth.
Photos courtesy of Shutterstock
SOURCE:
American Heart Association
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(Family Features) Staying up to date on recommended vaccines is important during pregnancy. This is especially true during the winter months when more people tend to get sick from flu, COVID-19 and RSV. These viruses can be especially dangerous for pregnant people and babies.
Vaccines are an important part of routine pregnancy care, both for you and your baby. Getting vaccinated against flu and COVID-19 can cut your risk of hospitalization by about half.
Now is the time to get vaccinated if you haven’t already. Flu vaccines help protect you from getting the flu and getting seriously ill, so it’s a good idea to schedule an appointment now. The latest COVID-19 vaccines are important too because they lower your risk of serious illness. An RSV vaccine may also be recommended for when you are 32-36 weeks pregnant. Be sure to talk to your doctor.
“Right now, we are seeing a concerning increase in cases of respiratory diseases, such as the flu, COVID-19 and RSV,” said Adm. Rachel Levin, MD, assistant secretary for health at the U.S. Department of Health and Human Services. “I encourage all pregnant people to take preventive action to protect their health and the health of their baby. The best and safest way to do this is to get vaccinated. Getting vaccinated is easy and is usually covered by insurance.”
Help Protect Your Baby
When you get flu, COVID-19 and RSV vaccines, you’re helping protect your baby by passing your immunity on to them. Getting vaccinated against flu, COVID-19 and RSV during pregnancy can protect your baby during the first 6 months of life. These viruses can be very harmful to newborns. In fact, RSV is the leading cause of hospitalization in infants
Talk to Your Doctor About Timing
Millions of people in the U.S. have already gotten vaccinated against flu, COVID-19 and RSV this season. If you haven’t gotten your vaccines yet, be sure to talk with your doctor. They can help you choose the right vaccines and determine the best timing to help protect you and your baby.
Get the Facts
Getting vaccinated can give you peace of mind, ensuring you have done everything you can to protect yourself and your baby from serious respiratory illness. Information can give you power and comfort, especially when you’re pregnant.
Go to cdc.gov/RiskLessDoMore to learn more about flu, COVID-19 and RSV vaccines, or go to vaccines.gov to get started today.
Photo courtesy of Shutterstock
SOURCE:
U.S. Department of Health and Human Services
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Lifestyle
Here’s to a Healthy New Year: What your family needs to know about vaccines
Vaccines for flu, COVID-19, and RSV are vital for family health, especially as respiratory viruses increase during colder months. Stay updated to reduce serious illness and hospitalizations.
(Family Features) This year, make a plan to keep your family healthy by helping them get vaccinated for respiratory infections like flu, COVID-19 and RSV. These respiratory illnesses are more likely to become serious for people who are not up to date on their vaccines.
In colder months, respiratory viruses tend to surge, and people spend more time indoors where they are more likely to be exposed. These respiratory infections can cause serious illness and hospitalization. This season’s flu and COVID-19 vaccines, as well as the RSV vaccine, are the best way to help your family risk less serious illness and do more of what they enjoy.
What should your family know?
Vaccines can keep you and your family from getting very sick from respiratory illnesses. The Centers for Disease Control and Prevention (CDC) recommends everyone ages 6 months and older get this season’s flu and COVID-19 vaccines.
In addition, all adults ages 75 and older – and those ages 60 and older with certain health conditions or who live in a nursing home – should get one dose of an RSV vaccine if they haven’t before. Pregnant people should also talk to their doctor about getting an RSV vaccine to protect their baby during their first 6 months of life.
Is your family at high risk?
It’s important to know the risks of getting very sick from flu, COVID-19 or RSV. According to the CDC, some people have a higher risk than others, including:
- People not up to date on their vaccines: Vaccines cut your risk of needing hospital care for flu or COVID-19 by about half, according to the CDC. In 2023, 90% of adults admitted to the hospital for COVID-19 were not up to date on their COVID-19 vaccine. People who skipped their flu shot were twice as likely to need to see a doctor for the flu.
- Older adults: Most flu, COVID-19 and RSV deaths are in people ages 65 and older. If you help care for an older family member or friend, let them know vaccines are their best protection from getting very sick.
- People with underlying health conditions: Heart and lung disease, diabetes, kidney disease and other chronic conditions can cause complications and more severe illness from flu, COVID-19 and RSV.
- Those who live in long-term care: Respiratory viruses can be a greater threat to older people in long-term care, who often have health issues that raise their risk of severe flu, COVID-19 or RSV.
- Pregnant people: Pregnancy raises the risk of severe illness from flu and COVID-19. Getting vaccinated during pregnancy helps protects the pregnant person and baby. An RSV vaccine during pregnancy protects the baby from severe RSV in their first 6 months of life.
Get your family vaccinated now for a healthy new year
Join the millions of people who’ve already gotten vaccinated this season. Take your family to get vaccinated now to risk less severe illness and do more of what you enjoy. It’s safe to get flu and COVID-19 vaccines (and an RSV vaccine, if eligible) at the same time.
Visit cdc.gov/RiskLessDoMore to learn more about flu, COVID-19 and RSV vaccines. Talk with your doctor about which vaccines are right for you or go to vaccines.gov to find a nearby pharmacy. You can order free COVID-19 test kits (up to four per household) at COVIDTests.gov.
Know Your Risk
In the United States, there are additional groups of people who are at higher risk from these respiratory illnesses.
- People in rural parts of the country: Vaccines matter even more in rural areas where there may be fewer doctors or clinics to help people who get very sick. Yet in these regions, less than half of adults got a flu vaccine last year. Fewer than 1 in 5 got an updated COVID-19 vaccine.
- Black and Hispanic people: At last year’s respiratory virus peak, Black people were more likely than white and Hispanic people to be in the hospital for flu, COVID-19 or RSV. By the end of last year’s virus season, Hispanic people were more likely than non-Hispanic white people to have been in the hospital for flu.
Photos courtesy of Shutterstock
SOURCE:
U.S. Department of Health and Human Services
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