Connect with us

Health

Three doses of COVID-19 mRNA vaccine associated with better outcomes for patients with cancer

Published

on

Study Title: Breakthrough SARS-CoV-2 infections among patients with cancer following two and three doses of COVID-19 mRNA vaccines

Publication (online): The Lancet Regional Health – Americas, February 13, 2023

Dana-Farber Cancer Institute author: Toni Choueiri, MD; Chris Labaki, MD; Ziad Bakouny, MD, MSc

Summary:

Breakthrough SARS-CoV-2 infections following vaccination against COVID-19 are of international concern and patients with cancer are highly vulnerable and susceptible to poor outcomes. It is recommended that patients with cancer receive a 3-dose COVID-19 vaccination series but it is noted that their immunological response to the vaccine series may be lessened, notably among those with hematologic malignancies. Utlizing data from the multi-institutional COVID-19 and Cancer Consortium (CCC19) scientists found vaccination with 2 or 3 doses of an mRNA vaccine prior to infection was associated with improved outcomes for patients with cancer diagnosed with COVID-19 in 2021 or 2022. Across all endpoints, including 30-day morality, ICU admission and hospitalization, the vaccine benefit was most pronounced for those patients receiving 3 doses. 

Impact:

This study shows vaccination against COVID-19 is an essential strategy to improve outcomes in this high-risk population. The results support guidelines that patients with cancer should receive at least 3 COVID-19 vaccine doses. This analysis represents one of the largest cohorts with comprehensive clinical and biological data on vaccinated patients with cancer and breakthrough COVID-19 to date and is one of the first studies to evaluate breakthrough infections following the receipt of 3 doses of mRNA vaccines among patients with cancer.

Advertisement
Big Dill Pickleball Co. Serving Up Fun!

Funding:

The research was partly supported grants from the National Cancer Institute (P30 CA068485; T32-CA236621; P30-CA046592); CTSA 2UL1TR001425-05A1; ACS/FHI Real-World Data Impact Award, P50 MD017341-01, R21 CA242044-01A1, Susan G. Komen Leadership Grant Hunt. REDCap is developed and supported by Vanderbilt Institute for Clinical and Translational Research grant support (UL1 TR000445 from NCATS / NIH).

Source: Dana-Farber Cancer Institute

Author


Discover more from Daily News

Subscribe to get the latest posts sent to your email.

Health

Know These 4 Core Factors to Avoid a Heart Health Syndrome

Published

on

heart

(Family Features) In the U.S., 1 in 3 adults is at risk for a newly recognized syndrome that comes from a combination of heart disease, kidney disease, type 2 diabetes and excess body weight. This cluster of conditions, called cardiovascular-kidney-metabolic (CKM) syndrome, is an example of how problems in one part of your body can affect other parts.

To avoid CKM syndrome, health experts suggest paying close attention to four of the American Heart Association’s Life’s Essential 8 – blood pressure, lipids, body weight and blood sugar level – which are core health factors that impact your metabolic health.

Good metabolic health means your body uses energy well and keeps these factors in a normal range. However, when numbers are off in one area, it can affect others, raising your risk for heart disease, stroke, kidney disease and diabetes.

Consider these tips from the American Heart Association to help keep your core health factors under control.

17326 detail image embed1

Blood Pressure
High blood pressure, also known as hypertension, happens when the force of your blood pushing against the walls of your blood vessels is too high. High blood pressure is a leading cause of heart disease, stroke and kidney disease.

Because high blood pressure doesn’t have symptoms, the only way to know you have it is to get your blood pressure checked. Healthy blood pressure is below 120/80. If your blood pressure is 130/80 or higher, talk to your doctor about checking your other core health factors.

Lifestyle changes can help reduce high blood pressure. One example is a Dietary Approaches to Stop Hypertension (DASH) eating pattern that’s low in fat and rich in fruits, vegetables, whole grains and low-fat dairy products. Losing 10 pounds and reducing alcohol consumption can also reduce blood pressure.

Cholesterol
Cholesterol is a waxy substance your liver makes then circulates in the blood where your body uses it to build cells and make vitamins and hormones. You may also get cholesterol from eating animal products. If there’s too much cholesterol circulating, your risk of type 2 diabetes, heart disease and stroke may increase.

For optimal CKM health, your LDL cholesterol should be below 100 and triglycerides below 150. Triglycerides are the most common type of fat in the body. If your triglyceride level is 135 or higher, talk to your doctor about decreasing your risk.

Advertisement
Big Dill Pickleball Co. Serving Up Fun!

Losing body weight and increasing physical activity decrease triglyceride levels. In addition, DASH and Mediterranean (plant-based, high-fiber, low-fat) eating patterns support healthy LDL and triglyceride levels.

Body Weight
Healthy weight may be determined by body mass index (BMI), a number that represents your weight in relation to your height. Extra body fat can mean a higher risk for many health problems, including heart disease, stroke, high blood pressure, high cholesterol and diabetes.

CKM syndrome starts when BMI is 25 or higher and waist circumference is 88 centimeters or higher for women and 102 centimeters or higher for men. Aim for a BMI between 18.5-25.

To lose weight and keep it off, start by setting realistic goals. Understand how much and why you eat, manage portion sizes, make smart snack substitutions and be physically active.

Blood Sugar
High blood sugar can slowly damage the kidneys. In fact, diabetes is the leading cause of kidney disease, and it increases the risk of heart attack and stroke.

Blood sugar is measured in two ways: a fasting blood glucose test (short term blood sugar) and an A1C test (long term blood sugar control). A normal fasting blood glucose level is 70-99 and a normal A1C level is below 5.7%. Fasting blood glucose above 125 and A1C of 6.5% or higher means you have diabetes.

Habits that help you avoid high blood pressure, weight gain and high cholesterol also keep your blood sugar in check. These are especially important if you have a family history of diabetes.

Advertisement
Big Dill Pickleball Co. Serving Up Fun!

Learn more about CKM syndrome and how to manage your risk at heart.org/CKMhealth.

Photos courtesy of Shutterstock

collect?v=1&tid=UA 482330 7&cid=1955551e 1975 5e52 0cdb 8516071094cd&sc=start&t=pageview&dl=http%3A%2F%2Ftrack.familyfeatures
SOURCE:
American Heart Association


Discover more from Daily News

Subscribe to get the latest posts sent to your email.

Continue Reading

Lifestyle

Expert Pregnancy Tips for Staying Healthy This Winter

Published

on

17229 detail intro image

(Family Features) Staying up to date on recommended vaccines is important during pregnancy. This is especially true during the winter months when more people tend to get sick from flu, COVID-19 and RSV. These viruses can be especially dangerous for pregnant people and babies.

Vaccines are an important part of routine pregnancy care, both for you and your baby. Getting vaccinated against flu and COVID-19 can cut your risk of hospitalization by about half.

Now is the time to get vaccinated if you haven’t already. Flu vaccines help protect you from getting the flu and getting seriously ill, so it’s a good idea to schedule an appointment now. The latest COVID-19 vaccines are important too because they lower your risk of serious illness. An RSV vaccine may also be recommended for when you are 32-36 weeks pregnant. Be sure to talk to your doctor.

“Right now, we are seeing a concerning increase in cases of respiratory diseases, such as the flu, COVID-19 and RSV,” said Adm. Rachel Levin, MD, assistant secretary for health at the U.S. Department of Health and Human Services. “I encourage all pregnant people to take preventive action to protect their health and the health of their baby. The best and safest way to do this is to get vaccinated. Getting vaccinated is easy and is usually covered by insurance.”

Help Protect Your Baby 
When you get flu, COVID-19 and RSV vaccines, you’re helping protect your baby by passing your immunity on to them. Getting vaccinated against flu, COVID-19 and RSV during pregnancy can protect your baby during the first 6 months of life. These viruses can be very harmful to newborns. In fact, RSV is the leading cause of hospitalization in infants

Talk to Your Doctor About Timing
Millions of people in the U.S. have already gotten vaccinated against flu, COVID-19 and RSV this season. If you haven’t gotten your vaccines yet, be sure to talk with your doctor. They can help you choose the right vaccines and determine the best timing to help protect you and your baby.

Get the Facts
Getting vaccinated can give you peace of mind, ensuring you have done everything you can to protect yourself and your baby from serious respiratory illness. Information can give you power and comfort, especially when you’re pregnant.

Go to cdc.gov/RiskLessDoMore to learn more about flu, COVID-19 and RSV vaccines, or go to vaccines.gov to get started today.

Advertisement
Big Dill Pickleball Co. Serving Up Fun!

Photo courtesy of Shutterstock

collect?v=1&tid=UA 482330 7&cid=1955551e 1975 5e52 0cdb 8516071094cd&sc=start&t=pageview&dl=http%3A%2F%2Ftrack.familyfeatures
SOURCE:
U.S. Department of Health and Human Services


Discover more from Daily News

Subscribe to get the latest posts sent to your email.

Continue Reading

Lifestyle

Here’s to a Healthy New Year: What your family needs to know about vaccines

Vaccines for flu, COVID-19, and RSV are vital for family health, especially as respiratory viruses increase during colder months. Stay updated to reduce serious illness and hospitalizations.

Published

on

vaccines

(Family Features) This year, make a plan to keep your family healthy by helping them get vaccinated for respiratory infections like flu, COVID-19 and RSV. These respiratory illnesses are more likely to become serious for people who are not up to date on their vaccines.

In colder months, respiratory viruses tend to surge, and people spend more time indoors where they are more likely to be exposed. These respiratory infections can cause serious illness and hospitalization. This season’s flu and COVID-19 vaccines, as well as the RSV vaccine, are the best way to help your family risk less serious illness and do more of what they enjoy.

What should your family know?
Vaccines can keep you and your family from getting very sick from respiratory illnesses. The Centers for Disease Control and Prevention (CDC) recommends everyone ages 6 months and older get this season’s flu and COVID-19 vaccines.

In addition, all adults ages 75 and older – and those ages 60 and older with certain health conditions or who live in a nursing home – should get one dose of an RSV vaccine if they haven’t before. Pregnant people should also talk to their doctor about getting an RSV vaccine to protect their baby during their first 6 months of life.

17299 detail image embed1

Is your family at high risk?

It’s important to know the risks of getting very sick from flu, COVID-19 or RSV. According to the CDC, some people have a higher risk than others, including:

  • People not up to date on their vaccines: Vaccines cut your risk of needing hospital care for flu or COVID-19 by about half, according to the CDC. In 2023, 90% of adults admitted to the hospital for COVID-19 were not up to date on their COVID-19 vaccine. People who skipped their flu shot were twice as likely to need to see a doctor for the flu.
  • Older adults: Most flu, COVID-19 and RSV deaths are in people ages 65 and older. If you help care for an older family member or friend, let them know vaccines are their best protection from getting very sick.
  • People with underlying health conditions: Heart and lung disease, diabetes, kidney disease and other chronic conditions can cause complications and more severe illness from flu, COVID-19 and RSV.
  • Those who live in long-term care: Respiratory viruses can be a greater threat to older people in long-term care, who often have health issues that raise their risk of severe flu, COVID-19 or RSV.
  • Pregnant people: Pregnancy raises the risk of severe illness from flu and COVID-19. Getting vaccinated during pregnancy helps protects the pregnant person and baby. An RSV vaccine during pregnancy protects the baby from severe RSV in their first 6 months of life.

Get your family vaccinated now for a healthy new year
Join the millions of people who’ve already gotten vaccinated this season. Take your family to get vaccinated now to risk less severe illness and do more of what you enjoy. It’s safe to get flu and COVID-19 vaccines (and an RSV vaccine, if eligible) at the same time.

Visit cdc.gov/RiskLessDoMore to learn more about flu, COVID-19 and RSV vaccines. Talk with your doctor about which vaccines are right for you or go to vaccines.gov to find a nearby pharmacy. You can order free COVID-19 test kits (up to four per household) at COVIDTests.gov

Know Your Risk 
In the United States, there are additional groups of people who are at higher risk from these respiratory illnesses.

  • People in rural parts of the country: Vaccines matter even more in rural areas where there may be fewer doctors or clinics to help people who get very sick. Yet in these regions, less than half of adults got a flu vaccine last year. Fewer than 1 in 5 got an updated COVID-19 vaccine.
  • Black and Hispanic people: At last year’s respiratory virus peak, Black people were more likely than white and Hispanic people to be in the hospital for flu, COVID-19 or RSV. By the end of last year’s virus season, Hispanic people were more likely than non-Hispanic white people to have been in the hospital for flu.

Photos courtesy of Shutterstock

collect?v=1&tid=UA 482330 7&cid=1955551e 1975 5e52 0cdb 8516071094cd&sc=start&t=pageview&dl=http%3A%2F%2Ftrack.familyfeatures
SOURCE:
U.S. Department of Health and Human Services


Discover more from Daily News

Subscribe to get the latest posts sent to your email.

Continue Reading

Trending