Jacob A Tennessen, Harvard University

The fight against infectious disease is a race against evolution. Bacteria become resistant to antibiotics. Viruses adapt to spread more quickly. Diseases transmitted by insects present another evolutionary front: Insects themselves can evolve resistance to the poisons that people use to kill them.

In particular, the mosquito-borne disease malaria kills over 600,000 people annually. Since World War II, people have battled malaria with insecticides – chemical weapons intended to kill Anopheles mosquitoes infected with the Plasmodium parasites that cause the disease.

However, mosquitoes are quickly evolving counterstrategies that make these insecticides ineffective, putting millions of people at greater risk of deadly infection. My colleagues and I have newly published research showing how.

Insecticide resistance threatens public health

As an evolutionary geneticist, I study natural selection – the basis for adaptive evolution. Genetic variants that best promote survival can replace less advantageous versions, causing species to change. Anopheles mosquitoes are frustratingly adept at evolving.

In the mid-1990s, most African Anopheles were susceptible to pyrethroids, a popular type of insecticide originally derived from chrysanthemums. Anopheles control relies on two pyrethroid-based methods: insecticide-treated bed nets to protect sleepers, and indoor residual spraying of insecticide against the walls of homes. These two methods alone likely prevented over a half-billion cases of malaria between 2000 and 2015.

However, mosquitoes today from Ghana to Malawi are often able to survive insecticide concentrations 10 times the previously lethal dose. Along with Anopheles control efforts, agriculture also inadvertently exposes mosquitoes to pyrethroids and contributes to insecticide resistance.

In some African locales, Anopheles is already showing resistance to all four main classes of insecticide used for malaria control.

Adaptation in Latin American mosquitoes

Anopheles mosquitoes and the malaria-causing Plasmodium also occur outside Africa, where insecticide resistance is less well-researched.

In much of South America, the main malaria vector is Anopheles darlingi. This mosquito species has diverged evolutionarily from the African vectors so extensively that it might be a different genus, Nyssorhynchus. Along with colleagues from eight countries, I analyzed over 1,000 Anopheles darlingi genomes to understand its genetic diversity, including any recent changes due to human activity. My collaborators collected these mosquitoes at 16 locations ranging from the Atlantic coast of Brazil to the Pacific side of the Andes in Colombia.

We found that, like its African counterparts, Anopheles darlingi shows extremely high genetic diversity – more than 20 times that of humans – indicating that very large populations of this insect exist. A species with such a vast gene pool is well poised to adapt to new challenges. The right mutation giving it the advantage it needs is more likely to pop up when there are so many individuals. And once that mutation starts to spread, it’s protected by numbers since it won’t be wiped out if a few mosquitoes die by chance.

In contrast, bald eagles in the contiguous U.S. were never able to evolve resistance against the insecticide DDT and approached extinction. Evolution is more efficient among millions of insects than mere thousands of birds. And indeed, we saw signals of adaptive evolution in the resistance-related genes of Anopheles darlingi occurring over the past few decades.

Advertisement

Mosquitoes evolve to detoxify poisons

Insecticides like pyrethroids and DDT share the same molecular target: channels in nerve cells that can open and close. When open, the nerve cell stimulates other cells. These insecticides force the channels to remain open and continuously fire, causing paralysis and death. However, insects can evolve resistance by changing the shape of the channel itself.

Earlier genetic scans performed by other researchers had not detected this type of resistance in Anopheles darlingi, and neither did ours. Instead, we found that resistance is evolving in another way: a group of genes encoding enzymes that break down toxic compounds. High activity of these enzymes, called P450, frequently underlies resistance to insecticides in other mosquitoes. The same cluster of P450 genes has changed independently at least seven times across South America since insecticide use began in the mid-20th century.

In French Guiana, a different set of P450 genes exhibits a similar evolutionary pattern, cementing the clear connection between these enzymes and adaptation. Moreover, when we exposed mosquitoes to pyrethroids in sealed bottles, differences among the P450 genes of individual mosquitoes were linked to the length of time they stayed alive.

Insecticide-heavy campaigns against malaria have been only sporadic in South America and may not be the main driver behind this evolution. Instead, it’s possible that mosquitoes are being exposed indirectly to agricultural insecticides. Intriguingly, we saw the strongest signs of evolution in places where farming is prevalent.

Toward more sophisticated vector control

Despite new vaccines and other recent advances against malaria, mosquito control remains essential for reducing disease.

Some countries are launching trials of gene drives to control malaria, which involve forcing a genetic modification into a mosquito population to reduce their numbers or their tolerance for Plasmodium. Such prospects are exciting, though the relentless adaptability of mosquitoes could be an obstacle.

I and others are revising methods to efficiently test for emerging insecticide resistance. Genome-scale sequencing remains important to detect new or unexpected evolutionary responses. The risk of adaptation is highest under a continuous, strong selection pressure, so minimizing, switching and staggering pesticides can help thwart resistance.

Success in the fight against evolving resistance will require a coordinated effort of monitoring, and reacting accordingly. Unlike evolution, humans can think ahead.

Jacob A Tennessen, Research Scientist in Immunology and Infectious Diseases, Harvard University

This article is republished from The Conversation under a Creative Commons license. Read the original article.

Advertisement

The science section of our news blog STM Daily News provides readers with captivating and up-to-date information on the latest scientific discoveries, breakthroughs, and innovations across various fields. We offer engaging and accessible content, ensuring that readers with different levels of scientific knowledge can stay informed. Whether it’s exploring advancements in medicine, astronomy, technology, or environmental sciences, our science section strives to shed light on the intriguing world of scientific exploration and its profound impact on our daily lives. From thought-provoking articles to informative interviews with experts in the field, STM Daily News Science offers a harmonious blend of factual reporting, analysis, and exploration, making it a go-to source for science enthusiasts and curious minds alike. https://stmdailynews.com/category/science/

Last Updated on April 12, 2026 by Daily News Staff

Today, we’re undertaking important site maintenance to improve the performance and user experience of the Sleeves SPR Store while completing the merger with STM-STORE.

This transition marks a key step in streamlining our online shopping experience—bringing all merchandise under one unified platform. Our goal is to deliver a faster, more reliable, and more seamless store for our community.

What to Expect During Maintenance

As we work through this upgrade and integration process, visitors may notice:

• Temporary downtime on both Sleeves SPR Store and STM-STORE
• Intermittent access interruptions
• Ongoing updates and improvements behind the scenes

We understand that downtime can be inconvenient, and we appreciate your patience as we complete these upgrades.

Staying Informed

We’ll continue to keep you updated on our progress and notify you as key milestones are reached. Our team is working to complete this transition as efficiently as possible while ensuring everything runs smoothly once fully launched.

Thank You for Your Support

We’re grateful for your continued support as we improve and grow. This merger represents an exciting step forward, and we look forward to delivering an enhanced shopping experience very soon.

Stay tuned for updates.

Source

• STM Daily News
• Sleeves Senior Pickleball Report

Last Updated on April 11, 2026 by Daily News Staff

Mike Sori, Purdue University

On Oct. 14, 2024, NASA launched a robotic spacecraft named Europa Clipper to Jupiter’s moons. Clipper will reach the ice-covered Jovian moon Europa in 2030 and spend several years collecting and sending valuable data on the moon’s potential habitability back to Earth.

Clipper isn’t the only mission highlighting researchers’ interest in Jupiter and its moons.

On April 13, 2023, the European Space Agency launched a rocket carrying a spacecraft destined for Jupiter. The Jupiter Icy Moons Explorer – or JUICE – will spend at least three years on Jupiter’s moons after it arrives in 2031.

I’m a planetary scientist who studies the structure and evolution of solid planets and moons in the solar system.

There are many reasons my colleagues and I are looking forward to getting the data that Europa Clipper and JUICE will hopefully be sending back to Earth in the 2030s. But perhaps the most exciting information will have to do with water. Three of Jupiter’s moons – Europa, Ganymede and Callisto – are home to large, underground oceans of liquid water that could support life.

Meet Io, Europa, Ganymede and Callisto

Jupiter has dozens of moons. Four of them in particular are of interest to planetary scientists.

Io, Europa, Ganymede and Callisto are, like Earth’s Moon, relatively large, spherical complex worlds. Two previous NASA missions have sent spacecraft to orbit the Jupiter system and collected data on these moons. The Galileo mission orbited Jupiter from 1995 to 2003 and led to geological discoveries on all four large moons. The Juno mission is still orbiting Jupiter today and has provided scientists with an unprecedented view into Jupiter’s composition, structure and space environment.

These missions and other observations revealed that Io, the closest of the four to its host planet, is abuzz with geological activity, including lava lakes, volcanic eruptions and tectonically formed mountains. But it is not home to large amounts of water.

Europa, Ganymede and Callisto, in contrast, have icy landscapes. Europa’s surface is a frozen wonderland with a young but complex history, possibly including icy analogs of plate tectonics and volcanoes. Ganymede, the largest moon in the entire solar system, is bigger than Mercury and has its own magnetic field generated internally from a liquid metal core. Callisto appears somewhat inert compared to the others, but serves as a valuable time capsule of an ancient past that is no longer accessible on the youthful surfaces of Europa and Io.

Most exciting of all: Europa, Ganymede and Callisto all almost certainly possess underground oceans of liquid water.

Advertisement

Ocean worlds

Europa, Ganymede and Callisto have chilly surfaces that are hundreds of degrees below zero. At these temperatures, ice behaves like solid rock.

But just like Earth, the deeper underground you go on these moons, the hotter it gets. Go down far enough and you eventually reach the temperature where ice melts into water. Exactly how far down this transition occurs on each of the moons is a subject of debate that scientists hope to resolve with JUICE and Europa Clipper. While the exact depths are still uncertain, scientists are confident that these oceans exist.

The best evidence of these oceans comes from Jupiter’s magnetic field. Saltwater is electrically conductive. So as these moons travel through Jupiter’s magnetic field, they generate a secondary, smaller magnetic field that signals to researchers the presence of an underground ocean. Using this technique, planetary scientists have been able to show that the three moons contain underground oceans. And these oceans are not small – Europa’s ocean alone might have more than double the water of all of Earth’s oceans combined.

An obvious and tantalizing next question is whether these oceans can support extraterrestrial life. Liquid water is an important piece of what makes for a habitable world, but far from the only requirement for life. Life also needs energy and certain chemical compounds in addition to water to flourish. Because these oceans are hidden beneath miles of solid ice, sunlight and photosynthesis are out. But it’s possible other sources could provide the needed ingredients.

On Europa, for example, the liquid water ocean overlays a rocky interior. That rocky seafloor could provide energy and chemicals through underwater volcanoes that could make Europa’s ocean habitable. But it is also possible that Europa’s ocean is a sterile, inhospitable place – scientists need more data to answer these questions.

Upcoming missions from ESA and NASA

Europa Clipper and JUICE are set up to give scientists game-changing information about the potential habitability of Jupiter’s moons. While both missions will gather data on multiple moons, JUICE will spend time orbiting and focusing on Ganymede, and Europa Clipper will make dozens of close flybys of Europa.

Both of the spacecraft will carry a suite of scientific instruments built specifically to investigate the oceans. Onboard radar will allow Europa Clipper and JUICE to probe into the moons’ outer layers of solid ice. Radar could reveal any small pockets of liquid water in the ice, or, in the case of Europa, which has a thinner outer ice layer than Ganymede and Callisto, hopefully detect the larger ocean.

Magnetometers will also be on both missions. These tools will give scientists the opportunity to study the secondary magnetic fields produced by the interaction of conductive oceans with Jupiter’s field in great detail and will hopefully give researchers clues to salinity and volumes of the oceans.

Scientists will also observe small variations in the moons’ gravitational pulls by tracking subtle movements in both spacecrafts’ orbits, which could help determine if Europa’s seafloor has volcanoes that provide the needed energy and chemistry for the ocean to support life.

Finally, both craft will carry a host of cameras and light sensors that will provide unprecedented images of the geology and composition of the moons’ icy surfaces.

Maybe one day, a spacecraft will be able to drill through the miles of solid ice on Europa, Ganymede or Callisto and explore oceans directly. Until then, observations from spacecraft like Europa Clipper and JUICE are scientists’ best bet for learning about these ocean worlds.

When Galileo discovered these moons in 1609, they were the first objects known to directly orbit another planet. Their discovery was the final nail in the coffin of the theory that Earth – and humanity – resides at the center of the universe. Maybe these worlds have another humbling surprise in store.

Advertisement

This article, originally published April 10, 2023, has been updated with details about the Europa Clipper launch.

Mike Sori, Assistant Professor of Planetary Science, Purdue University

This article is republished from The Conversation under a Creative Commons license. Read the original article.

The science section of our news blog STM Daily News provides readers with captivating and up-to-date information on the latest scientific discoveries, breakthroughs, and innovations across various fields. We offer engaging and accessible content, ensuring that readers with different levels of scientific knowledge can stay informed. Whether it’s exploring advancements in medicine, astronomy, technology, or environmental sciences, our science section strives to shed light on the intriguing world of scientific exploration and its profound impact on our daily lives. From thought-provoking articles to informative interviews with experts in the field, STM Daily News Science offers a harmonious blend of factual reporting, analysis, and exploration, making it a go-to source for science enthusiasts and curious minds alike. https://stmdailynews.com/category/science/