Lifestyle
Scientists Identify Unique Breast Cancer Cells That Control Their Ability to Proliferate and Colonize the Lungs
These cells can also trigger their own dormancy, allowing them to evade certain therapies
Last Updated on November 9, 2024 by Daily News Staff
These cells can also trigger their own dormancy, allowing them to evade certain therapies
Newswise — New York, NY (September 20, 2022) — Scientists from The Tisch Cancer Institute have uncovered a mechanism by which certain breast cancer cells regulate their own metastases, fuel dissemination from the original tumor site, and determine routes to invade distant organs such as the lungs, according to a study published in Cell Reports in September.
For the first time, scientists have identified a type of cancer cell in triple negative breast tumors, which is highly efficient in invading and colonizing distant organs but slow their growth upon colonization. These cells have a hallmark of slowed production of a protein called srGAP1, which is usually attributed to cancer growth.
Scientists also found in animal models that these unique cells trigger a phenomenon that keeps them in a dormant state in distant organs such as the lungs. This is an important finding because cancer cells have to efficiently survive at distant sites, and staying in this “asleep” existence allows these cells to evade therapies that target cancer cells’ normal rapid growth. Cells that are missed could later become metastatic.
“Our findings emphasize the importance of considering phenotypic changes that could occur when treating cancer cells with therapeutic strategies that target proliferating cells such as chemotherapy,” said Jose Javier Bravo-Cordero, PhD, Associate Professor of Medicine (Hematology and Medical Oncology) at The Tisch Cancer Institute at Mount Sinai. “While these treatment regimens target dividing cells, they may also be selecting for more invasive tumor cells. Our studies suggest that more selective therapeutic strategies combining treatments against both dividing cells and invasive dormant cells may be necessary to prevent metastatic disease.”
To conduct this study, researchers used high-resolution in vivo imaging to visualize extravasation, the process of tumor cells exiting the blood vessels to enter a target tissue. This event was observed in real time, revealing with unprecedented detail the early stages of tumor extravasation. The microscopy studies revealed that after these tumor cells invade the lungs, they enter into a dormant state by secreting the protein TGFβ2. The studies also showed that interfering with that protein can block tumor cell invasion into the lungs.
Partners who contributed to this work include Stony Brook University, University of Illinois at Chicago, Janelia Research Campus at Howard Hughes Medical Institute and University of California at Berkeley.
About the Mount Sinai Health System
Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 43,000 employees working across eight hospitals, over 400 outpatient practices, nearly 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it.
Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes approximately 7,300 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report‘s Best Hospitals, receiving high “Honor Roll” status, and are highly ranked: No. 1 in Geriatrics and top 20 in Cardiology/Heart Surgery, Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report’s “Best Children’s Hospitals” ranks Mount Sinai Kravis Children’s Hospital among the country’s best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is one of three medical schools that have earned distinction by multiple indicators: It is consistently ranked in the top 20 by U.S. News & World Report‘s “Best Medical Schools,” aligned with a U.S. News & World Report “Honor Roll” Hospital, and top 20 in the nation for National Institutes of Health funding and top 5 in the nation for numerous basic and clinical research areas. Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.
For more information, visit https://www.mountsinai.org or find Mount Sinai on Facebook, Twitter and YouTube.
Our Lifestyle section on STM Daily News is a hub of inspiration and practical information, offering a range of articles that touch on various aspects of daily life. From tips on family finances to guides for maintaining health and wellness, we strive to empower our readers with knowledge and resources to enhance their lifestyles. Whether you’re seeking outdoor activity ideas, fashion trends, or travel recommendations, our lifestyle section has got you covered. Visit us today at https://stmdailynews.com/category/lifestyle/ and embark on a journey of discovery and self-improvement.
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Community
Arizona Scholarships 2026: $1,500 Awards + Free ACF Virtual Workshops
Arizona scholarships 2026: Arizona scholarships are open through ACF: one application for 160+ awards, plus ARAC’s $1,500 Ashby-Herring scholarships due April 6, 2026.
Last Updated on March 11, 2026 by Daily News Staff
Arizona Scholarships 2026: $1,500 Awards + Free ACF Virtual Workshops
Scholarship season moves fast, and for a lot of Arizona families, the hardest part isn’t writing the essay or gathering transcripts—it’s simply finding the right opportunities in time.
The Archer Ragsdale Arizona Chapter (ARAC), Tuskegee Airmen, Inc. is encouraging students and the community to take advantage of scholarship resources through the Arizona Community Foundation (ACF), including an easy online application that can match applicants with 160+ scholarships—plus virtual workshops where students can get help directly from ACF’s scholarship team.
Whether you’re a high school senior, a current college student, or an adult re-entry student, ACF’s scholarship portal is designed to meet people where they are.
The Big Picture: One Application, 160+ Scholarships
According to the flyer, ACF awarded $6.3 million in scholarships last year, with over 160 scholarships available through a single, easy application.
- Application opens: January 1
- Most deadlines: March and April
- Where to start: https://azfoundation.org/scholarships
- ACF scholarship email: scholarship@azfoundation.org
What to watch for: Even if a student is only targeting one scholarship, completing the ACF application can surface additional matches they didn’t know existed.
ARAC Tuskegee Airmen Scholarship: Ashby-Herring Scholarships ($1,500) — Deadline April 6, 2026
ARAC (Tuskegee Airmen, Inc.) awards two or more scholarships to deserving Arizona students who are college-bound. The flyer highlights the Ashby-Herring scholarships, named in honor of late founding ARAC members who were original Tuskegee Airmen.
Award: Two Ashby-Herring scholarships (each $1,500)
Deadline:April 6, 2026
Apply here:https://www.azfoundation.org/archer-ragsdale
Eligibility:
- Graduating high school senior from Arizona
- Attending a 2-year or 4-year college/university
- African-American
- 3.0 GPA or higher
- Demonstrated financial need
Free Virtual Workshops (Zoom): Get Help With Your Application
If you’ve ever watched a student stall out halfway through an application, these workshops are a smart fix: they’re designed so applicants can work on their scholarship application with support from ACF’s scholarship team.
Workshop dates (Zoom):
- February 12, 2026 — 4:00 to 5:00 p.m.
- March 5, 2026 — 4:00 to 5:00 p.m.
- March 26 — 4:00 to 5:00 p.m. (date listed on flyer; confirm year when registering)
Register here:https://acf.cventevents.com/acfscholarships2026
View the flyer here: https://stmdailynews.com/wp-content/uploads/2026/03/Deadline-updated-12.29.2025-Archer-Ragsdale-Flyer-FINAL.pdf
Download Flyer (PDF)
What to watch for: Register for the dates you can attend and come prepared with what you already have (basic info, activities list, questions). One hour of guided progress can save days of procrastination.
Why This Matters (and Why Sharing Helps)
The Tuskegee Airmen legacy is rooted in excellence, discipline, and breaking barriers—and scholarships tied to that legacy are meant to elevate futures for the next generation.
If you’re a parent, teacher, coach, mentor, or neighbor, consider this your nudge: forward the link, post it in a group chat, or share it with a student who might qualify. Deadlines hit quickly, and the easiest scholarship to win is often the one you actually apply for.
View the press release: https://stmdailynews.com/wp-content/uploads/2026/03/FOR-IMMEDIATE-RELEASE.pdf
Related Links:
- https://azfoundation.org/scholarships
- https://acf.cventevents.com/acfscholarships2026
- https://www.azfoundation.org/archer-ragsdale
College Life
College isn’t just classes and credits — it’s learning how to manage your time, money, health, and relationships while you build a future that actually fits. In our College Life coverage, STM Daily News shares practical, real-world guides for students and families: campus living tips, study and productivity habits, career prep, budgeting basics, mental wellness check-ins, and smart ways to make the most of college in Arizona and beyond.
Expect quick reads, useful takeaways, and “what to do next” advice — whether you’re a first-year student, a transfer, or heading back to school.
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home gardening
Start Planning Now for a Thriving Spring Garden
Winter offers an ideal time to plan for a successful spring garden. Assess your current space, research planting ideas, and design an efficient layout. Enhance soil health with compost, start seeds indoors for stronger plants, and organize tools to ensure readiness for the growing season. Prepare now for a thriving garden.
Last Updated on March 11, 2026 by Daily News Staff
Start Planning Now for a Thriving Spring Garden
(Family Features) While winter weather puts outdoor gardening on pause in most parts of the country, the colder months offer a perfect opportunity to begin preparing for a lush garden come springtime.
With a little creativity, and some extra time spent creating a plan, you can set yourself on a path toward success before the growing season even begins.
Assess Your Space and Research Ideas
Evaluate your current garden, taking note of what worked well last season and where improvements can be made. Use this downtime to sketch an updated layout, research companion plants and decide which fruits, vegetables or flowers you want to grow next based on what did (or didn’t) work last spring.
Build an Updated Blueprint
Winter is the ideal time to upgrade your garden design and make tweaks for efficiency. Use the offseason to consider crop rotation patterns for optimal soil health as well as ways to maximize your space such as raised beds, trellises or containers. You can also make a list of materials needed for any new features you may be adding, such as an irrigation system, and map out their placement so you’re ready to build as soon as the weather allows.
Nourish the Soil
Even if the ground is frozen, you can prepare your garden beds by adding compost, leaves or organic matter in late winter, ensuring nutrients are available when spring arrives. Also remember to test your soil’s pH level now, which can help guide your fertilization plan.
Start Seeds Indoors
If you’re eager to get your hands dirty, consider starting your seeds indoors. Early seed starting gives plants a head start, allowing you to transplant stronger seedlings outdoors when temperatures warm.
Get Organized
Use the slower pace of winter to clean and sharpen your garden tools, sort through leftover seeds and make a supply checklist so you’re ready to dig in when warmer days arrive.
Find more advice to get your garden ready to burst to life in spring at eLivingtoday.com.
Photo courtesy of Shutterstock
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pets
‘Pawty’ Tips for Celebrating Your Pets
People spent $147 billion on pets last year. Dog birthday parties are trending. Tips: spacious play areas, engaging activities, personalized details, insect control, themed snacks, and friendly guest lists.
Last Updated on March 11, 2026 by Daily News Staff
(Family Features) It’s no secret – people love their pets. Last year alone, people spent $147 billion on their pets, according to the American Pet Products Association, which included throwing what has turned into one of the hottest invites on social media these days: pet parties. There have been more than 1 million posts using #DogBirthday to show off these celebrations.
With dog birthday parties and adoptions being celebrated across the country, entertainment ideas can be borrowed from regular parties – but the special guests will need to be taken into account when planning a party designed for pooches.
Plan a pup party with these tips from Mindy Weiss, a best-selling author and event planner for notable celebrity clients.
Plan for a Place to Play
When hosting a dog party, make sure there is plenty of space for the pups to play, whether it’s a fenced yard or a large indoor area. The more room they have to zoom around, the happier (and safer) everyone will be.
Keep the dogs entertained with activities like a ball pit, kiddie pool or basket of tennis balls. If you’re feeling ambitious, hide treats around the yard for the dogs to find. It’s a great way to keep their tails wagging and their minds engaged while they have a blast.
Personalize Party Details
Subtle accents can elevate any party. Pick a theme that can come to life through the decor and details, such as a “retro dog disco,” where both the humans and dogs can dress up. Small touches like personalized dog tags or themed water bowls and dog treats can make any pet party a memorable event.
Avoid Party Crashers
When guests and dogs are moving indoors and out, alongside (often messy) food, flying insects will likely try to sneak their way in. That’s why no party is complete without this top pet party essential – the STEM Attracts and Traps Flying Insects Light Trap. It is people- and pet-friendly when used as directed, insecticide-free and uses a soft UV light to attract flying insects with a dual-sided, refillable cartridge to trap them. It can also be used throughout the home in kitchens, garages, around pet feeding stations and more.
Remember the Pup Parents
Don’t forget about the humans. While the dogs are the guests of honor, the humans might also enjoy a nibble. Consider staying on theme with mini hot dogs, bone-shaped pretzels or “pup pop” cake pops.
Bring on the Besties
Just like humans have best friends, dogs do too. Before sending out invites, make sure the guest list includes dogs that are friendly with your pup and play well with others. A little pre-party check can help ensure everyone has a good time.
Learn more at stemforbugs.com.
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Our Lifestyle section on STM Daily News is a hub of inspiration and practical information, offering a range of articles that touch on various aspects of daily life. From tips on family finances to guides for maintaining health and wellness, we strive to empower our readers with knowledge and resources to enhance their lifestyles. Whether you’re seeking outdoor activity ideas, fashion trends, or travel recommendations, our lifestyle section has got you covered. Visit us today at https://stmdailynews.com/category/lifestyle/ and embark on a journey of discovery and self-improvement.
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