Lifestyle
Women are at a higher risk of dying from heart disease − in part because doctors don’t take major sex and gender differences into account
Heart disease impacts women differently than men due to genetic and gender biases in healthcare. Awareness and improved treatment approaches are essential for better outcomes.
Amy Huebschmann, University of Colorado Anschutz Medical Campus and Judith Regensteiner, University of Colorado Anschutz Medical Campus
A simple difference in the genetic code – two X chromosomes versus one X chromosome and one Y chromosome – can lead to major differences in heart disease. It turns out that these genetic differences influence more than just sex organs and sex assigned at birth – they fundamentally alter the way cardiovascular disease develops and presents.
While sex influences the mechanisms behind how cardiovascular disease develops, gender plays a role in how healthcare providers recognize and manage it. Sex refers to biological characteristics such as genetics, hormones, anatomy and physiology, while gender refers to social, psychological, and cultural constructs. Women are more likely to die after a first heart attack or stroke than men. Women are also more likely to have additional or different heart attack symptoms that go beyond chest pain, such as nausea, jaw pain, dizziness and fatigue. It is often difficult to fully disentangle the influences of sex on cardiovascular disease outcomes versus the influences of gender.
While women who haven’t entered menopause have a lower risk of cardiovascular disease than men, their cardiovascular risk accelerates dramatically after menopause. In addition, if a woman has Type 2 diabetes, her risk of heart attack accelerates to be equivalent to that of men, even if the woman with diabetes has not yet gone through menopause. Further data is needed to better understand differences in cardiovascular disease risk among nonbinary and transgender patients.
Despite these differences, one key thing is the same: Heart attack, stroke and other forms of cardiovascular disease are the leading cause of death for all people, regardless of sex or gender.
We are researchers who study women’s health and the way cardiovascular disease develops and presents differently in women and men. Our work has identified a crucial need to update medical guidelines with more sex-specific approaches to diagnosis and treatment in order to improve health outcomes for all.
Gender differences in heart disease
The reasons behind sex and gender differences in cardiovascular disease are not completely known. Nor are the distinct biological effects of sex, such as hormonal and genetic factors, versus gender, such as social, cultural and psychological factors, clearly differentiated.
What researchers do know is that the accumulated evidence of what good heart care should look like for women compared with men has as many holes in it as Swiss cheese. Medical evidence for treating cardiovascular disease often comes from trials that excluded women, since women for the most part weren’t included in scientific research until the NIH Revitalization Act of 1993. For example, current guidelines to treat cardiovascular risk factors such as high blood pressure are based primarily on data from men. This is despite evidence that differences in the way that cardiovascular disease develops leads women to experience cardiovascular disease differently.
In addition to sex differences, implicit gender biases among providers and gendered social norms among patients lead clinicians to underestimate the risk of cardiac events in women compared with men. These biases play a role in why women are more likely than men to die from cardiac events. For example, for patients with symptoms that are borderline for cardiovascular disease, clinicians tend to be more aggressive in ordering artery imaging for men than for women. One study linked this tendency to order less aggressive tests for women partly to a gender bias that men are more open than women to taking risks.
In a study of about 3,000 patients with a recent heart attack, women were less likely than men to think that their heart attack symptoms were due to a heart condition. Additionally, most women do not know that cardiovascular disease is the No. 1 cause of death among women. Overall, women’s misperceptions of their own risk may hold them back from getting a doctor to check out possible symptoms of a heart attack or stroke.
These issues are further exacerbated for women of color. Lack of access to health care and additional challenges drive health disparities among underrepresented racial and ethnic minority populations.
Sex difference in heart disease
Cardiovascular disease physically looks different for women and men, specifically in the plaque buildup on artery walls that contributes to illness.
Women have fewer cholesterol crystals and fewer calcium deposits in their artery plaque than men do. Physiological differences in the smallest blood vessels feeding the heart also play a role in cardiovascular outcomes.
Women are more likely than men to have cardiovascular disease that presents as multiple narrowed arteries that are not fully “clogged,” resulting in chest pain because blood flow can’t ratchet up enough to meet higher oxygen demands with exercise, much like a low-flow showerhead. When chest pain presents in this way, doctors call this condition ischemia and no obstructive coronary arteries. In comparison, men are more likely to have a “clogged” artery in a concentrated area that can be opened up with a stent or with cardiac bypass surgery. Options for multiple narrowed arteries have lagged behind treatment options for typical “clogged” arteries, which puts women at a disadvantage.
In addition, in the early stages of a heart attack, the levels of blood markers that indicate damage to the heart are lower in women than in men. This can lead to more missed diagnoses of coronary artery disease in women compared with men.
The reasons for these differences are not fully clear. Some potential factors include differences in artery plaque composition that make men’s plaque more likely to rupture or burst and women’s plaque more likely to erode. Women also have lower heart mass and smaller arteries than men even after taking body size into consideration.
Reducing sex disparities
Too often, women with symptoms of cardiovascular disease are sent away from doctor’s offices because of gender biases that “women don’t get heart disease.”
Considering how symptoms of cardiovascular disease vary by sex and gender could help doctors better care for all patients.
One way that the rubber is meeting the road is with regard to better approaches to diagnosing heart attacks for women and men. Specifically, when diagnosing heart attacks, using sex-specific cutoffs for blood tests that measure heart damage – called high-sensitivity troponin tests – can improve their accuracy, decreasing missed diagnoses, or false negatives, in women while also decreasing overdiagnoses, or false positives, in men.
Our research laboratory’s leaders, collaborators and other internationally recognized research colleagues – some of whom partner with our Ludeman Family Center for Women’s Health Research on the University of Colorado Anschutz Medical Campus – will continue this important work to close this gap between the sexes in health care. Research in this field is critical to shine a light on ways clinicians can better address sex-specific symptoms and to bring forward more tailored treatments.
The Biden administration’s recent executive order to advance women’s health research is paving the way for research to go beyond just understanding what causes sex differences in cardiovascular disease. Developing and testing right-sized approaches to care for each patient can help achieve better health for all.
Amy Huebschmann, Professor of Medicine, University of Colorado Anschutz Medical Campus and Judith Regensteiner, Professor of Medicine, University of Colorado Anschutz Medical Campus
This article is republished from The Conversation under a Creative Commons license. Read the original article.
Our Lifestyle section on STM Daily News is a hub of inspiration and practical information, offering a range of articles that touch on various aspects of daily life. From tips on family finances to guides for maintaining health and wellness, we strive to empower our readers with knowledge and resources to enhance their lifestyles. Whether you’re seeking outdoor activity ideas, fashion trends, or travel recommendations, our lifestyle section has got you covered. Visit us today at https://stmdailynews.com/category/lifestyle/ and embark on a journey of discovery and self-improvement.
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Discussing Vaccination
(Family Features) During the fall and winter months, respiratory infections such as flu, COVID-19 and RSV can surge. People who are vaccinated lower their risk of getting seriously ill and needing medical care if they get infected. About 70% of adults in the United States said they probably or definitely will get a flu shot, and more than 50% said they probably or definitely will get an updated COVID-19 vaccine. While many people are ready to get this season’s vaccines, others might still have questions.
“It is normal for people to have questions about vaccines,” said Peter Marks, MD, PhD, director of the U.S. Food and Drug Administration’s Center for Biologics Evaluation and Research, which oversees and reviews vaccine clinical trials. “It’s important for everyone to know that all vaccines go through extensive testing before they are approved and that following approval, they are carefully monitored to identify any safety concerns so that they can be addressed quickly. Hundreds of thousands of volunteers have taken part in respiratory vaccine trials. The results tell us that these vaccines are safe and effective in preventing severe disease caused by flu, COVID-19 and RSV.”
Here are some ways to talk about the importance of this season’s vaccines with a family member or friend who is unsure about getting vaccinated.
Hear them out.When talking about vaccination, it’s important to make others feel heard. There are many reasons why people may have questions and concerns about vaccines or even the health care system in general. Listen to their thinking and try not to judge. They want to know their thoughts and feelings matter.
Focus on the facts. Instead of calling out vaccine myths, focus on vaccine truths. Concentrating on myths can cause them to become the topic of your conversation. Instead, speak about the benefits of vaccines. For instance, you can mention vaccines cut your risk of being hospitalized for flu or COVID-19 by about half.
Ask if they need help getting vaccinated. Sometimes, people just need some help to find, schedule and get a vaccination. You can help them find a vaccine location at Vaccines.gov. They may also need help finding child care or figuring out whether they can take time off from work. Offering a ride or accompanying them can also be helpful, especially if the closest vaccination site is far away. If English is not their primary language, offer to help them schedule the appointment and arrange for a medical translator if needed. When it’s easier to get vaccinated, people are more likely to take this important step to help protect their health.
Having open, honest and supportive conversations about vaccines with family members and friends can make all the difference. For more information, visit cdc.gov/RiskLessDoMoreor talk to your doctor.
Flu, COVID-19 and RSV Vaccines Help People Risk Less Severe Illness and Do More of What They Enjoy
This season’s vaccines are now available. Everyone 6 months and older should get an updated flu and COVID-19 vaccine. Everyone ages 75 and older, or 60 and older with certain health conditions such as such as heart disease, lung disease, obesity or diabetes, should get an RSV vaccine if they have not been vaccinated for RSV before.
For certain people, the risk of serious respiratory illness remains high. These include adults ages 65 and older, residents of long-term care facilities, pregnant people, people with certain health conditions and those living in rural areas. People in some racial and ethnic groups, including people who are Black or Hispanic, are also at higher risk. People who are not up to date on flu, COVID-19 and RSV vaccines can reduce their risk by getting their 2024-25 vaccines as soon as they can.
To get started, visit Vaccines.gov.
Photos courtesy of Shutterstock
SOURCE:
United States Department of Health and Human Services
Our Lifestyle section on STM Daily News is a hub of inspiration and practical information, offering a range of articles that touch on various aspects of daily life. From tips on family finances to guides for maintaining health and wellness, we strive to empower our readers with knowledge and resources to enhance their lifestyles. Whether you’re seeking outdoor activity ideas, fashion trends, or travel recommendations, our lifestyle section has got you covered. Visit us today at https://stmdailynews.com/category/lifestyle/ and embark on a journey of discovery and self-improvement.
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Food and Beverage
5 Habits to Help Maintain Immune Health
To combat cold and flu season, adopt healthy habits like a nutrient-rich diet, prioritize hygiene, stay active, hydrate, and manage stress effectively for immune support.
(Family Features) Cold and flu season is here. The best way to battle cold and flu season is to prevent coming down with anything at all. While it’s impossible to stay entirely safe from germs, sniffles and coughs, there are a few healthy habits you can incorporate for extra protection this year.
Healthy Habits
Along with the guidance you receive from your health care provider, consider these dietary and lifestyle recommendations to support your immune system naturally.
Commit to a Healthier Diet: Essential for optimizing your immune system, eating a healthy diet consisting of more foods like fruits, vegetables, nuts, seeds, legumes and whole grains is recommended by experts. These foods contain beneficial plant compounds linked to health benefits in humans. Case in point: fresh grapes.
Natural grape compounds, including antioxidants and other polyphenols, may help protect the health and function of cells. At the most basic level, healthy cells are the foundation of good health.
Making simple swaps such as choosing fresh California grapes instead of processed snacks or adding grapes into favorite recipes for a healthy boost are tasty ways to add these beneficial compounds.
Studies suggest some grape compounds may positively influence immune function, including resveratrol and certain flavonoids. Additional studies show adding heart-healthy grapes to your daily diet can help support brain, colon and skin health. Grapes are also a good source of vitamin K, which may help support lung health. Incorporate the health benefits of grapes into your diet with an easy, convenient recipe like Grape and Brussels Sprout Slaw, perfect for eating on its own or pairing with a favorite protein such as grilled chicken breast.
Prioritize Basic Hygiene: Preventive practices can help you avoid germs, protecting yourself and others at the same time. Frequently wash your hands using soap and water, limit contact with others who may be sick and cover your nose and mouth with a tissue or elbow while coughing or sneezing.
Stay Active: Cold and flu season lines up with brisk temperatures, often making it more difficult to get outside for exercise. Find an activity you enjoy like moderate-intensity walking, jogging, biking or playing an aerobic sport. The “Journal of Sport and Health Science” reports exercise can help improve immune response and reduce inflammation, making it a key way to prepare your body to fight back.
Hydrate, Hydrate, Hydrate: Staying hydrated helps your immune system by keeping the body’s defenses functioning properly. In addition to drinking water, you can increase hydration by eating foods with high water content like grapes, which contain about 82% water.
Manage Stress: You can help control stress – which has a negative impact on overall health and wellness – in a number of ways. Practice deep breathing or meditation, engage in activities and hobbies that bring joy and develop nighttime habits that promote good sleep. If snacking in the evening, choose foods such as grapes that are a natural source of melatonin, a compound which helps regulate sleep cycles. Talk with someone you trust, like a friend, family member or mental health professional, to help relieve stress.
Visit GrapesFromCalifornia.com to find more ways to support your immune health.
Grape and Brussels Sprout Slaw
Servings: 6
- 1 bag (12 ounces) shredded Brussels sprouts
- 2/3 cup finely shredded red cabbage
- 2 cups red Grapes from California, halved lengthwise
- 1/2 cup finely diced red onion
- 3 scallions, trimmed and thinly sliced
- 2 tablespoons rice vinegar
- 1 1/2 tablespoons honey
- 1 teaspoon fresh lemon or lime juice
- 1 teaspoon low-sodium soy sauce
- 2 tablespoons olive oil
- 1 tablespoon toasted (dark) sesame oil
- freshly ground black pepper, to taste
- 3 tablespoons toasted sesame seeds
- In large mixing bowl, combine shredded sprouts, cabbage, grapes, onion and scallions.
- In small bowl, whisk vinegar, honey, lemon or lime juice and soy sauce. Drizzle in olive and sesame oils while whisking. Toss well with slaw mixture. Chill 45 minutes to incorporate flavors. Season with pepper and sprinkle sesame seeds on top.
Nutritional information per serving: 170 calories; 4 g protein; 22 g carbohydrates; 9 g fat (48% calories from fat); 1.5 g saturated fat (8% calories from saturated fat); 0 mg cholesterol; 60 mg sodium; 4 g fiber.
SOURCE:
California Table Grape Commission
At our core, we at STM Daily News, strive to keep you informed and inspired with the freshest content on all things food and beverage. From mouthwatering recipes to intriguing articles, we’re here to satisfy your appetite for culinary knowledge.
Visit our Food & Drink section to get the latest on Foodie News and recipes, offering a delightful blend of culinary inspiration and gastronomic trends to elevate your dining experience.
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Matt Kasson, West Virginia University
Curious Kids is a series for children of all ages. If you have a question you’d like an expert to answer, send it to curiouskidsus@theconversation.com.
Is a zombie apocalypse caused by fungi, like the Cordyceps from “The Last of Us,” something that could realistically happen? – Jupiter, age 15, Ithaca, New York
Zombies strike fear into our hearts – and if they’re persistent, eventually they get inside our heads. Animals taken over by zombies no longer control their own bodies or behaviors. Instead, they serve the interests of a master, whether it’s a virus, fungus or some other harmful agent.
The term “zombi” comes from Vodou, a religion that evolved in the Caribbean nation of Haiti. But the idea of armies of undead, brain-eating human zombies comes from movies, such as “Night of the Living Dead,” television shows like “The Walking Dead” and video games like Resident Evil.
Those all are fictional. Nature is where we can find real examples of zombification – one organism controlling another organism’s behavior.
I study fungi, a huge biological kingdom that includes molds, mildews, yeasts, mushrooms and zombifying fungi. Don’t worry – these “brain-eating organisms” tend to target insects.
The fungus Ophiocordyceps unilateralis infects and kills ants. Over time, they can diminish the local ant population.
Insect body snatchers
One of the most famous examples is the zombie ant fungus, Ophiocordyceps unilateralis, which is part of a larger group known as Cordyceps fungi. This fungus inspired the video game and HBO series “The Last of Us,” in which a widespread fungal infection turns people into zombie-like creatures and causes society to collapse.
In the real world, ants usually come into contact with this fungus when spores – pollen-size reproductive particles that the fungus makes – fall onto the ant from a tree or plant overhead. The spores penetrate the ant’s body without killing it.
Once inside, the fungus spreads in the form of a yeast. The ant stops communicating with nestmates and staggers around aimlessly. Eventually it becomes hyperactive.
Finally, the fungus causes the ant to climb up a plant and lock onto a leaf or a stem with its jaws – a behavior called summiting. The fungus changes into a new phase and consumes the ant’s organs, including its brain. A stalk erupts from the dead insect’s head and produces spores, which fall onto healthy ants below, starting the cycle again.
Scientists have described countless species of Ophiocordyceps. Each one is tiny, with a very specialized lifestyle. Some live only in specific areas: for example, Ophiocordyceps salganeicola, a parasite of social cockroaches, is found only in Japan’s Ryukyu Islands. I expect that there are many more species around the world awaiting discovery.
The zombie cicada fungus, Massospora cicadina, has also received a lot of attention in recent years. It infects and controls periodical cicadas, which are cicadas that live underground and emerge briefly to mate on 13- or 17-year cycles.
The fungus keeps the cicadas energized and flying around, even as it consumes and replaces their rear ends and abdomens. This prolonged “active host” behavior is rare in fungi that invade insects. Massospora has family members that target flies, moths, millipedes and soldier beetles, but they cause their hosts to summit and die, like ants affected by Ophiocordyceps.
The real fungal threats
These diverse morbid partnerships – relationships that lead to death – were formed and refined over millions of years of evolutionary time. A fungus that specializes in infecting and controlling ants or cicadas would have to evolve vastly new tools over millions more years to be able to infect even another insect, even one that’s closely related, let alone a human.
In my research, I’ve collected and handled hundreds of living and dead zombie cicadas, as well as countless fungus-infected insects, spiders and millipedes. I’ve dissected hundreds of specimens and uncovered fascinating aspects of their biology. Despite this prolonged exposure, I still control my own behavior.
Some fungi do threaten human health. Examples include Aspergillus fumigatus and Cryptococcus neoformans, both of which can invade people’s lungs and cause serious pneumonia-like symptoms. Cryptococcus neoformans can spread outside the lungs into the central nervous system and cause symptoms such as neck stiffness, vomiting and sensitivity to light.
Invasive fungal diseases are on the rise worldwide. So are common fungal infections, such as athlete’s foot – a rash between your toes – and ringworm, a rash that despite its name is caused by a fungus.
Fungi thrive in perpetually warm and wet environments. You can protect yourself against many of them by showering after you get sweaty or dirty and not sharing sports gear or towels with other people.
Not all fungi are scary, and even the alarming ones won’t turn you into the walking dead. The closest you’re likely to come to a zombifying fungus is through watching scary movies or playing video games.
If you’re lucky, you might find a zombie ant or fly in your own neighborhood. And if you think they’re cool, you could become a scientist like me and spend your life seeking them out.
Hello, curious kids! Do you have a question you’d like an expert to answer? Ask an adult to send your question to CuriousKidsUS@theconversation.com. Please tell us your name, age and the city where you live.
And since curiosity has no age limit – adults, let us know what you’re wondering, too. We won’t be able to answer every question, but we will do our best.
Matt Kasson, Associate Professor of Mycology and Plant Pathology, West Virginia University
This article is republished from The Conversation under a Creative Commons license. Read the original article.
The science section of our news blog STM Daily News provides readers with captivating and up-to-date information on the latest scientific discoveries, breakthroughs, and innovations across various fields. We offer engaging and accessible content, ensuring that readers with different levels of scientific knowledge can stay informed. Whether it’s exploring advancements in medicine, astronomy, technology, or environmental sciences, our science section strives to shed light on the intriguing world of scientific exploration and its profound impact on our daily lives. From thought-provoking articles to informative interviews with experts in the field, STM Daily News Science offers a harmonious blend of factual reporting, analysis, and exploration, making it a go-to source for science enthusiasts and curious minds alike. https://stmdailynews.com/category/science/
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