health and wellness
Geneoscopy Completes Pivotal Colorectal Cancer Trial Enrollment with Diverse Participant Population
Last Updated on May 19, 2024 by Daily News Staff
Trial Enrollment Over Indexes in Traditionally Under-Represented Black Community
ST. LOUIS /PRNewswire/ — Geneoscopy Inc., a life sciences company focused on the development of diagnostic tests for gastrointestinal health, today announced completed enrollment of the CRC-PREVENT pivotal trial for its noninvasive, at-home diagnostic screening test to detect colorectal cancer (CRC) and advanced adenomas in average-risk individuals. Through a decentralized recruitment strategy, Geneoscopy enrolled more than 14,000 individuals across all 48 continental United States, many from traditionally under-represented communities in clinical trials, in terms of gender, race, ethnicity, socioeconomic status, and geography.
Of the participants:
- More than a quarter were racial or ethnic minorities
- 16% were Black or African American – an over-index proportionally based on:
- Just 5% of U.S. clinical trial participants are Black1
- 12% of the U.S. population is Black or African American2
- 3% were Asian
- 7% were Hispanic or Latino
- 16% were Black or African American – an over-index proportionally based on:
According to the American Cancer Society, CRC disproportionately affects the Black community, where the incidence and mortality rates are the highest of any racial/ethnic group in the U.S. In fact, Black people are about 20 percent more likely to be diagnosed with CRC and about 40 percent more likely to die from CRC than most other groups.
“Too often, underserved communities face barriers that exclude them from participating in important clinical trials. Our decentralized recruitment strategy helped mitigate these challenges, resulting in a diverse group of participants that are representative of the individuals that may use our noninvasive CRC screening tool,” said Dr. Erica Barnell, Chief Science Officer and co-founder of Geneoscopy. “We were particularly encouraged to see a substantial number of Black participants in our trial. Unfortunately, these individuals have a greater chance of having and dying from CRC compared with other racial groups, and yet too often, are underrepresented in clinical research. We believe that basing advances in cancer screening and prevention on data from all Americans will build greater confidence in new screening tests and, ultimately, save more lives.”
Complete efficacy and enrollment findings from the trial will be presented later this year. These findings will support a Pre-market Approval application to the U.S. Food and Drug Administration by the end of 2022.
About Colorectal Cancer & Screening
Responsible for over 50,000 deaths annually, colorectal cancer (CRC) is the second leading cause of cancer death in the United States. CRC usually begins as a growth (or polyp) that may or may not develop into cancer over time. Early detection and treatment are crucial to improve survival; however, many newly diagnosed patients suffer from advanced disease. Colonoscopy remains the gold standard for CRC screening in the U.S., yet this method is frequently met with patient aversion due to its required bowel preparation, sedation, and associated discomfort, resulting in low patient compliance. Currently available noninvasive screening methods lack sufficient sensitivity to reliably detect both early-stage CRC and high-risk precancerous lesions, including advanced adenomas which are a precursor in up to 70 percent of CRC cases.
About Geneoscopy Inc.
Geneoscopy Inc. is a life sciences company focused on the development of diagnostic tests for gastrointestinal health. Geneoscopy’s lead diagnostic uses stool-derived eukaryotic RNA (seRNA) to detect colorectal cancer and precancerous adenomas. This device was awarded Breakthrough Device Designation from the U.S. FDA for its ability to reduce morbidity associated with colorectal cancer through advanced adenoma detection. Indicative of its breakthrough status, initial trials suggest that the diagnostic can detect these lesions at a higher rate than that demonstrated by all existing noninvasive screening tests in their respective studies. Visit geneoscopy.com to learn more.
Geneoscopy Inc. Forward-Looking Statements
The information contained in this release includes information about Geneoscopy’s future plans concerning its noninvasive molecular test that can detect colorectal cancer and precancerous adenomas, and as such constitute forward-looking statements. These forward-looking statements are based on the Company’s reasonable estimates of future results or trends. Because forward-looking statements relate to the future, they are subject to inherent uncertainties, risks and changes in circumstances that are difficult to predict and many of which are outside of the Company’s control. Geneoscopy’s actual results and financial condition may differ materially from those indicated in the forward-looking statements. Although the Company believes that its business plans and objectives reflected in or suggested by these forward-looking statements are reasonable, such plans or objectives may not be achieved, and the actual results may differ substantially from the projected results.
SOURCE Geneoscopy Inc.
Last Updated on July 17, 2026 by Daily News Staff
(Family Features) Most people think of heart attacks as debilitating pain in the chest. However, that’s not always the case, especially for women, and missing the signs can be a matter of life and death.
Although heart disease is the leading cause of death among American women, according to the American Heart Association, symptoms are often overlooked or explained away as less worrisome conditions.
“Men and women experience many aspects of life differently, and heart disease is no exception,” said LeAnne Bloedon, MS, RD, vice president of clinical development, Esperion Therapeutics. “Symptoms of a heart attack aren’t as obvious as many women think, and failing to recognize the danger and get help can have catastrophic results.”
One heart disease risk factor, for example, is high LDL cholesterol. Often referred to as a “silent killer,” it doesn’t always present noticeable symptoms. In fact, data suggests women with high LDL cholesterol are not diagnosed or treated as early or aggressively as men, which can put women at an increased risk for cardiovascular events. Understanding how men’s and women’s risk and symptoms differ may help identify and treat a serious heart health problem before it causes lasting damage.
Anatomy Differences
Some differences between men and women are present in the body’s internal systems, including the cardiovascular system. Women generally have smaller hearts and narrower blood vessels.
This can affect heart health in numerous ways, including less efficient stress responses and greater risk of widespread plaque buildup, especially in smaller vessels, called microvasculature, which can pose treatment challenges.
Cholesterol Buildup
Hormones influence aspects of the body’s function, including cholesterol levels. Estrogen, a female sex hormone, raises HDL (good) cholesterol levels. This may be why women tend to have more HDL cholesterol and lower LDL (bad) cholesterol than men, especially before they reach menopause, though inherited high cholesterol can affect women of all ages.
“It’s critical to raise awareness about the importance of measuring LDL cholesterol, diagnosing high cholesterol and treating elevated LDL cholesterol per guidelines and individual patient needs,” Bloedon said.
Risk Factors
While there are shared risk factors for heart disease among men and women (such as obesity, high blood pressure and diabetes), some risk factors disproportionately affect women. For example, uncontrolled cholesterol in women, particularly after menopause, can increase the risk of heart disease and stroke.
Care and Treatment
“While you may not be able to fully prevent heart disease, you can understand the risks and take proactive steps,” Bloedon said. “Commit to a healthy, smoke-free lifestyle. Exercise regularly and eat a well-balanced diet with limits on processed foods, sugar, sodium and alcohol. Take any medications as directed by your health care provider.”
Statins, which reduce the production of cholesterol in the liver and lower cholesterol levels in the bloodstream, are the medications most often prescribed to help manage high LDL cholesterol. While generally well-tolerated, statin intolerance (the inability to take a statin at any dose or the recommended dose) does occur in some patients and is more common in women.
Talk with your doctor about other steps you can take to manage elevated LDL cholesterol levels and learn more about women’s heart health at goredforwomen.org.
Symptoms of Heart Attacks in Women
Women’s experiences with heart disease may be quite different from men.
For example, according to the Heart Disease Foundation, women are likely to be older when they experience a heart attack. They may also attribute symptoms to other conditions, such as diabetes or arthritis.
Further complicating matters, several diseases mimic heart attacks so getting to the root of the problem can be tricky. Women are more apt than men to experience a coronary spasm, coronary dissection or broken heart syndrome.
What to Watch For:
- Like men, women experiencing a heart attack may notice prolonged or reoccurring chest pain or pressure.
- In women, that pain may extend to the arms, back, neck, jaw and stomach.
- Some women experience shortness of breath with no chest pain at all.
- Other symptoms women are more likely to report can be easily mistaken for other conditions. Some of these signs include unexplained fatigue, disruptions to normal sleep patterns, lightheadedness, nausea and cold sweats.
Photo courtesy of Shutterstock
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health and wellness
Heat waves can leave homes dangerously hot – even for young, healthy adults
Heat waves can turn homes into dangerous heat traps—especially during blackouts or in houses without AC—pushing indoor temperatures and humidity into lethal territory even for young, healthy adults, not just the elderly.
Heat waves can leave homes dangerously hot – even for young, healthy adults
Zoltan Nagy, Eindhoven University of Technology
Most people know that heat waves can be dangerous, but what they may not realize is that the heat indoors can be much worse than outdoors.
When the power goes out and air conditioning stops, or in homes without cooling, a house starts to function like a greenhouse during a heat wave. Heat enters through windows and walls and has nowhere to go. Air stagnates.
Within hours, indoor temperatures can climb well above what the thermometer shows outside, especially on upper floors and in rooms with south-facing windows. Over longer periods, especially if temperatures don’t cool off overnight, conditions can become lethal.
Most heat-related deaths occur indoors. When a heat dome sent temperatures soaring in the Pacific Northwest in 2021, 98% of the more than 600 deaths in British Columbia happened inside homes. Washington and Oregon also saw high numbers of deaths in homes that lacked air conditioning.
In Europe, where only 1 in 10 households have air conditioning, heat waves killed an estimated 60,000 people in 2022 and 47,000 in 2023, largely inside buildings never designed for these temperatures.
People of all ages are at risk in heat waves like these. I spent eight years at the University of Texas at Austin studying how buildings respond to extreme heat. In a recent study, my team assessed the heat risk in every single-family home in Austin.
We found that even younger, healthy adults face far more risk than they realize.
How hot is too hot for a human body?
Your body maintains a core temperature of about 98.6 degrees Fahrenheit (37 degrees Celsius). To cool down, it pushes blood to the skin and sweats. But when air temperature is high, that convective cooling weakens. When humidity is also high, sweat cannot evaporate.
If the body has no way to release heat, core temperature rises. If the core temperature increases past about 104 F (40 C), the body’s thermoregulation starts to fail. Past 109 F (42.8 C), death becomes likely.
What makes indoor heat especially dangerous is that it does not let up at night in homes that lack air conditioning. Outdoor temperatures typically drop after sunset, and someone outside can get a few hours of recovery. But a poorly insulated home that has been absorbing heat all day releases that heat slowly, keeping indoor temperatures elevated through the night. A person inside the home never gets a break.
After two or three nights of this, even healthy people start to be at serious risk for heat-related illnesses.
Why homes heat up more than people expect
People tend to underestimate indoor heat for a few reasons.
One is that the thermostat typically sits on one wall in one room. It does not tell what the temperature is in an upstairs bedroom or near a sun-facing window. In older, underinsulated homes, the actual felt temperature can exceed 90 F (32.2 C) even when a thermostat reads 75 F (23.9 C). The hot walls, ceilings and windows can radiate heat directly onto your body.
Another reason is that people assume all homes respond to heat the same way. However, a newer home with double-pane windows and good insulation acts like a thermos, keeping heat out for a longer time. An older home with single-pane windows and cracks in the walls heats up fast.
Two houses on the same street, exposed to the same outdoor conditions, can have completely different temperatures inside. And in a blackout, where neither home has cooling, those differences can become a matter of life and death.
What we found in Austin
Our study combined two datasets. From Austin’s tax appraisal records, we pulled basic property information, such as the year the home was built, the size and the number of stories for each of the city’s 213,000 single-family homes. We then matched each home to the most similar energy simulation models in a U.S. Department of Energy database that contains thousands of detailed, physics-based building energy models representing the U.S. residential building stock.
Using those models, we simulated each building’s indoor temperatures over time during a three-day heat wave and power outage with outdoor temperatures above 110 F (43 C).
We found that 85% of homes got hot enough to pose a significant risk of death for an elderly occupant. But what surprised us was the risk to younger people.
Under today’s climate conditions in Austin, about 15% of homes already have the potential to get hot enough without air conditioning to pose serious heat risks to healthy adults. Under future warming scenarios, that number jumps to as high as 65% if average summer highs reach 104 F (40 C). Further, climate projections for Austin show that heat waves will double in frequency by the end of the century.
We found three types of buildings and accompanying risks:
- Resilient homes, which are newer and well insulated, tended to have temperature and humidity conditions that would be survivable for an elderly occupant throughout the simulated heat wave with blackout.
- Critical-risk buildings, which are mostly older homes, became dangerous almost immediately.
- And then there was the middle group – homes where temperatures rose slowly during the simulated blackout, day by day, possibly giving occupants a false sense of security until it was too late.
Texas has already seen conditions like our case study’s – a heat wave paired with a power outage. In 2024, a derecho knocked out power for nearly 900,000 Houston households while the heat index climbed to 100 F (37.8 C). Seven weeks later, Hurricane Beryl cut power to 2.6 million homes, leaving them without power for over three days, with temperatures over 90 F (32.2 C).
What you can do to stay safe
If you can’t get cooling at home, there are steps you can take that can help.
Move to the lowest floor of your home, where it will be coolest. Close the blinds and curtains on sun-facing windows. Drink water constantly to stay hydrated, which is essential for regulating body temperature.
If you’re facing a blackout, be sure to also check on elderly neighbors, especially those living alone. You can also try to find a public cooling center; many cities now open them during heat emergencies.
Longer term, upgrades such as reflective window film, attic insulation and lighter-colored roofing can reduce how much a home heats up. After the 2021 heat dome, British Columbia’s coroner recommended updating building codes to address heat.
Our own findings point in the same direction: We propose that new homes should be required by building codes to maintain conditions in which at least light physical activity remains possible for all occupants for at least 72 hours during a power outage.
As summers get hotter with climate change and blackouts become more frequent, the risks of people suffering heat illnesses will only continue to rise.
Zoltan Nagy, Professor of Building Services, Eindhoven University of Technology
Heat waves can leave homes dangerously hot – even for young, healthy adults
This article is republished from The Conversation under a Creative Commons license. Read the original article.
💪 Your health journey starts here! Explore the latest health news, fitness tips, wellness trends, and healthy living advice. Share your thoughts in the comments and subscribe to the STM Daily News newsletter to stay informed and inspired every day.
(Feature Impact) Relationships and plumbing have something in common: they can both benefit from practicing smarter bathroom habits. Whether you’re sharing a household with your family, a partner or roommates, good etiquette in these frequently shared spaces can save everyone’s sanity – just like rethinking your flushing routines can save your pipes.
From simple annoyances like leaving the toilet seat up to potentially costly mistakes like clogging your plumbing by flushing the wrong items, a new survey from the Responsible Flushing Alliance (RFA) illuminated a variety of bad habits that cause the most tension in American homes.
In addition to shedding light on these problems, the alliance outlined solutions you can implement at home to restore peace in your restroom. Plus, you can gamify the habit changes to make them more entertaining.
“Our goal is to revolutionize public education by keeping it highly engaging, memorable and fun,” RFA President Lara Wyss said. “We are challenging the public to rethink their everyday habits.”
Get started with these seven tips:
Replace the toilet roll properly
Don’t be the reason someone gets stranded with nothing but a cardboard tube in their moment of need. Keep extra rolls nearby, and when you’re down to the last square of toilet paper, make it a race against the clock to replace it.
Use the (flush) force
An unflushed toilet was listed as the biggest bathroom pet peeve by 37% of survey respondents. To make it fun for the family, introduce a new tradition: before you leave the bathroom, pretend there’s an invisible force field pushing you back to make sure you’ve flushed and are good to go.
Hunt for sink and shower hair
Leaving hair in the drain isn’t just a source of potential plumbing clogs – it’s also an irritant for 35% of respondents. After you shower or style your hair, make it a game to see how many stray strands you can capture and deliver to the trash can.
Clean it and close it
You’ve probably heard jokes about people who leave the toilet seat up, so don’t make yourself the punchline. For a completely un-mockable routine, grab the brush to give the bowl a quick swish after you flush, ensure the seat is down and use an anti-bacterial wipe to leave everything sparkling. You’ll notice cleaning wipes bear the Do Not Flush symbol, which means they go in the trash and never the toilet.
Conquer the counter
Toothpaste and water often splatter all over the place, so to be a polite bathroom roommate, wipe up the mess before it’s even had a chance to dry. Keep cleaning wipes or rags within easy reach and give yourself a 10-second deadline to leave surfaces spotless.
Practice good towel etiquette
Wet towels don’t belong on bathroom floors. If they still have a use or two left in them, banish them back to your towel rack. Otherwise, challenge yourself to a game of laundry basketball, aiming for the hamper.
Don’t flush the un-flushable
According to an RFA survey, half of Americans are still flushing things they know they shouldn’t, like paper towels, feminine hygiene products and non-flushable wipes. Since clearing a clog in your home can cost anywhere from $300-$15,000 or more, the only thing you’ll be draining with habits like these is your wallet.
“Always check wet wipes for the Do Not Flushsymbol and disposal instructions, which helps us protect not only the health of our homes and environment but our relationships, too,” Wyss said.
Visit FlushSmart.org to learn more about good bathroom etiquette, take an interactive quiz and put these tips into practice with a seven-day challenge.
Photo courtesy of Shutterstock (throwing away non-flushable wipe)
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