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How to slow the spread of deadly ‘superbugs’

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Newswise — Harnessing new advances in genomic surveillance technology could help detect the rise of deadly ‘superbugs’ and slow their evolution and spread, improving global health outcomes, a new Australian study suggests.

Antimicrobial resistance occurs when bacteria, viruses, fungi and parasites change over time and no longer respond to the medicines and chemicals we use to kill them. These ‘superbugs’ make infections harder to treat and increase the risk of disease spread, severe illness and death.

Without significant intervention, global annual deaths involving antimicrobial resistance are estimated to reach 10 million by 2050, with low and middle-income countries bearing the highest burden. 

The new study, Genomic surveillance for antimicrobial resistance — a One Health perspective, published in Nature Reviews Genetics, highlights the need for a multifaceted ‘One Health’ approach to the surveillance of antimicrobial resistance in the environment.

The research was led by Distinguished Professor Steven Djordjevic from the Australian Institute for Microbiology and Infection at the University of Technology Sydney, together with researchers from the University of Melbourne and the University of South Australia. 

“Antimicrobial resistance is a complex and global threat requiring large-scale, co-ordinated and cross-disciplinary collaboration to tackle,” said Professor Djordjevic. 

“Understanding the evolution, emergence and spread of antimicrobial resistance within and between humans, animals, plants and natural environments is critical in mitigating the colossal impacts associated with this phenomenon.”

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The use of genomic tracing during the Covid-19 pandemic has provided insight into the potential of genomic technologies to monitor the development and spread of antimicrobial genes and mutations.

“Antimicrobial resistance can occur when microorganisms acquire genetic information, either by mutation, recombination or transfer of antibiotic resistance genes from the bacterial gene pool,” said Professor Erica Donner from the University of South Australia.

“Genomic technologies, combined with AI and machine learning, are powerful platforms for determining resistance trends. They can identify instances where microbes and their genetic material move between different environments, evaluating the impact of intervention strategies.

“The evolution of antimicrobial resistance is a complex process that includes the overuse and misuse of antibiotics, metals and disinfectants in medicine and agriculture, and widely varying standards of water, sanitation and hygiene.”

The paper is a call to action for policymakers, highlighting the need to establish national genomic surveillance programs spanning human health, animal health, agriculture, food and environmental management sectors and to share data at both a national and international level.

“Utilising the technology of microbial genomics in the context of effective cross-sectoral data integration will enhance the understanding of antimicrobial resistance emergence and spread within and across these sectors and identify targeted interventions” said Professor Ben Howden from the University of Melbourne.

The researchers provide practical recommendations to implement genomics-enabled surveillance and mitigation strategies and underscore the need for equitable solutions that allow integration of partners from lower- and middle-income countries. 

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The recommendations include:

  • Establishing a national One Health antimicrobial resistance surveillance programme incorporating genomics
  • Increase antimicrobial resistance awareness and education and foster collaboration
  • Enhancing laboratory capacity in lower and middle-income countries
  • Encouraging research and innovation
  • Strengthening regulation and oversight in agriculture
  • Improving antibiotic stewardship

“The evolutionary nature of antimicrobial resistance makes it a constantly changing and evolving threat. There is no easy solution, but ongoing genomic surveillance can help us better understand and mitigate this global health challenge,” said Professor Djordjevic.

Journal Link: Nature Reviews Genetics

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Connected Communities: Reducing the Impact of Isolation in Rural Areas

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isolation (Family Features) Throughout history, humans’ ability to rely on one another has been crucial to survival. Despite modern developments that help individuals live with minimal human engagement, the human need to connect remains. However, in many parts of America, a trend toward isolation is emerging. Over the past two decades, people are spending more time alone and less time engaging with others in person, according to data from the Office of the U.S. Surgeon General. One segment of Americans at particular risk of social isolation, loneliness and their negative impacts are select populations who live in rural areas. “There is an urgent need to take action and improve mental health in rural America,” said Jeff Winton, dairy farmer and founder and chairman of Rural Minds, a nonprofit mental health advocacy organization that partnered with Pfizer to raise awareness about the physical and mental risks of social isolation. “Challenges to mental health can be inherent in a rural lifestyle, including a belief in self-reliance as a virtue, fear of judgment and difficulty getting an appointment with a limited number of mental health professionals, among others.” Many Americans are increasingly spending more time alone according to the American Time Use Survey. They are increasingly more likely to take meetings, shop, eat and enjoy entertainment at home, making it easier for them to stay within their own four walls and avoid social interactions. Authentic human connection is a basic but often unacknowledged necessity for health, “as essential to survival as food, water and shelter,” according to the U.S. Surgeon General’s Advisory on the Health Effects of Social Connection and Community. Understanding Social Isolation According to the Centers for Disease Control and Prevention (CDC), about one-third of U.S. adults reported feeling lonely and about one-fourth said they don’t have social and emotional support (the basis of social isolation). The concepts of social isolation and loneliness can go hand-in-hand, but the two are actually quite different. Social isolation is defined by an absence of relationships or contact with others. Someone experiencing loneliness may or may not have social connections, but lacks feelings of closeness, support or belonging. Despite the distinction, both can have a negative impact on a person’s mental and even physical health. Several factors can influence a person’s risk for social isolation and loneliness. “Social connection is a dynamic that changes over time,” said Nikki Shaffer, senior director, occupational health and wellness, Pfizer. “Transient feelings of loneliness or solitude may be beneficial because they can serve as motivation to reconnect. However, chronic loneliness (even if someone is not isolated) and isolation (even if someone is not lonely) can represent significant health concerns.” 17384 detail image embed1 Isolation in Rural America Compared to people who live in urban areas, many rural Americans experience higher rates of depression and suicide but are less likely to access mental health care services, according to the “Health Disparities in Rural America: Current Challenges and Future Solutions” study published in “Clinical Advisor.” What’s more, CDC data shows suicide rates among people living in rural areas can be 64-68% higher than those in large urban areas. Rural areas have 20% fewer primary care providers compared to urban areas, according to a report in JAMA, and the Health Resources and Services Administration reports more than 25 million rural Americans, more than half of rural residents, live in mental health professional shortage areas. Among rural counties, 65% lack a psychiatrist. Nearly 30% of rural Americans don’t have internet access in their homes, which complicates the option for telehealth. These figures from Rural Minds exemplify the challenges facing rural America. “Some people in rural communities still don’t understand or accept that mental illness is a disease,” said Winton, who grew up on a rural farm. “Rather, a mental illness can often be viewed as a personal weakness or character flaw. A lot of the stigma around mental illness results in unwarranted shame, which adds to the burden for someone already suffering from mental illness.” Health Impacts of Social Isolation Loneliness is far more than just a bad feeling; it harms both individual and societal health. In fact, loneliness and social isolation can increase the risk for premature death by 26% and 29%, respectively. Lacking social connection can increase the risk for premature death as much as smoking up to 15 cigarettes a day or drinking six alcoholic drinks daily. In addition, poor or insufficient social connection is associated with increased risk of disease, including a 29% increased risk of heart disease and a 32% increased risk of stroke. Social isolation is also associated with increased risk for anxiety, depression and dementia. Additionally, a lack of social connection may increase susceptibility to viruses and respiratory illness. Learn more about the impact of social isolation, especially on residents of rural areas, and the steps you can take to reduce isolation and loneliness by visiting ruralminds.org.

Boost Your Social Connections

Take a proactive approach to combatting social isolation and loneliness with these everyday actions that can promote stronger social ties.
  • Invest time in nurturing your relationships through consistent, frequent and high-quality engagement with others. Take time each day to reach out to a friend or family member.
  • Minimize distractions during conversation to increase the quality of the time you spend with others. For instance, don’t check your phone during meals with friends, important conversations and family time.
  • Seek out opportunities to serve and support others, either by helping your family, co-workers, friends or people in your community or by participating in community service.
  • Be responsive, supportive and practice gratitude. As you practice these behaviors, others are more likely to reciprocate, strengthening social bonds, improving relationship satisfaction and building social capital.
  • Participate in social and community groups such as religious, hobby, fitness, professional and community service organizations to help foster a sense of belonging, meaning and purpose.
  • Seek help during times of struggle with loneliness or isolation by reaching out to a family member, friend, counselor, health care provider or the 988 crisis line.
  Photos courtesy of Shutterstock   collect?v=1&tid=UA 482330 7&cid=1955551e 1975 5e52 0cdb 8516071094cd&sc=start&t=pageview&dl=http%3A%2F%2Ftrack.familyfeatures SOURCE: Rural Minds and Pfizer

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Living with a Bleeding Disorder

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(Family Features) Many people don’t think much about whether their blood is clotting properly. However, when you have a bleeding disorder, a condition that affects the way your body controls clots, it’s no small matter.

According to the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health, abnormal clotting can lead to a host of problems, including excessive bleeding after an injury or during surgery.

About 3 million people in the U.S. have bleeding disorders. Some types, such as hemophilia, are inherited, meaning a person who has it is born with it. Inherited bleeding disorders are caused by certain genes passed down from parents to children. These genes contain instructions for how to make proteins in the blood called clotting factors, which help blood clot. If there is a problem with one of these genes, such as a mutation – a change in the gene’s instructions – the body may make a clotting factor incorrectly or not make it at all.

You can also have what’s called an acquired bleeding disorder, meaning you develop it during your lifetime. Acquired bleeding disorders can be caused by medical conditions, medicines or something unknown. Your risk of developing a bleeding disorder depends on your age, family history, genes, sex, or other medical conditions. If bleeding disorders run in your family, you may have a higher risk of developing or inheriting one.

Symptoms of a bleeding disorder may appear soon after birth or develop later in life and can include:

  • Excessive bleeding or bruising, such as frequent or long nose bleeds (longer than 15 minutes) or frequent or long menstrual periods
  • Petechiae, which are tiny purple, red, or brown spots caused by bleeding under the skin
  • Redness, swelling, stiffness, or pain from bleeding into muscles or joints
  • Blood in urine or stool
  • Excessive umbilical stump bleeding
  • Excessive bleeding during surgery or after trauma

If you believe you, or someone you care for, may have a bleeding disorder, talk to a health care provider. Your provider may make a diagnosis based on symptoms, risk factors, family history, a physical exam, and diagnostic tests. Health care providers typically screen for bleeding disorders only if you have known risk factors or before certain surgeries.

How your bleeding disorder is treated depends on its type. If your disorder causes few or no symptoms, you may not need treatment. If you have symptoms, you may need daily treatment to prevent bleeding episodes, or you may need it only on certain occasions, such as when you have an accident or before a planned surgery.

If you have been diagnosed with a bleeding disorder, it’s important to be proactive about your health and follow your treatment plan. To lower your risk of complications:

  • Receive follow-up care
  • Monitor your condition
  • Adopt healthy lifestyle changes

To learn more about bleeding disorders, visit nhlbi.nih.gov/health/bleeding-disorders.

A Story of Bravery, Balance, and a Bleeding Disorder

There are lots of things that make Mikey White Jr. special. He’s a dedicated athlete. He’s determined, disciplined, and optimistic. He’s also living with hemophilia, a type of bleeding disorder.

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White was diagnosed with hemophilia at age 3 after experiencing several severe bleeding episodes. He had to give up baseball and basketball, his passions, because of the high risk of injuries, but he found competitive swimming – and he’s been breaking records ever since.

“Competitive swimming is a noncontact sport, so it complements my hemophilia while still being an intense and rigorous sport,” White said.

Being an athlete with hemophilia requires support, White admits. He works with his healthcare team and coaching staff to make sure he safely manages his condition and balances it with his training. He hopes his story encourages others living with bleeding disorders to accept and appreciate their bodies the way they are.

“It doesn’t have to be a limitation,” White said.

Photo courtesy of Shutterstock

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SOURCE:
National Heart, Lung, and Blood Institute

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Lifestyle

5 Things Funeral Directors Wish Everyone Knew

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Funeral directors (Family Features) Most people don’t want to think about death – let alone talk about it. When the time comes, families often find themselves overwhelmed, not only by grief but by the many decisions that need to be made quickly. Funeral directors witness this every day. They see the stress and confusion that can come when there is no plan in place and the peace of mind that comes with thoughtful preparation. After consulting funeral directors nationwide, the National Funeral Directors Association (NFDA) uncovered five things they wish families knew before a death occurs.
  1. It’s Never Too Early to Start Planning

While everyone knows death and taxes are inevitable, conversations about death are often avoided.

Simply documenting your wishes and discussing your preferences with your family can alleviate the difficult decisions your loved ones will have to make in the future. Speak with a funeral director to explore the many options for planning a meaningful funeral.

  1. Legal and Financial Details Can Cause Unexpected Issues

Families often don’t realize power of attorney ends at death, meaning a designated person can no longer make decisions or access bank accounts once an individual dies.

To avoid complications, consider adding a trusted loved one to your bank account and ensure life insurance beneficiaries are up to date. Too often, deceased individuals leave minor children, deceased spouses or former partners as beneficiaries, leading to legal and financial challenges.

  1. Final Wishes Shouldn’t Be In Your Will

Many people believe the best place to document their final wishes is in their will. However, wills are often not read until after funeral services take place, making them an unreliable way to communicate last requests. Instead, discuss and document your wishes with family members or a trusted funeral professional who can keep your wishes on file until there is a need.

  1. There Are a Variety of Memorialization Options

End-of-life planning offers more choices than many realize. While burial remains a common preference, cremation is an increasingly popular choice and can even include a viewing and funeral service. Additionally, eco-friendly options, such as alkaline hydrolysis, natural burial and natural organic reduction are becoming more widely available for those seeking green memorialization. In fact, according to NFDA’s 2024 Consumer Awareness and Preferences Study, 68% of respondents expressed interest in green funeral options.

Exploring these possibilities with a funeral professional can help ensure your final arrangements reflect your values, traditions and personal wishes.

  1. Funeral Directors Don’t Just Manage Funerals – They’re Trusted Guides In Honoring Life

Funeral directors play a vital role in helping families create meaningful services that reflect their loved one’s life, values and traditions. Whether planning ahead or facing a recent loss, funeral professionals provide expertise, compassionate care and personalized guidance during one of life’s most difficult moments.

Choosing the right funeral director is an important decision and finding someone who understands your needs can make all the difference in honoring your loved one in a personal and meaningful way. Start the conversation today by talking about end-of-life planning. It isn’t easy, but it’s one of the most important conversations you can have with your loved ones. A little planning today can make a world of difference tomorrow. Use comprehensive resources like RememberingALife.com, which is designed to guide families through every stage of the journey, including planning, funeral options and grief resources. The site offers valuable tools and support, such as the “Find a Funeral Home” tool to connect families with compassionate, local funeral directors and much more.   Photo courtesy of Shutterstock collect?v=1&tid=UA 482330 7&cid=1955551e 1975 5e52 0cdb 8516071094cd&sc=start&t=pageview&dl=http%3A%2F%2Ftrack.familyfeatures SOURCE: National Funeral Directors Association


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