Lifestyle
Scientists Identify Unique Breast Cancer Cells That Control Their Ability to Proliferate and Colonize the Lungs
These cells can also trigger their own dormancy, allowing them to evade certain therapies
Last Updated on November 9, 2024 by Daily News Staff
These cells can also trigger their own dormancy, allowing them to evade certain therapies
Newswise — New York, NY (September 20, 2022) — Scientists from The Tisch Cancer Institute have uncovered a mechanism by which certain breast cancer cells regulate their own metastases, fuel dissemination from the original tumor site, and determine routes to invade distant organs such as the lungs, according to a study published in Cell Reports in September.
For the first time, scientists have identified a type of cancer cell in triple negative breast tumors, which is highly efficient in invading and colonizing distant organs but slow their growth upon colonization. These cells have a hallmark of slowed production of a protein called srGAP1, which is usually attributed to cancer growth.
Scientists also found in animal models that these unique cells trigger a phenomenon that keeps them in a dormant state in distant organs such as the lungs. This is an important finding because cancer cells have to efficiently survive at distant sites, and staying in this “asleep” existence allows these cells to evade therapies that target cancer cells’ normal rapid growth. Cells that are missed could later become metastatic.
“Our findings emphasize the importance of considering phenotypic changes that could occur when treating cancer cells with therapeutic strategies that target proliferating cells such as chemotherapy,” said Jose Javier Bravo-Cordero, PhD, Associate Professor of Medicine (Hematology and Medical Oncology) at The Tisch Cancer Institute at Mount Sinai. “While these treatment regimens target dividing cells, they may also be selecting for more invasive tumor cells. Our studies suggest that more selective therapeutic strategies combining treatments against both dividing cells and invasive dormant cells may be necessary to prevent metastatic disease.”
To conduct this study, researchers used high-resolution in vivo imaging to visualize extravasation, the process of tumor cells exiting the blood vessels to enter a target tissue. This event was observed in real time, revealing with unprecedented detail the early stages of tumor extravasation. The microscopy studies revealed that after these tumor cells invade the lungs, they enter into a dormant state by secreting the protein TGFβ2. The studies also showed that interfering with that protein can block tumor cell invasion into the lungs.
Partners who contributed to this work include Stony Brook University, University of Illinois at Chicago, Janelia Research Campus at Howard Hughes Medical Institute and University of California at Berkeley.
About the Mount Sinai Health System
Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 43,000 employees working across eight hospitals, over 400 outpatient practices, nearly 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it.
Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes approximately 7,300 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report‘s Best Hospitals, receiving high “Honor Roll” status, and are highly ranked: No. 1 in Geriatrics and top 20 in Cardiology/Heart Surgery, Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report’s “Best Children’s Hospitals” ranks Mount Sinai Kravis Children’s Hospital among the country’s best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is one of three medical schools that have earned distinction by multiple indicators: It is consistently ranked in the top 20 by U.S. News & World Report‘s “Best Medical Schools,” aligned with a U.S. News & World Report “Honor Roll” Hospital, and top 20 in the nation for National Institutes of Health funding and top 5 in the nation for numerous basic and clinical research areas. Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.
For more information, visit https://www.mountsinai.org or find Mount Sinai on Facebook, Twitter and YouTube.
Our Lifestyle section on STM Daily News is a hub of inspiration and practical information, offering a range of articles that touch on various aspects of daily life. From tips on family finances to guides for maintaining health and wellness, we strive to empower our readers with knowledge and resources to enhance their lifestyles. Whether you’re seeking outdoor activity ideas, fashion trends, or travel recommendations, our lifestyle section has got you covered. Visit us today at https://stmdailynews.com/category/lifestyle/ and embark on a journey of discovery and self-improvement.
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Family
5 Tips to Pull Off Holiday Hosting
With stay-at-home holidays a thing of the past for many families, they’re now busy preparing for full-blown celebrations. The return of traditional festivities brings seemingly never-ending to-do lists and pressure to be the perfect host.
Last Updated on December 17, 2025 by Daily News Staff
(Family Features) With stay-at-home holidays a thing of the past for many families, they’re now busy preparing for full-blown celebrations. The return of traditional festivities brings seemingly never-ending to-do lists and pressure to be the perfect host.
From mastering a mouthwatering menu and donning your home with decadent decor to ensuring guests enjoy the evening to the fullest, hosting duties bring plenty of responsibilities. This year, though, you can avoid those anxious feelings with some preparation ahead of the big day.
To help pull off a sensational seasonal soiree, consider these tips from the entertaining experts at Sun-Maid to make the holidays brighter and more manageable so you can navigate the stresses of hosting.
Invite Others to Share Favorite Traditions
Especially with stay-at-home holidays in recent years, some friends and family members may have developed their own special traditions from new recipes and foods to seasonal games and activities. Inviting your guests to bring or share something that represents their favorite part of the holidays can help everyone feel welcome.
Take Time for Yourself
Remember to make time for yourself so you can enjoy the fruits of your labor right alongside guests. The busyness of this time of year can add stress but reflecting on the true meaning of the season and reveling in your favorite parts of the holidays can help you avoid feeling overwhelmed.
Add New Ingredients to Your Menu
While pairing this year’s turkey or ham with the classics provides comfort and calls to mind holiday memories of the past, cooking with new ingredients and adding fresh recipes to the menu can put a fun spin on the season and maybe even create your own traditions to carry forward.
For example, baking with an option like Sun-Maid Raisins provides a whole fruit option with zero grams of added sugars per 1/4-cup serving. They’re an easy, better-for-you substitution to reduce overall sugar intake without compromising flavor or texture when compared with dried cranberries, which contain 27 grams of added sugars per 1/4-cup serving. The natural sugars of raisins make them a versatile, useful addition to a wide variety of holiday-worthy dishes.
Hop On Hot Food Trends
One of this year’s most popular trends in the kitchen is food boards, a fun and easy way to elevate flavor while incorporating favorites like cured meats, cold cuts, cheese slices and cubes, dips, nuts and more. Plus, you can keep your board balanced with nutritious items like vegetables and fruit, such as raisins, which provide sweet flavor without the added sugars.
A Time for Truce
Gathering for the holidays is about coming together with loved ones, family, friends and neighbors – and pulling it off means catering to everyone’s needs and wants. It’s a time for compromises and truces. To help add a little extra spark this year, try incorporating a theme to the party or coordinate fun activities and games that can be enjoyed by all. For example, holiday-themed charades, a seasonal “name that tune” game and gift exchanges all give guests ways to get in on the excitement.
To find more holiday entertaining inspiration and recipe ideas, visit SunMaid.com/PullOffTheHolidays .
Photos courtesy of Getty Images
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Sun-Maid Raisins
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Food and Beverage
Unwrap the Holidays: Whataburger Launches 12 Days of Whatacheer With Daily App Deals
Celebrate the holidays with Whataburger’s 12 Days of Whatacheer! Discover daily in-app deals, exclusive to Rewards members, from December 12–23. Unwrap new menu favorites, BOGO offers, and festive savings—only on the Whataburger App.
12 Days of Whatacheer: Festive Deals for Rewards Members
How It Works
- Who: Whataburger Rewards members (sign up in the app if you’re not already!)
- When: December 12–23, with a new offer every day
- How: Open the Whataburger App, claim the day’s deal, and enjoy with your next order
Holiday-themed graphic reading ‘12 Days of WhataCheer’ on a red background with white dots. Below the text are images of Whataburger menu items: a Cinnamon Roll, Onion Rings, a Whataburger, a Whatafresher, a Honey Butter Chicken Biscuit, and a Strawberry Shake.
Why Join the Whataburger Rewards Fun?
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Recipe of the Week
Holiday Desserts Just Got a Dairy-Forward Upgrade
Holiday Desserts: From festive cookies to indulgent dips, these delicious desserts bring people together to create memories that will last a lifetime. If you’re looking to impress guests, Santa Cookies are the ultimate treat. For a unique twist, try Gingerbread Dip, featuring vanilla Greek yogurt made with 100% grass-fed organic milk.
Last Updated on December 17, 2025 by Rod Washington
Holiday Desserts Just Got a Dairy-Forward Upgrade
(Family Features) Holiday desserts set the stage for seasonal delight and add a touch of joy to gatherings. From festive cookies to indulgent dips, these delicious desserts bring people together to create memories that will last a lifetime. If you’re looking to impress guests, Santa Cookies are the ultimate treat. Made with Maple Hill Salted Butter, they’re rich, soft and full of festive spirit. For a unique twist, try Gingerbread Dip, featuring vanilla Greek yogurt made with 100% grass-fed organic milk. Whether you’re hosting or deciding what to bring to the potluck, Maple Hill’s 100% grass-fed organic dairy makes it easy to whip up desserts that are as wholesome as they are delicious. Rich in nutrients and free from GMOs, hormones and antibiotics, each product comes from farms that prioritize regenerative practices as nature intended. With a 40% healthier ratio of omega 3:6 and 40% higher levels of CLA fatty acids compared to traditional organic dairy, you can feel good about sweet treats at the holiday table. To find more recipes, visit MapleHill.com.
Santa Cookies
Yield: 14 cookies- 1 cup (2 sticks) Maple Hill Salted Butter, at room temperature
- 1/2 cup brown sugar
- 1 tablespoon vanilla extract
- 1 large egg, at room temperature
- 2 1/4 cups all-purpose flour
- 1/4 teaspoon salt
- 1 teaspoon red food coloring
- mini chocolate chips
- mini red chocolate-coated candies
- 1/2 cup (1 stick) Maple Hill Salted Butter, at room temperature
- 4 ounces cream cheese, at room temperature
- 1 teaspoon vanilla extract
- 2 1/2 cups powdered sugar
- Preheat oven to 350 F and line two baking sheets with parchment paper.
- In large mixing bowl, beat butter, sugar and vanilla until light and fluffy. Add egg and beat until combined. Add flour and salt; mix until dough begins to form ball.
- Remove 1 cup dough and set aside. Add red food coloring to remaining dough.
- From red cookie dough, make one 1-inch ball and five 1/2-inch balls. From plain cookie dough, make one 3/4-inch ball and five 1/4-inch balls.
- On prepared baking sheet, place red 1-inch ball and gently flatten until 1/2-inch thick. Attach four red 1/2-inch balls for arms and legs. Attach plain 3/4-inch ball for head and gently flatten until 1/2-inch thick. Attach plain 1/4-inch balls for hands and feet. Shape remaining red 1/2-inch ball into triangle for hat and attach. Repeat with remaining dough, arranging cookies 2 inches apart on baking sheet. Add chocolate candies for eyes and buttons.
- Bake 12-15 minutes, or until lightly golden.
- To make frosting: In medium bowl, beat butter and cream cheese until light and fluffy, about 3 minutes. Add vanilla and powdered sugar; mix until combined.
- To decorate: Place half of frosting in piping bag with small tip to line Santa’s arms and legs. Place other half in second piping bag with small star tip to add Santa’s beard, hat and hands. Put small dot of icing between eyes and beard and place red mini chocolate-coated candy on face for nose.
Gingerbread Dip
Servings: 8-12- 4 ounces cream cheese, at room temperature
- 1/4 cup brown sugar
- 1/4 cup powdered sugar
- 3 tablespoons molasses
- 1 container (16 ounces) Maple Hill Vanilla Greek Yogurt
- 1 teaspoon ground ginger
- 1 teaspoon ground cinnamon
- 1 teaspoon ground nutmeg
- 2 cups whipped cream
- graham crackers
- fruit
- In medium bowl using electric mixer on medium speed, beat cream cheese and sugars about 1 minute. Add molasses and mix until combined.
- Add Greek yogurt, ginger, cinnamon and nutmeg; beat until combined. Fold in whipped cream and mix until fully incorporated. Refrigerate 1 hour before serving or overnight.
- Serve with graham crackers and fruit.
At our core, we at STM Daily News, strive to keep you informed and inspired with the freshest content on all things food and beverage. From mouthwatering recipes to intriguing articles, we’re here to satisfy your appetite for culinary knowledge.
Visit our Food & Drink section to get the latest on Foodie News and recipes, offering a delightful blend of culinary inspiration and gastronomic trends to elevate your dining experience. https://stmdailynews.com/food-and-drink/
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