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FDA Moves Forward with Mail-back Envelopes for Opioid Analgesics Dispensed in Outpatient Settings
Agency Continues to Take Steps to Reduce New Cases of Opioid Use Disorder
Agency Continues to Take Steps to Reduce New Cases of Opioid Use Disorder
Today, the U.S. Food and Drug Administration announced it is requiring manufacturers of opioid analgesics dispensed in outpatient settings to make prepaid mail-back envelopes available to outpatient pharmacies and other dispensers as an additional opioid analgesic disposal option for patients.
“Expanding impactful opioid disposal options, such as mail-back envelopes and in-home disposal, for patients to safely and securely dispose of their unused opioid medications is part of the agency’s comprehensive approach to addressing the overdose crisis,” said FDA Commissioner Robert M. Califf, M.D. “We believe these efforts will not only increase convenient disposal options for many Americans, but also reduce unfortunate opportunities for nonmedical use, accidental exposure, overdose and potential new cases of opioid use disorder. We’re pleased to take this first critical step to increase mail-back envelope options in partnership with the U.S. Postal Service.”
The FDA issued notice today to all manufacturers of opioid analgesics used in outpatient settings that they are required to submit the proposed modification to the Opioid Analgesic Risk Evaluation and Mitigation Strategy (OA REMS) within 180 days of the date of the notification letter. The agency anticipates approval of the modified REMS in 2024. When implemented, outpatient pharmacies and other dispensers will have the option to order prepaid mail-back envelopes from opioid analgesic manufacturers, which they may then provide to patients prescribed opioid analgesics. The REMS modification also requires manufacturers to develop educational materials for patients on safe disposal of opioid analgesics, which outpatient pharmacies and other dispensers may also provide to patients.
This action follows a Federal Register notice issued in April 2022 that sought public comment on a potential modification of the OA REMS to require that mail-back envelopes be dispensed and education on safe disposal be provided with opioid analgesics dispensed in an outpatient setting.
Patients commonly report having unused opioid analgesics following surgical procedures and many Americans gain access to opioids through friends or relatives who have unused opioids. Data show educating patients about disposal options may increase the disposal rate of unused opioids and that providing a disposal option along with education could further increase that rate.
Currently, there are multiple mail-back envelope programs operating in the U.S. and mail-back envelopes are commercially available from multiple entities. There are long-standing regulations and policies, under the Drug Enforcement Administration and United States Postal Service, in place to ensure that mail-back envelopes are nondescript, fit for purpose, and can safely and securely transport unused medicines from the patient’s home to the location where they will be destroyed.
“The U.S. Postal Service is proud to partner with the FDA to expand the use of mail-back envelopes as a safe and secure disposal option for prescription opioid analgesics,” said Postal Service Chief Customer and Marketing Officer and Executive Vice President Steven Monteith. “Serving nearly 165 million addresses each day, with more than 31,000 retail locations across the country, the Postal Service makes it convenient for Americans to dispose of unused prescription drugs to help prevent accidental exposure and overdose.”
The FDA continues to consider additional ways to increase safe disposal of unused opioid analgesics. Specifically, the agency is exploring whether manufacturers of opioid analgesic should also be required to make in-home disposal products available to patients who are prescribed opioid analgesics. In an effort to further evaluate this potential option, the agency will participate in the workshop, Defining and Evaluating In-Home Drug Disposal Systems for Opioid AnalgesicsExternal Link Disclaimer, to examine current in-home disposal options hosted by the National Academies of Sciences, Engineering and Medicine’s (NASEM’s) Forum on Drug Discovery, Development, and Translation in June 2023. The FDA has also issued a Federal Register Notice to seek information and comments from the public to aid the agency’s assessment of in-home disposal methods.
These collective efforts are part of the agency’s implementation of the FDA Overdose Prevention Framework that aims to prevent drug overdoses and reduce deaths through impactful and creative actions. The FDA remains focused on responding to all facets of substance use, misuse, substance use disorders, overdose and death in the U.S. through the four priorities of the framework, including; supporting primary prevention by eliminating unnecessary initial prescription drug exposure and inappropriate prolonged prescribing; encouraging harm reduction through innovation and education; advancing development of evidence-based treatments for substance use disorders; and protecting the public from unapproved, diverted or counterfeit drugs presenting overdose risks.
Related Information
- FDA Overdose Prevention Framework
- Information About Naloxone
- Timeline of Selected FDA Activities and Significant Events Addressing Opioid Misuse and Abuse
Source: FDA
Author
Last Updated on April 11, 2026 by Daily News Staff
April 10, 2026 — NASA’s Artemis II crew has safely returned to Earth, marking the successful completion of the first crewed mission to the Moon’s vicinity in more than 50 years.
Credit: NASA/Joel Kowsky
The Orion spacecraft splashed down in the Pacific Ocean off the coast of California at 5:07 p.m. PDT, carrying NASA astronauts Reid Wiseman, Victor Glover, Christina Koch, and Canadian astronaut Jeremy Hansen back home after a nearly 10-day journey through deep space.
🚀 A Mission for the Record Books
During the mission, the crew traveled a total of 694,481 miles, reaching a maximum distance of 252,756 miles from Earth—farther than any humans have ever gone, surpassing the Apollo 13 record set in 1970.
Launched on April 1 aboard NASA’s powerful Space Launch System (SLS) rocket, Artemis II tested critical systems needed for future missions, including life support, navigation, and deep space communication.
🌕 Science, Exploration, and Stunning Views
While orbiting the Moon, the astronauts captured more than 7,000 images, including views of the lunar far side, a rare solar eclipse, and detailed observations of craters, lava flows, and surface features.
The mission also included scientific experiments to better understand how the human body responds to deep space conditions, helping prepare for longer missions to the Moon and Mars.
🛰️ Safe Return and Recovery
Following splashdown, recovery teams quickly reached the spacecraft and transported the crew by helicopter to the USS John P. Murtha for initial medical evaluations. The astronauts are expected to return to NASA’s Johnson Space Center for further assessments.
🌍 What Comes Next
With Artemis II complete, NASA is now turning its focus to Artemis III, the next mission aimed at landing astronauts on the Moon and establishing a long-term human presence.
The success of Artemis II marks a major step forward in humanity’s return to deep space—and the beginning of a new era of exploration.
For more information on NASA’s Artemis program, visit the official NASA website.
🔗 Source & Further Reading
- NASA Blog: Artemis II Flight Day 10 – Re-entry Live Updates
- NASA Artemis II Mission Overview
- NASA Artemis Program – Return to the Moon
- Orion Spacecraft Details and Technology
- NASA Image and Video Library (Artemis II Photos & Media)
Dive into “The Knowledge,” where curiosity meets clarity. This playlist, in collaboration with STMDailyNews.com, is designed for viewers who value historical accuracy and insightful learning. Our short videos, ranging from 30 seconds to a minute and a half, make complex subjects easy to grasp in no time. Covering everything from historical events to contemporary processes and entertainment, “The Knowledge” bridges the past with the present. In a world where information is abundant yet often misused, our series aims to guide you through the noise, preserving vital knowledge and truths that shape our lives today. Perfect for curious minds eager to discover the ‘why’ and ‘how’ of everything around us. Subscribe and join in as we explore the facts that matter. https://stmdailynews.com/the-knowledge/
Last Updated on April 7, 2026 by Daily News Staff
🕒 [UPDATE] Artemis II Reaches the Moon
Orion has reached lunar proximity, giving astronauts a historic view of the Moon as the spacecraft performs its flyby maneuver.
Artemis II Successfully Launches
CAPE CANAVERAL, Fla. — NASA has successfully launched its Artemis II mission, marking the first crewed journey toward the Moon in more than 50 years.
The powerful Space Launch System (SLS) rocket lifted off from Kennedy Space Center on April 1, carrying four astronauts on a 10-day mission around the Moon and back.
On board are Commander Reid Wiseman, Pilot Victor Glover, Mission Specialist Christina Koch, and Canadian astronaut Jeremy Hansen. The mission is already being hailed as a major milestone in NASA’s effort to return humans to deep space.
Shortly after liftoff, the Orion spacecraft successfully reached orbit and deployed its solar arrays, beginning its journey that will eventually send the crew on a translunar trajectory toward the Moon. 
Artemis II is a lunar flyby mission, meaning astronauts will not land but will travel farther from Earth than any human mission in decades while testing critical systems needed for future landings.
The mission also marks several historic firsts, including the first woman and the first person of color—Victor Glover—to travel into lunar space.
NASA says the mission is a key step toward future lunar landings and long-term plans to establish a human presence on the Moon later this decade.
🛰️ Artemis II Mission Timeline
The 10-day Artemis II mission follows a carefully planned trajectory from Earth to the Moon and back:
- Day 1: Launch and Earth orbit
- Day 1–2: Translunar injection burn
- Days 2–4: Deep space travel
- Days 4–5: Lunar flyby
- Days 5–8: Return to Earth
- Days 9–10: Reentry and splashdown
For official updates and in-depth mission details, visit the following trusted sources:
- NASA: Artemis II Mission Overview
- NASA Artemis Program (Return to the Moon)
- Orion Spacecraft – Mission Details
- Space Launch System (SLS) Rocket Overview
- Kennedy Space Center – Launch Operations
- Watch NASA Live Coverage and Replays
🧾 Sources
- NASA official launch coverage and mission updates
- NASA Artemis II press materials and briefings
- NASA Kennedy Space Center launch operations updates
Stay with STM Daily News for live updates on Artemis II.
News
Breaking: Chuck Norris Dies at 86
Chuck Norris Dies at 86: Chuck Norris, legendary martial artist and star of Walker, Texas Ranger, has died at age 86 following a reported medical emergency.
Last Updated on March 20, 2026 by Daily News Staff
Legendary martial artist and actor Chuck Norris has died at the age of 86, according to statements released by his family on Friday.
Norris reportedly passed away peacefully while surrounded by loved ones. The news comes shortly after reports surfaced that he had been hospitalized in Hawaii following a medical emergency. Details regarding the cause of death have not yet been publicly disclosed.
Best known for his role in the long-running television series Walker, Texas Ranger, Norris became a global icon through his martial arts expertise and action film career. His influence extended beyond Hollywood, shaping pop culture and inspiring generations of fans worldwide.
Over a career spanning decades, Norris starred in numerous action films and television projects, building a reputation as one of the most recognizable figures in the genre.
This is a developing story. STM Daily News will continue to provide updates as more information becomes available.
Related Coverage & Sources
People: Chuck Norris Dies at 86
TMZ: Chuck Norris Hospitalized After Medical Emergency
Euronews: Reports on Chuck Norris Medical Emergency
WLIX: Family Confirms Death of Chuck Norris
Note: This is a developing story. Source details and confirmations may be updated as more information becomes available.
Note: This is a developing story. Source details and confirmations may be updated as more information becomes available.
STM Daily News delivers timely breaking news coverage that keeps readers informed on the stories shaping their communities and the wider world. From local developments and national headlines to business, technology, entertainment, and public interest reporting, STM Daily News provides fast, accessible coverage with a clear focus on relevance, accuracy, and impact.
Live Updates
March 20, 2026 – 7:00 AM (PT): Initial reports confirm the death of Chuck Norris at age 86, according to family statements.
Earlier: Reports indicated Norris had been hospitalized in Hawaii following a medical emergency. Additional details are still emerging.
This live blog will be updated as new information becomes available.
