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Finding the Missing Piece: One man’s journey to a von Willebrand disease diagnosis
Frank, a 65-year-old man, spent decades suffering from von Willebrand disease (VWD) without a diagnosis. His journey, marked by severe bleeds and uncertainty, changed when his granddaughter was diagnosed with VWD. This discovery led to Frank’s diagnosis and treatment with VONVENDI, which allows him to better manage his condition and regain control of his life.
Last Updated on October 19, 2025 by Daily News Staff
Finding the Missing Piece: One man’s journey to a von Willebrand disease diagnosis
(Family Features) “I wanted to live my life like there was nothing wrong, but the fear was always there.”
That’s how 65-year-old Frank described life with von Willebrand disease (VWD), the most common bleeding disorder, affecting more than 3 million Americans.
For Frank, the signs started early with nosebleeds so severe they seemed unstoppable. In his 30s, one gastrointestinal bleed required nearly 7 pints of blood to stabilize him – a staggering amount, considering most adults only have 8-12 pints total.
Life with VWD can mean living in constant uncertainty. Any injury, surgery or even simple dental procedure can trigger a dangerous bleed. Symptoms like frequent bruising or heavy menstrual bleeding in women can affect quality of life. The consequences for Frank, even before his diagnosis, were often urgent and life-threatening.
Hospital visits and bleeds became routine, draining both his body and spirit. Frank lost weight, struggled with temperature swings and each trip home from the hospital felt like borrowed time before his next bleeding episode.
Eventually, his body began rejecting the blood transfusions meant to treat him during these mysterious bleeding episodes – a complication known as hemolytic anemia. With few options left, Frank and his partner, Carla, faced a future filled with fear and uncertainty, unsure how much longer his body could keep going.
Journey to a Diagnosis
Like many living with VWD, Frank spent years searching for answers – managing symptoms without understanding their cause. Bleeds came without warning. Triggers were a mystery. A diagnosis felt out of reach.
Through it all, Frank and Carla were their own fiercest advocates. Carla became his second set of eyes and ears by researching symptoms, writing down questions and sitting beside him in countless exam rooms.
“I realized when he was in the hospital, I must be there with him,” Carla said. “I needed to be there when the doctors and the nurses were talking to him. I slept in his room to be there for morning rounds to make sure everyone had the correct information.”
For years, they pressed on without answers or an official diagnosis until 2013, when everything changed.
Frank’s granddaughter was diagnosed with VWD, which they learned is a hereditary bleeding disorder. In that moment, something clicked. After decades of uncertainty, Frank finally had a clue and a connection.
He and Carla immediately sought out VWD education. Testing confirmed what they suspected: Frank had been living with VWD all along.
“Getting the diagnosis was a turning point,” Frank said. “For the first time, we weren’t just waiting for the next bleed – we finally had a way to take control.”
A Path Forward
Frank finally found hope and a path forward. After discussing which treatment option may be right for him with his health care team, Frank began using VONVENDI® [von Willebrand factor (Recombinant)] on-demand to treat and control his bleeding episodes.
VONVENDI is the only von Willebrand factor (VWF) treatment made without human blood or plasma with approved uses in both adults and children with VWD. For someone whose body had begun rejecting transfusions, having a recombinant option was important. But more than that – it worked for Frank.
“Since starting VONVENDI, I feel like I finally found the right path forward for me,” Frank said. “I can control my bleeds when they happen, and I have a plan in place to treat the next one.”
The U.S. Food and Drug Administration recently approved an expanded indication for VONVENDI, which is now indicated for adults and children with VWD to treat and control bleeding episodes (on-demand), to prevent excessive bleeding during and after surgery (perioperative) and for adult patients only, to reduce the number of bleeding episodes when used regularly (prophylaxis). Please see below for Detailed Important Risk Information or click here for the full Prescribing Information.
With this expanded indication, VONVENDI can now help more patients like Frank – not just control bleeds but also try to prevent them. Frank and Carla know there’s no cure, but for the first time in a long time, they have a plan to address Frank’s VWD bleeds.
Visit VONVENDI.com or speak with your doctor to learn more about VWD and discuss if treatment may be right for you.
VONVENDI [von Willebrand factor (Recombinant)] Important Information
What is VONVENDI?
VONVENDI is used in adults and children with von Willebrand disease to:
- treat and control bleeding episodes
- prevent excessive bleeding during and after surgery
For adult patients only:
- reduce the number of bleeding episodes when used regularly (prophylaxis)
Detailed Important Risk Information
Who should not use VONVENDI?
You should not use VONVENDI if you:
- Are allergic to any ingredients in VONVENDI.
- Are allergic to mice or hamsters.
Tell your healthcare provider if you are pregnant or breastfeeding because VONVENDI may not be right for you.
How should I use VONVENDI?
Your first dose of VONVENDI for each bleeding episode may be administered with a recombinant factor VIII as instructed by your healthcare provider.
Your healthcare provider will instruct you whether additional doses of VONVENDI with or without recombinant factor VIII are needed.
What should I tell my healthcare provider before I use VONVENDI?
You should tell your healthcare provider if you:
- Have or have had any medical problems.
- Take any medicines, including prescription and non-prescription medicines, such as over-the-counter medicines, supplements or herbal remedies.
- Have any allergies, including allergies to mice or hamsters.
- Are breastfeeding. It is not known if VONVENDI passes into your milk and if it can harm your baby.
- Are pregnant or planning to become pregnant. It is not known if VONVENDI can harm your unborn baby.
- Have been told that you have inhibitors to von Willebrand factor (because VONVENDI may not work for you).
- Have been told that you have inhibitors to blood coagulation factor VIII.
What else should I know about VONVENDI and von Willebrand Disease?
Your body can form inhibitors to von Willebrand factor or factor VIII. An inhibitor is part of the body’s normal defense system. If you form inhibitors, they may stop VONVENDI or factor VIII from working properly.
Consult with your healthcare provider to make sure you are carefully monitored with blood tests for the development of inhibitors to von Willebrand factor or factor VIII.
What are the possible side effects of VONVENDI?
You can have an allergic reaction to VONVENDI.
Call your healthcare provider right away and stop treatment if you get a rash or hives, itching, tightness of the throat, chest pain or tightness, difficulty breathing, lightheadedness, dizziness, nausea or fainting.
Side effects that have been reported with VONVENDI include: headache, nausea, vomiting, tingling or burning at infusion site, chest discomfort, dizziness, hot flashes, itching, high blood pressure, muscle twitching, unusual taste, blood clots and increased heart rate.
Tell your healthcare provider about any side effects that bother you or do not go away.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
Please see VONVENDI full Prescribing Information.
©2025 Takeda Pharmaceuticals U.S.A., Inc., 500 Kendall Street, Cambridge, MA 02142. 1-877-TAKEDA-7 (1-877-825-3327). All rights reserved. TAKEDA and the TAKEDA Logo are registered trademarks or registered trademarks of Takeda Pharmaceutical Company Limited. VONVENDI is a registered trademark of Baxalta Incorporated. US-VON-1006v1.0 10/25
SOURCE:
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The Knowledge
How Water Towers Work: The Simple System That Keeps Water Flowing in American Cities
Learn how water towers work in the United States, why they are so tall, and how gravity helps cities maintain water pressure and emergency water supplies.
How Water Towers Work
Water towers are one of the most recognizable pieces of infrastructure across the United States. Rising above towns, suburbs, and cities, these elevated tanks quietly perform a vital function every day: maintaining water pressure and storing emergency water for local communities.
Although they may look simple, water towers are an essential part of modern municipal water systems and remain one of the most reliable ways to deliver water to homes and businesses.
The Basic Science Behind Water Towers
Water towers work using a simple principle of physics: gravity.
Water from treatment plants or underground wells is pumped into a storage tank located high above the ground—typically between 100 and 200 feet tall. Because the tank is elevated, gravity naturally pushes the water downward through the city’s pipeline network.
This gravitational force creates the water pressure needed to supply homes, businesses, irrigation systems, and fire hydrants throughout the community.
Most residential plumbing systems in the United States operate best at 40 to 60 PSI (pounds per square inch), which water towers can easily provide through elevation alone.
Why Water Towers Are Built So Tall
The height of a water tower determines how much pressure it can create. Engineers use a common rule:
For example, a water tower standing 120 feet tall can generate roughly 50 PSI of pressure—perfect for delivering water throughout a residential neighborhood.
Why Cities Still Use Water Towers
While modern pumping systems could theoretically move water through pipes continuously, water towers provide several major advantages that make them a preferred design in many municipal systems.
- Stable Water Pressure – Water towers maintain consistent pressure even during peak usage times.
- Energy Efficiency – Pumps can refill towers overnight when electricity demand is lower.
- Emergency Water Supply – If power fails, gravity can continue delivering water.
- Fire Protection – Fire hydrants depend on strong, immediate water pressure.
The Daily Fill-and-Use Cycle
Water towers typically operate on a daily cycle based on community demand.
- Night: Pumps refill the tower while water demand is low.
- Morning: Water levels drop as residents shower and prepare for the day.
- Daytime: Businesses and homes continue drawing water from the tower.
- Evening: The system begins refilling the tank for the next day.
How Much Water Can a Tower Store?
Water towers come in many sizes depending on the population they serve.
- Small towns: 50,000–300,000 gallons
- Suburban communities: 500,000–1 million gallons
- Larger urban systems: up to 2 million gallons or more
Even a single tower holding one million gallons can supply thousands of homes for several hours during peak demand or emergencies.
Modern Technology Inside Water Towers
Today’s water towers are equipped with advanced monitoring systems that help utilities maintain safe and reliable water supplies.
- Digital water level sensors
- Automated pump controls
- Water quality monitoring
- Protective interior coatings
- Regular inspections and maintenance
Landmarks in the American Skyline
Many cities turn their water towers into local landmarks by painting them with city names, mascots, or community slogans. Some towns even design towers shaped like giant objects such as fruit, coffee cups, or sports balls.
Despite their distinctive appearance, water towers remain one of the simplest and most reliable engineering solutions for delivering clean water to millions of Americans every day.
Next time you see a water tower rising above a town skyline, remember: it’s not just a landmark—it’s the gravity-powered system that keeps water flowing.
Related External Coverage
For more information about how water towers and municipal water systems work, explore the following resources:
- U.S. Environmental Protection Agency – Drinking Water Regulations
- American Water Works Association – Water Storage and Water Towers
- HowStuffWorks – How Water Distribution Systems Work
- U.S. Geological Survey – Drinking Water and Groundwater Basics
- U.S. Department of Energy – How Water Towers Work
Dive into “The Knowledge,” where curiosity meets clarity. This playlist, in collaboration with STMDailyNews.com, is designed for viewers who value historical accuracy and insightful learning. Our short videos, ranging from 30 seconds to a minute and a half, make complex subjects easy to grasp in no time. Covering everything from historical events to contemporary processes and entertainment, “The Knowledge” bridges the past with the present. In a world where information is abundant yet often misused, our series aims to guide you through the noise, preserving vital knowledge and truths that shape our lives today. Perfect for curious minds eager to discover the ‘why’ and ‘how’ of everything around us. Subscribe and join in as we explore the facts that matter. https://stmdailynews.com/the-knowledge/
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unknown
The Unfavorable Semicircle Mystery: The YouTube Channel That Uploaded Tens of Thousands of Cryptic Videos
In 2015, the YouTube channel Unfavorable Semicircle gained attention for its enigmatic and abundant video uploads, totaling over 70,000 before its deletion in 2016. Theories about its purpose vary, from automated content generation to digital art experimentation, leaving its intent unresolved.
In the vast digital landscape of the internet, strange phenomena occasionally emerge that leave investigators, tech enthusiasts, and everyday viewers scratching their heads. One of the most puzzling cases appeared in 2015, when a mysterious YouTube channel called Unfavorable Semicircle began uploading an astonishing number of cryptic videos.
Within months, the channel had published tens of thousands of bizarre clips, many of which seemed random, incomprehensible, and visually chaotic. But as internet detectives began analyzing the content more closely, they discovered that these videos might not have been random at all.
The Sudden Appearance of an Internet Mystery
The Unfavorable Semicircle channel reportedly appeared in March 2015, with its first uploads arriving in early April.
Almost immediately, the channel began publishing videos at an incredible pace. Observers estimated that the account uploaded thousands of videos per week, sometimes multiple videos per minute. By the time the channel disappeared in early 2016, researchers believed it had uploaded well over 70,000 videos, possibly far more.
The scale alone made the project seem impossible for a human to manage manually.
Strange Visuals and Cryptic Titles
Most of the videos shared similar characteristics:
- Extremely short or very long runtime
- Abstract visuals such as flashing colors, static, or distorted imagery
- Little or no audio, or heavily distorted sounds
- Titles made of random characters, symbols, or numbers
To casual viewers, the videos looked like pure digital noise. However, online investigators suspected something more deliberate was happening.
Hidden Images Discovered
The mystery deepened when researchers began extracting individual frames from some videos.
When thousands of frames from certain clips were stitched together, the results sometimes formed coherent images. One of the most famous examples involved a video titled “LOCK.” While the footage appeared chaotic at first, combining the frames revealed a recognizable composite image.
This discovery suggested the videos were carefully constructed rather than random uploads.
Theories About the Channel’s Purpose
Because the creator never explained the project, several theories emerged across Reddit, YouTube, and internet forums.
Automated Experiment
Many believe the channel was created using automated software that generated and uploaded content at scale.
Alternate Reality Game (ARG)
Some viewers suspected the channel might be part of a hidden puzzle or digital scavenger hunt.
Encrypted Communication
Others compared the channel to Cold War “numbers stations,” suggesting the videos could contain coded messages.
Digital Art Project
Another theory suggests the channel was an experimental art project exploring algorithms, data, and visual noise.
Despite years of investigation, no single explanation has been confirmed.
Why the Channel Disappeared
In February 2016, YouTube removed the channel, reportedly due to spam or automated activity violations.
By that time, the channel had already become a minor internet legend. Fortunately, some researchers managed to archive a large portion of the videos before they disappeared.
Even today, archived clips continue to circulate online as investigators attempt to decode them.
Other Mysterious YouTube Channels
The Unfavorable Semicircle mystery is not the only strange case on YouTube.
One well-known example is Webdriver Torso, a channel that uploaded hundreds of thousands of videos showing red and blue rectangles with simple beeping sounds. Internet speculation ran wild before Google eventually confirmed it was an internal YouTube testing account.
Another example is AETBX, which posts distorted visuals and unusual audio that some viewers believe contain hidden patterns or encoded information.
These cases highlight how automation, experimentation, and creativity can sometimes blur the line between technology and mystery.
A Digital Mystery That Remains Unsolved
Nearly a decade later, the true purpose behind Unfavorable Semicircle remains unknown.
Was it a sophisticated experiment? A piece of algorithmic art? Or simply an automated test that accidentally captured the internet’s imagination?
Whatever the explanation, the channel stands as a reminder that even in a world filled with billions of videos and endless information, the internet can still produce mysteries that challenge our understanding of technology.
Why Internet Mysteries Still Fascinate Us
Stories like Unfavorable Semicircle capture attention because they combine technology, creativity, and the unknown. They invite people from around the world to collaborate, analyze patterns, and search for meaning hidden in the noise.
And sometimes, the most intriguing part of the mystery is that the answer may never fully be known.
Related Coverage & Further Reading
- Atlas Obscura – The Unsettling Mystery of the Creepiest Channel on YouTube
- Her Campus – Top 5 Most Obscure Internet Mysteries
- Medium – Unfavorable Semicircle: The YouTube Mystery No One Can Solve
- Gazette Review – Top 10 Strangest YouTube Channels Ever
- Decoding the Unknown – Unfavorable Semicircle YouTube Mystery Archive
- Wikipedia – Unfavorable Semicircle
Dive into “The Knowledge,” where curiosity meets clarity. This playlist, in collaboration with STMDailyNews.com, is designed for viewers who value historical accuracy and insightful learning. Our short videos, ranging from 30 seconds to a minute and a half, make complex subjects easy to grasp in no time. Covering everything from historical events to contemporary processes and entertainment, “The Knowledge” bridges the past with the present. In a world where information is abundant yet often misused, our series aims to guide you through the noise, preserving vital knowledge and truths that shape our lives today. Perfect for curious minds eager to discover the ‘why’ and ‘how’ of everything around us. Subscribe and join in as we explore the facts that matter. https://stmdailynews.com/the-knowledge/
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The Bridge
Celebrating International Women’s Day!
International Women’s Day is celebrated globally on March 8th to honor women’s achievements and promote gender equality, originating from a 1908 march in New York for better rights.
Last Updated on March 7, 2026 by Daily News Staff
International Women’s Day is a global celebration that honors the achievements of women and highlights the progress still to be made in the fight for gender equality. On this day, people around the world come together to recognize the amazing contributions of women everywhere and to rally for greater gender equity in all areas of life.
The origins of International Women’s Day can be traced back to 1908, when 15,000 women marched through the streets of New York City to demand better working conditions and the right to vote. Since then, the celebration has grown to be an international event, with more than 100 countries recognizing the day. The United Nations even declared March 8th as International Women’s Day in 1975, to honor the struggles of women around the world.
This year’s International Women’s Day theme is #ChooseToChallenge, meaning that everyone is encouraged to call out gender bias and inequality when they see it. We’re also encouraged to celebrate women’s achievements, support each other, and take action for equality.
It’s important to recognize the progress we’ve made in terms of gender equality, but we still have a long way to go. International Women’s Day serves as a reminder that we must continue to fight for gender equality in all areas of life. Let’s use this day to honor the contributions of women around the world, and to continue the fight for a more equitable world.
https://www.internationalwomensday.com/
https://stmdailynews.com/category/science/
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