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Stroke, Clot Risk Halved in Heart Disease and Arrhythmia Patients Who Took Blood Thinners Apixaban Versus Rivaroxaban

A difference in the effectiveness against strokes and other blood clots was easily visible in the first year among patients who’d taken the anticoagulant apixaban rather than rival rivaroxaban, according to researchers at the Perelman School of Medicine at the University of Pennsylvania.

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Newswise — PHILADELPHIA—A difference in the effectiveness against strokes and other blood clots was easily visible in the first year among patients who’d taken the anticoagulant apixaban rather than rival rivaroxaban, according to researchers at the Perelman School of Medicine at the University of Pennsylvania.

In the “emulated” clinical trial—an analysis comparing matched patients in a large health insurance database—all of the patients whose data were analyzed were those who have atrial fibrillation (AF) and associated valvular heart disease (VHD). Each patient took one form of an anticoagulant, also known as blood thinners, to slow down the formation of new blood clots and help avoid existing clots from growing larger and potentially more harmful. The study showed that those who took apixaban had their dangerous clot risk decrease almost by half compared with rivaroxaban.

At least several million Americans have AF, a type of irregular heartbeat that lead to blood clots in the heart, and it is thought that more than 60 percent of these patients have associated VHD, which essentially means that they also have significant heart valve damage. Stroke or systemic embolism risk increase by several times in those with AF compared to those without it, and VHD is suspected of adding to the risk of stroke or death.

Since 2016, apixaban and rivaroxaban have been the most prescribed anticoagulants for reducing stroke and systemic embolism risk in AF/VHD patients. While some traditional blood thinners can be affected by a patient’s diet, apixaban and rivaroxaban do not, making them easier to manage. But, so far, there have been no clinical trials directly comparing the two drugs in this patient population.

“The lack of clinical trial evidence and wide use of both drugs in patients with AF and VHD calls for real-world evidence that can guide treatment selection in clinical practice,” said Ghadeer Dawwas, PhD, a postdoctoral fellow in Biostatistics, Epidemiology, and Informatics at Penn, and first author of the study, published today in the Annals of Internal Medicine.

Almost 10,000 patients who had recently started taking apixaban were compared with another 10,000 newly taking rivaroxaban. The study was not of the clinical trial type, in which patients are randomly assigned to different groups to minimize differences between them. Rather, the researchers emulated a clinical trial by matching each patient in the apixaban group to one in the rivaroxaban group with similar age and other characteristics that could affect outcomes. The patient records compared in the study came from a large commercial health insurance database with de-identified data from 2013 to 2020.

The number of strokes, as well as blood clots in the body other than the brain (called “systemic embolisms”) in the patients seen over the span of several years after they began taking the medications suggested that patients in the apixaban group had a 43 percent lower risk of a clotting event, and a 49 percent lower risk of a gastrointestinal or intracranial bleeding event.

“Until evidence from randomized controlled trials becomes available, we believe clinicians should consider our findings when selecting anticoagulants in patients with AF and VHD,” said study senior author Sean Hennessy, PharmD, PhD, a professor of Epidemiology and director of Penn’s Center for Real-world Effectiveness and Safety of Therapeutics.

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The analysis showed that the numbers of patients who had strokes or systemic emboli in each group diverged almost immediately. Patients in the rivaroxaban group had markedly more of these events at six months and twelve months of follow-up. The researchers calculated that the rate of stroke or systemic embolism per patient per year of follow-up was about one percent (0.91 percent) for rivaroxaban users, and about half that (0.52 percent) for apixaban users. Similarly, the rate of bleeding events in the rivaroxaban group was about double that in the apixaban group.

Overall the results suggested that, in comparison to the rivaroxaban group, the apixaban group had 43 percent lower risk of stroke or systemic embolism, and 49 percent the risk of a bleeding events compared with rivaroxaban.

Support for the research was provided by the National Institutes of Health (K99HL159230).

Source: Perelman School of Medicine at the University of Pennsylvania

Our Lifestyle section on STM Daily News is a hub of inspiration and practical information, offering a range of articles that touch on various aspects of daily life. From tips on family finances to guides for maintaining health and wellness, we strive to empower our readers with knowledge and resources to enhance their lifestyles. Whether you’re seeking outdoor activity ideas, fashion trends, or travel recommendations, our lifestyle section has got you covered. Visit us today at https://stmdailynews.com/category/lifestyle/ and embark on a journey of discovery and self-improvement.

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3 Unforgettable Mother’s Day Meals That Will Make Her Heart (and Taste Buds) Sing

Create an unforgettable Mother’s Day with a home-cooked meal featuring three easy yet impressive recipes: Lemon Ricotta Pancakes, Mediterranean Brunch Board, and Herb-Crusted Salmon, paired with wines to enhance flavors and create lasting memories.

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A beautifully arranged table set with plates, silverware, and candles. Perfect for formal dining or special occasions.

Want to make this Mother’s Day extra special? Skip the crowded restaurants and show Mom your love through a home-cooked meal she’ll never forget. We’ve crafted three foolproof recipes that even kitchen novices can master – because nothing says “I love you” quite like a meal made from the heart.

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🌟 1. Heavenly Lemon Ricotta Pancakes with Berry Compote

Picture golden, cloud-like pancakes that practically float off the plate, their edges delicately crispy while their centers remain pillowy-soft and tender. The rich, creamy ricotta creates pockets of moisture that melt in your mouth, while bright lemon zest cuts through with citrusy sparkle. The warm berry compote cascades over the stack, its jewel-toned fruits bursting with sweet-tart juice that mingles perfectly with pure maple syrup.

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🍳 2. Mediterranean Brunch Board

A feast for both eyes and palate, this stunning spread features eggs with golden yolks that ooze luxuriously when broken, their richness enhanced by aromatic dukkah’s nutty crunch. Creamy, house-made hummus swirled with extra virgin olive oil sits alongside prosciutto roses that fold like silk. Fresh figs, split to reveal their honey-sweet crimson centers, nestle against wedges of artisanal cheese that range from buttery-soft to crystalline-sharp. Every bite tells a story of Mediterranean sunshine.

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👑 3. Herb-Crusted Salmon with Champagne Cream Sauce

A masterpiece of textures and flavors: the salmon’s herb crust offers a satisfying crackle before revealing the perfectly cooked, rose-pink flesh beneath that flakes at the mere touch of a fork. The champagne cream sauce, velvety and sophisticated, pools elegantly around the fish, its subtle bubbles lending an air of celebration. Bright green asparagus spears provide the perfect crisp-tender contrast, while the wild mushroom risotto, infused with earthy aromatics and finished with a generous shower of Parmesan, creates a bed of creamy comfort that ties the whole dish together.

Why These Recipes Work:

Each recipe can be partially prepped in advance

Ingredients are easily found in most supermarkets

They’re impressive without being overly complicated

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Perfect balance of flavors and textures

Suitable for various dietary preferences

Each bite is carefully crafted to create not just a meal, but a memorable experience that shows Mom just how special she is. The interplay of textures and flavors in each dish creates a symphony of tastes that will linger in her memory long after the last bite.

Here are some Wine Pairings to make these dishes perfect:

🌟 Lemon Ricotta Pancakes

Perfect Pairing: Prosecco or Moscato d’Asti

Why it works: The light bubbles and subtle sweetness complement the citrus notes while cutting through the richness of the ricotta.

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🍳 Mediterranean Brunch Board

Perfect Pairing: Rosé or Albariño

Why it works: A crisp, dry rosé enhances the salty prosciutto and creamy cheeses, while Albariño’s mineral notes complement the Mediterranean flavors.

👑 Herb-Crusted Salmon

Perfect Pairing: Chardonnay or Pinot Noir

Why it works: A lightly oaked Chardonnay matches the richness of the champagne sauce, while a light-bodied Pinot Noir works beautifully with the herb crust.

Plating Instructions:

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Lemon Ricotta Pancakes:

Stack 3-4 pancakes slightly off-center on a warm, white plate

Drizzle berry compote in an artistic swoosh from 2 o’clock to 7 o’clock

Garnish with fresh mint leaves and a light dusting of powdered sugar

Pro tip: Use a wide, flat plate to let the colors pop against the white background

Mediterranean Brunch Board:

Start with a large wooden board or slate platter

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Create height by placing small bowls of hummus and dips at different points

Arrange prosciutto roses in a cascading pattern

Group cheeses by type, creating a gradient from soft to hard

Fill negative space with fresh herbs and edible flowers

Pro tip: Use small olive wood bowls for dips to add rustic elegance

Herb-Crusted Salmon:

Place the risotto in a shallow bowl using a ring mold

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Position the salmon at a 45-degree angle, slightly overlapping the risotto

Arrange asparagus spears like a fan

Drizzle champagne sauce in an elegant circle around the plate

Garnish with micro herbs and edible flowers

Pro tip: Warm the plates before serving to keep everything at perfect temperature

Remember: The most important ingredient isn’t listed in any recipe – it’s the love and thought you put into making Mom’s day special. These meals aren’t just about the food; they’re about creating precious moments together.

Ready to make Mom’s day unforgettable? Save these recipes now and start planning your Mother’s Day menu. Trust us – seeing her face light up will be worth every minute in the kitchen.

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Here are some related links to further help you make Mother’s Day special:

Good Housekeeping: 55 Best Mother’s Day Dinner Ideas – Good Housekeeping

Food Network: Mother’s Day Recipes: Brunch, Dinner, Desserts and More

NYT Cooking: Mother’s Day Recipes – NYT Cooking

Happy Mother’s Day!

At our core, we at STM Daily News, strive to keep you informed and inspired with the freshest content on all things food and beverage. From mouthwatering recipes to intriguing articles, we’re here to satisfy your appetite for culinary knowledge.

Visit our Food & Drink section to get the latest on Foodie News and recipes, offering a delightful blend of culinary inspiration and gastronomic trends to elevate your dining experience.

https://stmdailynews.com/food-and-drink/

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Lifestyle

Engineering students explore how to ethically design and locate nuclear facilities in this college course

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While nuclear power can reap enormous benefits, it also comes with some risks. Michel Gounot/GODONG/Stone via Getty Images
Aditi Verma, University of Michigan and Katie Snyder, University of Michigan Uncommon Courses is an occasional series from The Conversation U.S. highlighting unconventional approaches to teaching.

Title of course:

Socially Engaged Design of Nuclear Energy Technologies

What prompted the idea for the course?

The two of us had some experience with participatory design coming into this course, and we had a shared interest in bringing virtual reality into a first-year design class at the University of Michigan. It seemed like a good fit to help students learn about nuclear technologies, given that hands-on experience can be difficult to provide in that context. We both wanted to teach students about the social and environmental implications of engineering work, too. Aditi is a nuclear engineer and had been using participatory design in her research, and Katie had been teaching ethics and design to engineering students for many years.

What does the course explore?

Broadly, the course explores engineering design. We introduce our students to the principles of nuclear engineering and energy systems design, and we go through ethical concerns. They also learn communication strategies – like writing for different audiences. Students learn to design the exterior features of nuclear energy facilities in collaboration with local communities. The course focuses on a different nuclear energy technology each year. In the first year, the focus was on fusion energy systems. In fall 2024, we looked at locating nuclear microreactors near local communities. The main project was to collaboratively decide where a microreactor might be sited, what it might look like, and what outcomes the community would like to see versus which would cause concern. Students also think about designing nuclear systems with both future generations and a shared common good in mind. The class explores engineering as a sociotechnical practice – meaning that technologies are not neutral. They shape and affect social life, for better and for worse. To us, a sociotechnical engineer is someone who adheres to scientific and engineering fundamentals, communicates ethically and designs in collaboration with the people who are likely to be affected by their work. In class, we help our students reflect on these challenges and responsibilities.

Why is this course relevant now?

Nuclear energy system design is advancing quickly, allowing engineers to rethink how they approach design. Fusion energy systems and fission microreactors are two areas of rapidly evolving innovation. Microreactors are smaller than traditional nuclear energy systems, so planners can place them closer to communities. These smaller reactors will likely be safer to run and operate, and may be a good fit for rural communities looking to transition to carbon-neutral energy systems. But for the needs, concerns and knowledge of local people to shape the design process, local communities need to be involved in these reactor siting and design conversations.
A woman wearing a black VR headset, which looks like a large, bulky pair of glasses with no lenses.
Students in the course explore nuclear facilities in virtual reality. Thomas Barwick/DigitalVision via Getty Images

What materials does the course feature?

We use virtual reality models of both fission and fusion reactors, along with models of energy system facilities. AI image generators are helpful for rapid prototyping – we have used these in class with students and in workshops. This year, we are also inviting students to do some hands-on prototyping with scrap materials for a project on nuclear energy systems.

What will the course prepare students to do?

Students leave the course understanding that community engagement is an essential – not optional – component of good design. We equip students to approach technology use and development with users’ needs and concerns in mind. Specifically, they learn how to engage with and observe communities using ethical, respectful methods that align with the university’s engineering research standards.

What’s a critical lesson from the course?

As instructors, we have an opportunity – and probably also an obligation – to learn from students as much as we are teaching them course content. Gen Z students have grown up with environmental and social concerns as centerpieces of their media diets, and we’ve noticed that they tend to be more strongly invested in these topics than previous generations of engineering students. Aditi Verma, Assistant Professor of Nuclear Engineering and Radiological Sciences, University of Michigan and Katie Snyder, Lecturer III in Technical Communication, College of Engineering, University of Michigan This article is republished from The Conversation under a Creative Commons license. Read the original article.

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How bird flu differs from seasonal flu − an infectious disease researcher explains

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There is currently no bird flu vaccine for people. Digicomphoto/ Science Photo Library via Getty Images
Hanna D. Paton, University of Iowa The flu sickens millions of people in the U.S. every year, and the past year has been particularly tough. Although infections are trending downward, the Centers for Disease Control and Prevention has called the winter of 2024-2025 a “high severity” season with the highest hospitalization rate in 15 years. Since early 2024, a different kind of flu called bird flu, formally known as avian influenza, has been spreading in birds as well as in cattle. The current bird flu outbreak has infected 70 Americans and caused two deaths as of April 8, 2025. Public health and infectious disease experts say the risk to people is currently low, but they have expressed concern that this strain of the bird flu virus may mutate to spread between people. As a doctoral candidate in immunology, I study how pathogens that make us sick interact with our immune system. The viruses that cause seasonal flu and bird flu are distinct but still closely related. Understanding their similarities and differences can help people protect themselves and their loved ones.

What is influenza?

The flu has long been a threat to public health. The first recorded influenza pandemic occurred in 1518, but references to illnesses possibly caused by influenza stretch back as as early as 412 B.C., to a treatise called Of the Epidemics by the Greek physician Hippocrates. Today, the World Health Organization estimates that the flu infects 1 billion people every year. Of these, 3 million to 5 million infections cause severe illness, and hundreds of thousands are fatal. Influenza is part of a large family of viruses called orthomyxoviruses. This family contains several subtypes of influenza, referred to as A, B, C and D, which differ in their genetic makeup and in the types of infections they cause. Influenza A and B pose the largest threat to humans and can cause severe disease. Influenza C causes mild disease, and influenza D is not known to infect people. Since the turn of the 20th century, influenza A has caused four pandemics. Influenza B has never caused a pandemic.
An ad from 1918 for preventing influenza
A notice from Oct. 18, 1918, during the Spanish flu pandemic, about protecting yourself from infection. Illustrated Current News/National Library of Medicine, CC BY
An influenza A strain called H1N1 caused the famous 1918 Spanish flu pandemic, which killed about 50 million people worldwide. A related H1N1 virus was responsible for the most recent influenza A pandemic in 2009, commonly referred to as the swine flu pandemic. In that case, scientists believe multiple different types of influenza A virus mixed their genetic information to produce a new and especially virulent strain of the virus that infected more than 60 million people in the U.S. from April 12, 2009, to April 10, 2010, and caused huge losses to the agriculture and travel industries. Both swine and avian influenza are strains of influenza A. Just as swine flu strains tend to infect pigs, avian flu strains tend to infect birds. But the potential for influenza A viruses that typically infect animals to cause pandemics in humans like the swine flu pandemic is why experts are concerned about the current avian influenza outbreak.

Seasonal flu versus bird flu

Different strains of influenza A and influenza B emerge each year from about October to May as seasonal flu. The CDC collects and analyzes data from public health and clinical labs to determine which strains are circulating through the population and in what proportions. For example, recent data shows that H1N1 and H3N2, both influenza A viruses, were responsible for the vast majority of cases this season. Standard tests for influenza generally determine whether illness is caused by an A or B strain, but not which strain specifically. Officials at the Food and Drug Administration use this information to make strain recommendations for the following season’s influenza vaccine. Although the meeting at which FDA advisers were to decide the makeup of the 2026 flu vaccine was unexpectedly canceled in late February, the FDA still released its strain recommendations to manufacturers. The recommendations do not include H5N1, the influenza A strain that causes avian flu. The number of strains that can be added into seasonal influenza vaccines is limited. Because cases of people infected with H5N1 are minimal, population-level vaccination is not currently necessary. As such, seasonal flu vaccines are not designed to protect against avian influenza. No commercially available human vaccines currently exist for avian influenza viruses.

How do people get bird flu?

Although H5N1 mainly infects birds, it occasionally infects people, too. Human cases, first reported in 1997 in Hong Kong, have primarily occurred in poultry farm workers or others who have interacted closely with infected birds. Initially identified in China in 1996, the first major outbreak of H5 family avian flu occurred in North America in 2014-2015. This 2014 outbreak was caused by the H5N8 strain, a close relative of H5N1. The first H5N1 outbreak in North America began in 2021 when infected birds carried the virus across the ocean. It then ripped through poultry farms across the continent.
A bird and an image of H5N1 viral particles on a blue background. Bird flu
The H5N1 strain of influenza A generally infects birds but has infected people, too. NIAID and CDC/flickr, CC BY
In March 2024, epidemiologists identified H5N1 infections in cows on dairy farms. This is the first time that bird flu was reported to infect cows. Then, on April 1, 2024, health officials in Texas reported the first case of a person catching bird flu from infected cattle. This was the first time transmission of bird flu between mammals was documented. As of March 21, 2025, there have been 988 human cases of H5N1 worldwide since 1997, about half of which resulted in death. The current outbreak in the U.S. accounts for 70 of those infections and one death. Importantly, there have been no reports of H5N1 spreading directly from one person to another. Since avian flu is an influenza A strain, it would show up as positive on a standard rapid flu test. However, there is no evidence so far that avian flu is significantly contributing to current influenza cases. Specific testing is required to confirm that a person has avian flu. This testing is not done unless there is reason to believe the person was exposed to sick birds or other sources of infection.

How might avian flu become more dangerous?

As viruses replicate within the cells of their host, their genetic information can get copied incorrectly. Some of these genetic mutations cause no immediate differences, while others alter some key viral characteristics. Influenza viruses mutate in a special way called reassortment, which occurs when multiple strains infect the same cell and trade pieces of their genome with one another, potentially creating new, unique strains. This process prolongs the time the virus can inhabit a host before an infection is cleared. Even a slight change in a strain of influenza can result in the immune system’s inability to recognize the virus. As a result, this process forces our immune systems to build new defenses instead of using immunity from previous infections. Reassortment can also change how harmful strains are to their host and can even enable a strain to infect a different species of host. For example, strains that typically infect pigs or birds may acquire the ability to infect people. Influenza A can infect many different types of animals, including cattle, birds, pigs and horses. This means there are many strains that can intermingle to create novel strains that people’s immune systems have not encountered before – and are therefore not primed to fight. It is possible for this type of transformation to also occur in H5N1. The CDC monitors which strains of flu are circulating in order prepare for that possibility. Additionally, the U.S. Department of Agriculture has a surveillance system for monitoring potential threats for spillover from birds and other animals, although this capacity may be at risk due to staff cuts in the department. These systems are critical to ensure that public health officials have the most up-to-date information on the threat that H5N1 poses to public health and can take action as early as possible when a threat is evident.The Conversation Hanna D. Paton, PhD Candidate in Immunology, University of Iowa This article is republished from The Conversation under a Creative Commons license. Read the original article.
STM Daily News is a vibrant news blog dedicated to sharing the brighter side of human experiences. Emphasizing positive, uplifting stories, the site focuses on delivering inspiring, informative, and well-researched content. With a commitment to accurate, fair, and responsible journalism, STM Daily News aims to foster a community of readers passionate about positive change and engaged in meaningful conversations. Join the movement and explore stories that celebrate the positive impacts shaping our world. https://stmdailynews.com/  

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