Health
Help Wanted: How clinical trials help fight disease
(Family Features) Clinical trials are necessary for finding new ways of preventing, detecting or treating diseases, but often, limited participation creates challenges for meeting clinical trial goals. Despite decades of effort and strategies to identify and address barriers to recruiting and enrolling study participants, recruitment challenges persist, particularly among women, older adults and diverse patient populations.
Clinical trials
“Potential study participants are reluctant to get involved for a variety of reasons, including the time commitment, lack of clarity regarding safeguards for their well-being and concerns about how their medical condition will be handled during the study,” said Alan Moss, MD, chief scientific officer with the Crohn’s & Colitis Foundation, the leading nonprofit organization focused on both research and support of people living with inflammatory bowel disease (IBD). “Taking part in a clinical trial gives patients an opportunity to access new therapies and can help shape future treatment, including how diseases are diagnosed, treated and even prevented.”
Learning more about the important role clinical trials play in health care may ultimately help you or someone you love find a new treatment or manage a condition, such as IBD, more effectively.
Importance of Clinical Trials
Finding a treatment that relieves patients’ symptoms and helps induce and maintain remission is important. However, these treatments wouldn’t be available without clinical trials. In fact, all U.S. Food & Drug Administration (FDA)-approved medicines currently available on the market are the result of clinical trials and the patients who participated in them. When enrollment targets aren’t reached due to low patient participation, there may be delays in the drug approval process.
What You Should Know
There are plenty of reasons to consider participating in a clinical trial, especially if you’re looking for further options to treat a serious condition. Taking part in a clinical trial is a big step, so it’s important to be well-informed.
- Safety: Investigational treatments must be studied extensively before the FDA will approve them. Each trial follows thorough protocols to ensure the health and safety of its participants. Additionally, patients are followed continuously throughout a trial to monitor their health.
- Eligibility: Who can participate in a clinical trial depends greatly on the specific limits of the study. Each clinical trial has its own goals to achieve, which means different trials have different criteria for patients to meet in order to enroll. Some trials are for patients who have moderate to severe disease and others may seek patients with mild disease. Other trials look for patients without any diagnosis. Prior to enrolling in a trial, a research coordinator will review your complete medical history to see if you meet the inclusion criteria.
- Treatment: When you decide to enroll in a clinical trial, you may have access to the study drug as a form of treatment. Typically, participants will not know if they are receiving the study drug during the trial. This helps reduce potential biases and ensures the fairness of the trial. However, all participants are monitored closely. If there is any change in your medical condition while participating in the study, the research staff will inform you immediately and discuss the situation.
- Cost: The majority of clinical trials are federally or privately funded, so there is typically no cost to participants. While federal law requires most health insurance plans to cover the majority of routine patient care costs associated with clinical trials, there are some costs you may incur, such as travel, gas, parking, child care and time away from work. Trial sponsors commonly cover these costs, as well as any non-routine patient care that isn’t covered by insurance. However, it’s a good idea to get a clear understanding of how the trial you’re considering would handle these expenses.
- Leaving the study: At any point you wish to drop out of the trial, you can, and for any reason. In that case, it’s common for a research coordinator to ask you to complete a final visit and schedule follow-up visits, if needed, to ensure you do not experience any side effects.
How to Learn More
If you’re interested in participating in a clinical trial, it’s important to go to trusted sources to learn more and ask questions. For example, the Crohn’s & Colitis Foundation can point you toward clinical trial opportunities. Your doctor’s office can also be a good source of information about local studies.
If you’re hesitant about joining a trial involving a treatment but are eager to help, you might consider other types of research studies, such as prevention, diagnostic, screening or quality of life trials instead.
Once you identify a clinical trial that interests you and you may be eligible for, contact the research coordinator to learn more. You’ll also want to discuss the study in greater detail with your doctor and talk to loved ones within your support system who may have questions or helpful insight to consider.
Visit crohnscolitisfoundation.org/clinical-trials-community to learn more about IBD clinical trials and find opportunities near you.
Understanding IBD
Inflammatory bowel disease (IBD) affects nearly 1 in 100 people living in the United States, according to a study led by the Crohn’s & Colitis Foundation. IBD is an umbrella term used to describe disorders that cause chronic inflammation of the gastrointestinal (GI) tract.
Symptoms include diarrhea, as well as abdominal pain, nausea, fever, loss of appetite, fatigue and, at times, rectal bleeding. No single test can confirm IBD, which includes Crohn’s disease and ulcerative colitis. There are currently no cures for IBD. Medication and managing your diet and nutrition are two of the most common treatment recommendations.
Photos courtesy of Shutterstock
SOURCE:
Crohn’s & Colitis Foundation
Our Lifestyle section on STM Daily News is a hub of inspiration and practical information, offering a range of articles that touch on various aspects of daily life. From tips on family finances to guides for maintaining health and wellness, we strive to empower our readers with knowledge and resources to enhance their lifestyles. Whether you’re seeking outdoor activity ideas, fashion trends, or travel recommendations, our lifestyle section has got you covered. Visit us today at https://stmdailynews.com/category/lifestyle/ and embark on a journey of discovery and self-improvement.
Discover more from Daily News
Subscribe to get the latest posts sent to your email.
health and wellness
What Older Adults Need to Know About Vaccines for a Healthy New Year
(Family Features) Around the new year, many people set goals for better health. People ages 65 and older can kick off a healthy new year by getting vaccinated for flu, COVID-19 and RSV. These respiratory infections can become more dangerous as people age. Vaccines can help older people risk less severe illness and do more of what they enjoy.
Those who provide care for older adults can support their health by helping them get vaccinated now. That’s especially important because older people have a higher risk of getting very sick or even dying from flu, COVID-19 and RSV.
Vaccines help protect older adults from serious illness
As people get older, their ability to fight off infection decreases, putting them at higher risk for complications if they get a respiratory infection. They are more likely to get severely ill and need medical or hospital care from flu, COVID-19 and RSV. Those living in long-term care facilities often have health issues that make flu, COVID-19 and RSV serious risks.
The Centers for Disease Control and Prevention (CDC) urges all people ages 6 months and older to get this season’s flu and COVID-19 vaccines.
Those ages 75 and older – or ages 60 and older with certain health issues or who live in a nursing home – should get one dose of an RSV vaccine if they haven’t had it before. It’s safe to get vaccines for flu and COVID-19 (and RSV, for those who are eligible) all at the same time. Any side effects from the vaccines are usually mild and go away on their own in a few days.
Get vaccinated for a healthy new year
Vaccines are a great way for older people to start the year by protecting their health. Most deaths from flu, COVID-19 and RSV are in people ages 65 and older, and the risk grows with age. However, vaccines cut your risk of being in the hospital for flu or COVID-19 by about half and for RSV by about 70%, according to the CDC.
Those who look after older loved ones can help them avoid severe respiratory illness by helping them get vaccinated. In addition to getting vaccinated, there are other ways to help prevent serious illness. When around others indoors, use fans or open windows for better ventilation. Wearing a mask, using physical distancing and washing your hands often can also help. You can use home tests to check for COVID-19 if you have symptoms.
Visit cdc.gov/RiskLessDoMore to learn more about flu, COVID-19 and RSV vaccines. Order your free COVID-19 test kits (up to four per household) at COVIDTests.gov.
Talk with your doctor about which vaccines are right for you or an older adult you care for. Or go to vaccines.gov to get started and find a pharmacy near you.
Photo courtesy of Shutterstock
SOURCE:
U.S. Department of Health and Human Services
Discover more from Daily News
Subscribe to get the latest posts sent to your email.
Consumer Corner
Bird flu flares up again in Michigan poultry – an infectious disease expert explains the risk to humans, chickens, cows and other animals
Kimberly Dodd, Michigan State University
After a relatively quiet fall, there’s been another spike in cases of bird flu in Michigan.
When state officials announced on Dec. 16, 2024, that bird flu had been found in another poultry facility in Ottawa County, it was the first time the H5N1 virus had been detected in Michigan poultry in over six months. Since then, the U.S. Department of Agriculture has confirmed seven more outbreaks – in five commercial and two backyard flocks – in the state, the most recent in Oakland County.
Meanwhile, on Jan. 6, 2025, the Centers for Disease Control and Prevention reported the first human death from bird flu in the U.S., in Louisiana.
Bird flu is a complex and evolving disease with significant impact to the poultry and dairy industries. Since the beginning of the outbreaks in poultry and cattle, almost 135 million birds and more than 900 cattle herds have been affected nationwide. A significant number of wild animals – such as raccoon, skunks, foxes and bobcats – as well as marine mammals and domestic cats have also died from the virus.
Kimberly Dodd, dean of Michigan State University’s College of Veterinary Medicine, is an expert in outbreak response for emerging infectious diseases. Michigan was among the first states to see H5N1 outbreaks in commercial poultry and dairy facilities. Both state and federal officials have worked closely with the Michigan State University Veterinary Diagnostic Laboratory to identify newly infected herds, while continuing to provide surveillance for the virus in poultry and wild birds.
Dodd talked to The Conversation U.S. about the risks H5N1 presents to families, pets and livestock, and how researchers are working together to find ways to limit its spread.
What are Michigan researchers learning about the outbreak?
In the case of H5N1 in cows, scientists and animal health experts here in Michigan and around the country are working to understand a familiar disease in a novel species.
The transmission of the avian flu virus H5N1 to dairy cattle was first confirmed in March 2024 in Texas and has since spread to 15 other U.S. states, most recently California.
The virus impacts milk production and poses significant risks to other bird species, particularly domestic poultry as well as some mammals. The CDC has also confirmed mild cases in humans, and a fatal one in Louisiana in January 2025.
Diagnosticians at Michigan State University and the USDA’s National Animal Health Laboratory Network provide rapid diagnostics to identify infected herds and monitor the virus in wild birds and mammals, helping control the spread.
We’ve learned, based on sequencing the circulating viruses, that there is a specific virus strain or H5N1 genotype, B3.13, circulating in cows and poultry. Subtle changes over time in the genetic makeup of the virus points to a single spillover event. This means the virus likely spread from wild birds to a cow in Texas, and then spread from cow to cow. We also know that there is a separate H5N1 genotype, D1.1, that is currently circulating in wild birds and domestic poultry.
Researchers in our College of Veterinary Medicine are working with federal and state officials and farmers to determine how long cows produce infectious milk. The goal is to understand how cows are becoming infected within and across herds so that we can better mitigate the spread.
Why is it called bird flu if it sickens other animals too?
Influenza viruses affect many animals including humans, pigs, dogs and horses.
There are four types of influenza viruses: A, B, C and D, which are loosely defined by the species they can infect. Avian influenza viruses are considered influenza A viruses. Interestingly, influenza D viruses are the ones that primarily infect cattle. But the current H5N1 circulating in dairy cattle is the same influenza A virus as seen in the ongoing outbreak in birds.
This is of particular concern, as only influenza A viruses have been associated with human pandemics.
Avian influenza viruses circulate in wild birds but don’t typically cause them significant disease. While many avian influenza viruses can infect poultry, their behavior in those hosts classifies the virus as either highly pathogenic or low pathogenic. It’s important to note that this classification doesn’t necessarily indicate how easily it spreads or the likelihood that the virus will jump to other species.
The currently circulating strain is classified as highly pathogenic avian influenza, or HPAI, based on the high mortality it causes domestic poultry. One of the many unusual characteristics of the current outbreak is the high mortality seen in wild birds; as a result, we have seen many species of young carnivores and scavengers infected by the virus.
Infection in other species often requires exposure to a large amount of virus, or a compromised or underdeveloped immune system. These are typically “dead-end hosts.” They become infected but do not play a role in virus spread because either the animal dies or it becomes infected but not infectious.
The current outbreak of HPAI H5N1 has been ongoing since 2021. The outbreak is notable for its duration, wide geographic spread and unusual impact on nonpoultry species as well. It has caused significant illness and death in wild birds like ducks and geese, as well as mammals exposed to infected bird carcasses like cats and skunks.
However when the USDA unexpectedly confirmed that H5N1 was the cause of significant disease in dairy cattle in early 2024, it marked the first time that the virus was detected in U.S. dairy cattle.
What does the virus do to cattle?
Most cows infected with H5N1 recover on their own without treatment. Symptoms include fever and sluggishness. There is also decreased appetite and a significant drop in milk production in lactating cows, as the virus is concentrated in the mammary glands and milk.
There are three reasons to care about the ongoing H5N1 outbreak in dairy cattle:
First, the drop in milk production and the virus’s infectious nature create challenges for farmers to control the infection and lead to economic losses. In addition to the production losses, there are additional labor and supply costs to manage the outbreak in the herd, including separation and supportive care of sick cows. Workers also need to use personal protective equipment to prevent spread of the virus to healthy animals and to protect themselves from potential infection.
Second, dairy cows produce large amounts of the virus in milk, which is highly infectious. While pasteurization kills the virus, raw milk remains a major infection risk. Significant numbers of wild mammals and domestic cats on dairy farms have died from the virus after consuming raw milk. It also poses a risk to dairy workers.
The virus has also spread from dairy farms to poultry facilities, causing high bird mortality. Experts are exploring the possibility that clothing, shoes, trucks, equipment and other items that have been contaminated with raw milk containing the virus can lead to inadvertent, and lethal, exposure for poultry.
Third, prolonged circulation in cattle increases the risk of the virus adapting to mammals, including humans.
To monitor this risk, all H5N1-positive samples are sent to the USDA for genetic sequencing to identify mutations that may increase the virus’s ability to infect mammals and to provide important information about how the virus spreads within and between populations.
How do we manage H5N1 moving forward?
Biosecurity for poultry and dairy facilities is more critical than ever. Biosecurity measures include limiting visitors to farms and facilities; disinfecting tools, footwear and equipment; avoiding contact between infected and noninfected species; and isolating sick animals.
These measures play an important role in both containing the virus and keeping it away from other animals, properties and people.
Kimberly Dodd, Dean of College of Veterinary Medicine, Michigan State University
This article is republished from The Conversation under a Creative Commons license. Read the original article.
Discover more from Daily News
Subscribe to get the latest posts sent to your email.
health and wellness
Nutrition advice is rife with misinformation − a medical education specialist explains how to tell valid health information from pseudoscience
Aimee Pugh Bernard, University of Colorado Anschutz Medical Campus
The COVID-19 pandemic illuminated a vast landscape of misinformation about many topics, science and health chief among them.
Since then, information overload continues unabated, and many people are rightfully confused by an onslaught of conflicting health information. Even expert advice is often contradictory.
On top of that, people sometimes deliberately distort research findings to promote a certain agenda. For example, trisodium phosphate is a common food additive in cakes and cookies that is used to improve texture and prevent spoilage, but wellness influencers exploit the fact that a similarly named substance is used in paint and cleaning products to suggest it’s dangerous to your health.
Such claims can proliferate quickly, creating widespread misconceptions and undermining trust in legitimate scientific research and medical advice. Social media’s rise as a news and information source further fuels the spread of pseudoscientific views.
Misinformation is rampant in the realm of health and nutrition. Findings from nutrition research is rarely clear-cut because diet is just one of many behaviors and lifestyle factors affecting health, but the simplicity of using food and supplements as a cure-all is especially seductive.
I am an assistant professor specializing in medical education and science communication. I also train scientists and future health care professionals how to communicate their science to the general public.
In my view, countering the voices of social media influencers and health activists promoting pseudoscientific health claims requires leaning into the science of disease prevention. Extensive research has produced a body of evidence-based practices and public health measures that have consistently been shown to improve the health of millions of people around the world. Evaluating popular health claims against the yardstick of this work can help distinguish which ones are based on sound science.
Navigating the terrain of tangled information
Conflicting information can be found on just about everything we eat and drink.
That’s because a food or beverage is rarely just good or bad. Instead, its health effects can depend on everything from the quantity a person consumes to their genetic makeup. Hundreds of scientific studies describe coffee’s health benefits and, on the flip side, its health risks. A bird’s-eye view can point in one direction or another, but news articles and social media posts often make claims based on a single study.
Things can get even more confusing with dietary supplements because people who promote them often make big claims about their health benefits. Take apple cider vinegar, for example – or ACV, if you’re in the know.
Apple cider vinegar has been touted as an all-natural remedy for a variety of ailments, including digestive issues, urinary health and weight management. Indeed, some studies have shown that it might help lower cholesterol, in addition to having other health benefits, but overall those studies have small sample sizes and are inconclusive.
Advocates of this substance often claim that one particular component of it – the cloudy sediment at the bottom of the bottle termed “the mother” – is especially beneficial because of the bacteria and yeast it contains. But there is no research that backs the claim that it offers any health benefits.
One good rule of thumb is that health hacks that promise quick fixes are almost always too good to be true. And even when supplements do offer some health benefits under specific circumstances, it’s important to remember that they are largely exempt from Food and Drug Administration regulations. That means the ingredients on their labels might contain more or less of the ingredients promised or other ingredients not listed, which can potentially cause harms such as liver toxicity.
It’s also important to keep in mind that the global dietary supplements industry is worth more than US$150 billion per year, so companies – and wellness influencers – selling supplements have a financial stake in convincing the public of their value. https://www.youtube.com/embed/VM1zCZLCClM?wmode=transparent&start=0 Misinformation about nutrition is nothing new, but that doesn’t make it any less confusing.
How nutrition science gets twisted
There’s no doubt that good nutrition is fundamental for your health. Studies consistently show that a balanced diet containing a variety of essential nutrients can help prevent chronic diseases and promote overall well-being.
For instance, minerals such as calcium and iron support bone health and oxygen circulation in the blood, respectively. Proteins are essential for muscle repair and growth, and healthy fats, like those found in avocados and nuts, are vital for brain health.
However, pseudoscientific claims often twist such basic facts to promote the idea that specific diets or supplements can prevent or treat illness. For example, vitamin C is known to play a role in supporting the immune system and can help reduce the duration and severity of colds.
But despite assertions to the contrary, consuming large quantities of vitamin C does not prevent colds. In fact, the body needs only a certain amount of vitamin C to function properly, and any excess is simply excreted.
Companies sometimes claim their supplement is “scientifically proven” to cure illness or boost brain function, with no credible research to back it up.
Some companies overstate the benefits while underplaying the hazards.
For example, wellness influencers have promoted raw milk over pasteurized milk as a more natural and nutritious choice, but consuming it is risky. Unpasteurized milk can contain harmful bacteria that leads to gastrointestinal illness and, in some cases, much more serious and potentially life-threatening diseases such as avian influenza, or bird flu.
Such dietary myths aren’t harmless. Reliance on nutrition alone can lead to neglecting other critical aspects of health, such as regular medical checkups and lifesaving vaccinations.
The lure of dietary myths has led people with cancer to replace proven science-backed treatments, such as chemotherapy or radiation, with unproven and misleading nutrition programs.
How to spot less-than-solid science
Pseudoscience exploits your insecurities and emotions, taking advantage of your desire to live the healthiest life possible.
While the world around you may be uncertain and out of your control, you want to believe that at the very least, you have control over your own health. This is where the wellness industry steps in.
What makes pseudoscientific claims so confusing is that they use just enough scientific jargon to sound believable. Supplements or powders that claim to “boost immunity” often list ingredients such as adaptogens and superfoods. While these words sound real and convincing, they actually don’t mean anything in science. They are terms created by the wellness industry to sell products.
I’ve researched and written about reliable ways to distinguish science facts from false health claims. To stay alert and find credible information, I’d suggest you follow a few key steps.
First, check your emotions – strong emotional reactions, such as fear and anger, can be a red flag.
Next, check that the author has experience or expertise in the field of the topic. If they’re not an expert, they might not know what they are talking about. It’s always a good idea to make sure the source is reputable – ask yourself, would this source be trusted by scientists?
Finally, search for references that back up the information. If very little or nothing else exists in the science world to back up the claims, you may want to put your trust in a different source.
Following these steps will separate the facts from fake news and empower you to make evidence-based decisions.
Aimee Pugh Bernard, Assistant Professor of Immunology and Microbiology, University of Colorado Anschutz Medical Campus
This article is republished from The Conversation under a Creative Commons license. Read the original article.
Discover more from Daily News
Subscribe to get the latest posts sent to your email.
-
Urbanism1 year ago
Signal Hill, California: A Historic Enclave Surrounded by Long Beach
-
News2 years ago
Diana Gregory Talks to us about Diana Gregory’s Outreach Services
-
Senior Pickleball Report2 years ago
The Absolute Most Comfortable Pickleball Shoe I’ve Ever Worn!
-
STM Blog2 years ago
World Naked Gardening Day: Celebrating Body Acceptance and Nature
-
Senior Pickleball Report2 years ago
ACE PICKLEBALL CLUB TO DEBUT THEIR HIGHLY ANTICIPATED INDOOR PICKLEBALL FRANCHISES IN THE US, IN EARLY 2023
-
Travel2 years ago
Unique Experiences at the CitizenM
-
Automotive2 years ago
2023 Nissan Sentra pricing starts at $19,950
-
Senior Pickleball Report2 years ago
“THE PEOPLE’S CHOICE AWARDS OF PICKLEBALL” – VOTING OPEN