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Mount Sinai Scientists Unlock Secrets of Red Blood Cell Transporter, Potentially Paving the Way for New Drugs

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A detailed image of the bicarbonate transporter AE1 shows how bicarbonate attaches to the protein. This helped the researchers create a drug-like molecule that could stop bicarbonate transport, which could potentially be used for new treatments for blood disorders.

Newswise — New York, NY—Researchers at the Icahn School of Medicine at Mount Sinai have identified the structure of a special transporter found in red blood cells and how it interacts with drugs.  Details on the findings, which were reported in the September 7 issue of Nature Structural & Molecular Biology [DOI: 10.1038/s41594-023-01085-6], could lead to the development of more targeted medicines.

The research team, led by Daniel Wacker, PhDBin Zhang, PhD, and Avner Schlessinger, PhD, found that this transporter facilitates the movement of a substance called bicarbonate, which certain drugs can inhibit. They discovered how these drugs block the transporter and devised novel compounds capable of achieving the same effect.

“Our findings provide a detailed understanding of how bicarbonate transporters work, and the newly identified tool compounds open doors to studying conditions involving red blood cells, including hemolytic anemias,” says Dr. Wacker, corresponding author and an Assistant Professor of Pharmacological Sciences, Neuroscience, and Genetic and Genomic Sciences at Icahn Mount Sinai.

Previously, human bicarbonate transporters were poorly understood, despite being involved in many aspects of human physiology, including regulating pH that involves keeping the level of acidity within a specific range.

Using cryo-electron microscopy, the team identified high-resolution structures revealing bicarbonate and inhibitor binding, and their impact on the transport mechanism. With these insights, the researchers used computer simulations to analyze millions of compounds that could interact with the substrate binding site.

Their experiments pinpointed a group of innovative chemical inhibitors specifically designed for anion exchanger 1, a protein that is crucial for maintaining the proper function of the blood and red blood cells.

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“Our study also demonstrates the potential for developing new inhibitors with medical potential for other solute carrier (SLC) proteins, a protein family gaining importance in drug development,” says co-author Dr. Zhang, the Willard T.C Johnson Research Professor of Neurogenetics and Director of the Mount Sinai Center for Transformative Disease Modeling at Icahn Mount Sinai.

Next, the researchers plan to expand their studies to other SLC proteins involved in a variety of disorders including neurodegenerative diseases, psychiatric maladies, and cancer.

“This study effectively paves the way to using atomic-level insights toward the rapid development of promising drug-like molecules for SLC proteins,” says co-author Dr. Schlessinger, Associate Professor of Pharmacological Sciences and Associate Director of the Mount Sinai Center for Therapeutics Discovery at Icahn Mount Sinai.

The paper is titled “Substrate binding and inhibition of the anion exchanger 1 transporter.”

Additional co-authors, all with Icahn Mount Sinai except where indicated, are Michael J. Capper, PhD; Shifan Yang, PhD; Alexander C. Stone; Sezen Vatansever, MD, PhD (Amgen); Gregory Zilberg, PhD Candidate; Yamuna Kalyani Mathiharan, PhD; Raul Habib, (University of California, Berkeley);

Keino Hutchinson, PhD; Yihan Zhao, PhD Candidate; Mihaly Mezei, PhD; and Roman Osman, PhD.

The project was supported by National Institutes of Health grants R35GM133504, R01GM108911, U01AG046170, RF1AG057440, R01AG068030, R01DK073681, R01DK067555, R01DK061659, T32GM062754, T32DA053558, as well as a Sloan Research Fellowship in Neuroscience, an Edward Mallinckrodt, Jr. Foundation Grant, and a McKnight Foundation Scholars Award.

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Source: Mount Sinai Health System 

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Lifestyle

Combatting Loneliness in Older Adults

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(Family Features) The bonds found in friendships and other relationships are an important factor in health and wellness – even science says so.

According to the American Psychological Association, forming and maintaining social connections at any age is one of the most reliable predictors of a healthy, happy and long life. Studies show having strong and supportive friendships can fend off depression and anxiety, lower blood pressure and heart rates in stressful situations and change the way people perceive daunting tasks.

16967 FT detail image embed1However, statistics show approximately half of U.S. adults lack companionship and feel socially disconnected, according to the U.S. Surgeon General’s Advisory on the Healing Effects of Social Connection and Community. In fact, 12% don’t have anyone they consider a close friend, per the Survey Center on American Life. This “epidemic of loneliness,” as coined by U.S. Surgeon General Dr. Vivek Murthy, can take a severe toll on mental and physical health.

As people age, the risks of isolation increase. With America’s older population growing rapidly – the 65 and older population reached more than 55 million in 2020 – discussing how older adults can combat loneliness is relevant to public health and individual well-being.

Consider volunteering, which is one of the best and most rewarding ways to combat loneliness.

Volunteering Combats Loneliness
People often volunteer to find a sense of purpose, learn new skills, improve their communities or establish new routines after retiring or becoming empty nesters. For many, making friends through volunteer work is a welcome bonus. The act of volunteering provides proven benefits for older adults.

Forming connections can make all the difference in a person’s volunteer experience and sense of well-being. People who meet through volunteer work inherently share a common interest and something to bond over. These friendships can carry over outside of volunteer work and lead to bonding over other hobbies and interests.

Connection-Focused Volunteer Opportunities
In addition to making friends with fellow volunteers, many older adults also form relationships with the people they’re serving, especially if those recipients are their peers.

For example, AmeriCorps Seniors is the national service and volunteerism program in the federal agency of AmeriCorps that connects adults aged 55 and up to local service opportunities that match their interests. Its Senior Companion Program pairs volunteers with other older adults or those with disabilities who need companionship or assistance. Volunteers may help with tasks such as paying bills, shopping or getting companions to appointments. In some cases, volunteers may also provide support and respite for family members caring for loved ones with chronic illnesses.

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“We often think of volunteering as ‘giving back,’ but we’ve seen firsthand that it often becomes so much more than that,” said Atalaya Sergi, director of AmeriCorps Seniors. “By spending a few hours each week with another older adult in need of support, our volunteers are not only giving back to others, but they’re adding meaning to their own lives and establishing new connections. They’re helping to fight the loneliness epidemic one visit at a time.”

Growing older can come with challenges, but some of those can be minimized with a positive mindset and commitment to remaining connected and engaged – whether with friends, relatives or fellow community members. Fostering relationships is a key ingredient to a healthier and more fulfilling life.

For more information and to find volunteer opportunities near you, visit AmeriCorps.gov/YourMoment.

Meet Friends Who Connected Through Service

16967 FT detail image embed2Ray Maestas felt unfulfilled post-retirement and began volunteering with the AmeriCorps Seniors Senior Companion Program. He was connected with Bob Finnerty, a man with blindness looking for assistance a few days each week. They quickly struck up a routine of errands, reading and conversation that’s since become a friendship they both cherish.

“The Senior Companion Program has provided an avenue to enrich the lives of not only the participants but the people who are volunteering,” Maestas said. “Bob and I have gotten to the point where he’s a very important part of my life.”

Finnerty echoed those sentiments and shared his own appreciation for Maestas’ friendship.

“I’ve always relished my independence and I feel Ray is not just a person who reads for me – he’s a friend,” Finnerty said.

In the last few years, Maestas moved and now serves with a different chapter of the Senior Companion Program. He and Finnerty keep in touch. Maestas said they talk about every third day.

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Lifestyle

Stuff Those Stockings with Skin Care Solutions

The article suggests adding thoughtful skincare solutions as holiday stocking stuffers, highlighting Herbacin’s natural products that address various skin issues for women of all ages.

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(Family Features) Even if you have the perfect gifts picked out for your nearest and dearest, there’s still time to add some stocking stuffers that are sure to please all the favorite ladies in your life.

Stocking Stuffers

The holidays are the perfect time for gifting special skin care solutions they will love. Formulated for all ages and skin types, these curated formulas address multiple skin challenges for a wonderfully healthy glow. Ideal for slipping into a stocking at the last moment, thoughtful skin care products can show just how much you care.

To find solutions for your loved ones this holiday season, visit herbacinusa.com.

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7 Skin Care Solutions

Women of all ages and skin types can find a formula that fits their lifestyles from Herbacin’s Skin Solutions Series, which includes seven products formulated with 100% natural, vegan  ingredients to combat and alleviate any number of skin issues. Designed to integrate into a daily skin care regimen, they address various challenges such as dry and cracked skin, acne, psoriasis or pigmentation marks. Skin issues that affect external appearance can also lead to mental stress, making it important to address them with dermatologically tested solutions.

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Specialty Products to Tackle Skin Issues

Some skin problems are triggered by stress and genetic predisposition while others are caused by an unbalanced lifestyle and diet, hormonal imbalances or environmental influences. It’s important to meet your skin issues head on with products formulated for the challenge like Herbacin Creamy Face Wash, a plant-based cream that provides deep cleansing for the face, neck and decollete for a clean feeling without drying skin. Designed for women who enjoy the sun, Age Spot Primer reduces pigmentation spots with a langsat tree extract.

Photo courtesy of Adobe Stock (stockings on mantel)

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SOURCE:
Herbacin

Our Lifestyle section on STM Daily News is a hub of inspiration and practical information, offering a range of articles that touch on various aspects of daily life. From tips on family finances to guides for maintaining health and wellness, we strive to empower our readers with knowledge and resources to enhance their lifestyles. Whether you’re seeking outdoor activity ideas, fashion trends, or travel recommendations, our lifestyle section has got you covered. Visit us today at https://stmdailynews.com/category/lifestyle/ and embark on a journey of discovery and self-improvement.

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Life After Stroke: 5 tips for recovery and daily living

In the weeks and months immediately following a stroke, an early rehabilitation program offers the best possible recovery outcomes.

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Stroke

(Family Features) In the weeks and months immediately following a stroke, an early rehabilitation program offers the best possible recovery outcomes. While each person’s stroke recovery journey is unique, starting the path toward rehabilitation as soon as it’s medically safe allows stroke survivors to mitigate the lasting effects.

According to the American Stroke Association, a division of the American Heart Association, each year, approximately 800,000 people in the United States have a stroke. Strokes can happen to anyone, at any age. In fact, globally about 1 in 4 adults over the age of 25 will have a stroke in their lifetime.

Early Intervention
The rehabilitation and support a survivor receives can greatly influence health outcomes and recovery. The first three months after a stroke are especially critical. Although recovery may continue for years after a stroke, this time in the immediate aftermath of a stroke is when the brain is most able to adjust to the damage done by the stroke so the survivor can learn new ways to do things.

Physical, Communication and Cognitive Changes
Following a stroke, a survivor may experience physical changes, such as fatigue, seizures, weakness or paralysis on one side of the body or spasticity, stiff or rigid muscles which may cause difficulty with completing daily activities and tasks. If experiencing fatigue, speak with your health care provider about ways to reduce it. Your care team may also be able to provide medications to help with seizures and spasticity. Physical therapy is also an option.

Challenges after a stroke depend on the severity and location of the stroke. In addition to various physical disabilities, stroke survivors may experience aphasia, communication and thought problems related to speaking, listening, understanding or memory. Planning, organizing ideas or making decisions can also be harder.

“Remember to be patient when communicating with a stroke survivor,” said Elissa Charbonneau, M.S., D.O., chief medical officer of Encompass Health and an American Stroke Association national volunteer. “The impact of a stroke on cognitive, speech and language can be significant and isolating. When connecting with a stroke survivor, some helpful practices include demonstrating tasks, breaking actions into smaller steps, enunciating, asking multiple choice questions and repetition.”

Customized Rehabilitation
Once a stroke survivor’s medical condition is stabilized and he or she is ready to leave the hospital, rehabilitation can help restore function and teach new ways to complete everyday tasks. Rehabilitation may take place in an inpatient facility, skilled nursing facility or long-term acute care facility. Outpatient clinics and home health agencies can also provide rehabilitative care in certain circumstances.

One patient’s rehab journey might include therapy to improve balance, strength or mobility while another might need speech or other therapies. A rehabilitation designed for the individual is critical.

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Preventing a Recurrence
After a first stroke, nearly 1 in 4 survivors will have another. Stroke survivors can help reduce their risk of having another stroke by working with their health care team to identify what caused the stroke and uncover personal risk factors.

Taking steps such as healthy eating, reducing sedentary time and taking medications as prescribed can help your brain and reduce your risk of a repeat stroke. Controlling conditions such as high blood pressure, diabetes and sleep apnea also reduce your risk of having another stroke.

Support During Your Journey
Caregivers and other loved ones can provide important long-term support during your recovery and rehabilitation.

Find resources for stroke rehab and recovery including the “Life After Stroke” guide, “Simply Good” cookbook and a support network to connect with other survivors at Stroke.org/Recovery.

Photo courtesy of Getty Images
 

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SOURCE:
American Heart Association

The Bridge is a section of the STM Daily News Blog meant for diversity, offering real news stories about bona fide community efforts to perpetuate a greater good. The purpose of The Bridge is to connect the divides that separate us, fostering understanding and empathy among different groups. By highlighting positive initiatives and inspirational actions, The Bridge aims to create a sense of unity and shared purpose. This section brings to light stories of individuals and organizations working tirelessly to promote inclusivity, equality, and mutual respect. Through these narratives, readers are encouraged to appreciate the richness of diverse perspectives and to participate actively in building stronger, more cohesive communities.

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  • Rod Washington

    Rod: A creative force, blending words, images, and flavors. Blogger, writer, filmmaker, and photographer. Cooking enthusiast with a sci-fi vision. Passionate about his upcoming series and dedicated to TNC Network. Partnered with Rebecca Washington for a shared journey of love and art. View all posts

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