Lifestyle
Stroke, Clot Risk Halved in Heart Disease and Arrhythmia Patients Who Took Blood Thinners Apixaban Versus Rivaroxaban
A difference in the effectiveness against strokes and other blood clots was easily visible in the first year among patients who’d taken the anticoagulant apixaban rather than rival rivaroxaban, according to researchers at the Perelman School of Medicine at the University of Pennsylvania.
Last Updated on November 16, 2024 by Daily News Staff
Newswise — PHILADELPHIA—A difference in the effectiveness against strokes and other blood clots was easily visible in the first year among patients who’d taken the anticoagulant apixaban rather than rival rivaroxaban, according to researchers at the Perelman School of Medicine at the University of Pennsylvania.
In the “emulated” clinical trial—an analysis comparing matched patients in a large health insurance database—all of the patients whose data were analyzed were those who have atrial fibrillation (AF) and associated valvular heart disease (VHD). Each patient took one form of an anticoagulant, also known as blood thinners, to slow down the formation of new blood clots and help avoid existing clots from growing larger and potentially more harmful. The study showed that those who took apixaban had their dangerous clot risk decrease almost by half compared with rivaroxaban.
At least several million Americans have AF, a type of irregular heartbeat that lead to blood clots in the heart, and it is thought that more than 60 percent of these patients have associated VHD, which essentially means that they also have significant heart valve damage. Stroke or systemic embolism risk increase by several times in those with AF compared to those without it, and VHD is suspected of adding to the risk of stroke or death.
Since 2016, apixaban and rivaroxaban have been the most prescribed anticoagulants for reducing stroke and systemic embolism risk in AF/VHD patients. While some traditional blood thinners can be affected by a patient’s diet, apixaban and rivaroxaban do not, making them easier to manage. But, so far, there have been no clinical trials directly comparing the two drugs in this patient population.
“The lack of clinical trial evidence and wide use of both drugs in patients with AF and VHD calls for real-world evidence that can guide treatment selection in clinical practice,” said Ghadeer Dawwas, PhD, a postdoctoral fellow in Biostatistics, Epidemiology, and Informatics at Penn, and first author of the study, published today in the Annals of Internal Medicine.
Almost 10,000 patients who had recently started taking apixaban were compared with another 10,000 newly taking rivaroxaban. The study was not of the clinical trial type, in which patients are randomly assigned to different groups to minimize differences between them. Rather, the researchers emulated a clinical trial by matching each patient in the apixaban group to one in the rivaroxaban group with similar age and other characteristics that could affect outcomes. The patient records compared in the study came from a large commercial health insurance database with de-identified data from 2013 to 2020.
The number of strokes, as well as blood clots in the body other than the brain (called “systemic embolisms”) in the patients seen over the span of several years after they began taking the medications suggested that patients in the apixaban group had a 43 percent lower risk of a clotting event, and a 49 percent lower risk of a gastrointestinal or intracranial bleeding event.
“Until evidence from randomized controlled trials becomes available, we believe clinicians should consider our findings when selecting anticoagulants in patients with AF and VHD,” said study senior author Sean Hennessy, PharmD, PhD, a professor of Epidemiology and director of Penn’s Center for Real-world Effectiveness and Safety of Therapeutics.
The analysis showed that the numbers of patients who had strokes or systemic emboli in each group diverged almost immediately. Patients in the rivaroxaban group had markedly more of these events at six months and twelve months of follow-up. The researchers calculated that the rate of stroke or systemic embolism per patient per year of follow-up was about one percent (0.91 percent) for rivaroxaban users, and about half that (0.52 percent) for apixaban users. Similarly, the rate of bleeding events in the rivaroxaban group was about double that in the apixaban group.
Overall the results suggested that, in comparison to the rivaroxaban group, the apixaban group had 43 percent lower risk of stroke or systemic embolism, and 49 percent the risk of a bleeding events compared with rivaroxaban.
Support for the research was provided by the National Institutes of Health (K99HL159230).
Source: Perelman School of Medicine at the University of Pennsylvania
Our Lifestyle section on STM Daily News is a hub of inspiration and practical information, offering a range of articles that touch on various aspects of daily life. From tips on family finances to guides for maintaining health and wellness, we strive to empower our readers with knowledge and resources to enhance their lifestyles. Whether you’re seeking outdoor activity ideas, fashion trends, or travel recommendations, our lifestyle section has got you covered. Visit us today at https://stmdailynews.com/category/lifestyle/ and embark on a journey of discovery and self-improvement.
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Consumer Corner
Reduce, Reuse, Rejoice: 5 Holiday Hacks for Eco-Friendly Celebrations
Discover 5 simple holiday hacks to reduce waste and celebrate sustainably. Learn how to plan meals, recycle food scraps, give greener gifts, and properly sort holiday waste while saving money this season.
Last Updated on December 5, 2025 by Daily News Staff
Reduce, Reuse, Rejoice: 5 Holiday Hacks for Eco-Friendly Celebrations
(Family Features) Holiday celebrations bring joy, laughter and lasting memories – but they can also leave behind a sleigh full of waste. From food scraps and empty bottles to wrapping paper and decorations, the season can leave your home full of items that could be reused or recycled. In fact, household waste increases nearly 25% between Thanksgiving and New Year’s Day, according to survey results from the Center for Biological Diversity. That’s a lot of leftovers, garland and glass that could be kept out of landfills. To help you cut down on trash and embrace a joyful, less-waste holiday season, the experts at CalRecycle offer these five holiday hacks to help you save cash and protect the planet.- Plan Meals to Waste Less and Save More
- Shop your pantry first to avoid buying what you already have.
- Buy only what you need and prepare recipes based on guest count.
- Choose local ingredients from sources like farmers markets that minimize packaging.
- Send guests home with leftovers in reusable containers or freeze extras for future meals.
- Recycle Food Scraps
- Not all food can be saved, but it doesn’t have to go in the trash.
- Compost fruit and vegetable trimmings, eggshells, coffee grounds and plate scrapings. Trashed food makes climate pollution in landfills. Recycle it in your green bin instead.
- Most California communities now offer green bin composting. Learn what goes in the green bin by visiting the Curb Your Food Scraps page on RecyclingReimaginedCA.com.
- Set out a clearly labeled “food scraps” bin next to your trash, as well as a recycling bin for bottles, cans and other containers so everyone can participate.
- Eat, Drink and Be Eco-Friendly
- Use reusable plates, cups and utensils instead of disposable options.
- Decorate with items you can use year after year or make compostable decor from natural materials.
- Collect empty wine, liquor, juice or other California Redemption Value (CRV)-eligible containers and cash them in once the party is over.
- Serve water in reusable pitchers or carafes instead of single-use plastic bottles.
- Give Greener Gifts
- Choose experiences over stuff, like tickets to events, museum or club memberships, registrations for classes or shared adventures.
- Wrap gifts in fabric, scarves or reusable tins. Or use recyclable paper without glitter or foil.
- Personalize presents with homemade crafts, baked goods or services that reduce packaging.
- Prioritize gifts from local and sustainable businesses that are committed to ethical sourcing, minimal packaging and recycled materials.
- Sort Holiday Waste the Right Way
- After the celebrations, check local recycling rules for how to properly dispose of:
- Batteries
- Holiday lights
- Christmas trees
- Drop off CRV-eligible beverage containers, such as wine and spirit containers, at your nearest recycling site for cash back.
- Donate unwanted gifts or gently used holiday items to local charities or thrift stores.
Our Lifestyle section on STM Daily News is a hub of inspiration and practical information, offering a range of articles that touch on various aspects of daily life. From tips on family finances to guides for maintaining health and wellness, we strive to empower our readers with knowledge and resources to enhance their lifestyles. Whether you’re seeking outdoor activity ideas, fashion trends, or travel recommendations, our lifestyle section has got you covered. Visit us today at https://stmdailynews.com/category/lifestyle/ and embark on a journey of discovery and self-improvement.
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Family
5 Trending Holiday Looks for the Whole Family
Creating trendy ensembles when you just want to stay warm can be a challenge, but this season’s hottest looks make it easy to keep cozy while dressing up or down.
Last Updated on December 3, 2025 by Daily News Staff
(Family Features) Creating trendy ensembles when you just want to stay warm can be a challenge, but this season’s hottest looks make it easy to keep cozy while dressing up or down. Whether you’re aiming for style for a holiday celebration or planning an evening out to shop and take in the holiday lights, this season’s trends have you covered.
Stylish layers and updates to winter wardrobe staples are two keys to nailing this season’s on-trend looks, according to acclaimed American fashion designer Brandon Maxwell, who is collaborating with Walmart as creative director for Free Assembly and Scoop, the retailer’s exclusive, elevated fashion brands.
“Like many people across the country who live in a small town, Walmart was the destination for everything where I grew up, including holiday fashion,” Maxwell said. “When I first teamed up with Walmart, I was excited to bring the joy of fashion to people across the country. Everyone deserves to enjoy their holidays in clothing they love. This year, we are proud to offer the biggest trends in holiday fashion, from cozy outwear to glamorous party looks.”
Maxwell offers these tips for creating the perfect affordable look, no matter where your plans take you this winter:
Metallic Shine: Metallic sweater sets, like a boxy crewneck and matching mini skirt in a glitzy gold shade, are must-have pieces for the holidays. Wear the show-stopping set with matching gold earrings and platform sandals for a head-turning party look.
Layers of Style: Layer festive multicolor patterns in intarsia knits like this Free Assembly fair isle sweater with a plaid puffer jacket for an easy update to winter closet staples like lightly distressed jeans and booties.
Party Perfect: Sophisticated outerwear pieces like a double-breasted coat add a modern touch to classic holiday party looks. Pair with a berry-hued mini dress, black tights and black boots for a look that stands out. For a bit of edge, choose a faux moto jacket layered over a sequin cami top or metallic sweater to complement a faux leather skirt.
Casual Comfort: This season, menswear is all about intentional layering and looks that prioritize both comfort and style. Update vintage-inspired flannels by layering with a quilted puffer pullover and matching them with wintry prints and cargo joggers for a look that’s casual and put together all at once.
Little Lookers: Fashionable little ones can also get decked out this season. Colorful sparkly girl’s dresses from Scoop perfectly complement matching versions for women, ideal for family photos and mommy-and-me moments that make the season extra special. For a more casual event, fair isle sweater dresses in fun shades like lavender can make a classic look oh-so-now.
Find more festive fashion inspiration by visiting Walmart.com.
SOURCE:
Walmart
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Blog
The Substitute Teacher Who Wanted Blueprints of Our House
A fifth-grade assignment took a strange turn when a substitute teacher asked students to draw schematics of their homes. What followed — a wildly fictional floor plan and a priceless reaction from my mom — turned into one of my funniest childhood memories.
Last Updated on December 3, 2025 by Daily News Staff
The Substitute Teacher Who Wanted Blueprints of Our House
Elementary school memories tend to blend together — cafeteria pizza, playground arguments, the eternal struggle of times tables — but every once in a while, something happens that sticks with you for life. For me, that moment came in the fifth grade during a week when our regular teacher was out, and we cycled through substitute teachers like we were testing models for durability. By midweek, in walked a substitute with a mysterious, slightly intense energy — the kind of vibe that suggested he either meditated at dawn or worked a graveyard shift doing something he couldn’t talk about. We settled into our seats, expecting worksheets or quiet reading time. But nope. He had other plans. “Today,” he announced, “we’re going to draw schematics of our houses.” Schematics. Not drawings. Not little houses with smoke coming out of the chimney. Actual blueprint-style schematics. He wanted the layout of our bedrooms, our parents’ rooms, and where the pets slept. Every detail. Now, to be fair, Highlights Magazine did have a feature that month teaching kids how to draw floor plans. So maybe he was just a bit overenthusiastic about cross-curricular learning. Or maybe — and this is my completely rhetorical adult theory — he worked the graveyard shift as a cat burglar gathering intel between heists. Just moonlighting between blueprints. While the rest of the class tried their best to recreate their actual homes, my imagination sprinted in a totally different direction. The house I drew had:- A massive master bedroom with an oversized bathroom for my parents
- Separate bedrooms for us kids on the opposite side of the house
- A kitchen placed right in the center like a command center
- And the dog — the true VIP — had a luxurious two-story doghouse
Later that day, my mom asked the usual question: “So, what did you guys do today?” “We drew schematics of our house,” I said casually. The look on her face was instant and intense. She wasn’t panicked, but there was definitely a “Why does a substitute teacher need to know the exact layout of my home?” expression happening. Parental instincts activated. But then I showed her my diagram. She stared at it. Blinked. Then sighed with massive relief. “This isn’t our house,” she said. “Nope! I made it up,” I replied proudly. Her shoulders relaxed so much she probably lost five pounds of tension in one instant. If the substitute was secretly planning a heist, my masterpiece of misinformation would have sent him to the wrong house entirely. Looking back, the whole moment feels like a sitcom setup — a mysterious substitute collecting “house schematics,” me creating a completely fictional piece of architecture, and my mom going on a full emotional journey in under 30 seconds. Maybe he was just excited about the Highlights Magazine floor-plan activity. Or maybe — just maybe — he moonlighted in cat burglary. We’ll never know. But if he was, I like to think I threw him completely off the scent.Enjoy this story?
Check out more nostalgic and humorous stories on STM Daily News and be sure to sign up for our newsletter!Our Lifestyle section on STM Daily News is a hub of inspiration and practical information, offering a range of articles that touch on various aspects of daily life. From tips on family finances to guides for maintaining health and wellness, we strive to empower our readers with knowledge and resources to enhance their lifestyles. Whether you’re seeking outdoor activity ideas, fashion trends, or travel recommendations, our lifestyle section has got you covered. Visit us today at https://stmdailynews.com/category/lifestyle/ and embark on a journey of discovery and self-improvement.
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