Health
What Enables Herpes Simplex Virus To Become Impervious to Drugs?
Research pinpoints key to the cold sore virus’s ability to evade treatment, offering broader clues on antiviral drug resistance
Newswise — All organisms — from fungi to mammals — have the capacity to evolve and adapt to their environments. But viruses are master shapeshifters with an ability to mutate greater than any other organism. As a result, they can evade treatments or acquire resistance to once-effective antiviral medications.
Is the Herpes Simplex Virus Becoming Impervious to Drugs?
Working with herpes simplex virus (HSV), a new study led by Harvard Medical School researchers sheds light on one of the ways in which the virus becomes resistant to treatment, a problem that could be particularly challenging among people with compromised immune function, including those receiving immune-suppressive treatment and those born with immune deficiencies.
Using a sophisticated imaging technique called cryogenic electron microscopy (cryo-EM), the researchers found that how parts of a protein responsible for viral replication move into different positions can alter the virus’s susceptibility to medicines.
The findings, published Aug. 27 in Cell, answer long-standing questions about why certain viruses, but not others, are susceptible to antiviral medications and how viruses become impervious to drugs. The results could inform new approaches that impede viruses’ capacity to outpace effective therapies.
Counterintuitive results
Researchers have long known changes that occur on the parts of a virus where antiviral drugs bind to it can render it resistant to therapy. However, the HMS researchers found that, much to their surprise, this was often not the case with HSV.
Instead, the investigators discovered that protein mutations linked to drug resistance often arise far from the drug’s target location. These mutations involve alterations that change the movements of a viral protein, or enzyme, that allows the virus to replicate itself. This raises the possibility that using drugs to block or freeze the conformational changes of these viral proteins could be a successful strategy for overcoming drug resistance.
“Our findings show that we have to think beyond targeting the typical drug-binding sites,” said the study’s senior author, Jonathan Abraham, associate professor of microbiology in the Blavatnik Institute at HMS and infectious disease specialist at Brigham and Women’s Hospital. “This really helps us see drug resistance in a new light.”
The new findings propel the understanding of how alterations in the conformation of a viral protein — or changes in how the different parts within that protein move when it carries out its function — fuel drug resistance and may be relevant for understanding drug effectiveness and drug resistance in other viruses, the researchers noted.
HSV, estimated to affect billions of people worldwide, is most commonly known as the cause of cold sores and fever blisters, but it can also lead to serious eye infections, brain inflammation, and liver damage in people with compromised immunity. Additionally, HSV can be transmitted from mother to baby via the birth canal during delivery and cause life-threatening neonatal infections.
Clues on resistance rooted in structure and movement
A virus can’t replicate on its own. To do so, viruses must enter a host cell, where they unleash their replication tools — proteins called polymerases — to make copies of themselves.
The current study focused on one such protein — a viral DNA polymerase — crucial for HSV’s ability to reproduce and propagate itself. The ability to carry out its function is rooted in the DNA polymerase’s structure, often likened to a hand with three parts: the palm, the thumb, and the fingers, each carrying out critical functions.
Given their role in enabling replication, these polymerases are critical targets of antiviral drugs, which aim to stop the virus from reproducing itself and halt the spread of infection. The HSV polymerase is the target of acyclovir, the leading antiviral drug for treating HSV infection, and of foscarnet, a second-line drug used for drug-resistant infections. Both drugs work by targeting the viral polymerase but do so in different ways.
Scientists have long struggled to fully understand how alterations in the polymerase render the virus impervious to normal doses of antiviral drugs and, more broadly, why acyclovir and foscarnet are not always effective against the altered forms of the HSV polymerase.
“Over the years, the structures of many polymerases from various organisms have been determined, but we still don’t fully understand what makes some polymerases, but not others, susceptible to certain drugs,” Abraham said. “Our study reveals that how the different parts of the polymerases move, known as their conformational dynamics, is a critical component of their relative susceptibility to drugs.”
Proteins, including polymerases, are not rigid, motionless objects. Instead, they are flexible and dynamic.Composed of amino acids, they initially fold into a steady, three‐dimensional shape known as the native conformation — their baseline structure. But as a result of various bonding and dispersing forces, the different parts of proteins can move when they come into contact with other cellular components as well as through external influences, such as changes in pH or temperature. For example, the fingers of a polymerase protein can open and close, as would the fingers of a hand.
Conformational dynamics — the ability of different parts of a protein to move — allow them to efficiently administer many essential functions with a limited number of ingredients. A better understanding of polymerase conformational dynamics is the missing link between structures and functions, including whether a protein responds to a drug and whether it could become resistant to it down the road.
Unraveling the mystery
Many structural studies have captured DNA polymerases in various distinct conformations. However, a detailed understanding of the impact of polymerase conformational dynamics on drug resistance is lacking. To solve the puzzle, the researchers carried out a series of experiments, focusing on two common polymerase conformations — an open one and a closed one — to determine how each affects drug susceptibility.
First, using cryo-EM, they conducted structural analysis to get high-resolution visualizations of the atomic structures of HSV polymerase in multiple conformations, as well as when bound to the antiviral drugs acyclovir and foscarnet. The drug-bound structures revealed how the two drugs selectively bind polymerases that more readily adopt one conformation versus another. One of the drugs, foscarnet, works by trapping the fingers of the DNA polymerase so that they are stuck in a so-called closed configuration.
Further, structural analysis paired with computational simulations suggested that several mutations that are distant from the sites of drug binding confer antiviral resistance by altering the position of the polymerase fingers responsible for closing onto the drug to halt DNA replication.
The finding was an unexpected twist. Up until now, scientists have believed that polymerases closed partially only when they attached to DNA and closed fully only when they added a DNA building block, a deoxynucleotide. It turns out, however, that HSV polymerase can fully close just by being near DNA. This makes it easier for acyclovir and foscarnet to latch on and stop the polymerase from working, thus halting viral replication.
“I’ve worked on HSV polymerase and acyclovir resistance for 45 years. Back then I thought that resistance mutations would help us understand how the polymerase recognizes features of the natural molecules that the drugs mimic,” said study co-author Donald Coen, professor of biological chemistry and molecular pharmacology at HMS. “I’m delighted that this work shows that I was wrong and finally gives us at least one clear reason why HSV polymerase is selectively inhibited by the drug.”
Authorship, funding, disclosures
Additional authors included Sundaresh Shankar, Junhua Pan, Pan Yang, Yuemin Bian, Gábor Oroszlán, Zishuo Yu, Purba Mukherjee, David J. Filman, James M. Hogle, Mrinal Shekhar.
This work was supported by the National Institutes of Health (awards R21 AI141940 and R01 AI19838), with additional funding from a Centers for Integrated Solutions in Infectious Diseases grant.
What Enables Herpes Simplex Virus To Become Impervious to Drugs?
Source: Harvard Medical School
Our Lifestyle section on STM Daily News is a hub of inspiration and practical information, offering a range of articles that touch on various aspects of daily life. From tips on family finances to guides for maintaining health and wellness, we strive to empower our readers with knowledge and resources to enhance their lifestyles. Whether you’re seeking outdoor activity ideas, fashion trends, or travel recommendations, our lifestyle section has got you covered. Visit us today at https://stmdailynews.com/category/lifestyle/ and embark on a journey of discovery and self-improvement.
The science section of our news blog STM Daily News provides readers with captivating and up-to-date information on the latest scientific discoveries, breakthroughs, and innovations across various fields. We offer engaging and accessible content, ensuring that readers with different levels of scientific knowledge can stay informed. Whether it’s exploring advancements in medicine, astronomy, technology, or environmental sciences, our science section strives to shed light on the intriguing world of scientific exploration and its profound impact on our daily lives. From thought-provoking articles to informative interviews with experts in the field, STM Daily News Science offers a harmonious blend of factual reporting, analysis, and exploration, making it a go-to source for science enthusiasts and curious minds alike. https://stmdailynews.com/category/science/
Health and Life Insurance
Review Your Medicare Coverage Options: Open Enrollment is Through Dec. 7
Medicare Coverage Options: Medicare Open Enrollment is your opportunity to give your Medicare plan a check-up. Plans change every year, and now is the time to check if a new plan could be better for you.
Review Your Medicare Coverage Options: Open Enrollment is Through Dec. 7
(Feature Impact)Medicare Open Enrollment is your opportunity to give your Medicare plan a check-up. Plans change every year, and now is the time to check if a new plan could be better for you.
If you have Medicare, taking the time to review your coverage options each fall is one of the most important health decisions you can make.
Give Your Medicare Plan a Check-up
- Check your coverage. Ensure your preferred doctors, prescriptions and preferred pharmacies are covered.
- Check your costs. Look at premiums, deductibles, copays and other out-of-pocket costs.
- Check for changes. See what will be different in your plan for the coming year.
- Check your options. Compare plans side by side based on the prescriptions you take. Find the right plan for your health needs and your budget. Make sure your drugs are covered.
Now is the one time you can make changes to your health and prescription drug plans and find a plan that’s better for you. Medicare Open Enrollment is your opportunity to review and compare options and take control of your expenditures and coverage.
Medicare plans change annually and so does your health. What worked for you last year may be different than what will work best this year. A review of your options can help you secure a plan best fit to your current lifestyle and health needs – while potentially saving you hundreds of dollars on out-of-pocket costs.
For instance, a person with Medicare compared drug plans to find the best costs and coverage for their prescriptions, including a blood thinner and a common cholesterol medication. Using medicare.gov, they found the yearly cost for a Medicare drug plan and these prescriptions ranged from $1,356-2,965. By choosing the lowest-cost plan, they saved more than $1,600 while keeping their essential medications covered.
Medicare.gov is the Official Source
For all your Open Enrollment needs, Medicare.gov is your official source. It’s the trusted resource to help you navigate Open Enrollment, allowing you to explore and compare every available Medicare health and drug plan available in your area. If you prefer speaking with someone directly, call 1-800-MEDICARE to connect with a team of experts who are available 24/7 to help you review your options and answer any questions about your Medicare coverage.
To get started, go to Medicare.gov and click on “Find Plans Now.” For the best shopping experience, log in or create a Medicare account. You can easily compare plan costs, side by side, based on the medications you take. Make sure the plan you choose covers your prescription drugs and your doctors.
Don’t Wait – Open Enrollment Ends Dec. 7
If you miss the Dec. 7 deadline, you may need to wait a full year before you can make any changes to your coverage. That’s why getting started early is important. Make sure you give yourself enough time to review and compare your options. You’ll want to consider factors like costs, benefits and prescription drug plans.
Medicare Open Enrollment is the perfect time to plan for the future and prioritize your health. Making sure you have a health plan that can support you in your wellness journey is critical, so don’t wait. Start reviewing your Medicare plan options today at Medicare.gov.
Information provided by the U.S. Department of Health & Human Services.
Photos courtesy of Shutterstock
SOURCE:
Centers for Medicare and Medicaid Services
health and wellness
Flu Season Arrives Early: Walgreens Launches 2026-2027 Flu Index as Activity Rises Across the U.S.
The 2026-2027 flu season is tracking four weeks ahead of recent years. Explore Walgreens’ new Flu Index, rising activity, and ways to stay protected.
Last Updated on October 31, 2026 by Daily News Staff
2026-2027 Flu Season: New tracking data suggests influenza activity is running approximately four weeks ahead of recent seasons, with increases reported across western states and Florida.
2026-2027 Flu Season Starts Early as Walgreens Launches New Flu Index
STM Daily News | Health & Wellness
October 30, 2026
Flu season may be getting an early start this year, and a new online tracking tool from Walgreens is giving Americans a closer look at respiratory illness activity in their communities.
On October 21, Walgreens announced the launch of its 2026-2027 Flu Index, an interactive tool that monitors influenza, COVID-19, and other acute respiratory illnesses across the United States.
According to the company’s initial findings, national flu activity is tracking approximately four weeks ahead of recent flu seasons, with increasing activity reported across several western states and Florida.
The early trends serve as a reminder that influenza doesn’t necessarily wait until winter to begin spreading.
Flu Activity Is Increasing Earlier Than Expected
Walgreens reports that its early-season data indicates influenza activity is already increasing in multiple parts of the country.
The company’s findings include:
- Earlier flu activity: National flu activity is tracking approximately four weeks ahead of recent seasons.
- Regional increases: Several western states and Florida are experiencing rising activity.
- More antiviral prescriptions: Walgreens reports dispensing more flu antiviral medications than during the same period in 2025.
- Growing demand for cold and flu products: Sales of cold and flu medications, at-home respiratory illness tests, cough drops, and tea have increased by double-digit percentages compared with last year.
Although these indicators suggest respiratory illness activity is increasing, they do not necessarily mean the current flu season will be more severe than previous seasons.
Increased purchases of cold medications and testing products can reflect changes in consumer behavior as well as illness trends.
The findings come from Walgreens’ pharmacy and retail data and should be considered alongside public health surveillance from the Centers for Disease Control and Prevention (CDC).
What Is the Walgreens Flu Index?
The Walgreens Flu Index is an interactive online platform designed to help consumers understand where respiratory illnesses are circulating and how activity is changing over time.
The tool combines several types of information, including:
- Flu and COVID-19 testing data from Walgreens locations
- Prescription antiviral medication trends
- Over-the-counter cold and flu product purchases
- Geographic patterns in respiratory illness activity
Using these indicators, Walgreens calculates an activity score ranging from 0 to 10.
A score of zero represents the lowest level of activity, while a score of ten represents the highest.
The index provides weekly information for states and territories, along with more than 1,500 counties where sufficient Walgreens data is available.
The map is updated every Monday, allowing users to compare current activity with previous weeks and the prior flu season.
Importantly, Walgreens emphasizes that the index measures relative illness activity, not disease severity. A higher score does not necessarily indicate more hospitalizations, more serious infections, or a greater risk of complications.
The index also does not represent a complete count of influenza cases nationwide.
Explore the interactive map:
https://www.walgreens.com/seasonal/respiratory-illness-index
Why Local Flu Activity Matters
Influenza does not spread evenly across the country.
Some communities may experience increasing cases weeks before others, making local information useful for families, schools, healthcare providers, and individuals who may be at higher risk of complications.
“Flu activity can vary significantly from one community to another, and knowing what’s happening locally can make a real difference,” said Rick Gates, Walgreens’ chief pharmacy and enterprise external affairs officer.
Gates added that the index is intended to help people make informed decisions about prevention, including vaccination before influenza becomes more widespread in their communities.
For residents of states such as Arizona, California, Nevada, and other western states, the reported regional increases make monitoring local respiratory illness trends particularly relevant.
However, the company’s announcement does not establish that every western county is experiencing elevated flu activity. Readers should consult the latest local data for a more accurate picture.
Why Getting a Flu Shot Still Matters
Annual influenza vaccination remains an important tool for reducing the risk of flu illness and serious complications.
Because influenza viruses change over time, flu vaccines are reviewed and updated each season to target strains expected to circulate.
The CDC recommends annual influenza vaccination for most people ages six months and older, with rare exceptions.
Vaccination is especially important for people who face a greater risk of serious complications, including:
- Adults ages 65 and older
- Young children, particularly those younger than five
- Pregnant individuals
- People with chronic conditions such as asthma, diabetes, or heart disease
- People with weakened immune systems
For adults 65 and older, the CDC preferentially recommends certain enhanced influenza vaccines, including higher-dose, recombinant, or adjuvanted options, when available.
Walgreens says its pharmacies offer standard-dose and higher-dose vaccines, along with a new mRNA influenza vaccine at select locations.
Vaccine selection should follow current CDC recommendations, individual eligibility, and guidance from a qualified healthcare professional.
It generally takes about two weeks after vaccination for the body to develop protective antibodies.
Even if influenza is already circulating locally, vaccination can still provide benefits throughout the season.
Practical Ways to Reduce Your Risk of Getting Sick
Vaccination is an important preventive measure, but it is not the only step people can take to reduce the spread of respiratory illnesses.
Public health guidance also encourages several everyday precautions.
Wash your hands regularly. Use soap and water, particularly after touching shared surfaces or being in public places. Alcohol-based hand sanitizer can help when soap and water are unavailable.
Cover coughs and sneezes. Use a tissue or your elbow to reduce the spread of respiratory droplets.
Improve indoor air quality. Opening windows when practical, improving ventilation, and using appropriate air filtration can help reduce exposure to airborne respiratory viruses.
Avoid close contact when sick. Staying home when experiencing respiratory illness symptoms can help protect coworkers, classmates, friends, and family members.
Consider wearing a well-fitting mask. Masks can provide an additional layer of protection, particularly in crowded indoor spaces or around people at higher risk.
Pay attention to symptoms. Fever, coughing, sore throat, fatigue, muscle aches, and congestion can occur with influenza and other respiratory infections.
Because flu and COVID-19 can produce similar symptoms, testing may help determine the cause of an illness.
People at higher risk of complications should contact a healthcare professional promptly if flu symptoms develop. Prescription antiviral medications work best when started early, ideally within the first two days of symptoms, although treatment can still benefit some patients later.
Walgreens Expands Vaccination Access for the 2026–2027 Season
Alongside the launch of its Flu Index, Walgreens announced several efforts to make seasonal vaccinations more convenient.
The company says it is increasing pharmacy staffing, expanding appointment availability, and allowing customers to schedule vaccinations further in advance.
Customers can arrange appointments through several methods:
- Online: https://www.walgreens.com/ScheduleVaccine
- Mobile: Walgreens app
- Text: Send “Flu” to 66879
- Telephone: 1-800-WALGREENS
- Walk-in: Participating Walgreens pharmacies, subject to availability
Walgreens also announced promotional Walgreens Cash rewards for eligible myWalgreens members receiving vaccinations.
Under the limited-time promotion, qualifying members may earn $15 in Walgreens Cash rewards on eligible purchases, along with an additional 10% back on qualifying purchases for a limited period.
Restrictions, exclusions, geographic limitations, and promotional deadlines apply. Customers should review the official terms before participating.
What About COVID-19 and Other Respiratory Illnesses?
Although influenza is the primary focus of the seasonal announcement, the Walgreens Flu Index also tracks COVID-19 and broader acute respiratory illness trends.
This distinction matters because several respiratory viruses can circulate simultaneously during the fall and winter months.
Influenza, COVID-19, respiratory syncytial virus (RSV), and common cold viruses can produce overlapping symptoms, but their potential complications and recommended treatments differ.
Vaccination eligibility and recommendations also vary by disease, age, and individual health circumstances.
Readers should consult current CDC guidance and their healthcare providers when considering flu, COVID-19, or RSV vaccination.
The Bottom Line: Flu Season May Be Early, but Prevention Still Matters
The launch of the 2026–2027 Walgreens Flu Index offers another resource for Americans who want to monitor respiratory illness activity in their communities.
While Walgreens’ early findings suggest influenza activity is increasing sooner than in recent years, it is still too early to determine how severe the overall season will become.
The most important message for consumers is to prepare before respiratory illnesses become widespread.
Staying current with recommended vaccinations, practicing good hygiene, monitoring local illness trends, and seeking medical attention when appropriate can help reduce the risk of serious illness.
With flu activity already rising in some regions, now is a good time for families to review their seasonal health plans.
Related Links for Further Information
Walgreens Resources
- Walgreens Respiratory Illness Index — Interactive map showing respiratory illness activity across the United States.
- Walgreens Vaccination Scheduling — Schedule a flu vaccination or explore available vaccines.
Public Health Resources
- CDC Seasonal Influenza Information — Information about influenza symptoms, prevention, vaccination, and treatment.
- CDC FluView Surveillance — National influenza surveillance and weekly activity reports.
- CDC: Flu and People 65 Years and Older — Guidance for older adults and influenza vaccination.
- CDC Respiratory Illnesses — Prevention information for flu, COVID-19, and RSV.
Source: Walgreen Co., press release, October 21, 2026, Walgreens Launches 2026–2027 Flu Index as Activity Tracks Four Weeks Ahead of Recent Seasons.
Editor’s Note: This article summarizes information from Walgreens’ October 21, 2026, announcement. The reported early-season trends reflect the company’s findings at that time and are not a substitute for current CDC surveillance or medical advice. Readers should consult healthcare professionals about individual vaccination and treatment decisions.
STM Daily News — News You Can Use This Moment!
Health and Life Insurance
Things Can Change So Review Your Medicare Coverage Options: Open Enrollment is Through Dec. 7
It’s time to visit your Medicare Coverage Options. Medicare Open Enrollment is your opportunity to give your Medicare plan a check-up. Plans change every year, and now is the time to check if a new plan could be better for you.
Things Can Change So Review Your Medicare Coverage Options: Open Enrollment is Through Dec. 7
(Feature Impact)Medicare Open Enrollment is your opportunity to give your Medicare plan a check-up. Plans change every year, and now is the time to check if a new plan could be better for you.
If you have Medicare, taking the time to review your coverage options each fall is one of the most important health decisions you can make.
Give Your Medicare Plan a Check-up
- Check your coverage. Ensure your preferred doctors, prescriptions and preferred pharmacies are covered.
- Check your costs. Look at premiums, deductibles, copays and other out-of-pocket costs.
- Check for changes. See what will be different in your plan for the coming year.
- Check your options. Compare plans side by side based on the prescriptions you take. Find the right plan for your health needs and your budget. Make sure your drugs are covered.
Now is the one time you can make changes to your health and prescription drug plans and find a plan that’s better for you. Medicare Open Enrollment is your opportunity to review and compare options and take control of your expenditures and coverage.
Medicare plans change annually and so does your health. What worked for you last year may be different than what will work best this year. A review of your options can help you secure a plan best fit to your current lifestyle and health needs – while potentially saving you hundreds of dollars on out-of-pocket costs.
For instance, a person with Medicare compared drug plans to find the best costs and coverage for their prescriptions, including a blood thinner and a common cholesterol medication. Using medicare.gov, they found the yearly cost for a Medicare drug plan and these prescriptions ranged from $1,356-2,965. By choosing the lowest-cost plan, they saved more than $1,600 while keeping their essential medications covered.
Medicare.gov is the Official Source
For all your Open Enrollment needs, Medicare.gov is your official source. It’s the trusted resource to help you navigate Open Enrollment, allowing you to explore and compare every available Medicare health and drug plan available in your area. If you prefer speaking with someone directly, call 1-800-MEDICARE to connect with a team of experts who are available 24/7 to help you review your options and answer any questions about your Medicare coverage.
To get started, go to Medicare.gov and click on “Find Plans Now.” For the best shopping experience, log in or create a Medicare account. You can easily compare plan costs, side by side, based on the medications you take. Make sure the plan you choose covers your prescription drugs and your doctors.
Don’t Wait – Open Enrollment Ends Dec. 7
If you miss the Dec. 7 deadline, you may need to wait a full year before you can make any changes to your coverage. That’s why getting started early is important. Make sure you give yourself enough time to review and compare your options. You’ll want to consider factors like costs, benefits and prescription drug plans.
Medicare Open Enrollment is the perfect time to plan for the future and prioritize your health. Making sure you have a health plan that can support you in your wellness journey is critical, so don’t wait. Start reviewing your Medicare plan options today at Medicare.gov.
Stay Vigilant Against Medicare Fraud
Stay vigilant against Medicare fraud, especially during Medicare Open Enrollment. Scammers take advantage of this time of year; they may pretend to be from Medicare or an insurance company in order to steal your personal information.
Remember that Medicare will never contact you unsolicited. If someone you do not know calls, texts or emails you about Medicare, simply hang up or delete the message. By staying alert, you can help stop fraud before it starts.
If you suspect Medicare fraud, report it immediately to Medicare at Medicare.gov/fraud or at 1-800-MEDICARE. As always, remember to never give out your Medicare Number, Social Security Number or financial information to anyone you don’t know.
Information provided by the U.S. Department of Health & Human Services.
Photos courtesy of Shutterstock
SOURCE:
Centers for Medicare and Medicaid Services
