
STM Blog
Finding the Missing Piece: One man’s journey to a von Willebrand disease diagnosis
Frank, a 65-year-old man, spent decades suffering from von Willebrand disease (VWD) without a diagnosis. His journey, marked by severe bleeds and uncertainty, changed when his granddaughter was diagnosed with VWD. This discovery led to Frank’s diagnosis and treatment with VONVENDI, which allows him to better manage his condition and regain control of his life.
Last Updated on October 19, 2025 by Daily News Staff
Finding the Missing Piece: One man’s journey to a von Willebrand disease diagnosis
(Family Features) “I wanted to live my life like there was nothing wrong, but the fear was always there.”
That’s how 65-year-old Frank described life with von Willebrand disease (VWD), the most common bleeding disorder, affecting more than 3 million Americans.
For Frank, the signs started early with nosebleeds so severe they seemed unstoppable. In his 30s, one gastrointestinal bleed required nearly 7 pints of blood to stabilize him – a staggering amount, considering most adults only have 8-12 pints total.
Life with VWD can mean living in constant uncertainty. Any injury, surgery or even simple dental procedure can trigger a dangerous bleed. Symptoms like frequent bruising or heavy menstrual bleeding in women can affect quality of life. The consequences for Frank, even before his diagnosis, were often urgent and life-threatening.
Hospital visits and bleeds became routine, draining both his body and spirit. Frank lost weight, struggled with temperature swings and each trip home from the hospital felt like borrowed time before his next bleeding episode.
Eventually, his body began rejecting the blood transfusions meant to treat him during these mysterious bleeding episodes – a complication known as hemolytic anemia. With few options left, Frank and his partner, Carla, faced a future filled with fear and uncertainty, unsure how much longer his body could keep going.
Journey to a Diagnosis
Like many living with VWD, Frank spent years searching for answers – managing symptoms without understanding their cause. Bleeds came without warning. Triggers were a mystery. A diagnosis felt out of reach.
Through it all, Frank and Carla were their own fiercest advocates. Carla became his second set of eyes and ears by researching symptoms, writing down questions and sitting beside him in countless exam rooms.
“I realized when he was in the hospital, I must be there with him,” Carla said. “I needed to be there when the doctors and the nurses were talking to him. I slept in his room to be there for morning rounds to make sure everyone had the correct information.”
For years, they pressed on without answers or an official diagnosis until 2013, when everything changed.
Frank’s granddaughter was diagnosed with VWD, which they learned is a hereditary bleeding disorder. In that moment, something clicked. After decades of uncertainty, Frank finally had a clue and a connection.
He and Carla immediately sought out VWD education. Testing confirmed what they suspected: Frank had been living with VWD all along.
“Getting the diagnosis was a turning point,” Frank said. “For the first time, we weren’t just waiting for the next bleed – we finally had a way to take control.”
A Path Forward
Frank finally found hope and a path forward. After discussing which treatment option may be right for him with his health care team, Frank began using VONVENDI® [von Willebrand factor (Recombinant)] on-demand to treat and control his bleeding episodes.
VONVENDI is the only von Willebrand factor (VWF) treatment made without human blood or plasma with approved uses in both adults and children with VWD. For someone whose body had begun rejecting transfusions, having a recombinant option was important. But more than that – it worked for Frank.
“Since starting VONVENDI, I feel like I finally found the right path forward for me,” Frank said. “I can control my bleeds when they happen, and I have a plan in place to treat the next one.”
The U.S. Food and Drug Administration recently approved an expanded indication for VONVENDI, which is now indicated for adults and children with VWD to treat and control bleeding episodes (on-demand), to prevent excessive bleeding during and after surgery (perioperative) and for adult patients only, to reduce the number of bleeding episodes when used regularly (prophylaxis). Please see below for Detailed Important Risk Information or click here for the full Prescribing Information.
With this expanded indication, VONVENDI can now help more patients like Frank – not just control bleeds but also try to prevent them. Frank and Carla know there’s no cure, but for the first time in a long time, they have a plan to address Frank’s VWD bleeds.
Visit VONVENDI.com or speak with your doctor to learn more about VWD and discuss if treatment may be right for you.
VONVENDI [von Willebrand factor (Recombinant)] Important Information
What is VONVENDI?
VONVENDI is used in adults and children with von Willebrand disease to:
- treat and control bleeding episodes
- prevent excessive bleeding during and after surgery
For adult patients only:
- reduce the number of bleeding episodes when used regularly (prophylaxis)
Detailed Important Risk Information
Who should not use VONVENDI?
You should not use VONVENDI if you:
- Are allergic to any ingredients in VONVENDI.
- Are allergic to mice or hamsters.
Tell your healthcare provider if you are pregnant or breastfeeding because VONVENDI may not be right for you.
How should I use VONVENDI?
Your first dose of VONVENDI for each bleeding episode may be administered with a recombinant factor VIII as instructed by your healthcare provider.
Your healthcare provider will instruct you whether additional doses of VONVENDI with or without recombinant factor VIII are needed.
What should I tell my healthcare provider before I use VONVENDI?
You should tell your healthcare provider if you:
- Have or have had any medical problems.
- Take any medicines, including prescription and non-prescription medicines, such as over-the-counter medicines, supplements or herbal remedies.
- Have any allergies, including allergies to mice or hamsters.
- Are breastfeeding. It is not known if VONVENDI passes into your milk and if it can harm your baby.
- Are pregnant or planning to become pregnant. It is not known if VONVENDI can harm your unborn baby.
- Have been told that you have inhibitors to von Willebrand factor (because VONVENDI may not work for you).
- Have been told that you have inhibitors to blood coagulation factor VIII.
What else should I know about VONVENDI and von Willebrand Disease?
Your body can form inhibitors to von Willebrand factor or factor VIII. An inhibitor is part of the body’s normal defense system. If you form inhibitors, they may stop VONVENDI or factor VIII from working properly.
Consult with your healthcare provider to make sure you are carefully monitored with blood tests for the development of inhibitors to von Willebrand factor or factor VIII.
What are the possible side effects of VONVENDI?
You can have an allergic reaction to VONVENDI.
Call your healthcare provider right away and stop treatment if you get a rash or hives, itching, tightness of the throat, chest pain or tightness, difficulty breathing, lightheadedness, dizziness, nausea or fainting.
Side effects that have been reported with VONVENDI include: headache, nausea, vomiting, tingling or burning at infusion site, chest discomfort, dizziness, hot flashes, itching, high blood pressure, muscle twitching, unusual taste, blood clots and increased heart rate.
Tell your healthcare provider about any side effects that bother you or do not go away.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
Please see VONVENDI full Prescribing Information.
©2025 Takeda Pharmaceuticals U.S.A., Inc., 500 Kendall Street, Cambridge, MA 02142. 1-877-TAKEDA-7 (1-877-825-3327). All rights reserved. TAKEDA and the TAKEDA Logo are registered trademarks or registered trademarks of Takeda Pharmaceutical Company Limited. VONVENDI is a registered trademark of Baxalta Incorporated. US-VON-1006v1.0 10/25
SOURCE:
Our Lifestyle section on STM Daily News is a hub of inspiration and practical information, offering a range of articles that touch on various aspects of daily life. From tips on family finances to guides for maintaining health and wellness, we strive to empower our readers with knowledge and resources to enhance their lifestyles. Whether you’re seeking outdoor activity ideas, fashion trends, or travel recommendations, our lifestyle section has got you covered. Visit us today at https://stmdailynews.com/category/lifestyle/ and embark on a journey of discovery and self-improvement.
Discover more from Daily News
Subscribe to get the latest posts sent to your email.
Blog
Atmospheric River Slams Southern California With Heavy Rainfall: A Traveler’s View From Interstate 10
Atmospheric River Slams Southern California: A powerful atmospheric river dropped record rainfall across Southern California on November 15, 2025, with Oxnard hitting 3.18 inches and inland areas exceeding 4 inches. During a drive from Ontario to Phoenix, we witnessed more than ten accidents on I-10 caused largely by reckless behavior in dangerous conditions. Here’s the full storm update, rainfall totals, and what this extreme weather teaches us about safe driving.
Last Updated on November 16, 2025 by Rod Washington
View of Stoney Point Park and Topanga Canyon Blvd in the Chatsworth neighborhood of Los Angeles, California.
Atmospheric River Slams Southern California With Heavy Rainfall: A Traveler’s View From Interstate 10
Driving Through a Storm: What We Learned From SoCal’s November Deluge
On Saturday, November 15, 2025, we made the decision to leave California and head back to Phoenix — but not before being swallowed by one of the most intense storms I’ve experienced in years. As we pulled out from Ontario on Interstate 10, the sky darkened, and what began as a routine drive turned into a lesson on risk, responsibility, and shared danger.
A Storm Like No Other
This was no simple rainstorm. It was a powerful atmospheric river, pushing deep moisture across Southern California and dumping historic amounts of rain:
Oxnard (Ventura County): 3.18 inches — a record-setting single day.
Santa Barbara Airport: 2.90 inches in one day, and upwards of 6 inches over several days in some areas.
San Antonio Heights / Cucamonga Canyon: Inland gauges saw 4+ inches in just a short time.
Ontario / I-10 Corridors: Our route wasn’t spared — roughly 1.9 inches was recorded near Ontario Airport, though I felt the ferocity of far more intense rain.
These numbers tell you part of the story — but not the whole thing. Rain intensity, how fast it fell, and where it fell mattered just as much.
When the Road Became Dangerous
Traveling east on I-10, between West Covina and Indio, we passed at least ten accidents. Given how sudden and brutal the rain was, it’s not surprising: water pooling, visibility drops, and drivers unsure how to react can combine dangerously.Here’s what stood out:
Some drivers did everything right: slowing down, flashing their hazard lights, switching lanes carefully when they saw standing water.
Others, though, acted as if they were immune to the flooding: speeding, swerving, tailgating, even deliberately splashing slower cars. Sadly, many of those behaviors contributed directly to crashes. We saw firsthand that reckless driving didn’t just affect the risk-takers — it also hurt people who were being cautious.
Why This Storm Was Especially Risky
Soil Saturation & Burn Scars
Areas burned by recent wildfires (hillsides in L.A. and Ventura) were a major concern. The soil was already saturated, and rain ran off steep slopes quickly — making debris flows a real threat.
High Rain Rates
Even if a station only recorded a few inches total, some of this rain came down very fast. That gives very little time for water to drain — increasing the likelihood of flash floods.
Traffic Hazards
On major corridors like I-10, low spots and drainage pinch points filled up fast. For someone driving, that means hidden water, hydroplaning risk, and less stopping margin.
Driving Out of the Storm: A Personal Look at Safety and Chaos on Interstate 10
What We Can Learn (and What to Do)
Drive like the conditions are worse than they seem. Even if rainfall totals look moderate, high rain rates or localized flash flooding can catch you off guard.
Use your hazard lights when visibility drops. It helps others see you, and it’s a sign you’re being cautious, not careless.
Don’t tailgate or speed. In rain, safe distance matters more than ever.
Slow down proactively. The best response to heavy rain is to brake early, not hard.
Be especially alert near hills / burn areas. Water may be running off slopes, and debris or loose rock can get carried into the roadway.
Storms like November’s atmospheric river are reminders — nature can humble any road trip. But it’s not just about rain or weather. It’s about how we treat one another when conditions go sideways. On a day when many drivers banded together to navigate safely, there were still too many who refused to adapt — and we saw exactly how risky that can be.
As the storm moves off and skies clear, the danger doesn’t disappear instantly. Saturated soils, weakened slopes, and hidden pools of water persist. For anyone traveling now — especially through canyons, foothills, and low freeway spots — cautious driving, respect for others, and shared responsibility remain the best tools to stay safe.
🔗 Sources
Dive into “The Knowledge,” where curiosity meets clarity. This playlist, in collaboration with STMDailyNews.com, is designed for viewers who value historical accuracy and insightful learning. Our short videos, ranging from 30 seconds to a minute and a half, make complex subjects easy to grasp in no time. Covering everything from historical events to contemporary processes and entertainment, “The Knowledge” bridges the past with the present. In a world where information is abundant yet often misused, our series aims to guide you through the noise, preserving vital knowledge and truths that shape our lives today. Perfect for curious minds eager to discover the ‘why’ and ‘how’ of everything around us. Subscribe and join in as we explore the facts that matter. https://stmdailynews.com/the-knowledge/
Discover more from Daily News
Subscribe to get the latest posts sent to your email.
News
National 211 hotline calls for food assistance quadrupled in a matter of days, a magnitude typically seen during disasters
Last Updated on November 16, 2025 by Daily News Staff

STM Daily News is a vibrant news blog dedicated to sharing the brighter side of human experiences. Emphasizing positive, uplifting stories, the site focuses on delivering inspiring, informative, and well-researched content. With a commitment to accurate, fair, and responsible journalism, STM Daily News aims to foster a community of readers passionate about positive change and engaged in meaningful conversations. Join the movement and explore stories that celebrate the positive impacts shaping our world.
Discover more from Daily News
Subscribe to get the latest posts sent to your email.
Blog
Driving Out of the Storm: A Personal Look at Safety and Chaos on Interstate 10
Driving Out of the Storm: Driving east on Interstate 10 from Ontario to Phoenix during the November 15 storm, we witnessed more than ten accidents caused largely by reckless driving in severe weather. Most drivers slowed down and used caution, but a few ignored conditions — leading to preventable crashes. Here’s what we saw and what it says about storm safety on I-10.
Last Updated on November 16, 2025 by Rod Washington
Driving the I10 near Palm Springs during Saturday’s storm. Image Credit: Rod Washington
Driving Out of the Storm: A Personal Look at Safety and Chaos on Interstate 10
As we were leaving California on our journey back to Phoenix on Saturday, November 15, 2025, we found ourselves driving straight into the heart of one of the most intense Southern California storms I’ve experienced in decades. Our final stop was in Ontario, and from there we headed east on Interstate 10, hoping to stay ahead of the worst of the weather. Instead, the storm followed us for nearly the entire route.
Visibility dropped to a few car lengths at times. Sheets of rain hammered the windshield. Even with the wipers on full speed, it felt like driving through a gray curtain that never fully lifted. But the toughest part wasn’t just the weather — it was what the weather revealed about how differently people respond to it.
Between West Covina and just past Indio, we saw at least 10 car accidents. Most looked like they could have been avoided. And the contrast between responsible and reckless behavior was on full display.
The majority of drivers were doing the right thing:
Reducing speed to match the conditions
Using hazard lights to alert others in areas of low visibility
Changing lanes safely to avoid flooded stretches
Showing courtesy and respect, understanding that everyone was just trying to get through safely
That kind of cognitive awareness on the road — recognizing danger, adjusting behavior, working collectively — makes all the difference in extreme weather.
But mixed among them were a smaller group of drivers who seemed to treat the storm like a challenge rather than a hazard. We saw cars speeding far beyond what was safe, weaving across multiple lanes, tailgating, and even deliberately splashing drivers who they felt were going “too slow.” Unfortunately, karma came quickly for some of them. Several of the accidents we passed looked like the direct result of that kind of behavior — and tragically, those choices didn’t just hurt the reckless drivers. They injured people who were taking the storm seriously.
It was a stark reminder that during severe weather, safety isn’t just a personal choice — it’s a shared responsibility. Most of us were out there trying to navigate a dangerous highway under extreme conditions. It only takes one careless driver to put several others at risk.
By the time the skies began to lighten, we were grateful not just to be out of the worst of the storm, but to have made it through under our own sense of caution, patience, and respect for the road. Storms like this show us a lot about nature — but just as much about one another.
TM Daily News is a multifaceted podcast that explores a wide range of topics, from life and consumer issues to the latest in food and beverage trends. Our discussions dive into the realms of science, covering everything from space and Earth to nature, artificial intelligence, and astronomy. We also celebrate the amateur sports scene, highlighting local athletes and events, including our special segment on senior Pickleball, where we report on the latest happenings in this exciting community. With our diverse content, STM Daily News aims to inform, entertain, and engage listeners, providing a comprehensive look at the issues that matter most in our daily lives. https://stories-this-moment.castos.com/
Dive into “The Knowledge,” where curiosity meets clarity. This playlist, in collaboration with STMDailyNews.com, is designed for viewers who value historical accuracy and insightful learning. Our short videos, ranging from 30 seconds to a minute and a half, make complex subjects easy to grasp in no time. Covering everything from historical events to contemporary processes and entertainment, “The Knowledge” bridges the past with the present. In a world where information is abundant yet often misused, our series aims to guide you through the noise, preserving vital knowledge and truths that shape our lives today. Perfect for curious minds eager to discover the ‘why’ and ‘how’ of everything around us. Subscribe and join in as we explore the facts that matter. https://stmdailynews.com/the-knowledge/
Discover more from Daily News
Subscribe to get the latest posts sent to your email.
