health and wellness
Scientists uncover how fermented-food bacteria can guard against depression, anxiety
Last Updated on November 9, 2024 by Daily News Staff
Newswise — University of Virginia School of Medicine researchers have discovered how Lactobacillus, a bacterium found in fermented foods and yogurt, helps the body manage stress and may help prevent depression and anxiety. The findings open the door to new therapies to treat anxiety, depression and other mental-health conditions.
The new research from UVA’s Alban Gaultier, Ph.D., and collaborators is notable because it pinpoints the role of Lactobacillus, separating it out from all the other microorganisms that naturally live in and on our bodies. These organisms are collectively known as the microbiota, and scientists have increasingly sought to target them to battle disease and improve our health. UVA’s new research represents a major step forward in that effort, providing scientists an innovative new approach to understand the role of individual microbes that could facilitate the development of new treatments and cures for a wide variety of diseases, both mental and physical.
“Our discovery illuminates how gut-resident Lactobacillus influences mood disorders, by tuning the immune system,” said Gaultier, of UVA’s Department of Neuroscience, the Center for Brain Immunology and Glia (BIG Center) and the TransUniversity Microbiome Initiative. “Our research could pave the way towards discovering much-needed therapeutics for anxiety and depression.”
The Microbiota and Depression
Our guts are naturally home to countless bacteria, fungi, and viruses. There are more microorganisms living in and on us than there are cells in our bodies. That may sound disgusting, even alarming, but scientists have increasingly realized that these tiny organisms and their endless interactions are critical to our immune systems’ health, our mental health, and many other facets of our well-being. Disruptions of the microbiota, whether from illness, poor diet, or other causes, are known to contribute to many diseases and even help cancer spread. So, researchers have been hugely excited in recent years about the potential to battle diseases by targeting the microbiota.
Early attempts to manipulate the gut flora with beneficial bacteria, called probiotics, have produced mixed results. A big part of the problem has been the sheer complexity of the microbiome. It’s estimated that there are 39 trillion microorganisms inside each of us, so trying to understand what specific bacteria or fungi do – much less how they interact with all the other microorganisms and their host – can be like trying to count grains of sand on the beach.
Gaultier and his team took an innovative approach to hone in on Lactobacilli in specific. Prior research from Gaultier’s lab suggested that the bacteria could reverse depression in lab mice – a hugely promising finding. But the researchers needed to understand how.
“We were aware from our prior research that Lactobacillus was beneficial in improving mood disorders and was lost following psychological stress, but the underlying reasons remained unclear, primarily due to the technical challenges associated with studying the microbiome.”
Gaultier and his team decided to continue their depression research using a collection of bacteria, known as Altered Schaedler Flora, which includes two strains of Lactobacillus and six other bacterial strains. With this rarely used bacterial community, the team was able to create mice both with and without Lactobacillus,circumventing the need for antibiotics.
Sure enough, the Altered Schaedler Flora produced exciting results. Gaultier and his colleagues were able to explain exactly how Lactobacilli influence behavior, and how a lack of the bacteria can worsen depression and anxiety. Lactobacilli in the family Lactobaccillacea, they found, maintain the levels of an immune mediator called interferon gamma that regulates the body’s response to stress and helps stave off depression.
Armed with this information, researchers are poised to develop new ways to prevent and treat depression and other mental-health conditions in which Lactobacillus plays an important role. For example, patients struggling with (or at risk for) depression might one day take specially formulated probiotic supplements that will optimize their levels of helpful Lactobacillus.
“With these results in hand, we have new tools to optimize the development of probiotics, which should speed up discoveries for novel therapies,” said researcher Andrea R. Merchak, Ph.D. “Most importantly, we can now explore how maintaining a healthy level of Lactobacillus and/or interferon gamma could be investigated to prevent and treat anxiety and depression.”
Findings Published
The UVA scientists have published their findings in the journal Brain Behavior and Immunity. The research team consisted of Merchak, Samuel Wachamo, Lucille C. Brown, Alisha Thakur, Brett Moreau, Ryan M. Brown, Courtney Rivet-Noor, Tula Raghavan and Gaultier. The researchers have no financial interest in the work.
The work was supported by the National Institutes of Health, grants T32 NS115657, T32 GM008136, F31 AI174782, T32 GM007267 and T32 GM148379; the Owens Family Foundation; the Miller Family; the UVA TransUniversity Microbiome Initiative; and the UVA Presidential Fellowship in Neuroscience.
UVA’s TransUniversity Microbiome Initiative, or TUMI, serves as the central hub for the University’s cutting-edge microbiome research. The initiative aims to expand our understanding of the microbiome to better treat and prevent disease.
To keep up with the latest medical research news from UVA, subscribe to the Making of Medicine blog at http://makingofmedicine.virginia.edu.
Source: University of Virginia Health System
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MINNEAPOLIS — The powerful new documentary Come Talk to ME is set to make its big-screen debut at the Minneapolis–Saint Paul International Film Festival (MSPIFF), marking a significant milestone for the independently produced film centered on Parkinson’s disease, communication, and human connection.
The 2026 festival, running April 8–19, will feature more than 200 films from around the world. Come Talk to ME is scheduled for two screenings, including a meaningful premiere on April 11—World Parkinson’s Day—followed by a second showing on April 14. Both screenings will take place at the Main Cinema at Saint Anthony Main in Minneapolis.
A Story About Communication and Connection
Directed by Deacon Warner and produced by Jackie Hunt Christensen, the documentary follows Christensen, her husband Paul, and a close-knit group of friends living with Parkinson’s disease.
The film explores how communication evolves as the disease progresses, highlighting the creative and deeply human ways individuals maintain relationships—with family, friends, and healthcare providers—even as traditional speech becomes more challenging.
Christensen, diagnosed with Parkinson’s at just 34, emphasizes that the film is ultimately about preserving connection:
“Having Parkinson’s does not mean that you stop loving, caring, and feeling… communication is everything.”
Innovative Use of AI Voice Technology
One of the film’s most groundbreaking elements is its use of AI-generated narration powered by ElevenLabs.
The filmmakers recreated Christensen’s voice using archival audio recorded shortly after her diagnosis in 2000. This AI-generated voice—nicknamed “JHC2K”—serves as the primary narrator, allowing Christensen to “speak” throughout the film in a way that would otherwise be difficult due to the progression of Parkinson’s.
Director Warner called the experience both innovative and deeply personal:
“To be part of [MSPIFF’s] rich history… while also utilizing cutting-edge AI technology to set us apart from other films is incredible.”
Festival Screenings and Accessibility
Come Talk to ME will screen twice during the festival:
- Saturday, April 11 (World Parkinson’s Day) – Early afternoon (time TBD)
- Tuesday, April 14 – Late afternoon (time TBD)
Ticket pricing:
- MSP Film Society Members: $11
- General Admission: $17 (+ online fee)
- Students: $10 (with ID)
In a move aligned with the film’s mission, the April 11 screening will offer free admission (donation-based) for individuals affected by Parkinson’s disease.
The venue also provides limited wheelchair seating on a first-come, first-served basis.
A Film Seeking Broader Impact
Beyond its festival debut, Come Talk to ME is actively seeking sponsors to expand its reach and impact. The filmmakers hope to bring the documentary to wider audiences, particularly within communities affected by Parkinson’s disease.
At its core, the film delivers a powerful message: even as physical abilities change, the need for connection—and the human drive to communicate—remains constant.
Why This Film Matters
As awareness of Parkinson’s disease continues to grow, Come Talk to ME stands out as both an emotional narrative and a technological milestone. By combining personal storytelling with AI innovation, the film offers a new way to understand life with Parkinson’s—and the enduring importance of being heard.
Source and Related Links
- Minneapolis–Saint Paul International Film Festival (MSPIFF) Official Site
- MSP Film Society Official Website
- World Parkinson’s Day – Official Information
- Parkinson’s Foundation – Resources & Support
- The Michael J. Fox Foundation for Parkinson’s Research
- ElevenLabs – AI Voice Technology Platform
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health and wellness
Heart Risks Go Beyond the Heart: Don’t Forget to Check Blood Sugar and Kidney Health
Heart Risks Go Beyond the Heart: Don’t Forget to Check Blood Sugar and Kidney Health
(Feature Impact) Diabetes and kidney disease are major risk factors for heart disease, yet many cases are undiagnosed. In fact, most people don’t realize their heart, kidney and metabolic health – how the body creates, uses and stores energy – are connected. Understanding these connections can help you take steps toward protecting your long-term health.
Cardiovascular-kidney-metabolic (CKM) syndrome is a health condition that includes heart disease, kidney disease, diabetes and obesity. Many people don’t realize they’re at risk, though, because they aren’t aware of health risks beyond the heart. Almost 1 in 4 U.S. adults with diabetes are unaware they have it, according to a 2026 statistics update from the American Heart Association. In addition, data from the Centers for Disease Control and Prevention shows that as many as 9 in 10 adults with chronic kidney disease don’t know they’re living with the condition.
Learning about CKM syndrome can be a helpful step in understanding your overall health picture.
How are CKM conditions connected?
Heart disease, kidney disease and diabetes have shared risk factors – including high blood pressure, cholesterol and blood sugar; excess weight; and reduced kidney function – and they’re closely linked. Having one condition often increases the likelihood of developing the others.
“We are encouraging people to become aware of the connection between conditions so they and their health care team can think about their overall health beyond individual conditions,” said Stacey E. Rosen, M.D., FAHA, volunteer president of the American Heart Association, executive director of the Katz Institute for Women’s Health and senior vice president of women’s health at Northwell Health. “Understanding the connection helps you better prevent complications through lifestyle changes and appropriate treatment.”
The biggest health threats from CKM syndrome are disability and death from heart disease and stroke, which make up the “cardiovascular” part of CKM. The “metabolic” part includes diabetes and obesity. Kidney disease is closely linked with both metabolic and cardiovascular diseases.
How common is CKM syndrome?
CKM-related risks are common. Nearly 90% of U.S. adults have at least one risk factor for CKM syndrome. The 2026 statistics report showed about half of all U.S. adults have high blood pressure, about 1 in 3 has high total cholesterol, more than half have prediabetes or diabetes, about 1 in 7 has kidney disease and more than half have a high waist circumference.
These risks often develop slowly, with few or no symptoms at first, but you can stay informed. Rosen emphasizes regular screening of your cardiovascular, kidney and metabolic health, which can catch problems early.
“Due to the current risk factor rates, everyone could benefit from being screened this way,” she said.
Regular check-ins with your health care team can offer a clearer picture of your CKM health. They can check your:
- Blood pressure
- Cholesterol panel (total cholesterol, LDL (bad) cholesterol, HDL (good) cholesterol and triglycerides)
- Blood glucose (blood sugar), measured in either the short term as fasting glucose or long term as A1C
- Body weight and size, measured by body mass index and waist circumference
- Kidney function, using both UACR and eGFR
These results can be used in the PREVENT online calculator to estimate your risk for cardiovascular disease over the next 10 or 30 years. CKM syndrome can often be prevented and improved with healthy daily habits like those in Life’s Essential 8 and science-based treatments.
The CKM Health Initiative was introduced by the American Heart Association to raise awareness of the connections between CKM syndrome conditions and improve diagnosis rates. It’s supported by founding sponsors Novo Nordisk and Boehringer Ingelheim, supporting sponsors Novartis Pharmaceuticals Corporation and Bayer, and champion sponsor DaVita.
Visit Heart.org/myCKMhealth to learn more about CKM health, including screening and treatment options.
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Our Lifestyle section on STM Daily News is a hub of inspiration and practical information, offering a range of articles that touch on various aspects of daily life. From tips on family finances to guides for maintaining health and wellness, we strive to empower our readers with knowledge and resources to enhance their lifestyles. Whether you’re seeking outdoor activity ideas, fashion trends, or travel recommendations, our lifestyle section has got you covered. Visit us today at https://stmdailynews.com/category/lifestyle/ and embark on a journey of discovery and self-improvement.
Last Updated on April 6, 2026 by Daily News Staff
(Feature Impact) Heart disease is something many adults push to the back of their minds if they are not experiencing symptoms; a concern for “later” in life. However, that mindset may be changing. New research suggests younger generations are thinking about their cardiovascular health earlier and with greater urgency.
They’re right to be thinking about it, too. Data from the American Heart Association shows heart disease is still the No. 1 killer of Americans. In fact, someone dies from cardiovascular disease every 34 seconds in the United States.
Risk factors such as obesity, high blood pressure, diabetes, and kidney disease are on the rise, too. Nearly half of U.S. adults have high blood pressure (47%), and obesity (42%), and more than half (57%) have type 2 diabetes or prediabetes.
Despite growing concern about heart health, many adults remain unclear about their personal risk. In fact, a majority of respondents (62%) in a survey conducted by Atomik Research on behalf of Doctor’s Best said they don’t know their current risk for heart disease. To provide context on these findings and highlight emerging heart health trends, Dr. Tania Elliott, a dual board-certified physician in internal medicine, offers some insights.
Feeling Fatigue
In the study, only 50% of respondents reported feeling energetic on a daily basis. Among those who reported feeling fatigued, 46% listed stress as their top perceived contributor, followed by insufficient sleep (38%), both of which are closely tied to cardiovascular health.
Troubling Symptoms
Among Gen Z respondents, 25% reported having shortness of breath during activity or while lying down, compared to just 16% of Baby Boomers, which is commonly associated with compromised heart health.
Statins and Youth
Statins, which help address cardiovascular risk factors such as high cholesterol, are among the most commonly prescribed drugs in America, with more than 92 million Americans currently taking them, according to the Cleveland Clinic. Although most survey respondents (76%) aren’t currently taking a statin, 17% of adults ages 25-34 reported using statin therapy, which is an unexpectedly high proportion given their age and the group’s low anticipated risk of cardiovascular disease.
Side Effects of Statins
Among those taking statins, which are considered a first-line treatment for treating high cholesterol and reducing heart disease risk, 54% reported experiencing side effects, particularly muscle pain (23%) and fatigue (31%). However, taking statins can also affect levels of Coenzyme Q10 (CoQ10), which supports cellular energy and cardiovascular function.
All About CoQ10
Cells use CoQ10 to produce energy and detoxify. Studies have shown people with heart failure who took CoQ10 had around a 50% reduction in mortality. Despite this, awareness is low. Nearly two-thirds (66%) of respondents had never heard of CoQ10 and that number jumps to 76% of adults ages 25-34. Additionally, only a small percentage of respondents (8%) who were on a statin reported having their CoQ10 level tested.
“We have a real opportunity to help younger adults take a more proactive approach to heart health,” Elliott said. “CoQ10 plays a critical role in cellular energy production and heart muscle function, and it can decline with age and statin use.”
If you’re among the 71% of survey respondents who expressed a willingness to learn more about improving your heart health, talk with your health care provider and visit DoctorsBest.com to learn more.
Strategies to Support Heart Health
While some risk factors for heart disease, like age and family history, are out of your control, you can make lifestyle changes to help lower your risk:
- Eat Whole Foods: A heart-healthy eating plan includes plenty of lean proteins as well as fruits, vegetables, beans, whole grains and foods high in omega-3s, such as salmon, nuts and plant oils.
- Know Your CoQ10 Levels: If you’re low, look for a high-quality, bioavailable formula, like Doctor’s Best High Absorption CoQ10 with BioPerine, which supports energy production and muscle function.
- Get Moving: The American Heart Association recommends 150 minutes of moderate-intensity or 75 minutes of vigorous aerobic activity per week to help control weight and lower the risk for conditions that negatively impact the heart.
Photo courtesy of Shutterstock (woman with hand over chest)
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Our Lifestyle section on STM Daily News is a hub of inspiration and practical information, offering a range of articles that touch on various aspects of daily life. From tips on family finances to guides for maintaining health and wellness, we strive to empower our readers with knowledge and resources to enhance their lifestyles. Whether you’re seeking outdoor activity ideas, fashion trends, or travel recommendations, our lifestyle section has got you covered. Visit us today at https://stmdailynews.com/category/lifestyle/ and embark on a journey of discovery and self-improvement.
