
Child Health
Using Machine Learning to Make Ventilator Support Safer for Children
Last Updated on September 6, 2025 by Daily News Staff

Robinder Khemani, MD, MsCI, Attending Physician in Pediatric Intensive Care at Children’s Hospital Los Angeles has received a $3.4 million grant from the National Institute of Health to examine to improve outcomes of children put on ventilators.
« Using Machine Learning to Make Ventilator Support Safer for Children
Newswise — LOS ANGELES — Critically ill children on ventilator support can experience a mismatch between their breathing efforts and) the rhythm delivered by the ventilator. This mismatch, called patient-ventilator asynchrony (PVA), is difficult to detect and can worsen patient outcomes. PVA is commonly associated with longer stays on a ventilator for adults and can raise the risks of infection, lung injury and brain damage. However, little is known about PVA in children, where it could be just as, if not more, common. Robinder Khemani, MD, MsCI, Attending Physician in Pediatric Intensive Care at Children’s Hospital Los Angeles, is using machine learning to improve the outcomes of children put on ventilators.
A CHLA research team led by Dr. Khemani has received a $3.4 million grant from the National Institutes of Health to examine the frequency and risk factors for common types of PVA in critically ill children. Working with hospitals in Canada and the Netherlands, the researchers will investigate whether PVA is independently associated with poor clinical outcomes and determine the effects on the body when breathing doesn’t match the flow of air provided by the ventilator.
Children can need ventilator support for multiple reasons, including severe pneumonia or acute respiratory distress syndrome (ARDS), when infection or trauma causes swelling, inflammation and fluid buildup in the lungs. The body’s response to the initial injury can harm the lungs even more than the infection or trauma itself.
“Many of these very sick patients can develop unexpected complications from the very procedures that we use to help them,” says Dr. Khemani. Ventilator-induced lung injury can lead to heart and kidney damage, or can increase vulnerability to future lung disease, asthma or sleep-disordered breathing.
“Brain function can also be impaired by all the medications, anesthetics and sedation patients receive to help them to tolerate the ventilator,” says Dr. Khemani. “We weigh the risks and benefits to minimize potential harms and hopefully get them off the ventilator as soon as they are ready.”
Measuring patient-ventilator mismatch
“There are many types of PVA, but we still don’t know which PVA subtypes are most harmful or are the most frequent,” says Dr. Khemani. “We need to develop a common set of definitions and measurements, especially for pediatric patients.”
Mismatches between patient breathing and the rhythm the ventilator provides can occur in different ways, as children’s breathing varies according to their weight, size and age. Respiration patterns can also change during the course of a child’s stay in the pediatric intensive care unit. But existing studies use different definitions for PVA subtypes and no study so far has been large enough to evaluate the relationship between different types of PVA and patient outcomes, or has yet focused on the highest-risk patients.
Automating ventilator-patient breathing
“It takes a very highly trained human to recognize PVA,” says Dr. Khemani. “But computers can do this very well. Our colleagues at the Virtual Pediatric Intensive Care Unit (vPICU) here at CHLA have been working with us on this project for a few years and have developed machine-learning algorithms that can identify different types of breathing asynchronies in children on ventilators.”
The study team will collect measurements from 200 children and combine this data with the analysis of 350 children in other studies, including a clinical trial that is testing a novel ventilator strategy. “By the end of this project, we hope to have developed these algorithms and validate that they work in three different hospitals using data from many different children,” says Dr. Khemani. “Simultaneously we will build a tool to automatically detect PVA by analyzing ventilator data through machine-learning algorithms. We will test how well the tool helps providers to identify the minute-to-minute changes in patients and potentially alert the bedside team that an adjustment to the ventilator may be needed.”
To minimize the risks of ventilator support, medical teams want to keep patients participating in breathing for themselves as much as possible. “So that’s where this study really comes into play, by constantly tracking the interaction between the child and the ventilator to ask if the ventilator is supplying just the right amount of help, precisely when needed,” says Dr. Khemani.
About Children’s Hospital Los Angeles
Founded in 1901, Children’s Hospital Los Angeles is the largest provider of hospital care for children in California. Renowned pediatric experts work together across disciplines to deliver inclusive and compassionate health care to one of the world’s most diverse populations, driving advances that set child health standards across the nation and around the globe. With a mission to create hope and build healthier futures for children, the hospital consistently ranks in the top 10 in the nation, No. 1 in California and No. 1 in the Pacific U.S. region on U.S. News & World Report’s Honor Roll of Best Children’s Hospitals. The Saban Research Institute of Children’s Hospital Los Angeles supports the full continuum of child health research and is among the top 10 pediatric academic medical centers for National Institutes of Health funding, meaning physicians and scientists translate discoveries into treatments and bring answers to families faster. Home to one of the largest pediatric training programs in the United States, Children’s Hospital Los Angeles graduates a new class of physicians each year who have learned world-class children’s health care at the forefront of medicine. And as an anchor institution, the hospital strengthens the economic health of surrounding communities by fighting food insecurity, enhancing health education and literacy, and introducing early careerists to health care. To learn more, follow us on Facebook, Instagram, LinkedIn, YouTube and Twitter, and visit our blog at CHLA.org/blog.
Source: Children’s Hospital Los Angeles
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Child Health
Recognizing the Signs of Pediatric Growth Hormone Deficiency: How Early Recognition and Advocacy Helped One Family Find Answers
Diane Benke noticed her son Alex’s height concerns starting at age 7, despite his pediatrician’s reassurances. After persistent worries, they consulted an endocrinologist, leading to a diagnosis of Pediatric Growth Hormone Deficiency (PGHD). Following treatment changes, including a switch to weekly hormone injections, Alex’s growth improved, allowing the family to focus on their well-being.
Last Updated on February 5, 2026 by Daily News Staff
(Family Features) “Our concerns about Alex’s growth began around the age of 7,” said his mother, Diane Benke.
Though Alex measured around the 50th percentile for weight, his height consistently hovered around the 20th percentile. Benke’s instincts told her something wasn’t quite right.
“I kept asking our pediatrician if this could mean something more,” she said. “Each time, I was reassured that everything was fine. After all, I’m only 5 feet tall myself.”
At first, Benke tried setting her worries aside. Alex was one of the youngest in his class, and she wondered if he could simply be a “late bloomer.”
However, as Alex progressed through elementary school, particularly in the 4th and 6th grades, his height percentile dropped into the single digits. The height difference between Alex and his peers became impossible to ignore.
Despite Benke’s growing concerns, their pediatrician continued to assure them Alex was fine.
“We were told as long as he was making some progress on the growth chart, there was no need to worry,” she said, “but we were never actually shown the charts.”
It wasn’t until one of Benke’s friends confided that her own daughter had recently been diagnosed with Pediatric Growth Hormone Deficiency (PGHD) that she decided to seek an endocrinologist.
“Although it took several months to get an appointment,” Benke said, “we were determined to get more answers.”
Navigating the Diagnosis Process
Getting a diagnosis for many medical conditions can be a long journey. However, early detection and diagnosis of PGHD is important. It can help minimize the impact on overall health and support optimal growth.
Once Alex was seen by a pediatric endocrinologist, he underwent a series of evaluations, including bloodwork, a bone age X-ray to compare his chronological age with his skeletal age and a growth hormone stimulation test, which measures the body’s ability to produce growth hormone. He also had a brain MRI to rule out the potential of any pituitary abnormalities.
The results of these tests confirmed the diagnosis of PGHD, a rare condition that occurs when the pituitary gland does not produce enough growth hormone. PGHD affects an estimated 1 in 4,000-10,000 children.
Some common signs parents might notice include: their child being significantly shorter than other kids their age, slower growth rate over time, delayed puberty, reduced muscle strength or lower energy levels, slower bone development and delayed physical milestones.
“Receiving Alex’s diagnosis was a relief,” Benke said. “It provided clarity and a path forward.”
Moving Forward with Treatment
“While the diagnosis process was exhausting, starting treatment made the process worthwhile,” Benke said.
For decades, daily injections of a drug called somatropin, which is similar to the growth hormone your body produces, have been the standard of care for PGHD. It wasn’t until 2015 that the Growth Hormone Research Society recognized the need for a long-acting growth hormone (LAGH), offering once-weekly dosing as an alternative to daily injections.
Benke explained navigating the insurance approval process was another challenge.
“Our insurance required us to try a daily medication before approving a weekly option,” she said.
Alex spent three months on daily medication, often missing doses, before he was approved to switch to a weekly treatment option.
“The weekly option made such a positive impact,” Benke said. “We now have minimal disruptions to our daily routine and Alex hasn’t missed a single dose since.”
Beyond a more convenient dosing option, the change gave Benke peace of mind.
“We could focus more on being a family again, without the daily worries of his next dose,” she said.
If you’re concerned about your child’s growth, talk to their doctor as soon as possible. Early diagnosis is important, as treatment becomes less effective once a child’s bones stop growing.
Benke’s advice to other parents: “Trust your instincts. If something feels wrong, seek out a specialist and push for answers and don’t give up, even when faced with hurdles… Stay hopeful and persistent – it’s a journey worth fighting for.”
Visit GHDinKids.com to download a doctor discussion guide to help prepare for your next appointment.
SOURCE:
Skytrofa
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Lifestyle
How to reduce gift-giving stress with your kids – a child psychologist’s tips for making magic and avoiding tears
Reduce gift-giving stress with kids: A child psychologist shares practical rules for stress-free gift giving with kids—how many gifts to give, what holds attention, and how to avoid holiday tears.
Last Updated on January 9, 2026 by Daily News Staff

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health and wellness
Texas cities have some of the highest preterm birth rates in the US, highlighting maternal health crisis nationwide

Texas cities have some of the highest preterm birth rates in the US, highlighting maternal health crisis nationwide
Revealing disparities that drive preterm birth rates
The March of Dimes report scored the U.S. overall a D+ grade on preterm birth rate at 10.4%, but states differ dramatically in their scores. New Hampshire, for example, scored an A- with 7.9% of infants born prematurely, while Mississippi, where 15% of infants are born prematurely, scored an F. Texas’ rates aren’t the worst in the country, but it scores notably worse than the national rate of 10.4%, with 11.1% of babies – 43,344 in total – born prematurely in 2024. And Texas has an especially large effect on the low national score because 10 of the 46 cities that receive a D or F grade – defined in the report as a rate higher than the national rate of 10.4% – are located there. In 2023, Texas had the highest number of such cities in the U.S. That may be in part because access to maternal care in Texas is so limited. Close to half of all counties across the state completely lack access to maternity care providers and birthing facilities, compared with one-third of counties across the U.S. Moreover, more counties in Texas are designated as health professional shortage areas, meaning they lack enough doctors for the number of people living in these areas. Shortages exist in 257 areas in Texas for primary care doctors, 149 for dentists and 251 for mental health providers. But even against the backdrop of geographic differences in health care access, the starkest contribution to the state’s preterm birth rates comes from ethnic and racial disparities. Mothers of non-Hispanic Black (14.7%), American Indian/Alaskan Native (12.5%), Pacific Islander (12.3%) and Hispanic (10.1%) descent have babies prematurely much more often than do mothers who are non-Hispanic white (9.5%) or Asian (9.1%). These numbers reflect the broader landscape of maternal health in the U.S. Although nationwide maternal mortality rates decreased from 22.3 to 18.6 deaths per 100,000 live births from 2022 to 2023, Black women died during pregnancy or within one year after childbirth at almost three times the rate (50.3%) of white (14.5%), Hispanic (12.4%) and Asian (10.7%) women.
Preterm birth in context
Having a baby early is not the normal or expected outcome during pregnancy. It occurs due to complex genetic and environmental factors, which are exacerbated by inadequate prenatal care. According to the World Health Organization, women should have eight or more doctor visits during their pregnancy. Without adequate and quality prenatal care, the chances of reversing the preterm birth trends are slim. Yet in Texas, unequal access to prenatal care remains a huge cause for concern. As the March of Dimes report documents, women of color in Texas receive adequate prenatal care at vastly lower rates than do white women – a fact that holds true in several other states as well. In addition, Texas has the highest uninsured rate in the nation, with 17% of women uninsured for health coverage, compared with a national average of 8%. Nationwide, public health experts, community advocates and families are calling for comprehensive health insurance to help cover the costs of prenatal care, particularly for low-income families that primarily rely on Medicaid for childbirth. Cuts to funding for the Affordable Care Act and Medicaid outlined in the 2025 Budget Reconciliation Act make it likely that more Americans will lose access to care or see their health care costs balloon. But state-level action may help reduce access barriers. In Texas, for example, a set of laws passed in 2025 may help improve access to care before, during and after pregnancy. Texas legislators funded initiatives targeted at workforce development in rural areas – particularly for obstetrician-gynecologists, emergency physicians and nurses, women’s preventive safety net programs, and maternal safety and quality improvement initiatives. Rising rates of chronic diseases, such as hypertension, obesity and diabetes, also contribute to women giving birth prematurely. While working with the state maternal mortality and morbidity review committee, my team and I found that cardiovascular conditions contributed to the 85 pregnancy-related deaths that occurred in 2020. An upward trend in obesity, diabetes and hypertension before pregnancy are pressing issues in the state, posing a serious threat to fetal and maternal health.Learning from other countries
These statistics are grim. But proven strategies to reduce these and other causes of maternal mortality and morbidity are available. In Australia, for instance, maternal deaths have significantly declined from 12.7 per 100,000 live births in the early 1970s to 5.3 per 100,000 between 2021 and 2022. The reduction can be linked to several medical interventions that are based on equitable, safe, woman-centered and evidence-based maternal health services. In Texas, some of my colleagues at Texas A&M University use an equitable, woman-centered approach to develop culturally competent care centered on educational health promotion, preventive health care and community services. Utilizing nurses and nonmedical support roles such as community health workers and doulas, my colleagues’ initiatives complement existing state efforts and close critical gaps in health care access for rural and low-income Texas families. Across the country, researchers are using similar models, including the use of doulas, to address the Black maternal health crisis. Research shows the use of doulas can improve access to care during pregnancy and childbirth, particularly for women of color.
It’s all hands on deck
There isn’t one, single risk factor that leads to a preterm birth, nor is there a universal approach to its prevention. Results from my work with Black mothers who had a preterm birth aligns with what other experts are saying: Addressing the maternal health crisis in the U.S. requires more than policy interventions. It involves the dismantling of system-level and policy-driven inequities that lead to high rates of preterm births and negative pregnancy and childbirth outcomes, particularly for women of color, through funding, research, policy changes and community voices. Although I had my preterm birth in Nigeria, my story and those shared by the Black mothers I have worked with in the U.S. show eerily similar underlying challenges across different settings. Kobi V. Ajayi, Research Assistant Professor of Maternal and Child Health, Texas A&M University This article is republished from The Conversation under a Creative Commons license. Read the original article.Discover more from Daily News
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