health and wellness
One Woman’s Path to Finding Treatment for Narcolepsy
Wendy’s childhood cataplexy led to a narcolepsy diagnosis after years of excessive sleepiness. She now effectively manages her symptoms with the LUMRYZ medication.
Wendy was compensated by Avadel Pharmaceuticals for her time. Individual results may vary.
(Family Features) For Wendy, playfully jumping on the bed as a child led to panic when, suddenly, her limbs ceased to function and she dropped to the floor. Although she needed help, she couldn’t use her voice. This was Wendy’s first experience with cataplexy, a sudden period of muscle weakness that can be triggered by strong emotions, like laughter, excitement, or anger – a hallmark symptom of narcolepsy type 1.
Narcolepsy is a complex, lifelong sleep disorder that includes symptoms like cataplexy and excessive daytime sleepiness and is estimated to affect 1 in 2,000 Americans.
Wendy’s childhood experience with cataplexy was followed by years of struggling with excessive daytime sleepiness (EDS) and trouble sleeping through the night. Her sleepiness, however, was dismissed for much of her life – often being told she was tired simply due to being busy.
“No one believed me when I said that something felt wrong,” Wendy said.
For people with narcolepsy, the lines between being asleep and awake are blurred. Instead of a natural sleep pattern, they often experience short periods of poor-quality sleep throughout the day and night, rather than restorative, consolidated sleep.
25 years after her first cataplexy attack, Wendy experienced a second episode while driving and was rushed to the emergency room.
“I stayed in the hospital for a week,” said Wendy. “Doctors first thought I likely had an attack similar to a stroke or a severe migraine. It wasn’t until I met with a neurologist and shared that I slept too much that I was referred for a sleep study and finally diagnosed with narcolepsy.”
After receiving the right diagnosis, the next challenge for Wendy was finding the right treatment.
Her doctors first prescribed several stimulants, which didn’t alleviate her daytime sleepiness. She was then prescribed a sodium oxybate, a treatment used for EDS and cataplexy, however this particular medication required waking up in the middle of the night to take a second dose, which Wendy found herself struggling to do.
Wendy turned to the narcolepsy community, where she learned about a once-nightly medication, LUMRYZ® (sodium oxybate) for extended-release oral suspension, CIII.
LUMRYZ is the first and only U.S. Food and Drug Administration approved once-at-bedtime sodium oxybate treatment for cataplexy or EDS in adults with narcolepsy, and a medication that Wendy says she is grateful for.
LUMRYZ has a boxed warning as a central nervous system depressant and for its potential for abuse and misuse. LUMRYZ is available only through a restricted program under a Risk Evaluation and Mitigation Strategy called the LUMRYZ REMS. Most common adverse reactions (incidence ≥ 5% and greater than placebo) reported for all doses of LUMRYZ combined were nausea, dizziness, bedwetting, headache and vomiting. Please see additional Important Safety Information, including Boxed Warning below.
“When I first heard about LUMRYZ being once-at-bedtime, I was ecstatic there was an option that might help with my cataplexy and EDS without having to wake in the middle of the night for a second dose,” said Wendy.
Today, Wendy has discovered a treatment that is right for her and helps improve her EDS and cataplexy symptoms, individual results may vary.
“My advice to others with narcolepsy is to be outspoken about your experience and learn as much as you can to be well-informed. I want to see people be diagnosed earlier, advocate for themselves, and find a treatment that’s right for them.”
If you are struggling with excessive daytime sleepiness, ask your healthcare provider about narcolepsy, and if you have been diagnosed, ask your physician if LUMRYZ is right for you. Learn more at www.lumryz.com.
Photo caption: Wendy, a person with narcolepsy
INDICATIONS
LUMRYZ (sodium oxybate) for extended-release oral suspension is a prescription medicine used to treat the following symptoms in adults with narcolepsy:
- sudden onset of weak or paralyzed muscles (cataplexy)
- excessive daytime sleepiness (EDS)
IMPORTANT SAFETY INFORMATION
WARNING: Taking LUMRYZ™ (sodium oxybate) with other central nervous system (CNS) depressants such as medicines used to make you fall asleep, including opioid analgesics, benzodiazepines, sedating antidepressants, antipsychotics, sedating anti-epileptic medicines, general anesthetics, muscle relaxants, alcohol, or street drugs, may cause serious medical problems, including trouble breathing (respiratory depression), low blood pressure (hypotension), changes in alertness (drowsiness), fainting (syncope), and death. The active ingredient of LUMRYZ (sodium oxybate) is a form of gamma hydroxybutyrate (GHB), a controlled substance. Abuse or misuse of illegal GHB alone or with other CNS depressants (drugs that cause changes in alertness or consciousness) have caused serious side effects. These effects include seizures, trouble breathing (respiratory depression), changes in alertness (drowsiness), coma, and death. Call your doctor right away if you have any of these serious side effects. Because of these risks, LUMRYZ is available only by prescription and filled through certified pharmacies in the LUMRYZ REMS program. You must be enrolled in the LUMRYZ REMS to receive LUMRYZ. Further information is available at www.LUMRYZREMS.com or by calling 1-877-453-1029.
It is not known if LUMRYZ is safe and effective in people less than 18 years of age.
Do not take LUMRYZ if you take other sleep medicines or sedatives (medicines that cause sleepiness), drink alcohol, or have a rare problem called succinic semialdehyde dehydrogenase deficiency.
Keep LUMRYZ in a safe place to prevent abuse and misuse. Selling or giving away LUMRYZ may harm others and is against the law. Tell your doctor if you have ever abused or been dependent on alcohol, prescription medicines, or street drugs.
Anyone who takes LUMRYZ should not do anything that requires them to be fully awake or is dangerous, including driving a car, using heavy machinery, or flying an airplane, for at least six (6) hours after taking LUMRYZ. Those activities should not be done until you know how LUMRYZ affects you.
Falling asleep quickly, including while standing or while getting up from the bed, has led to falls with injuries that have required some people to be hospitalized.
LUMRYZ can cause serious side effects, including the following:
- Breathing problems, including slower breathing, trouble breathing, and/or short periods of not breathing while sleeping (e.g., sleep apnea). People who already have breathing or lung problems have a higher chance of having breathing problems when they take LUMRYZ.
- Mental health problems, including confusion, seeing or hearing things that are not real (hallucinations), unusual or disturbing thoughts (abnormal thinking), feeling anxious or upset, depression, thoughts of killing yourself or trying to kill yourself, increased tiredness, feelings of guilt or worthlessness, and difficulty concentrating. Tell your doctor if you have or had depression or have tried to harm yourself. Call your doctor right away if you have symptoms of mental health problems or a change in weight or appetite.
- Sleepwalking. Sleepwalking can cause injuries. Call your doctor if you start sleepwalking.
Tell your doctor if you are on a salt-restricted diet or if you have high blood pressure, heart failure, or kidney problems. LUMRYZ contains a lot of sodium (salt) and may not be right for you.
The most common side effects of LUMRYZ in adults include nausea, dizziness, bedwetting, headache, and vomiting. Your side effects may increase when you take higher doses of LUMRYZ. LUMRYZ can cause physical dependence and craving for the medicine when it is not taken as directed. These are not all the possible side effects of LUMRYZ.
For more information, ask your doctor or pharmacist. Call your doctor for medical advice about side effects.
You are encouraged to report negative side effects of prescription drugs to the FDA.
Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
Please see full Prescribing Information, including BOXED Warning, and Medication Guide.
PM-US-AVGEN-0169-v2 07/2024
SOURCE:
Avadel
Our Lifestyle section on STM Daily News is a hub of inspiration and practical information, offering a range of articles that touch on various aspects of daily life. From tips on family finances to guides for maintaining health and wellness, we strive to empower our readers with knowledge and resources to enhance their lifestyles. Whether you’re seeking outdoor activity ideas, fashion trends, or travel recommendations, our lifestyle section has got you covered. Visit us today at https://stmdailynews.com/category/lifestyle/ and embark on a journey of discovery and self-improvement.
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health and wellness
Can you change your personality? Psychology research says yes, by tweaking what you think and do
Shannon Sauer-Zavala, University of Kentucky
Have you ever taken a personality test? If you’re like me, you’ve consulted BuzzFeed and you know exactly which Taylor Swift song “perfectly matches your vibe.”
It might be obvious that internet quizzes are not scientific, but many of the seemingly serious personality tests used to guide educational and career choices are also not supported by research. Despite being a billion-dollar industry, commercial personality testing used by schools and corporations to funnel people into their ideal roles do not predict career success.
Beyond their lack of scientific support, the most popular approaches to understanding personality are problematic because they assume your traits are static – that is, you’re stuck with the personality you’re born with. But modern personality science studies find that traits can and do change over time.
In addition to watching my own personality change over time from messy and lazy to off the charts in conscientiousness, I’m also a personality change researcher and clinical psychologist. My research confirms what I saw in my own development and in my patients: People can intentionally shape the traits they need to be successful in the lives they want. That’s contrary to the popular belief that your personality type places you in a box, dictating that you choose partners, activities and careers according to your traits.
What personality is and isn’t
According to psychologists, personality is your characteristic way of thinking, feeling and behaving.
Are you a person who tends to think about situations in your life more pessimistically, or are you a glass-half-full kind of person?
Do you tend to get angry when someone cuts you off in traffic, or are you more likely to give them the benefit of the doubt – maybe they’re rushing to the hospital?
Do you wait until the last minute to complete tasks, or do you plan ahead?
You can think of personality as a collection of labels that summarize your responses to questions like these. Depending on your answers, you might be labeled as optimistic, empathetic or dependable.
Research suggests that all these descriptive labels can be summarized into five overarching traits – what psychologists creatively refer to as the “Big Five.”
As early as the 1930s, psychologists literally combed through a dictionary to pull out all the words that describe human nature and sorted them in categories with similar themes. For example, they grouped words like “kind,” “thoughtful” and “friendly” together. They found that thousands of words could be accounted for by sorting them between five traits: neuroticism, extroversion, conscientiousness, agreeableness and openness.
What personality is not: People often feel protective about their personality – you may view it as the core of who you are. According to scientific definitions, however, personality is not your likes, dislikes or preferences. It’s not your sense of humor. It’s not your values or what you think is important in life.
In other words, shifting your Big Five traits does not change the core of who you are. It simply means learning to respond to situations in life with different thoughts, feelings and behaviors.
Can you change your personality?
Can personality change? Remember, personality is a person’s characteristic way of thinking, feeling and behaving. And while it might sound hard to change personality, people change how they think, feel and behave all the time.
Suppose you’re not super dependable. If you start to think “being on time shows others that I respect them,” begin to feel pride when you arrive to brunch before your friends, and engage in new behaviors that increase your timeliness – such as getting up with an alarm, setting appointment reminders and so on – you are embodying the characteristics of a reliable person. If you maintain these changes to your thinking, emotions and behaviors over time – voila! – you are reliable. Personality: changed.
Data confirms this idea. In general, personality changes across a person’s life span. As people age, they tend to experience fewer negative emotions and more positive ones, are more conscientious, place greater emphasis on positive relationships and are less judgmental of others.
There is variability here, though. Some people change a lot and some people hold pretty steady. Moreover, studies, including my own, that test whether personality interventions change traits over time find that people can speed up the process of personality change by making intentional tweaks to their thinking and behavior. These tweaks can lead to meaningful change in less than 20 weeks, instead of 20 years.
Cultivating personality traits that serve you best
The good news is that these cognitive-behavioral techniques are relatively simple, and you don’t need to visit a therapist if that’s not something you’re into.
The first component involves changing your thinking patterns – this is the cognitive piece. You need to become aware of your thoughts to determine whether they’re keeping you stuck acting in line with a particular trait. For example, if you find yourself thinking “people are only looking out for themselves,” you are likely to act defensively around others.
The behavioral component involves becoming aware of your current action tendencies and testing out new responses. If you are defensive around other people, they will probably respond negatively to you. When they withdraw or snap at you, for example, it then confirms your belief that you can’t trust others. By contrast, if you try behaving more openly – perhaps sharing with a co-worker that you’re struggling with a task – you have the opportunity to see whether that changes the way others act toward you.
These cognitive-behavioral strategies are so effective for nudging personality because personality is simply your characteristic way of thinking and behaving. Consistently making changes to your perspective and actions can lead to lasting habits that ultimately result in crafting the personality you desire.
Shannon Sauer-Zavala, Associate Professor of Psychology & Licensed Clinical Psychologist, University of Kentucky
This article is republished from The Conversation under a Creative Commons license. Read the original article.
Our Lifestyle section on STM Daily News is a hub of inspiration and practical information, offering a range of articles that touch on various aspects of daily life. From tips on family finances to guides for maintaining health and wellness, we strive to empower our readers with knowledge and resources to enhance their lifestyles. Whether you’re seeking outdoor activity ideas, fashion trends, or travel recommendations, our lifestyle section has got you covered. Visit us today at https://stmdailynews.com/category/lifestyle/ and embark on a journey of discovery and self-improvement.
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health and wellness
Tips to Be Prepared for Cooler Weather
Cooler weather fosters the spread of germs and illnesses, so it’s essential to protect your immune system by maintaining healthy habits, practicing good hygiene, and staying hydrated. Spending time outdoors can boost vitamin D levels and mood, while managing congestion through humidifiers or products like Mucinex can relieve symptoms. Engaging with these practices aids in staying healthy during colder months.
(Family Features) Although cold weather isn’t directly to blame when you get sick, it creates an environment that makes it easier for germs and illnesses to thrive. In fact, understanding how cooler temperatures affect your chances of getting sick may be your best approach for preventive care.
Despite the old adage that “you’ll catch your death of cold,” the cold itself doesn’t cause illness. More accurately, the cold is more hospitable to viruses, making it easier for them to spread. While you can’t control Mother Nature, you can take steps to protect your health when temperatures drop.
Protect Your Immune System
A weakened immune system makes it harder for your body to ward off intrusive germs. If you’re otherwise healthy, protecting your immune system can be as simple as stepping up typical healthy habits, like eating plenty of nutrient-rich produce, getting enough sleep and exercising. Managing stress and limiting alcohol consumption are also helpful in managing your body’s immune response.
If your immune system is compromised by an underlying condition, it’s a good idea to talk with your doctor about what you can do to add an extra layer of protection during the cooler months, including any vaccines that may help boost immunity.
Combat Congestion
Cool, dry conditions can wreak havoc on your nasal passages, drying them out and reducing the protective layer of mucus that helps fight infection. Sinus pressure and congestion are often some of the first warning signs you’re coming down with something.
To treat your congestion symptoms, you can use a non-medicated option like Mucinex Sinus Saline Nasal Spray. This is the first-ever saline product with a nozzle that lets you switch between two spray pressures. The “gentle mist” helps clear everyday congestion and soothes the nose while the “power jet” helps clear tough nasal congestion often associated with colds. An added benefit is that the product can be used for children 2 years of age and older on the gentle mist setting and children 6 years of age and older on the power jet mode.
Spend Time Outdoors
People naturally spend more time indoors when temperatures drop, but there are some benefits to getting outdoors. One is the natural exposure to vitamin D. Sunlight is a natural source of this important vitamin, which plays a pivotal role in immunity. Sunlight also triggers the body to produce serotonin, which boosts your mood, and multiple studies show a strong correlation between mental and physical health.
Fresh air and exercise are also good for your overall health, and exposure to daylight can help keep your circadian rhythms regulated, which in turn promotes better sleep. What’s more, acute exposure to cold can trigger your body to produce infection-fighting cells, so you’re less prone to illness.
Practice Good Hygiene
It may seem overly simple, but the everyday act of washing your hands can play a big role in preventing illness, especially after you spend time in public places. While out and about, you likely come in contact with many surfaces others may have touched, including door handles, shopping carts, touch screens and menus.
Washing your hands frequently can help prevent you from transferring germs to your body when you touch your eyes, mouth or nose. Also make a habit of wiping down surfaces you touch frequently, such as your keyboard and phone, with disinfectant wipes.
Stay Hydrated
Keeping your body well-hydrated throughout the day can help ensure all your body’s systems are functioning as they should. If you’re dehydrated, your body can’t use the nutrients you consume properly, which affects your immunity. In addition, drinking plenty of water helps flush toxins out of the body before they can cause an infection.
Find more practical tips and products to help manage your health during the colder months at Mucinex.com.
How to Relieve Nasal Congestion
Normally your sinuses are empty except for a thin layer of mucus. When you’re exposed to irritating triggers, like bacteria, a cold or flu virus, allergies or environmental triggers like tobacco smoke and dry air, your body responds by mounting an immune response.
The delicate tissues lining your sinuses start to swell, and this, in turn, puts pressure on the underlying tissues in your face, causing painful sinus pressure.
You can relieve sinus pressure symptoms in several different ways, including:
- Using a humidifier or vaporizer.
- Taking a long, hot shower; it may have the same effect as using a humidifier if one is not available.
- Drinking plenty of fluids.
- Using a warm compress on your face; resting a warm towel over your sinuses may provide relief.
- Irrigating your sinuses. Using a neti pot; saline nasal spray, such as Mucinex Sinus Saline Nasal Spray; or syringe with salt water may help flush debris from your sinuses to relieve sinus congestion.
- Sleeping with your head elevated.
If these steps don’t work, the next approach is typically over-the-counter medicine. When trying to relieve sinus pressure and nasal congestion, look for a decongestant. A decongestant can help shrink mucus membranes that have swollen in your sinuses, allowing the trapped mucus to drain.
Photos courtesy of Shutterstock
SOURCE:
Mucinex
Our Lifestyle section on STM Daily News is a hub of inspiration and practical information, offering a range of articles that touch on various aspects of daily life. From tips on family finances to guides for maintaining health and wellness, we strive to empower our readers with knowledge and resources to enhance their lifestyles. Whether you’re seeking outdoor activity ideas, fashion trends, or travel recommendations, our lifestyle section has got you covered. Visit us today at https://stmdailynews.com/category/lifestyle/ and embark on a journey of discovery and self-improvement.
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Lifestyle
Brooke Shields Advocates for Health at Age 50+
Brooke Shields
- Brooke Shields convenes other celebrities, influencers and patient advocates over 50 to discuss the power of aging and how to protect their health
- Shields directs a short film, encouraging adults 50 years of age and older to talk to their doctor or pharmacist about their risk for shingles — a disease that affects about 1 million people annually in the US — and about vaccination
- The partnership is part of GSK’s national THRIVE@50+ campaign
PHILADELPHIA, Sept. 16, 2024 /PRNewswire/ — GSK plc (LSE/NYSE: GSK) is partnering with Brooke Shields, as part of its THRIVE@50+ campaign, to encourage people 50 and older to embrace and protect the power they’ve found in aging by asking their doctor or pharmacist about their risk for shingles and about vaccination.
Experience the full interactive Multichannel News Release here: https://www2.multivu.com/gsk/9290451-en-brooke-shields-gsk-shingles-risk-adults-50-and-older
Shields exemplifies what it means to thrive at any age, including now, at her current age of 59. The actress, TV personality, model and entrepreneur now adds fierce health advocate to her resume. Like so many others her age, at a time when Shields was stepping into a new, unapologetic power, she also learned that with age comes the important lesson of protecting one’s health from vulnerabilities like shingles. In fact, 99% of people over the age of 50 are at risk for developing shingles, although not everyone will.1
Brooke Shields said: “For so long, we’ve been conditioned to fear aging, but the reality is that age is power. As I’ve gotten older, my life experiences have really solidified who I am and what I stand for, and when I talked to other women who were a part of this campaign, it’s clear that I’m not the only one who feels this way. The unfair twist is that just as we’ve reached this time of our lives where we feel like the best version of ourselves, we’re also experiencing new health risks. When I learned that people over 50 are at an increased risk for shingles, I couldn’t help myself from starting the conversation. This matters because our power is worth protecting.”
Part of Shields’ partnership with GSK’s THRIVE@50+ campaign involved her directing and producing videos with other influential women who are thriving in their 50s and beyond, including football mom Donna Kelce, actress Gina Torres, reality TV star Susan Noles and former shingles patients, among others, each sharing their own unique stories and radiating the power they’ve come into with age. World-renowned fashion and lifestyle photographer Pamela Hanson joined the group to capture that power in her iconic portrait style.
Leah Smith, PharmD, GSK medical educator, said: “Shingles can be an isolating experience that can also really take a toll on one’s quality of life. And it’s not as uncommon as you might think — every year, there are about one million cases of shingles in the US alone. Age is the most important risk factor for shingles, so anyone over 50 should consider asking their doctor or pharmacist about shingles and about vaccination.”
GSK’s goal with their THRIVE@50+ campaign is to create a cultural movement around healthy aging, grounded in the genuine and authentic experiences that bring the community together.
About THRIVE@50+
THRIVE@50+ is a national public health initiative from GSK to educate people 50 and older about their risk for shingles, due to the natural aging of the immune system, and the impact the disease can have on everyday life. We encourage people 50 and older to understand how they can help prevent shingles, like asking their doctor or pharmacist about their risk of shingles and about vaccination, so they can stay ahead of this health challenge and continue to thrive.
About shingles
Shingles is caused by the reactivation of the varicella-zoster virus (VZV), the same virus that causes chickenpox.1 By age 50, VZV is present in most adults2 and may reactivate with advancing age.3 As people age, the strength of the immune system’s response to infection wanes, increasing the risk of developing shingles.1
Shingles typically presents as a rash, with painful blisters across the chest, abdomen or face.3 The pain is often described as aching, burning, stabbing or shock-like.4
Following the rash, a person may experience post-herpetic neuralgia (PHN), a long-lasting nerve pain that can last weeks or months and occasionally persists for several years.4 PHN is the most common complication of shingles, occurring in 5–30% of all shingles cases, from findings in various studies.5
About GSK
GSK is a global biopharma company with a purpose to unite science, technology, and talent to get ahead of disease together. Find out more at gsk.com.
Cautionary statement regarding forward-looking statements
GSK cautions investors that any forward-looking statements or projections made by GSK, including those made in this announcement, are subject to risks and uncertainties that may cause actual results to differ materially from those projected. Such factors include, but are not limited to, those described under Item 3.D “Risk factors” in GSK’s Annual Report on Form 20-F for 2023, and GSK’s Q2 Results for 2024.
Registered in England & Wales:
No. 3888792
Registered Office:
79 New Oxford Street
London
WC1A 1DG
References:
- CDC. Shingles (Herpes Zoster): Clinical Overview. Available at: https://www.cdc.gov/shingles/hcp/clinical-overview/
- Johnson RW, et al. Herpes zoster epidemiology, management, and disease and economic burden in Europe: a multidisciplinary perspective. Ther Adv Vaccines. 2015;3(4):109-120.
- Mueller NH, et al. Varicella zoster virus infection: clinical features, molecular pathogenesis of disease and latency. Neurologic Clinics. 2008;26;675-697.
- Cheng J, Rosenquist RW. Herpes zoster and postherpetic neuralgia. Fundamentals of Pain Medicine. 2018:221-5.
- Kawai K, Gebremeskel BG, Acosta CJ. Systematic review of incidence and complications of herpes zoster: towards a global perspective. BMJ Open. 2014;4:e004833. doi: 10.1136/bmjopen-2014-0048
SOURCE GSK
Our Lifestyle section on STM Daily News is a hub of inspiration and practical information, offering a range of articles that touch on various aspects of daily life. From tips on family finances to guides for maintaining health and wellness, we strive to empower our readers with knowledge and resources to enhance their lifestyles. Whether you’re seeking outdoor activity ideas, fashion trends, or travel recommendations, our lifestyle section has got you covered. Visit us today at https://stmdailynews.com/category/lifestyle/ and embark on a journey of discovery and self-improvement.
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