Newswise — University of Virginia School of Medicine researchers have discovered how Lactobacillus, a bacterium found in fermented foods and yogurt, helps the body manage stress and may help prevent depression and anxiety. The findings open the door to new therapies to treat anxiety, depression and other mental-health conditions.
The new research from UVA’s Alban Gaultier, Ph.D., and collaborators is notable because it pinpoints the role of Lactobacillus, separating it out from all the other microorganisms that naturally live in and on our bodies. These organisms are collectively known as the microbiota, and scientists have increasingly sought to target them to battle disease and improve our health. UVA’s new research represents a major step forward in that effort, providing scientists an innovative new approach to understand the role of individual microbes that could facilitate the development of new treatments and cures for a wide variety of diseases, both mental and physical.
“Our discovery illuminates how gut-resident Lactobacillus influences mood disorders, by tuning the immune system,” said Gaultier, of UVA’s Department of Neuroscience, the Center for Brain Immunology and Glia (BIG Center) and the TransUniversity Microbiome Initiative. “Our research could pave the way towards discovering much-needed therapeutics for anxiety and depression.”
The Microbiota and Depression
Our guts are naturally home to countless bacteria, fungi, and viruses. There are more microorganisms living in and on us than there are cells in our bodies. That may sound disgusting, even alarming, but scientists have increasingly realized that these tiny organisms and their endless interactions are critical to our immune systems’ health, our mental health, and many other facets of our well-being. Disruptions of the microbiota, whether from illness, poor diet, or other causes, are known to contribute to many diseases and even help cancer spread. So, researchers have been hugely excited in recent years about the potential to battle diseases by targeting the microbiota.
Early attempts to manipulate the gut flora with beneficial bacteria, called probiotics, have produced mixed results. A big part of the problem has been the sheer complexity of the microbiome. It’s estimated that there are 39 trillion microorganisms inside each of us, so trying to understand what specific bacteria or fungi do – much less how they interact with all the other microorganisms and their host – can be like trying to count grains of sand on the beach.
Gaultier and his team took an innovative approach to hone in on Lactobacilli in specific. Prior research from Gaultier’s lab suggested that the bacteria could reverse depression in lab mice – a hugely promising finding. But the researchers needed to understand how.
“We were aware from our prior research that Lactobacillus was beneficial in improving mood disorders and was lost following psychological stress, but the underlying reasons remained unclear, primarily due to the technical challenges associated with studying the microbiome.”
Gaultier and his team decided to continue their depression research using a collection of bacteria, known as Altered Schaedler Flora, which includes two strains of Lactobacillus and six other bacterial strains. With this rarely used bacterial community, the team was able to create mice both with and without Lactobacillus,circumventing the need for antibiotics.
Sure enough, the Altered Schaedler Flora produced exciting results. Gaultier and his colleagues were able to explain exactly how Lactobacilli influence behavior, and how a lack of the bacteria can worsen depression and anxiety. Lactobacilli in the family Lactobaccillacea, they found, maintain the levels of an immune mediator called interferon gamma that regulates the body’s response to stress and helps stave off depression.
Armed with this information, researchers are poised to develop new ways to prevent and treat depression and other mental-health conditions in which Lactobacillus plays an important role. For example, patients struggling with (or at risk for) depression might one day take specially formulated probiotic supplements that will optimize their levels of helpful Lactobacillus.
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“With these results in hand, we have new tools to optimize the development of probiotics, which should speed up discoveries for novel therapies,” said researcher Andrea R. Merchak, Ph.D. “Most importantly, we can now explore how maintaining a healthy level of Lactobacillus and/or interferon gamma could be investigated to prevent and treat anxiety and depression.”
Findings Published
The UVA scientists have published their findings in the journal Brain Behavior and Immunity. The research team consisted of Merchak, Samuel Wachamo, Lucille C. Brown, Alisha Thakur, Brett Moreau, Ryan M. Brown, Courtney Rivet-Noor, Tula Raghavan and Gaultier. The researchers have no financial interest in the work.
The work was supported by the National Institutes of Health, grants T32 NS115657, T32 GM008136, F31 AI174782, T32 GM007267 and T32 GM148379; the Owens Family Foundation; the Miller Family; the UVA TransUniversity Microbiome Initiative; and the UVA Presidential Fellowship in Neuroscience.
UVA’s TransUniversity Microbiome Initiative, or TUMI, serves as the central hub for the University’s cutting-edge microbiome research. The initiative aims to expand our understanding of the microbiome to better treat and prevent disease.
Our Lifestyle section on STM Daily News is a hub of inspiration and practical information, offering a range of articles that touch on various aspects of daily life. From tips on family finances to guides for maintaining health and wellness, we strive to empower our readers with knowledge and resources to enhance their lifestyles. Whether you’re seeking outdoor activity ideas, fashion trends, or travel recommendations, our lifestyle section has got you covered. Visit us today at https://stmdailynews.com/category/lifestyle/ and embark on a journey of discovery and self-improvement.
Writing builds resilience by changing your brain, helping you face everyday challenges
Writing builds resilience: Discover how writing changes your brain and strengthens resilience. Learn 5 science-backed writing techniques to process emotions, reduce stress, and navigate everyday challenges with clarity and purpose.
Writing builds resilience by changing your brain, helping you face everyday challenges
Emily Ronay Johnston, University of California, Merced Ordinary and universal, the act of writing changes the brain. From dashing off a heated text message to composing an op-ed, writing allows you to, at once, name your pain and create distance from it. Writing can shift your mental state from overwhelm and despair to grounded clarity — a shift that reflects resilience. Psychology, the media and the wellness industry shape public perceptions of resilience: Social scientists study it, journalists celebrate it, and wellness brands sell it. They all tell a similar story: Resilience is an individual quality that people can strengthen with effort. The American Psychological Association defines resilience as an ongoing process of personal growth through life’s challenges. News headlines routinely praise individuals who refuse to give up or find silver linings in times of hardship. The wellness industry promotes relentless self-improvement as the path to resilience. In my work as a professor of writing studies, I research how people use writing to navigate trauma and practice resilience. I have witnessed thousands of students turn to the written word to work through emotions and find a sense of belonging. Their writing habits suggest that writing fosters resilience. Insights from psychology and neuroscience can help explain how.
Writing rewires the brain
In the 1980s, psychologist James Pennebaker developed a therapeutic technique called expressive writing to help patients process trauma and psychological challenges. With this technique, continuously journaling about something painful helps create mental distance from the experience and eases its cognitive load. In other words, externalizing emotional distress through writing fosters safety. Expressive writing turns pain into a metaphorical book on a shelf, ready to be reopened with intention. It signals the brain, “You don’t need to carry this anymore.”Sometimes you can write your way through difficult emotions.Grace Cary/Moment via Getty Images Translating emotions and thoughts into words on paper is a complex mental task. It involves retrieving memories and planning what to do with them, engaging brain areas associated with memory and decision-making. It also involves putting those memories into language, activating the brain’s visual and motor systems. Writing things down supports memory consolidation — the brain’s conversion of short-term memories into long-term ones. The process of integration makes it possible for people to reframe painful experiences and manage their emotions. In essence, writing can help free the mind to be in the here and now.
Taking action through writing
The state of presence that writing can elicit is not just an abstract feeling; it reflects complex activity in the nervous system. Brain imaging studies show that putting feelings into words helps regulate emotions. Labeling emotions — whether through expletives and emojis or carefully chosen words — has multiple benefits. It calms the amygdala, a cluster of neurons that detects threat and triggers the fear response: fight, flight, freeze or fawn. It also engages the prefrontal cortex, a part of the brain that supports goal-setting and problem-solving. In other words, the simple act of naming your emotions can help you shift from reaction to response. Instead of identifying with your feelings and mistaking them for facts, writing can help you simply become aware of what’s arising and prepare for deliberate action. Even mundane writing tasks like making a to-do list stimulate parts of the brain involved in reasoning and decision-making, helping you regain focus.
Making meaning through writing
Choosing to write is also choosing to make meaning. Studies suggest that having a sense of agency is both a prerequisite for, and an outcome of, writing. Researchers have long documented how writing is a cognitive activity — one that people use to communicate, yes, but also to understand the human experience. As many in the field of writing studies recognize, writing is a form of thinking — a practice that people never stop learning. With that, writing has the potential to continually reshape the mind. Writing not only expresses but actively creates identity. Writing also regulates your psychological state. And the words you write are themselves proof of regulation — the evidence of resilience. Popular coverage of human resilience often presents it as extraordinary endurance. News coverage of natural disasters implies that the more severe the trauma, the greater the personal growth. Pop psychology often equates resilience with unwavering optimism. Such representations can obscure ordinary forms of adaptation. Strategies people already use to cope with everyday life — from rage-texting to drafting a resignation letter — signify transformation.
Building resilience through writing
These research-backed tips can help you develop a writing practice conducive to resilience: 1. Write by hand whenever possible. In contrast to typing or tapping on a device, handwriting requires greater cognitive coordination. It slows your thinking, allowing you to process information, form connections and make meaning. 2. Write daily. Start small and make it regular. Even jotting brief notes about your day — what happened, what you’re feeling, what you’re planning or intending — can help you get thoughts out of your head and ease rumination. 3. Write before reacting. When strong feelings surge, write them down first. Keep a notebook within reach and make it a habit to write it before you say it. Doing so can support reflective thinking, helping you act with purpose and clarity. 4. Write a letter you never send. Don’t just write down your feelings — address them to the person or situation that’s troubling you. Even writing a letter to yourself can provide a safe space for release without the pressure of someone else’s reaction. 5. Treat writing as a process. Any time you draft something and ask for feedback on it, you practice stepping back to consider alternative perspectives. Applying that feedback through revision can strengthen self-awareness and build confidence. Resilience may be as ordinary as the journal entries people scribble, the emails they exchange, the task lists they create — even the essays students pound out for professors. The act of writing is adaptation in progress.Emily Ronay Johnston, Assistant Teaching Professor of Global Arts, Media and Writing Studies, University of California, Merced This article is republished from The Conversation under a Creative Commons license. Read the original article.
Wishing you all a Happy Thanksgiving! As we gather with loved ones to express gratitude and share a meal, let’s take a moment to appreciate the blessings in our lives. It’s a time to reflect on the goodness that surrounds us and cherish the moments of joy and togetherness. Whether you’re celebrating with family, friends, or even virtually, may this Thanksgiving be filled with warmth, love, and laughter. Let’s remember to extend kindness and lend a helping hand to those in need, spreading the spirit of gratitude and generosity. Enjoy the holiday and create beautiful memories. Happy Thanksgiving!
Rod: A creative force, blending words, images, and flavors. Blogger, writer, filmmaker, and photographer. Cooking enthusiast with a sci-fi vision. Passionate about his upcoming series and dedicated to TNC Network. Partnered with Rebecca Washington for a shared journey of love and art.
Don’t let food poisoning crash your Thanksgiving dinner
Safe thanksgiving dinner: Protect your Thanksgiving guests from foodborne illness with these expert food safety tips. Learn why you shouldn’t wash your turkey, how to avoid the danger zone, and essential prep strategies to prevent the 48 million annual cases of food poisoning in the U.S.
Don’t let food poisoning crash your Thanksgiving dinner
Lisa Cuchara, Quinnipiac University Thanksgiving is a time for family, friends and feasting. However, amid the joy of gathering and indulging in delicious food, it is essential to keep food safety in mind. Foodborne illnesses can quickly put a damper on your celebrations. As an immunologist and infectious disease specialist, I study how germs spread – and how to prevent them from doing so. In my courses, I teach my students how to reduce microbial risks, including those tied to activities such as hosting a big Thanksgiving gathering, without becoming germophobes. Foodborne illnesses sicken 48 million Americans – 1 in 6 people – each year. Holiday meals such as Thanksgiving pose special risks because these spreads often involve large quantities, long prep times, buffet-style serving and mingling guests. Such conditions create many opportunities for germs to spread. This, in turn, invites a slew of microbial guests such as Salmonella and Clostridium perfringens. Most people recover from infections with foodborne bacteria, but each year around 3,000 Americans die from the illnesses they cause. More routinely, these bugs can cause nausea, vomiting, stomach cramps and diarrhea within hours to a couple of days after being consumed – which are no fun at a holiday celebration.
Foods most likely to cause holiday illness
Most foodborne illnesses come from raw or undercooked food and foods left in the so-called danger zone of cooking temperature – 40 degrees to 140 degrees Fahrenheit – in which bacteria multiply rapidly. Large-batch cooking without proper reheating or storage as well as cross contamination of foods during preparation can also cause disease.Put that bird right in the oven as soon as you’ve stuffed it to keep bacteria from multiplying inside.kajakiki/E+ via Getty Images Not all dishes pose the same risk. Turkey can harbor Salmonella, Campylobacter and Clostridium perfringens. Undercooked turkey remains a leading cause of Thanksgiving-related illness. Raw turkey drippings can also easily spread bacteria onto hands, utensils and counters. And don’t forget the stuffing inside the bird. While the turkey may reach a safe internal temperature, the stuffing often does not, making it a higher-risk dish. Leftovers stored too long, reheated improperly or cooled slowly also bring hazards. If large pieces of roasted turkey aren’t divided and cooled quickly, any Clostridium perfringens they contain might have time to produce toxins. This increases the risk of getting sick from snacking on leftovers – even reheated leftovers, since these toxins are not killed by heat. Indeed, each November and December outbreaks involving this bacterium spike, often due to encounters with turkey and roast beef leftovers.
Don’t wash the turkey!
Washing anything makes it cleaner and safer, right? Not necessarily. Many people think washing their turkey will remove bacteria. However, it’s pretty much impossible to wash bacteria off a raw bird, and attempting to do so actually increases cross contamination and your risk of foodborne illness. Since 2005, federal food safety agencies have advised against washing turkey or chicken. Despite this, a 2020 survey found that 78% of people still reported rinsing their turkey before cooking – often because older recipes or family habits encourage it. When you rinse raw poultry, water can splash harmful bacteria around your kitchen, contaminating counter tops, utensils and nearby foods. If you do choose to wash turkey, it’s critical to immediately clean and disinfect the sink and surrounding area. A 2019 USDA study found that 60% of people who washed their poultry had bacteria in their sink afterward – and 14% had bacteria in the sink even after cleaning it.A few food prep precautions can help keep the holiday free of gastrointestinal distress.Drazen Zigic/iStock via Getty Images Plus
Food prep tips for a safe and healthy Thanksgiving
Wash your hands regularly. Before cooking and after touching raw meat, poultry or eggs, wash your hands thoroughly with soap and water for at least 20 seconds. Improper handwashing by people handling food is a major source of bacterial contamination with Staphylococcus aureus. This bacterium’s toxins are hard to break down, even after cooking or reheating. Thaw turkey safely. The safest way to thaw a turkey is in the refrigerator. Allow 24 hours per 4-5 pounds. There’s also a faster method, which involves submerging the turkey in cold water and changing the water every 30 minutes – but it’s not as safe because it requires constant attention to ensure the water temperature stays below 40 F in order to prevent swift bacteria growth. Stuff your turkey immediately before cooking it. Stuffing the turkey the night before is risky because it allows bacteria in the stuffing to multiply overnight. The toxins produced by those bacteria do not break down upon cooking, and the interior of the stuffing may not get hot enough to kill those bacteria. The USDA specifically warns against prestuffing. So cook stuffing separately, if possible, or if you prefer it inside the bird, stuff immediately before roasting, making sure it reaches 165 F. Cook food to the right temperature. A thermometer is your best friend – use it to ensure turkey and stuffing both reach 165 F. Check casseroles and other dishes too. It’s best not to rely on an internal pop-up thermometer, since they can be inaccurate, imprecise and could even malfunction. Avoid cross contamination. Use separate cutting boards for raw meat, vegetables and bread. Change utensils and plates after handling raw meat before using them for cooked foods. Keep food at safe temperatures.Serve hot foods immediately, and make sure hot foods are served above 140 F and cold dishes below 40 F to keep them out of the microbial danger zone. Be cautious with buffet-style serving. Limit food time on the table to two hours or less – longer than that, any bacteria present can double every 20 minutes. Provide dedicated serving utensils, and avoid letting guests serve with utensils they have eaten from. Be mindful of expiration dates. Don’t forget to check dates on food items to make sure that what you are serving isn’t expired or left from last Thanksgiving. Educate guests on food safety. Remind guests to wash their hands before preparing or serving food, and politely discourage double-dipping or tasting directly from communal dishes. Thanksgiving should be a time of gratitude, not gastrointestinal distress. By following these simple food safety tips, you can help ensure a safe and healthy holiday. Lisa Cuchara, Professor of Biomedical Sciences, Quinnipiac University This article is republished from The Conversation under a Creative Commons license. Read the original article.
Our Lifestyle section on STM Daily News is a hub of inspiration and practical information, offering a range of articles that touch on various aspects of daily life. From tips on family finances to guides for maintaining health and wellness, we strive to empower our readers with knowledge and resources to enhance their lifestyles. Whether you’re seeking outdoor activity ideas, fashion trends, or travel recommendations, our lifestyle section has got you covered. Visit us today at https://stmdailynews.com/category/lifestyle/ and embark on a journey of discovery and self-improvement.
Emily Ronay Johnston, Assistant Teaching Professor of Global Arts, Media and Writing Studies, University of California, Merced This article is republished from The Conversation under a Creative Commons license. Read the original article.
