STM Blog
Finding the Missing Piece: One man’s journey to a von Willebrand disease diagnosis
Frank, a 65-year-old man, spent decades suffering from von Willebrand disease (VWD) without a diagnosis. His journey, marked by severe bleeds and uncertainty, changed when his granddaughter was diagnosed with VWD. This discovery led to Frank’s diagnosis and treatment with VONVENDI, which allows him to better manage his condition and regain control of his life.
Last Updated on October 19, 2025 by Daily News Staff
Finding the Missing Piece: One man’s journey to a von Willebrand disease diagnosis
(Family Features) “I wanted to live my life like there was nothing wrong, but the fear was always there.”
That’s how 65-year-old Frank described life with von Willebrand disease (VWD), the most common bleeding disorder, affecting more than 3 million Americans.
For Frank, the signs started early with nosebleeds so severe they seemed unstoppable. In his 30s, one gastrointestinal bleed required nearly 7 pints of blood to stabilize him – a staggering amount, considering most adults only have 8-12 pints total.
Life with VWD can mean living in constant uncertainty. Any injury, surgery or even simple dental procedure can trigger a dangerous bleed. Symptoms like frequent bruising or heavy menstrual bleeding in women can affect quality of life. The consequences for Frank, even before his diagnosis, were often urgent and life-threatening.
Hospital visits and bleeds became routine, draining both his body and spirit. Frank lost weight, struggled with temperature swings and each trip home from the hospital felt like borrowed time before his next bleeding episode.
Eventually, his body began rejecting the blood transfusions meant to treat him during these mysterious bleeding episodes – a complication known as hemolytic anemia. With few options left, Frank and his partner, Carla, faced a future filled with fear and uncertainty, unsure how much longer his body could keep going.
Journey to a Diagnosis
Like many living with VWD, Frank spent years searching for answers – managing symptoms without understanding their cause. Bleeds came without warning. Triggers were a mystery. A diagnosis felt out of reach.
Through it all, Frank and Carla were their own fiercest advocates. Carla became his second set of eyes and ears by researching symptoms, writing down questions and sitting beside him in countless exam rooms.
“I realized when he was in the hospital, I must be there with him,” Carla said. “I needed to be there when the doctors and the nurses were talking to him. I slept in his room to be there for morning rounds to make sure everyone had the correct information.”
For years, they pressed on without answers or an official diagnosis until 2013, when everything changed.
Frank’s granddaughter was diagnosed with VWD, which they learned is a hereditary bleeding disorder. In that moment, something clicked. After decades of uncertainty, Frank finally had a clue and a connection.
He and Carla immediately sought out VWD education. Testing confirmed what they suspected: Frank had been living with VWD all along.
“Getting the diagnosis was a turning point,” Frank said. “For the first time, we weren’t just waiting for the next bleed – we finally had a way to take control.”
A Path Forward
Frank finally found hope and a path forward. After discussing which treatment option may be right for him with his health care team, Frank began using VONVENDI® [von Willebrand factor (Recombinant)] on-demand to treat and control his bleeding episodes.
VONVENDI is the only von Willebrand factor (VWF) treatment made without human blood or plasma with approved uses in both adults and children with VWD. For someone whose body had begun rejecting transfusions, having a recombinant option was important. But more than that – it worked for Frank.
“Since starting VONVENDI, I feel like I finally found the right path forward for me,” Frank said. “I can control my bleeds when they happen, and I have a plan in place to treat the next one.”
The U.S. Food and Drug Administration recently approved an expanded indication for VONVENDI, which is now indicated for adults and children with VWD to treat and control bleeding episodes (on-demand), to prevent excessive bleeding during and after surgery (perioperative) and for adult patients only, to reduce the number of bleeding episodes when used regularly (prophylaxis). Please see below for Detailed Important Risk Information or click here for the full Prescribing Information.
With this expanded indication, VONVENDI can now help more patients like Frank – not just control bleeds but also try to prevent them. Frank and Carla know there’s no cure, but for the first time in a long time, they have a plan to address Frank’s VWD bleeds.
Visit VONVENDI.com or speak with your doctor to learn more about VWD and discuss if treatment may be right for you.
VONVENDI [von Willebrand factor (Recombinant)] Important Information
What is VONVENDI?
VONVENDI is used in adults and children with von Willebrand disease to:
- treat and control bleeding episodes
- prevent excessive bleeding during and after surgery
For adult patients only:
- reduce the number of bleeding episodes when used regularly (prophylaxis)
Detailed Important Risk Information
Who should not use VONVENDI?
You should not use VONVENDI if you:
- Are allergic to any ingredients in VONVENDI.
- Are allergic to mice or hamsters.
Tell your healthcare provider if you are pregnant or breastfeeding because VONVENDI may not be right for you.
How should I use VONVENDI?
Your first dose of VONVENDI for each bleeding episode may be administered with a recombinant factor VIII as instructed by your healthcare provider.
Your healthcare provider will instruct you whether additional doses of VONVENDI with or without recombinant factor VIII are needed.
What should I tell my healthcare provider before I use VONVENDI?
You should tell your healthcare provider if you:
- Have or have had any medical problems.
- Take any medicines, including prescription and non-prescription medicines, such as over-the-counter medicines, supplements or herbal remedies.
- Have any allergies, including allergies to mice or hamsters.
- Are breastfeeding. It is not known if VONVENDI passes into your milk and if it can harm your baby.
- Are pregnant or planning to become pregnant. It is not known if VONVENDI can harm your unborn baby.
- Have been told that you have inhibitors to von Willebrand factor (because VONVENDI may not work for you).
- Have been told that you have inhibitors to blood coagulation factor VIII.
What else should I know about VONVENDI and von Willebrand Disease?
Your body can form inhibitors to von Willebrand factor or factor VIII. An inhibitor is part of the body’s normal defense system. If you form inhibitors, they may stop VONVENDI or factor VIII from working properly.
Consult with your healthcare provider to make sure you are carefully monitored with blood tests for the development of inhibitors to von Willebrand factor or factor VIII.
What are the possible side effects of VONVENDI?
You can have an allergic reaction to VONVENDI.
Call your healthcare provider right away and stop treatment if you get a rash or hives, itching, tightness of the throat, chest pain or tightness, difficulty breathing, lightheadedness, dizziness, nausea or fainting.
Side effects that have been reported with VONVENDI include: headache, nausea, vomiting, tingling or burning at infusion site, chest discomfort, dizziness, hot flashes, itching, high blood pressure, muscle twitching, unusual taste, blood clots and increased heart rate.
Tell your healthcare provider about any side effects that bother you or do not go away.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
Please see VONVENDI full Prescribing Information.
©2025 Takeda Pharmaceuticals U.S.A., Inc., 500 Kendall Street, Cambridge, MA 02142. 1-877-TAKEDA-7 (1-877-825-3327). All rights reserved. TAKEDA and the TAKEDA Logo are registered trademarks or registered trademarks of Takeda Pharmaceutical Company Limited. VONVENDI is a registered trademark of Baxalta Incorporated. US-VON-1006v1.0 10/25
SOURCE:
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The Knowledge
So, Here’s the Story of Mound Bayou, Mississippi
Discover the inspiring history of Mound Bayou, Mississippi — one of America’s most successful Black-founded towns and a symbol of resilience, freedom, and progress.
Last Updated on June 9, 2026 by Daily News Staff
Did you know there was once a thriving Black-founded town in the Mississippi Delta built on the dream of freedom, self-reliance, and opportunity?
Mound Bayou
Founded in 1887 by Isaiah T. Montgomery and Benjamin T. Green, Mound Bayou, Mississippi became one of the most successful all-Black communities in American history. Established just decades after the Civil War, the town represented hope during a time when racial segregation and violence dominated much of the South.
Mound Bayou quickly grew into a center of Black business, education, healthcare, and agriculture. Residents built schools, churches, newspapers, banks, and medical facilities, proving that economic independence and community leadership could flourish despite enormous challenges.
The city even gained national attention from leaders like Booker T. Washington and President Theodore Roosevelt, who recognized Mound Bayou as a symbol of progress and determination.
During the Civil Rights era, the town also played a role in the fight for justice, particularly through the work of Dr. T.R.M. Howard following the murder of Emmett Till.
Today, Mound Bayou stands as a powerful reminder of resilience, entrepreneurship, and a chapter of American history that deserves far more recognition.
Now you know.
Here are some related article links you can include at the bottom of your STM Daily News post for further reading:
Related Articles & Further Reading
• The Official History of Mound Bayou
https://www.cityofmoundbayou.com/our-history
• Mound Bayou: The Historic Black Community in Mississippi
https://en.wikipedia.org/wiki/Mound_Bayou,_Mississippi
• The Historic Bank of Mound Bayou
https://en.wikipedia.org/wiki/Bank_of_Mound_Bayou
• The Legacy of Dr. T.R.M. Howard and Civil Rights Activism
https://www.cityofmoundbayou.com/our-history
• How Mound Bayou Became Known as “The Jewel of the Delta”
https://cityofmoundbayou.com/
• Community Discussion About Mound Bayou’s History
https://www.reddit.com/r/BlackHistoryPhotos/comments/1ta0r2e/famous_allblack_american_cities_towns_mound_bayou/
Dive into “The Knowledge,” where curiosity meets clarity. This playlist, in collaboration with STMDailyNews.com, is designed for viewers who value historical accuracy and insightful learning. Our short videos, ranging from 30 seconds to a minute and a half, make complex subjects easy to grasp in no time. Covering everything from historical events to contemporary processes and entertainment, “The Knowledge” bridges the past with the present. In a world where information is abundant yet often misused, our series aims to guide you through the noise, preserving vital knowledge and truths that shape our lives today. Perfect for curious minds eager to discover the ‘why’ and ‘how’ of everything around us. Subscribe and join in as we explore the facts that matter. https://stmdailynews.com/the-knowledge/
Entertainment
Life isn’t all diamonds – money and fame don’t shield the many ‘Real Housewives’ facing criminal charges
“The Real Housewives” is more than messy drama—it’s a crash course in real-world crime, as cast members face charges from DUIs and theft to fraud, assault, and federal prison.
C. Clare Strange, Drexel University
“The Real Housewives” reality TV series, which showcases the lives of a rotating cast of wealthy women in 11 cities in the U.S. and places in several other countries, is famous for its characters’ over-the-top drama and messy personal antics.
But there are also useful lessons that the characters’ lives and frequent run-ins with the law offer to casual observers and criminology students alike.
I developed the idea for The Real Housewives of Criminology course when I heard a story on NPR in 2023 about how the Bravo Network franchise was becoming more like a true-crime TV series.
Jen Shah, a cast member from “The Real Housewives of Salt Lake City,” had recently been sentenced to six years in federal prison for her role in a nationwide telemarketing scheme – but she wasn’t the only one on the show who met such a fate.
Many people who appear on “Housewives” share a real-life penchant for crime – from driving-under-the-influence charges and theft to fraud and assault.
During any given episode, viewers may find “Housewives” stars and their families navigating the fallout – from court dates to public shaming.
I realized that these scenes illustrate core concepts from criminal justice theory and practice as well as any textbook.
A window into the course
The course examines the criminal cases of the “Housewives” and compares them to those of the general public.
Students discuss how factors such as social class, age and race can impact people’s experiences with the justice system. At the same time, they come to understand that factors such as how serious a crime is, a person’s criminal history and the harm done to victims tend to drive case outcomes more than any other factor.
I believe that this course is especially relevant now, because it is increasingly common for undergraduate students to consume news about crime and punishment from streaming platforms and social media.
It seems there is a new “Housewife” arrest every several months, which brings with it new circumstances and a new case study to dissect.
Critical lessons
One key takeaway from the course is that there are many meaningful differences – and similarities – between the criminal cases shown in “Housewives” and those of most people.
While money and power can often go a long way in fighting a criminal conviction, sometimes they fall short when the harm to victims or society is too great, or the pattern of behavior is too obvious.
Many “Housewives” stars and their families have learned this lesson the hard way.
Read along
This course requires students to view footage from “The Real Housewives,” read peer-reviewed criminological research, and listen to podcast episodes from “The Bravo Docket.”
We even read book chapters straight from some of the Housewives’ memoirs. All of this culminates in a “Final Reunion,” meaning a final verbal exam for students, in which they embody one of the “Housewives” cast members and answer questions from me – dressed as host Andy Cohen – about their criminal cases.
Real takeaways
While the court of public opinion tends to quickly draw conclusions from limited information, my honors students learn that there is more than meets the eye when it comes to the U.S. justice system.
The Real Housewives of Criminology helps them to navigate the nuance beneath the headlines about popular crime news stories, in and beyond the “Bravosphere.”
C. Clare Strange, Assistant Research Professor of Criminology and Justice Studies, Drexel University
This article is republished from The Conversation under a Creative Commons license. Read the original article.
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Blog
The Substitute Teacher Who Wanted Blueprints of Our House
A fifth-grade assignment took a strange turn when a substitute teacher asked students to draw schematics of their homes. What followed — a wildly fictional floor plan and a priceless reaction from my mom — turned into one of my funniest childhood memories.
Last Updated on June 4, 2026 by Daily News Staff
The Substitute Teacher Who Wanted Blueprints of Our House
Elementary school memories tend to blend together — cafeteria pizza, playground arguments, the eternal struggle of times tables — but every once in a while, something happens that sticks with you for life. For me, that moment came in the fifth grade during a week when our regular teacher was out, and we cycled through substitute teachers like we were testing models for durability.
By midweek, in walked a substitute with a mysterious, slightly intense energy — the kind of vibe that suggested he either meditated at dawn or worked a graveyard shift doing something he couldn’t talk about. We settled into our seats, expecting worksheets or quiet reading time.
But nope.
He had other plans.
“Today,” he announced, “we’re going to draw schematics of our houses.”
Schematics. Not drawings. Not little houses with smoke coming out of the chimney. Actual blueprint-style schematics. He wanted the layout of our bedrooms, our parents’ rooms, and where the pets slept. Every detail.
Now, to be fair, Highlights Magazine did have a feature that month teaching kids how to draw floor plans. So maybe he was just a bit overenthusiastic about cross-curricular learning. Or maybe — and this is my completely rhetorical adult theory — he worked the graveyard shift as a cat burglar gathering intel between heists. Just moonlighting between blueprints.
While the rest of the class tried their best to recreate their actual homes, my imagination sprinted in a totally different direction. The house I drew had:
- A massive master bedroom with an oversized bathroom for my parents
- Separate bedrooms for us kids on the opposite side of the house
- A kitchen placed right in the center like a command center
- And the dog — the true VIP — had a luxurious two-story doghouse
I had basically created a dream home designed by a 10-year-old watching too much Fantasy Homes by the Yard.
Later that day, my mom asked the usual question: “So, what did you guys do today?”
“We drew schematics of our house,” I said casually.
The look on her face was instant and intense. She wasn’t panicked, but there was definitely a “Why does a substitute teacher need to know the exact layout of my home?” expression happening. Parental instincts activated.
But then I showed her my diagram.
She stared at it. Blinked. Then sighed with massive relief.
“This isn’t our house,” she said.
“Nope! I made it up,” I replied proudly.
Her shoulders relaxed so much she probably lost five pounds of tension in one instant. If the substitute was secretly planning a heist, my masterpiece of misinformation would have sent him to the wrong house entirely.
Looking back, the whole moment feels like a sitcom setup — a mysterious substitute collecting “house schematics,” me creating a completely fictional piece of architecture, and my mom going on a full emotional journey in under 30 seconds.
Maybe he was just excited about the Highlights Magazine floor-plan activity. Or maybe — just maybe — he moonlighted in cat burglary. We’ll never know.
But if he was, I like to think I threw him completely off the scent.
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Our Lifestyle section on STM Daily News is a hub of inspiration and practical information, offering a range of articles that touch on various aspects of daily life. From tips on family finances to guides for maintaining health and wellness, we strive to empower our readers with knowledge and resources to enhance their lifestyles. Whether you’re seeking outdoor activity ideas, fashion trends, or travel recommendations, our lifestyle section has got you covered. Visit us today at https://stmdailynews.com/category/lifestyle/ and embark on a journey of discovery and self-improvement.
