health and wellness
One Woman’s Path to Finding Treatment for Narcolepsy
Wendy’s childhood cataplexy led to a narcolepsy diagnosis after years of excessive sleepiness. She now effectively manages her symptoms with the LUMRYZ medication.
Last Updated on September 24, 2024 by Daily News Staff
Wendy was compensated by Avadel Pharmaceuticals for her time. Individual results may vary.
(Family Features) For Wendy, playfully jumping on the bed as a child led to panic when, suddenly, her limbs ceased to function and she dropped to the floor. Although she needed help, she couldn’t use her voice. This was Wendy’s first experience with cataplexy, a sudden period of muscle weakness that can be triggered by strong emotions, like laughter, excitement, or anger – a hallmark symptom of narcolepsy type 1.
Narcolepsy is a complex, lifelong sleep disorder that includes symptoms like cataplexy and excessive daytime sleepiness and is estimated to affect 1 in 2,000 Americans.
Wendy’s childhood experience with cataplexy was followed by years of struggling with excessive daytime sleepiness (EDS) and trouble sleeping through the night. Her sleepiness, however, was dismissed for much of her life – often being told she was tired simply due to being busy.
“No one believed me when I said that something felt wrong,” Wendy said.
For people with narcolepsy, the lines between being asleep and awake are blurred. Instead of a natural sleep pattern, they often experience short periods of poor-quality sleep throughout the day and night, rather than restorative, consolidated sleep.
25 years after her first cataplexy attack, Wendy experienced a second episode while driving and was rushed to the emergency room.
“I stayed in the hospital for a week,” said Wendy. “Doctors first thought I likely had an attack similar to a stroke or a severe migraine. It wasn’t until I met with a neurologist and shared that I slept too much that I was referred for a sleep study and finally diagnosed with narcolepsy.”
After receiving the right diagnosis, the next challenge for Wendy was finding the right treatment.
Her doctors first prescribed several stimulants, which didn’t alleviate her daytime sleepiness. She was then prescribed a sodium oxybate, a treatment used for EDS and cataplexy, however this particular medication required waking up in the middle of the night to take a second dose, which Wendy found herself struggling to do.
Wendy turned to the narcolepsy community, where she learned about a once-nightly medication, LUMRYZ® (sodium oxybate) for extended-release oral suspension, CIII.
LUMRYZ is the first and only U.S. Food and Drug Administration approved once-at-bedtime sodium oxybate treatment for cataplexy or EDS in adults with narcolepsy, and a medication that Wendy says she is grateful for.
LUMRYZ has a boxed warning as a central nervous system depressant and for its potential for abuse and misuse. LUMRYZ is available only through a restricted program under a Risk Evaluation and Mitigation Strategy called the LUMRYZ REMS. Most common adverse reactions (incidence ≥ 5% and greater than placebo) reported for all doses of LUMRYZ combined were nausea, dizziness, bedwetting, headache and vomiting. Please see additional Important Safety Information, including Boxed Warning below.
“When I first heard about LUMRYZ being once-at-bedtime, I was ecstatic there was an option that might help with my cataplexy and EDS without having to wake in the middle of the night for a second dose,” said Wendy.
Today, Wendy has discovered a treatment that is right for her and helps improve her EDS and cataplexy symptoms, individual results may vary.
“My advice to others with narcolepsy is to be outspoken about your experience and learn as much as you can to be well-informed. I want to see people be diagnosed earlier, advocate for themselves, and find a treatment that’s right for them.”
If you are struggling with excessive daytime sleepiness, ask your healthcare provider about narcolepsy, and if you have been diagnosed, ask your physician if LUMRYZ is right for you. Learn more at www.lumryz.com.
Photo caption: Wendy, a person with narcolepsy
INDICATIONS
LUMRYZ (sodium oxybate) for extended-release oral suspension is a prescription medicine used to treat the following symptoms in adults with narcolepsy:
- sudden onset of weak or paralyzed muscles (cataplexy)
- excessive daytime sleepiness (EDS)
IMPORTANT SAFETY INFORMATIONWARNING: Taking LUMRYZ™ (sodium oxybate) with other central nervous system (CNS) depressants such as medicines used to make you fall asleep, including opioid analgesics, benzodiazepines, sedating antidepressants, antipsychotics, sedating anti-epileptic medicines, general anesthetics, muscle relaxants, alcohol, or street drugs, may cause serious medical problems, including trouble breathing (respiratory depression), low blood pressure (hypotension), changes in alertness (drowsiness), fainting (syncope), and death. The active ingredient of LUMRYZ (sodium oxybate) is a form of gamma hydroxybutyrate (GHB), a controlled substance. Abuse or misuse of illegal GHB alone or with other CNS depressants (drugs that cause changes in alertness or consciousness) have caused serious side effects. These effects include seizures, trouble breathing (respiratory depression), changes in alertness (drowsiness), coma, and death. Call your doctor right away if you have any of these serious side effects. Because of these risks, LUMRYZ is available only by prescription and filled through certified pharmacies in the LUMRYZ REMS program. You must be enrolled in the LUMRYZ REMS to receive LUMRYZ. Further information is available at www.LUMRYZREMS.com or by calling 1-877-453-1029.
It is not known if LUMRYZ is safe and effective in people less than 18 years of age.
Do not take LUMRYZ if you take other sleep medicines or sedatives (medicines that cause sleepiness), drink alcohol, or have a rare problem called succinic semialdehyde dehydrogenase deficiency.
Keep LUMRYZ in a safe place to prevent abuse and misuse. Selling or giving away LUMRYZ may harm others and is against the law. Tell your doctor if you have ever abused or been dependent on alcohol, prescription medicines, or street drugs.
Anyone who takes LUMRYZ should not do anything that requires them to be fully awake or is dangerous, including driving a car, using heavy machinery, or flying an airplane, for at least six (6) hours after taking LUMRYZ. Those activities should not be done until you know how LUMRYZ affects you.
Falling asleep quickly, including while standing or while getting up from the bed, has led to falls with injuries that have required some people to be hospitalized.
LUMRYZ can cause serious side effects, including the following:
- Breathing problems, including slower breathing, trouble breathing, and/or short periods of not breathing while sleeping (e.g., sleep apnea). People who already have breathing or lung problems have a higher chance of having breathing problems when they take LUMRYZ.
- Mental health problems, including confusion, seeing or hearing things that are not real (hallucinations), unusual or disturbing thoughts (abnormal thinking), feeling anxious or upset, depression, thoughts of killing yourself or trying to kill yourself, increased tiredness, feelings of guilt or worthlessness, and difficulty concentrating. Tell your doctor if you have or had depression or have tried to harm yourself. Call your doctor right away if you have symptoms of mental health problems or a change in weight or appetite.
- Sleepwalking. Sleepwalking can cause injuries. Call your doctor if you start sleepwalking.
Tell your doctor if you are on a salt-restricted diet or if you have high blood pressure, heart failure, or kidney problems. LUMRYZ contains a lot of sodium (salt) and may not be right for you.
The most common side effects of LUMRYZ in adults include nausea, dizziness, bedwetting, headache, and vomiting. Your side effects may increase when you take higher doses of LUMRYZ. LUMRYZ can cause physical dependence and craving for the medicine when it is not taken as directed. These are not all the possible side effects of LUMRYZ.
For more information, ask your doctor or pharmacist. Call your doctor for medical advice about side effects.
You are encouraged to report negative side effects of prescription drugs to the FDA.
Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
Please see full Prescribing Information, including BOXED Warning, and Medication Guide.
PM-US-AVGEN-0169-v2 07/2024
SOURCE:
Avadel
Our Lifestyle section on STM Daily News is a hub of inspiration and practical information, offering a range of articles that touch on various aspects of daily life. From tips on family finances to guides for maintaining health and wellness, we strive to empower our readers with knowledge and resources to enhance their lifestyles. Whether you’re seeking outdoor activity ideas, fashion trends, or travel recommendations, our lifestyle section has got you covered. Visit us today at https://stmdailynews.com/category/lifestyle/ and embark on a journey of discovery and self-improvement.
A Healthier, Greener Home: Eco-Friendly Cleaning Hacks
(Feature Impact) Keeping your home clean doesn’t have to mean filling your cabinets with harsh chemicals or single-use cleaning products. In fact, some of the most effective solutions may already be in your pantry.
By swapping a few everyday products for simple, eco-friendly solutions, you can clean effectively, save money and make your home a little greener. If you’re looking to reduce waste, cut back on toxins and simplify your cleaning routine, natural ingredients like vinegar, baking soda and lemon can deliver results while also being safer for your home – and the environment.
Make Your Own All-Purpose Cleaner
Instead of buying multiple cleaners for different surfaces, try a DIY solution that works in many areas of the home. In a spray bottle, combine 1 cup white vinegar, 1 cup water and 10 drops of the essential oil of your choice – such as lemon, lavender or tea tree – then use it on countertops, sinks, glass and other surfaces to curb grease and grime. Avoid using vinegar-based cleaners on natural stone like granite or marble, however, as its acidity can cause damage.
Let Baking Soda Do the Scrubbing
One of the most versatile eco-friendly cleaners around, baking soda acts as a gentle abrasive that helps lift stains without scratching surfaces. Simply sprinkle baking soda onto sinks, bathtubs, cookware, stovetops or tile grout then scrub with a damp sponge or cloth for a sparkling clean finish.
Freshen Carpets Naturally
Carpets and rugs can trap odors, but a DIY deodorizer made of 1 cup baking soda and 10-15 drops of the essential oil of your choice can replace chemical sprays and keep floor surfaces smelling fresh. Just sprinkle across the carpet, let sit for 15-20 minutes then vacuum.
Use Lemon to Cut Grease and Stains
Lemon juice is a powerful natural cleaner due to its acidity and antibacterial properties. It can leave behind a fresh scent when used to clean cutting boards, remove soap scum and water spots or deodorize garbage disposals. For stubborn grime, mix lemon juice with baking soda to create a paste that can tackle tough surface stains.
Naturally Deodorize Drains
If your kitchen sink smells unpleasant, skip the harsh chemical drain cleaners. Pour 1/2 cup baking soda down the drain then add 1/2 cup white vinegar. Let the mixture fizz a few minutes then flush with hot water to help loosen buildup while neutralizing odors.
Polish Stainless Steel with Pantry Staples
Remove grimy fingerprints and give stainless steel appliances a streak-free shine with a simple mixture of 1 tablespoon white vinegar and 1 tablespoon olive oil.
Find more DIY, eco-friendly cleaning tips and tricks at eLivingtoday.com.
Photo courtesy of Shutterstock
SOURCE:
Our Lifestyle section on STM Daily News is a hub of inspiration and practical information, offering a range of articles that touch on various aspects of daily life. From tips on family finances to guides for maintaining health and wellness, we strive to empower our readers with knowledge and resources to enhance their lifestyles. Whether you’re seeking outdoor activity ideas, fashion trends, or travel recommendations, our lifestyle section has got you covered. Visit us today at https://stmdailynews.com/category/lifestyle/ and embark on a journey of discovery and self-improvement.
health and wellness
Cannabis Legalization Drives Innovation, Raises Health Concerns
Cannabis legalization is driving innovation, but much of it focuses on commercial products rather than patient health. New research highlights gaps between market growth and medical evidence.
Lucy Xiaolu Wang, UMass Amherst and Nathan W. Chan, UMass Amherst
Cannabis legalization
Innovation in health care saves lives. But not all health innovations have enough evidence to actually benefit patients.
Barriers to innovation are often higher in illicit or restricted markets, including cannabis, stem cells and cryptocurrencies. Researchers face higher costs, limited access to raw materials and data, and stricter regulations.
Cannabis illustrates a particularly confusing tension between regulatory restrictions on one hand and research and innovation on the other.
While the U.S. federal government still classifies cannabis as having “no accepted medical use,” many states have legalized it for medical or recreational use. Meanwhile, the Department of Health and Human Services obtained a cannabis-related patent in 2003 covering potential medical uses of cannabis compounds for protecting the brain from damage or degeneration. The patent was exclusively licensed for commercialization.
Research and innovation on cannabis can take many forms. Clinical trials may study cannabis products as medical treatments, the effects of cannabis on its users, or factors related to abuse and dependence. Meanwhile, cannabis-related patents can be filed for wide-ranging purposes, such as chemical formulations, methods for production or new consumer products like edibles, beverages or vaporizers.
But do these innovations actually benefit consumers and patients?
We are economists studying how institutional changes affect innovation in different markets. Our recently published research found that legalization of recreational cannabis use appears to spur innovation, but primarily in ways that expand commercial opportunities rather than scientific understanding or health benefits for patients.
Cannabis’ evolving legality in the US
Cannabis is a plant that contains chemical compounds called cannabinoids. One such compound, tetrahydrocannabinol, or THC, produces psychoactive effects, while another compound called cannabidiol, or CBD, is often used to relieve anxiety and pain. However, there has been insufficient evidence on how effective cannabis products are in treating medical conditions, as well as a lack of consistent medical and dosing guidance.
At the federal level in the U.S., cannabis has been classified as a Schedule I drug for over a half-century. This classification indicates that the federal government considers cannabis to have a high potential for abuse and no accepted medical use.
As a Schedule I drug, there are significant restrictions on cannabis research. Researchers who seek to conduct cannabis-related clinical trials must obtain approval from both the Food and Drug Administration and the Drug Enforcement Administration, a process that can take over a year. They are also limited to using select varieties of cannabis obtained from federally authorized cannabis suppliers, and are generally prohibited from studying products available in state-authorized markets.
There are ongoing pushes to relax these restrictions. Meanwhile, cannabis has been legalized to varying extents in many states. California became the first state to pass a medical cannabis law in 1996, allowing qualified patients to grow, possess and use cannabis for medical purposes. Many states followed suit in the late 1990s and early 2000s. As of June 2025, 40 states allow medical cannabis use.
A number of states also allow recreational or nonmedical cannabis use among adults, which is regulated in similar ways to alcohol. Colorado and Washington enacted the first recreational cannabis laws in 2012, and there are 24 states that permit adults to use cannabis recreationally as of January 2026.
Altogether, the legal landscape for cannabis in the U.S. has varied considerably across states and over time. States with more permissive laws can lower the costs of medical research and product development with cannabis, even if federal drug scheduling continues to restrict access. For instance, one group of Washington State University researchers asked participants to independently purchase and smoke cannabis from a legal dispensary before returning to their lab for study.
State legalization and cannabis innovation
To systematically examine how state legalization affects cannabis-related innovation, we compiled and analyzed datasets tracking cannabis-related clinical trials and patent applications.
We distinguished different types of cannabis-related innovation. Specifically, we categorized cannabis-related clinical trials based on whether they focused on its potential as a treatment, its usage and effects, or its role in drug abuse. Similarly, we categorized cannabis-related patents based on whether they focused on chemical compounds, medical uses, methods or products.
We also assessed public health concerns across three measures: patents explicitly involving THC; patents with a high risk of misuse; and patents targeting consumers directly, such as high-potency formulations, edibles or vaporizers.
Then, we compared changes in cannabis-related innovation over time in states that legalized cannabis earlier with those in states that did so later or not at all. We measured innovation by counting the number of cannabis-related clinical trials and patent filings. We distinguished between medical and recreational legalization to assess how different policies affect innovation.
Overall, we found that when states legalize cannabis for recreational use, cannabis-related patents increase – but mostly in commercial-oriented areas rather than health-focused ones. Patents were concentrated in market-oriented innovations like cultivation equipment and consumer products, rather than in clinical or science-based research. We also found some evidence that these innovations may raise public health concerns.
Legalization did not result in meaningful increases in clinical trials. This suggests that barriers to cannabis-related clinical research – such as limited access to research-grade cannabis, limited funding and stigma around working with a federally controlled substance – remain substantial.
Gaps between research and product
As 420 – signifying April 20, a day celebrating cannabis culture – approaches each year, public attention turns toward the legal status of cannabis.
The legal landscape has evolved rapidly over the past few decades, and further changes are in the pipeline. Both the Biden and second Trump administrations have made efforts to reclassify cannabis as a Schedule III substance, which would indicate that it has an accepted medical use and low-to-moderate potential for dependence.
These reevaluations of the legality of cannabis come at a critical time. There has been an explosion of recreational cannabis products in recent years, including increasingly potent strains and a wider variety of ways to use cannabis. Meanwhile, critical research on the health and safety of cannabis use has lagged due to heavy restrictions accompanying Schedule I status.
This gap between medical research and product innovation can have significant public health consequences. The 2019 to 2020 outbreak of lung injuries related to e-cigarette or vape use was linked partly to the use of unregulated or illicit cannabis vaping products. These harms highlight the risks of allowing product innovation for controlled substances to outpace scientific understanding.
Policies that significantly reduce obstacles to clinical research can in turn help close the widening gap between cannabis markets and addressing their public health implications.
Lucy Xiaolu Wang, Assistant Professor of Resource Economics, UMass Amherst and Nathan W. Chan, Professor of Resource Economics, UMass Amherst
This article is republished from The Conversation under a Creative Commons license. Read the original article.
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home improvement
Fresh Start, Fresh Planet: 5 Steps to Reduce Waste During Spring Cleaning
Spring cleaning is a perfect opportunity to reset, reorganize and make small changes that can help the planet. Consider these five easy waste-reduction tips to help you jump into the season feeling organized and eco-friendly.
(Feature Impact) As the days get longer and the weather improves, many people often find the motivation to refresh their homes – and their habits.
Spring cleaning is a perfect opportunity to reset, reorganize and make small changes that can help the planet. What’s more, these changes are simple to implement and can even earn you some extra cash.
Steps to Reduce Waste During Spring Cleaning
Consider these five easy waste-reduction tips from the experts at CalRecycle to help you jump into the season feeling organized and eco-friendly.
1. Recycle Kitchen Waste
As you clear out expired or forgotten food, sort items for maximum impact:
- Remove plastic and non-compostable packaging and put spoiled or freezer-burned food into your green bin. These scraps can be turned into compost and clean energy, helping cut methane emissions from landfills.
- Toss empty, dry recyclables, including condiment bottles, glass jars, metal cans and plastic food containers, into your blue bin.
2. Cash in Empty Beverage Containers
- Cleaning out your home may uncover some empty or forgotten beverage containers. Empty out leftover liquids and take eligible beverage containers for soda, water, juice, wine and distilled spirits to your nearest recycling site for cash back. Every California Redemption Value (CRV) beverage container you recycle saves resources and puts money back in your pocket.
- If you’re short on time, donate your empty CRV beverage containers to your favorite nonprofit organization. Set up a separate bin just for eligible beverage containers and drop them off for donation when it’s full.
3. Give Clothes and Household Items a Second Life
- Dig into your closets and shelves to see what you can repair, repurpose or donate. Fix a missing button, turn old fabric into cleaning rags or give gently used items to a local free-exchange group or thrift store to reduce textile waste. Simple steps like these can keep usable items out of the landfill and help someone else put them to good use.
4. Declutter Paper and Electronics
- Recycle junk mail, magazines and newspapers in your blue bin. Remove any plastic windows, wrap or stickers first. If you shred documents, place the shredded paper inside a paper bag before recycling. Bonus tip: Switching to digital statements and bills can help prevent paper clutter in the first place.
- Old electronics and used batteries don’t belong in the trash. Gather them from drawers and cabinets then take them to an e-waste drop-off site or local household hazardous waste collection center for safe handling.
5. Refresh the Bathroom
- When restocking soaps or cleaners, look for products that offer refillable containers (especially reusable glass and aluminum ones). It’s a simple way to cut down on plastic waste.
- When you finish bottles of shampoo, conditioner, soap or cleaning sprays, make sure they land in your recycling bin after you empty them out.
- Swap out single-use paper towels for washable cloths or rags. They’re reusable, durable and kinder to the environment.
For more details, CRV redemption locations and food scrap recycling tips, visit RecyclingReimaginedCA.com.
Photos courtesy of Shutterstock
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