Lifestyle
Scientists Identify Unique Breast Cancer Cells That Control Their Ability to Proliferate and Colonize the Lungs
These cells can also trigger their own dormancy, allowing them to evade certain therapies
Last Updated on November 9, 2024 by Daily News Staff
These cells can also trigger their own dormancy, allowing them to evade certain therapies
Newswise — New York, NY (September 20, 2022) — Scientists from The Tisch Cancer Institute have uncovered a mechanism by which certain breast cancer cells regulate their own metastases, fuel dissemination from the original tumor site, and determine routes to invade distant organs such as the lungs, according to a study published in Cell Reports in September.
For the first time, scientists have identified a type of cancer cell in triple negative breast tumors, which is highly efficient in invading and colonizing distant organs but slow their growth upon colonization. These cells have a hallmark of slowed production of a protein called srGAP1, which is usually attributed to cancer growth.
Scientists also found in animal models that these unique cells trigger a phenomenon that keeps them in a dormant state in distant organs such as the lungs. This is an important finding because cancer cells have to efficiently survive at distant sites, and staying in this “asleep” existence allows these cells to evade therapies that target cancer cells’ normal rapid growth. Cells that are missed could later become metastatic.
“Our findings emphasize the importance of considering phenotypic changes that could occur when treating cancer cells with therapeutic strategies that target proliferating cells such as chemotherapy,” said Jose Javier Bravo-Cordero, PhD, Associate Professor of Medicine (Hematology and Medical Oncology) at The Tisch Cancer Institute at Mount Sinai. “While these treatment regimens target dividing cells, they may also be selecting for more invasive tumor cells. Our studies suggest that more selective therapeutic strategies combining treatments against both dividing cells and invasive dormant cells may be necessary to prevent metastatic disease.”
To conduct this study, researchers used high-resolution in vivo imaging to visualize extravasation, the process of tumor cells exiting the blood vessels to enter a target tissue. This event was observed in real time, revealing with unprecedented detail the early stages of tumor extravasation. The microscopy studies revealed that after these tumor cells invade the lungs, they enter into a dormant state by secreting the protein TGFβ2. The studies also showed that interfering with that protein can block tumor cell invasion into the lungs.
Partners who contributed to this work include Stony Brook University, University of Illinois at Chicago, Janelia Research Campus at Howard Hughes Medical Institute and University of California at Berkeley.
About the Mount Sinai Health System
Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 43,000 employees working across eight hospitals, over 400 outpatient practices, nearly 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it.
Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes approximately 7,300 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report‘s Best Hospitals, receiving high “Honor Roll” status, and are highly ranked: No. 1 in Geriatrics and top 20 in Cardiology/Heart Surgery, Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report’s “Best Children’s Hospitals” ranks Mount Sinai Kravis Children’s Hospital among the country’s best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is one of three medical schools that have earned distinction by multiple indicators: It is consistently ranked in the top 20 by U.S. News & World Report‘s “Best Medical Schools,” aligned with a U.S. News & World Report “Honor Roll” Hospital, and top 20 in the nation for National Institutes of Health funding and top 5 in the nation for numerous basic and clinical research areas. Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.
For more information, visit https://www.mountsinai.org or find Mount Sinai on Facebook, Twitter and YouTube.
Our Lifestyle section on STM Daily News is a hub of inspiration and practical information, offering a range of articles that touch on various aspects of daily life. From tips on family finances to guides for maintaining health and wellness, we strive to empower our readers with knowledge and resources to enhance their lifestyles. Whether you’re seeking outdoor activity ideas, fashion trends, or travel recommendations, our lifestyle section has got you covered. Visit us today at https://stmdailynews.com/category/lifestyle/ and embark on a journey of discovery and self-improvement.
Health
Caring for the Caregiver: 7 Ways to Support Those Who Care for Others
Caring for the Caregiver:Whether it’s helping an older family member manage appointments and medications, caring for a sick child or coordinating disability services for a loved one, almost everyone will be a caregiver, need a caregiver or both at some point in their lifetime.
Caring for the Caregiver: 7 Ways to Support Those Who Care for Others
(Feature Impact) Caregiving is some of the most important work a person can do, yet it’s often overlooked and undervalued in society. Whether it’s helping an older family member manage appointments and medications, caring for a sick child or coordinating disability services for a loved one, almost everyone will be a caregiver, need a caregiver or both at some point in their lifetime.
In fact, more than 53 million Americans support the health, quality of life and independence of an older adult or family member with a serious illness or disability each year, according to the Administration for Community Living.
Caregiving can be exhausting, stressful and overwhelming at times. In fact, research shows caregivers face real health impacts from physical and emotional strain, according to research published by the National Institutes of Health. Having the right support, however, can improve life for them and those they care for. Consider these practical, accessible ways to support caregivers from the experts at Community Catalyst.
Build a Caregiving Team
Support can begin with reimagining caregiving as a team effort instead of expecting one person to handle every task. Involving other family members, neighbors, local support services and healthcare professionals means many hands and lighter work, whether their help comes in the form of cooking meals, handling transportation or assisting with paperwork.
Make Time for Your Own Health and Emotions
As a caregiver, you may be tempted to put the needs of others before yours. In fact, many caregivers find themselves scheduling doctors’ appointments for others while skipping their own. Remember your needs are just as important, and you can’t pour from an empty cup. Carve out time for self-care activities like healthy eating, movement, therapy and time with friends. Online support groups and forums can connect you with people who understand, so you feel less isolated.
Look for Respite Care Opportunities
Even if an ill or disabled loved one doesn’t require full-time in-home support, it may be possible to arrange occasional professional respite care. Depending on where you live, Medicaid waivers or local grants could help cover costs – but keep in mind that waitlists can be long, so don’t wait to start exploring these opportunities. For help accessing respite care and other caregiver support, reach out to your state’s “No Wrong Door” center, which can connect you to long-term services and assistance.
Talk to Your Employer
Juggling full-time work and caregiving can be a recipe for burnout, but an understanding employer can make a world of difference. Discuss possibilities like flexible scheduling, remote work, expanded family leave or intermittent leave via the Family and Medical Leave Act, dependent care assistance options and peer support networks.
Get Help Navigating Coverage and Benefits
Between insurance coverage, benefits programs, medical bills and more, the logistics of caregiving can make your head spin. Organizations like Community Catalyst work with local, state and community partners to help caregivers sort through the noise and take actions to improve their families’ lives, like signing up for Medicaid or Medicare.
Through a program funded by the Administration for Community Living, the organization is helping states build systems designed to support caregivers’ health, well-being and financial security. Furthermore, it shares education around family caregiving issues, features the stories of real people who often feel invisible and provides practical, usable guidance for those struggling to navigate insurance and healthcare.
Stay Connected and Organized with Technology
Coordinating care often feels like staying on top of hundreds of details simultaneously. Tools like group chats, video calls, shared calendars, medication apps, remote monitoring devices and telehealth portals can streamline some everyday logistics and keep you in touch with your support network.
Discuss Long-Term Plans Openly
Caregiving is a marathon, not a sprint. Open, honest conversations about the future can help caregivers make more informed decisions, share responsibilities and have greater peace of mind. Discuss medical care, living arrangements, finances, future goals and your loved one’s preferences as you look toward the years ahead.
When caregivers have the support they need, the people they care for – and the communities around them – are stronger. Learn more and find additional caregiver resources at CommunityCatalyst.org.
Photos courtesy of Shutterstock
SOURCE:
Community Catalyst
fitness
Real-World Weight Journeys: Exploring Health Experiences to Improve Care
Exploring Health Experiences: A number on a scale tells only part of the story. Living well is also about having energy, feeling your best and enjoying a good quality of life. Yet each person’s path is different, and lifestyle changes, medicines and other approaches to managing weight can affect health in different ways.
Real-World Weight Journeys: Exploring Health Experiences to Improve Care
(Feature Impact) A number on a scale tells only part of the story. Living well is also about having energy, feeling your best and enjoying a good quality of life. Yet each person’s path is different, and lifestyle changes, medicines and other approaches to managing weight can affect health in different ways.
No two weight-management journeys look the same. Some people are taking their first steps toward healthier habits. Others are balancing health conditions, caring for family members, coping with stress or exploring new treatment options. Along the way, they may find support that helps them succeed or encounter obstacles that make progress more difficult.
These stories provide valuable insights into what it takes to improve health in everyday life.
That’s the idea behind the American Heart Association’s Healthy Living BEYOND Weight Study. By learning directly from adults across the country, researchers aim to better understand the challenges, motivations and factors that shape weight and health outcomes over time. The goal is to generate insights that can help improve support, inform care and empower more people to live healthier lives.
What Factors Influence Weight
Nearly 1 in 3 U.S. adults are overweight and 2 in 5 are obese, according to the National Institutes of Health. Weight is shaped by many factors, including:
- Genetics and hormones
- Access to healthy food, safe places to exercise and healthcare
- Chronic stress and mental health
- Medications and metabolism
- Community conditions, as where you live can influence your ability to live a healthy life
How Joining a Study Can Make a Difference
Led by the American Heart Association, the Healthy Living BEYOND Weight Study is open to U.S. adults with a BMI of 25 or higher, including those who have tried lifestyle changes, weight-management medicines or weight-loss surgery. By sharing information about their health and daily lives, participants can help researchers better understand how to improve care.
Interest in newer weight-loss medicines, such as GLP-1s, has grown rapidly. While these treatments are helping many people, researchers are still learning about their long-term effects and how they fit into everyday life. People who currently use or previously used a GLP-1 may be eligible to participate and help generate insights that could improve care for others.
Reasons to Join This Study
By joining this study, participants can help researchers better understand the long-term impact of treatments, identify what helps people succeed and uncover the challenges they face along the way. The information they share can help fill important gaps in research, shape better and more compassionate care and guide future health recommendations.
According to the Pew Research Center, 31% of U.S. adults report they’re online “almost constantly.” The study is conducted entirely online, making participation convenient and easy. It can be completed from home on a schedule that works best for each participant.
Consider these reasons to participate:
- Your story matters. By participating, you may help build knowledge that can improve care, guide health recommendations and help people live healthier lives.
- It’s easy. The study is conducted entirely online, making it simple to join and stay involved at your own pace.
- It’s safe and respectful. All data is collected with your informed consent, protected by privacy safeguards and handled according to rigorous ethical and scientific standards.
- You won’t be alone. Millions of people are navigating weight and health challenges. By sharing your journey, you can help researchers better understand what works, what support is needed and how to shape better and more compassionate care for others.
Learn more and consider signing up at Heart.org/GoBeyond.
Photo courtesy of Shutterstock
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Health and Life Insurance
Review Your Medicare Coverage Options: Open Enrollment is Through Dec. 7
Medicare Coverage Options: Medicare Open Enrollment is your opportunity to give your Medicare plan a check-up. Plans change every year, and now is the time to check if a new plan could be better for you.
Review Your Medicare Coverage Options: Open Enrollment is Through Dec. 7
(Feature Impact)Medicare Open Enrollment is your opportunity to give your Medicare plan a check-up. Plans change every year, and now is the time to check if a new plan could be better for you.
If you have Medicare, taking the time to review your coverage options each fall is one of the most important health decisions you can make.
Give Your Medicare Plan a Check-up
- Check your coverage. Ensure your preferred doctors, prescriptions and preferred pharmacies are covered.
- Check your costs. Look at premiums, deductibles, copays and other out-of-pocket costs.
- Check for changes. See what will be different in your plan for the coming year.
- Check your options. Compare plans side by side based on the prescriptions you take. Find the right plan for your health needs and your budget. Make sure your drugs are covered.
Now is the one time you can make changes to your health and prescription drug plans and find a plan that’s better for you. Medicare Open Enrollment is your opportunity to review and compare options and take control of your expenditures and coverage.
Medicare plans change annually and so does your health. What worked for you last year may be different than what will work best this year. A review of your options can help you secure a plan best fit to your current lifestyle and health needs – while potentially saving you hundreds of dollars on out-of-pocket costs.
For instance, a person with Medicare compared drug plans to find the best costs and coverage for their prescriptions, including a blood thinner and a common cholesterol medication. Using medicare.gov, they found the yearly cost for a Medicare drug plan and these prescriptions ranged from $1,356-2,965. By choosing the lowest-cost plan, they saved more than $1,600 while keeping their essential medications covered.
Medicare.gov is the Official Source
For all your Open Enrollment needs, Medicare.gov is your official source. It’s the trusted resource to help you navigate Open Enrollment, allowing you to explore and compare every available Medicare health and drug plan available in your area. If you prefer speaking with someone directly, call 1-800-MEDICARE to connect with a team of experts who are available 24/7 to help you review your options and answer any questions about your Medicare coverage.
To get started, go to Medicare.gov and click on “Find Plans Now.” For the best shopping experience, log in or create a Medicare account. You can easily compare plan costs, side by side, based on the medications you take. Make sure the plan you choose covers your prescription drugs and your doctors.
Don’t Wait – Open Enrollment Ends Dec. 7
If you miss the Dec. 7 deadline, you may need to wait a full year before you can make any changes to your coverage. That’s why getting started early is important. Make sure you give yourself enough time to review and compare your options. You’ll want to consider factors like costs, benefits and prescription drug plans.
Medicare Open Enrollment is the perfect time to plan for the future and prioritize your health. Making sure you have a health plan that can support you in your wellness journey is critical, so don’t wait. Start reviewing your Medicare plan options today at Medicare.gov.
Information provided by the U.S. Department of Health & Human Services.
Photos courtesy of Shutterstock
SOURCE:
Centers for Medicare and Medicaid Services
