Health

Nicotine dose in a single cigarette blocks estrogen production in women’s brains

A dose of nicotine, equivalent to that found in a single cigarette blocks estrogen production in women’s brains. This may explain several behavioural differences in women who smoke, including why they are more resistant than men to quitting smoking.

Published

2 years ago

October 18, 2022

Daily News Staff

Newswise — A dose of nicotine, equivalent to that found in a single cigarette blocks estrogen production in women’s brains. This may explain several behavioural differences in women who smoke, including why they are more resistant than men to quitting smoking. This work is presented for the first time at the ECNP Congress in Vienna.

Lead researcher, Associate Professor Erika Comasco (Uppsala University, Sweden) said:

“For the first time, we can see that nicotine works to shuts down the estrogen production mechanism in the brain of women. We were surprised to see that this effect could be seen even with a single dose of nicotine, equivalent to just one cigarette, showing how powerful the effects of smoking are on a woman’s brain. This is a newly-discovered effect, and it’s still preliminary work. We’re still not sure what the behavioural or cognitive outcomes are; only that nicotine acts on this area of the brain, however we note that the affected brain system is a target for addictive drugs, such as nicotine”.

The effect has been shown in the thalamus, which is part of the limbic system in the brain. This system is involved in behavioural and emotional responses.

The researchers, from Uppsala University in Sweden, worked with a group of ten healthy female volunteers. The women were given a commercially available nicotine dose intranasally, and at the same time were injected with a radioactive tracer attached to a molecule which binds to the enzyme aromatase: aromatase, also known as estrogen synthase, is the enzyme responsible for the production of estrogen. MRI and PET brain scans enabled the researchers to visualise both the quantity of aromatase, and where it was located in the brain. The researchers found that a single dose moderately reduced the amount of aromatase in the brain.

It has been known for some time that women and men respond differently to nicotine, with women being more resistant to nicotine replacement therapy, and showing a greater tendency than men to relapse when trying to quit smoking. However, the biological basis for these differences is not understood. This is the first time that this inhibitory effect on aromatase production has been shown in humans. The effect on men was not studied.

Professor Comasco continued “This discovery leads us to believe that nicotine’s effect on estrogen production has a significant impact on the brain, but perhaps also on other functions, such as the reproductive system – we don’t know that yet. There are significant differences in the way men and women react to smoking. Women seem to be more resistant to nicotine replacement therapy, they experience more relapses, show greater vulnerability for heritability of smoking, and are at greater risk of developing primary smoking-related illnesses, such as lung cancer and heart attacks. We need now to understand if this action of nicotine on the hormonal system is involved in any of these reactions.

Of course this is a comparatively small group of women, we need a larger sample to confirm these findings. Nevertheless, the message is that nicotine has various effects on the brain, including on the production of sex hormones such as estrogen”.

Commenting, Professor Wim van den Brink, Emeritus Professor of Psychiatry and Addiction at the Academic Medical Center, University of Amsterdam said:

“This is indeed an important first finding. Smoking has many adverse effects in men and in women, but this particular effect of nicotine on the reduction of estrogen production in woman was not known before. It should be noted, however, that tobacco addiction is a complex disorder with many contributing factors. It’s unlikely that this specific effect of nicotine on the thalamus (and the production of estrogen) explains all the observed differences in the development, treatment and outcomes between male and female smokers. It is still a long way from a nicotine induced reduction in estrogen production to a reduced risk of nicotine addiction and negative effects of treatment and relapse in female cigarette smokers, but this work merits further investigation”.

Professor van den Brink was not involved in this work, it is an independent comment.

This work is presented at the 35^th European College of Neuropsychopharmacology annual conference, which takes place in Vienna and online from 15-18 October, see https://www.ecnp.eu/Congress2022/ECNPcongress. Up to 5000 delegates are expected to attend. The ECNP is Europe’s main organisation working in applied neuroscience.

Source: European College of Neuropsychopharmacology

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Health

Sleep Apnea is More Than a Snore

Published

3 days ago

July 23, 2024

Daily News Staff

(Family Features) Snoring throughout the night. Gasping for air suddenly while sleeping. Feeling tired after a night of rest. These aren’t just signs of a poor night’s sleep – they could be symptoms of obstructive sleep apnea.

Sleep apnea is a serious sleep disorder characterized by a repetitive collapse of the airway during sleep. Most people with sleep apnea don’t even know they have it – in fact, 80% of people with sleep apnea in the United States are undiagnosed, according to research published in the “American Journal of Epidemiology.”

Experts from the American Academy of Sleep Medicine (AASM) recommend most adults get at least seven hours of sleep each night without waking frequently. If you have untreated sleep apnea, healthy, uninterrupted sleep can be hard to achieve. When the airway collapses or becomes blocked while you sleep, it causes you to wake briefly – maybe with a snore or gasp for air – to unblock the airway.

Untreated sleep apnea can contribute to long-term health problems, including hypertension (high blood pressure), heart disease, stroke, Type 2 diabetes and depression. Overall quality of life can also suffer. It can lead to a decline in mood, lower work productivity, difficulty concentrating and making decisions and an increased likelihood of getting into a traffic accident due to sleepiness.

The disorder may even affect your family and relationships; snoring or poor sleep due to sleep apnea can keep your family members up at night, affect your mood with others and impact your general decision-making. Consider this additional information about sleep apnea from Count on Sleep, a collaborative awareness program led by the AASM.

Signs and symptoms of OSA:

Snoring or noisy breathing
Stopping breathing while asleep
Waking up gasping or choking
Restless sleep or waking up tired and groggy after a full night’s sleep
Insomnia
Waking up frequently to use the bathroom
Having headaches in the morning
Feeling sleepy or falling asleep during the day
Having difficulty with memory or concentrating
Mood changes or irritability
Drowsy driving

Risk factors for OSA:

Overweight or obesity (BMI of more than 30)
High blood pressure
Neck size of more than 17 inches for men; 16 inches for women
Coronary artery disease (a type of heart disease) or heart attack
Atrial fibrillation or other heart rhythm problems
Congestive heart failure
Type 2 diabetes
Stroke
Daytime sleepiness

If you think you may have undiagnosed sleep apnea, talk to your doctor about your signs, symptoms, risk factors and concerns. If friends or family members exhibit these symptoms, urge them to talk to a doctor.

Your doctor may screen or test you for sleep apnea, which could include an at-home sleep test or sleep study at an accredited sleep center. If diagnosed, treatment options include continuous positive airway pressure (CPAP) therapy, oral appliance, surgery or lifestyle changes.

Learn more about how sleep apnea affects health and take a short quiz to see if you may be at risk at countonsleep.org.

Sleep Apnea Treatments

When followed properly, sleep apnea treatment improves breathing, sleepiness and quality of life. Some people may find the disorder improves through lifestyle changes such as losing weight, sleeping on their side or quitting smoking or drinking alcohol. Most of the time, however, other treatment options are necessary, such as:

CPAP
The most common and recognized treatment for sleep apnea, a CPAP machine provides a steady stream of air to keep your airway open throughout the night.

Oral appliance therapy
Similar to a mouthguard, an oral appliance can be worn at night to prevent the airway from collapsing by moving the jaw forward.

Surgery
If lifestyle changes, CPAP or oral appliance therapy don’t work, there are surgical options to treat sleep apnea. They include upper airway stimulation, which uses an implanted device to stimulate a nerve that controls the tongue, moving it forward while you sleep.

Photos courtesy of Shutterstock

SOURCE:
American Academy of Sleep Medicine

Our Lifestyle section on STM Daily News is a hub of inspiration and practical information, offering a range of articles that touch on various aspects of daily life. From tips on family finances to guides for maintaining health and wellness, we strive to empower our readers with knowledge and resources to enhance their lifestyles. Whether you’re seeking outdoor activity ideas, fashion trends, or travel recommendations, our lifestyle section has got you covered. Visit us today at https://stmdailynews.com/category/lifestyle/ and embark on a journey of discovery and self-improvement.

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Lifestyle

Important Recall Alert: Expanded Produce Recall Due to Listeria Concerns

Published

4 days ago

July 23, 2024

Charles Elliot, Daily News Staff

In a significant public health alert, the Ohio Department of Agriculture (ODA) has announced an expanded recall of fresh produce supplied by Wiers Farm Inc., based in Huron County. This comes amidst growing concerns about potential listeria contamination, prompting vigilance among consumers shopping at select retailers, including Walmart, Aldi, and Kroger stores across Ohio and several other states.

people at supermarket. recall — Photo by Sebastián Mera Jaramillo on Pexels.com

What You Need to Know

On July 22, 2024, Wiers Farm Inc. expanded its voluntary recall to include additional produce items that were packed between July 5 and July 12. While there have been no reported illnesses or consumer complaints to date, the ODA is taking proactive measures to ensure public safety.

Affected Products

The recall includes a variety of retail packaged items and bulk produce sold at various grocery chains. Here’s a comprehensive list of the impacted products:

Retail Packaged Items

Sold at select Walmart stores in multiple states:

Wiers Farm Bagged Poblano – UPC 073064202581 – 16 oz bag
Wiers Farm Bagged Cubanelle – UPC 073064201836 – 16 oz bag
Wiers Farm Bagged Green Beans – UPC 073064200846 – variable weight bag
Wiers Farm Bagged Salad Cucumber – UPC 073064459619 – 2 lb. bag
Wiers Farm Bagged Serrano – UPC 073064201829 – 4 oz bag
Wiers Farm Organic Bell Pepper – UPC 073064201416 – 2 count tray
Wiers Farm Organic Cucumber – UPC 073064201423 – 2 count tray
Wiers Farm Organic Yellow Squash – UPC 073064201447 – 2 count tray
Wiers Farm Organic Zucchini Squash – UPC 073064201430 – 2 count tray

Sold at Aldi stores in Ohio and nearby states:

Freshire Farms Bagged Green Beans – 16 oz bag
Freshire Farms Bagged Jalapenos – 8 oz bag

Bulk Retail Items (sold individually or by the pound)

Anaheim peppers
Cilantro (sold in bunches)
Cubanelle peppers
Whole cucumbers
Green beans
Green Bell Pepper
Habanero peppers
Hungarian Wax peppers
Jalapeno peppers
Mustard Greens (sold in bunches)
Poblano peppers
Serrano peppers
Tomatillos

In Ohio, these bulk items were distributed to Walmart, Kroger, Save-a-Lot, and local food banks in Cleveland and Youngstown.

What Should Consumers Do?

The ODA is urging consumers who may have purchased any of the listed products to discard them immediately. It’s crucial to stay informed, as listeria monocytogenes can lead to serious health issues, particularly in vulnerable populations such as pregnant women, the elderly, and those with weakened immune systems. Symptoms of listeriosis can include fever, muscle aches, and gastrointestinal distress—anyone experiencing these symptoms after consuming the recalled products should seek medical attention promptly.

Commitment to Safety

Wiers Farm Inc. has expressed its dedication to resolving this situation and ensuring the safety of its products. The ODA is actively investigating the matter, a response initiated after potential contamination was flagged during routine testing by the Michigan Department of Agriculture and Rural Development.

Stay Informed

For further inquiries or concerns, consumers can reach out to Wiers Farm at 419-933-2161. It’s essential to stay updated on recalls and food safety alerts to protect your health and the health of your loved ones.

As we navigate through these recalls, let’s remain vigilant and prioritize food safety to ensure a healthy dining experience for everyone. Remember, when in doubt, it’s better to be safe than sorry—check your pantry and fridge today!

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Lifestyle

OFF!® Brand and The Weather Channel Partner to Launch New In-App Mosquito Forecast

Published

2 weeks ago

July 14, 2024

Daily News Staff

The partnership aims to leverage weather data and insights to allow people to get their local OFF!Cast Mosquito Forecast™ as easily as their local weather forecast

ATLANTA and RACINE, Wis. /PRNewswire/ — As summer’s higher heat and humidity nears, people prepare for an influx of mosquitoes. To help individuals and their families better protect themselves from mosquitoes, The Weather Company and its flagship consumer brand, The Weather Channel, has teamed up with OFF!®, America’s #1 trusted Insect Repellent brand in 2024¹, to bring local mosquito forecasts to The Weather Channel app. Launched in the U.S. in 2022, Brazil in 2023, and Canada in 2024, OFF!Cast Mosquito Forecast™ predicts mosquito behavior and populations to help consumers better plan summer activities and optimize their outdoor time this summer.

Off! — Better plan for outdoor time with the OFF!Cast Mosquito Forecast, now available within The Weather Channel app and with improved weather data. Now checking your local mosquito forecast is as easy as checking your local weather forecast.

Through The Weather Company’s newly launched data and insights platform, The Weather Engine™, OFF!® brand is enhancing its OFF!Cast Mosquito Forecast™ from SC Johnson’s Center for Insect Science with weather data and analytics from The Weather Company, the world’s most accurate weather forecaster,² to include a mosquito index in The Weather Channel app, the world’s most downloaded weather app.³

How it works: Helping people become mosquito-ready
The collaboration focuses on combining OFF!® and The Weather Channel teams’ respective expertise to help people live well and enjoy the outdoors.

Incorporating over 15 billion climate data points and real-world mosquito data from 5,000 locations, the OFF!Cast Mosquito Forecast combines entomology research on local mosquito species with detailed weather data inputs to predict mosquito populations and activity levels by ZIP code. Historic activity patterns, varying weather conditions, and weather and climate factors are accounted for when building these regional models.

Now leveraging The Weather Company’s deep meteorological expertise, enhanced datasets include historical and forecast temperature, humidity and precipitation for predicting mosquito sources, as well as forecast conditions that drive day-of mosquito activity.

How to view your OFF!Cast Forecast
By integrating OFF!Cast Mosquito Forecast™ into The Weather Channel app, millions more consumers can now get into a routine of checking their local mosquito and weather forecasts simultaneously across multiple platforms:

For those who already depend on the OFF!Cast Mosquito Forecast™, it continues to be available on OFF.com, but now with improved weather data from The Weather Channel.
The OFF!Cast tool will also be visible in The Weather Channel app’s new experience on iOS. Check out the Daily tab and Outdoor Activity tabs for camping, hiking, golf and gardening for an at-a-glance risk level – low, medium, high, very high, severe – of mosquito activity based on local weather conditions for today and the days ahead.
To know mosquito risk for the area, sign up for weekly forecasts on the OFF.com website or from within the OFF!Cast tool on The Weather Channel properties.
Learn more about mosquitoes and how to avoid them with educational, integrated content across The Weather Channel app and OFF.com.
When weather conditions are ripe for heightened mosquito activity, OFF! will share relevant, informative messaging on The Weather Channel digital properties and beyond.

“Mosquito activity is very dependent on weather patterns,” said Tom Mascari, principal entomologist with SC Johnson’s Center for Insect Science. “Checking the weather and local mosquito forecasts for the week can improve people’s ability to prepare themselves to spend time outdoors.”

What the partnership means: New, expanded mosquito forecasting resources
The Weather Company will now host the OFF!Cast mosquito model for users in the U.S., Brazil and Canada to start within The Weather Engine, a platform that combines proprietary weather data, first-party data and other supporting data sources to create multivariate models and analysis based on AI and 30 different weather variables. The result delivers deeper insights on the impact of weather with neighborhood-level precision to harness weather and scale its use across an enterprise.

“As weather patterns change and increasingly impact the health of both people and businesses, innovative teams like the OFF!® brand are using weather intelligence and factoring changing weather conditions into how they help consumers from the start,” said Sheri Bachstein, CEO of The Weather Company. “This partnership is a natural fit, and the inspired innovation by both companies turned a trove of trusted, scalable data into invaluable insights to activate across a business, helping people understand their mosquito risk and plan ahead for mosquito protection.”

Since 2022, OFF!® brand has been helping people and families plan ahead for mosquitoes with OFF!Cast Mosquito Forecast.™ This color-coded 7-day forecast of mosquito populations uses the SC Johnson Center for Insect Science’s 65 years of entomology expertise to provide consumers with an accurate view of mosquito activity. Similarly, The Weather Company helps people plan ahead to prepare for weather’s impact on their lives, which all starts with having accurate, reliable, actionable weather data.

The purpose-driven collaboration leverages deep content alignment and organic integration of weather data and insights to help people prepare for mosquito activity and stay safe. Check out the OFF!Cast Mosquito Forecast™ from OFF.com and The Weather Channel app for iOS.

ABOUT OFF!

OFF! brand is a pioneer in personal insect repellents for over 65 years. As one of SC Johnson’s leading pest control brands, OFF! is on a mission to make life better for the next generation. In addition to providing protection against mosquitoes, OFF! is a part of SC Johnson’s mission to develop mosquito prevention programs and supports scientific studies on mosquitoes that help make a difference in millions of lives. OFF! is proud to create products with proven effectiveness that repel mosquitoes, ticks and biting flies so families can have a trusted line of protection. No matter the activity or time outdoors, there is an OFF! product for every occasion. Ranging in both personal and area repellents, OFF! product offerings include: OFF! Deep Woods®, OFF! Clean Feel, OFF! Kids, OFF! FamilyCare, OFF! Defense, OFF! Botanicals®, OFF! Active, OFF! Backyard or OFF! products should always be used as directed. Effectiveness against pests differs by product and each OFF! product label should be read and followed carefully. Learn more at OFF.com.

ABOUT SC JOHNSON
Founded in 1886 and headquartered in Racine, Wisconsin USA, SC Johnson believes that a more sustainable, healthier and transparent world that inspires people and creates opportunities isn’t just possible – it’s our responsibility.

A heritage of innovation and bold, transparent decisions is why our high-quality products and iconic brands – including OFF!® Raid®, Glade®, Windex®, Scrubbing Bubbles®, Ziploc®, Mrs. Meyer’s Clean Day®, method®, Autan®, Baygon®, Mr Muscle®, Duck®, Lysoform® and more – are in homes, schools and businesses in virtually every country worldwide.

As a global, purpose-led company, we are committed to making the world a better place today and for future generations. That means relentlessly bringing our expertise in science, innovation and partnerships to bear on some of the world’s most pressing environmental and health issues like reducing plastic waste and helping to eradicate malaria. Around the world, we use our resources to unlock greater economic and educational opportunities for people and communities where access may be limited, but curiosity and potential are limitless.

See how SC Johnson is a Family Company At Work For a Better World by visiting scjohnson.com or joining us on Facebook, Twitter, LinkedIn, Instagram and YouTube.

About The Weather Company
The Weather Company helps people and businesses around the world make more informed decisions and take action in the face of weather. With its deep industry expertise and highly accurate, high-volume weather data combined with advanced technology and AI, The Weather Company provides insights and solutions that harness the power of weather in a scalable, privacy-forward way. The world’s most accurate forecaster, the company serves hundreds of enterprise customers across media, advertising, aviation and more, and is trusted by hundreds of millions of monthly active users via digital properties from The Weather Channel (weather.com) and Weather Underground (wunderground.com). For more, visit weathercompany.com.

¹ Voted most trusted Insect Repellent (for Use on Body) brand by American shoppers based on the 2024 BrandSpark® American Trust Study. For details visit www.BrandSparkMostTrusted.com
² ForecastWatch, Global and Regional Weather Forecast Accuracy Overview, 2017-2022, https://forecastwatch.com/AccuracyOverview2017-2022, commissioned by The Weather Company.
³ According to data.ai Intelligence, The Weather Channel has been the world’s most-downloaded weather app across Apple’s App Store and the Google Play store beginning on July 4, 2010 and into 2023.

SOURCE The Weather Company