Lifestyle
Stroke, Clot Risk Halved in Heart Disease and Arrhythmia Patients Who Took Blood Thinners Apixaban Versus Rivaroxaban
A difference in the effectiveness against strokes and other blood clots was easily visible in the first year among patients who’d taken the anticoagulant apixaban rather than rival rivaroxaban, according to researchers at the Perelman School of Medicine at the University of Pennsylvania.
Last Updated on November 16, 2024 by Daily News Staff
Newswise — PHILADELPHIA—A difference in the effectiveness against strokes and other blood clots was easily visible in the first year among patients who’d taken the anticoagulant apixaban rather than rival rivaroxaban, according to researchers at the Perelman School of Medicine at the University of Pennsylvania.
In the “emulated” clinical trial—an analysis comparing matched patients in a large health insurance database—all of the patients whose data were analyzed were those who have atrial fibrillation (AF) and associated valvular heart disease (VHD). Each patient took one form of an anticoagulant, also known as blood thinners, to slow down the formation of new blood clots and help avoid existing clots from growing larger and potentially more harmful. The study showed that those who took apixaban had their dangerous clot risk decrease almost by half compared with rivaroxaban.
At least several million Americans have AF, a type of irregular heartbeat that lead to blood clots in the heart, and it is thought that more than 60 percent of these patients have associated VHD, which essentially means that they also have significant heart valve damage. Stroke or systemic embolism risk increase by several times in those with AF compared to those without it, and VHD is suspected of adding to the risk of stroke or death.
Since 2016, apixaban and rivaroxaban have been the most prescribed anticoagulants for reducing stroke and systemic embolism risk in AF/VHD patients. While some traditional blood thinners can be affected by a patient’s diet, apixaban and rivaroxaban do not, making them easier to manage. But, so far, there have been no clinical trials directly comparing the two drugs in this patient population.
“The lack of clinical trial evidence and wide use of both drugs in patients with AF and VHD calls for real-world evidence that can guide treatment selection in clinical practice,” said Ghadeer Dawwas, PhD, a postdoctoral fellow in Biostatistics, Epidemiology, and Informatics at Penn, and first author of the study, published today in the Annals of Internal Medicine.
Almost 10,000 patients who had recently started taking apixaban were compared with another 10,000 newly taking rivaroxaban. The study was not of the clinical trial type, in which patients are randomly assigned to different groups to minimize differences between them. Rather, the researchers emulated a clinical trial by matching each patient in the apixaban group to one in the rivaroxaban group with similar age and other characteristics that could affect outcomes. The patient records compared in the study came from a large commercial health insurance database with de-identified data from 2013 to 2020.
The number of strokes, as well as blood clots in the body other than the brain (called “systemic embolisms”) in the patients seen over the span of several years after they began taking the medications suggested that patients in the apixaban group had a 43 percent lower risk of a clotting event, and a 49 percent lower risk of a gastrointestinal or intracranial bleeding event.
“Until evidence from randomized controlled trials becomes available, we believe clinicians should consider our findings when selecting anticoagulants in patients with AF and VHD,” said study senior author Sean Hennessy, PharmD, PhD, a professor of Epidemiology and director of Penn’s Center for Real-world Effectiveness and Safety of Therapeutics.
The analysis showed that the numbers of patients who had strokes or systemic emboli in each group diverged almost immediately. Patients in the rivaroxaban group had markedly more of these events at six months and twelve months of follow-up. The researchers calculated that the rate of stroke or systemic embolism per patient per year of follow-up was about one percent (0.91 percent) for rivaroxaban users, and about half that (0.52 percent) for apixaban users. Similarly, the rate of bleeding events in the rivaroxaban group was about double that in the apixaban group.
Overall the results suggested that, in comparison to the rivaroxaban group, the apixaban group had 43 percent lower risk of stroke or systemic embolism, and 49 percent the risk of a bleeding events compared with rivaroxaban.
Support for the research was provided by the National Institutes of Health (K99HL159230).
Source: Perelman School of Medicine at the University of Pennsylvania
Our Lifestyle section on STM Daily News is a hub of inspiration and practical information, offering a range of articles that touch on various aspects of daily life. From tips on family finances to guides for maintaining health and wellness, we strive to empower our readers with knowledge and resources to enhance their lifestyles. Whether you’re seeking outdoor activity ideas, fashion trends, or travel recommendations, our lifestyle section has got you covered. Visit us today at https://stmdailynews.com/category/lifestyle/ and embark on a journey of discovery and self-improvement.
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Travel
What’s Trending in Travel in 2026
In 2026, travelers are prioritizing immersive experiences over quick vacations, with a strong demand for personalized, intentional trips. Despite economic concerns, a survey reveals nearly all respondents plan to travel, often seeking the guidance of travel advisors. Trends include spacious accommodations, cultural immersion, wellness experiences, and multi-generational travel.
What’s Trending in Travel in 2026
(Feature Impact) After years of fast-paced itineraries and social media-inspired vacations, travelers are looking to slow down in 2026, instead focusing on more personal, immersive experiences.
That’s not to say Americans will be looking to travel any less – just more intentionally. Despite economic, political and cultural shifts, travel shows no signs of slowing down this year. In fact, according to a survey conducted on behalf of ALG Vacations, 100% of respondents plan to take a vacation in the next year, with 97% likely to travel for leisure in the next 6 months despite those concerns.
Even with tightened budgets, 95% of those surveyed would still travel – even if it meant scaling back. To help travelers zero in on what they’re looking to experience in 2026, working with a travel advisor when starting to plan that annual getaway can make the process easier.
Additional survey data shows 7 in 10 travelers are turning to professionals to plan their next trips with the younger generations leading the way; 83% of Gen Z and 78% of Millennials are likely to turn to a travel advisor for help with planning and booking.
“What’s really interesting is that travel advisors are resonating with a new wave of travelers,” said ALG Vacations’ Travel Advisor Champion Carson Kressley, the renowned style expert and world traveler best known for his role on “Queer Eye for the Straight Guy” and his current Emmy Award-winning judge role on “RuPaul’s Drag Race.” “They want help uncovering hidden-gem destinations and great-value packages, and a new generation of advisors is meeting them exactly where they are.”
In addition to booking your next excursion with the assistance of a travel advisor, consider these trends Kressley identified for the year ahead.
Space and Privacy
In 2026, spaciousness is an expression of luxury – private villas, low-density boutique resorts and nature-framed hideaways where quiet feels curated and beauty isn’t shared with the masses. As travelers prioritize serenity over scene, this trend reflects an emotional need for clarity as they look for time to reset and environments that support genuine presence.
Immersion in Culture and Hyper-Local
Travelers desire authentic experiences shaped by local chefs, artisans and storytellers who bring a destination’s heritage to life. It’s no longer about observing culture from a distance; it’s about actively participating in it with the destination’s native citizens, reflecting a desire for meaning and perspective.
Longer, More Intentional Vacations
Instead of rushing through multiple destinations, travelers are embracing itineraries that allow them to breathe through longer stays and experiences that unfold naturally. From a lingering lunch to an unstructured afternoon, this shift toward savoring prioritizes depth and connection.
Transformational Wellness
As wellness continues to evolve into deeply personal territory, travelers seek experiences that restore mind, body and perspective such as sunrise rituals, nature-led healing, cultural wellness traditions and programs designed for renewal.
Screen-Inspired Destinations
Pop culture continues to influence travel, but today’s travelers seek more than filming locations. In 2026, they’re searching for dramatic landscapes, atmospheric architecture, richly layered cultures and experiences that evoke emotion and capture the feeling of their favorite cinematic worlds. This evolution of set-jetting is about stepping into a story rather than tracing its steps.
Shared Multi-Generational Moments
Multi-generational travel is shifting toward more purpose-driven experiences – milestone celebrations, cultural reconnection trips and meaningful moments together. The emphasis is on togetherness, personalization and experiences that feel like legacy.
To learn more and start booking your next adventure, visit traveladvisorsgetyouthere.com.
Photos courtesy of Shutterstock
Source: ALG Vacations
Our Lifestyle section on STM Daily News is a hub of inspiration and practical information, offering a range of articles that touch on various aspects of daily life. From tips on family finances to guides for maintaining health and wellness, we strive to empower our readers with knowledge and resources to enhance their lifestyles. Whether you’re seeking outdoor activity ideas, fashion trends, or travel recommendations, our lifestyle section has got you covered. Visit us today at https://stmdailynews.com/category/lifestyle/ and embark on a journey of discovery and self-improvement.
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pets
Understanding Winter Pet Health Risks
Pet Health: Winter poses health risks to dogs, including frostbite and hypothermia. Pet owners should limit exposure, provide adequate shelter, adjust diets, and ensure safe indoor environments to maintain their pets’ well-being.
Last Updated on February 21, 2026 by Daily News Staff
(Family Features) While some dogs prefer to be outdoors regardless of the weather, the cold and often snowy and icy conditions winter brings can pose serious threats to their health.
Much like the well-publicized challenges of keeping your four-legged family members healthy during the warmer weather, it’s important for pet owners to be aware of the unique threats that can arise during colder conditions.
Recognizing Cold Weather Hazards
Winter weather can pose various hazards to pets, including frostbite and hypothermia. Dogs left outside for extended periods, particularly those with short coats or pre-existing health conditions, are at greater risk. It’s essential to limit exposure to extreme cold, provide adequate shelter and recognize the symptoms of winter-related illnesses.
Signs of hypothermia include shivering, lethargy and pale gums. Frostbite may present as discolored, cold skin, particularly on extremities like ears, paws and tails.
Protecting Your Pet’s Skin and Paws in Winter
Cold, dry air can cause pets’ skin to become dry and flaky. Regular grooming and moisturizing can help maintain their skin’s health. Consider using pet-safe moisturizers and avoid bathing them too frequently, as it can strip natural oils.
Additionally, be cautious of salt and de-icing chemicals, which can irritate dogs’ paws and skin. Protect their paws by using booties or applying a pet-safe balm to help prevent cracks and irritation caused by ice, salt and cold surfaces. If not covering paws, always clean them after walks to check for any signs of injury or discomfort and consider using pet-safe ice melters.
Adjusting Diets for Winter
During the winter months, dogs may require a different diet to maintain their energy levels and body heat. Consult with your veterinarian about adjusting your four-legged friend’s food intake, especially if his or her activity level changes. Monitor your pet’s weight and adjust feeding portions as needed to prevent obesity or malnutrition.
Also ensure your pet has access to fresh water, as dehydration can still occur in cold weather. In fact, warm water may encourage pets to drink more.
Keeping Pets Safe Indoors
If your winter pet safety plan includes keeping your dog indoors more often, ensure you provide him or her a warm and comfortable place to rest. Avoid placing your pet’s bed near drafty windows or doors, cold tile floors or uninsulated areas.
Also be mindful of potential hazards such as space heaters, fireplaces, holiday decorations and chemicals such as antifreeze, which is toxic to dogs. Keep them out of reach to prevent burns or accidental ingestion.
If you notice any unusual behavior or symptoms, contact your veterinarian immediately. Early intervention can prevent severe complications and ensure your furry friend remains healthy throughout the winter months. Find more tips to help keep your pets happy and healthy all year long at eLivingtoday.com.
Photo courtesy of Shutterstock
SOURCE:
eLivingtoday.com
Our Lifestyle section on STM Daily News is a hub of inspiration and practical information, offering a range of articles that touch on various aspects of daily life. From tips on family finances to guides for maintaining health and wellness, we strive to empower our readers with knowledge and resources to enhance their lifestyles. Whether you’re seeking outdoor activity ideas, fashion trends, or travel recommendations, our lifestyle section has got you covered. Visit us today at https://stmdailynews.com/category/lifestyle/ and embark on a journey of discovery and self-improvement.
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Lifestyle
How to Practice Thoughtful Grief Etiquette Online
Grief experts advise caution in sharing condolences and loss-related information on social media, emphasizing the importance of prioritizing the grieving family’s needs. Thoughtful posting practices include waiting for family approval, reaching out privately first, and avoiding speculation about the cause of death. Compassionate communication is essential in these sensitive situations.
(Feature Impact) News of a death can spread online in seconds – often before families have notified close family members privately. That’s why grief experts urge people to rethink how they share condolences, tributes and loss-related information on social media, particularly during the winter months when grief can feel especially isolating.
“Grief etiquette is about putting the needs of the grieving family first, not our urge to say something publicly,” said Dr. Camelia L. Clarke, National Funeral Directors Association (NFDA) spokesperson, funeral director and grief educator with nearly 30 years of experience. “Just because information can be shared instantly doesn’t mean it should be.”
Social media has become a common place for sharing condolences, tributes and memories. However, grief experts caution that, without thoughtful consideration, online posts can unintentionally cause harm. Knowing when to post, what to say and when to remain silent can make a meaningful difference for families experiencing loss.
Consider this advice from the experts at the NFDA.
Grief Etiquette in the Digital Age
Grief etiquette refers to the unspoken guidelines for how individuals acknowledge death, loss and mourning, particularly online.
According to Clarke, one of the most important principles is restraint.
“When a death is shared online too quickly, families can feel exposed and overwhelmed at a moment when they’re still processing the loss themselves,” she said. “Waiting is an act of compassion.”
Best Practices for Posting About Loss Online
As social media continues to play a role in modern mourning, grief professionals encourage users to pause before posting and consider a few key guidelines:
- Let the family lead. Don’t post about a death until the immediate family has made it public.
- Ask permission. Obtain consent before sharing photos, stories or tributes.
- Reach out privately first. A direct message, call or handwritten note can be more meaningful than a public comment.
- Avoid speculation. Don’t ask about or share details regarding the cause of death.
- Offer ongoing support. Grief extends far beyond the first days or weeks after a loss.
What to Say (and Avoid)
When expressing condolences online, experts recommend simplicity, sincerity and sensitivity. Messages that acknowledge loss without attempting to explain or minimize it are often the most supportive.
Helpful phrases include:
- “I’m sorry for your loss.”
- “Thinking of you and your family.”
- “I’m here if you want to talk or need anything.”
By contrast, well-meaning cliches can unintentionally cause harm. Phrases such as “They’re in a better place” or “Everything happens for a reason” may reflect the speaker’s beliefs, but they can feel dismissive to someone grieving.
“Grieving people don’t need answers – they need presence,” Clarke said. “Listening matters more than saying the perfect thing.”
Resources for Families and Friends
As digital spaces continue to shape how people communicate during life’s most difficult moments, experts agree empathy, patience and respect remain timeless.
“Grief is deeply personal,” Clarke said. “When we slow down and lead with compassion, we honor both the person who has died and those who are left to grieve.”
To learn more about how to support a grieving person and access free, expert-reviewed resources for navigating grief, expressing condolences and supporting loved ones before, during and after a loss, visit RememberingALife.com, an initiative of the NFDA.
Photo courtesy of Shutterstock
<img src="https://ssl.google-analytics.com/collect?v=1&tid=UA-482330-7&cid=1955551e-1975-5e52-0cdb-8516071094cd&sc=start&t=pageview&dl=http%3A%2F%2Ftrack.familyfeatures.com%2F17832%2F10240&dt=HOW-TO-PRACTICE-THOUGHTFUL-GRIEF-ETIQUETTE-ONLINE" />
<img src="https://erp.featureimpact.com/api/v1/tracking/17832/10240/track.gif" />SOURCE:
National Funeral Directors Association
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